Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 89255957

GI number: 89255957

Start: 535007

End: 535870

Strand: Direct

Name: lepB [H]

Synonym: FTL_0553

Alternate gene names: 89255957

Gene position: 535007-535870 (Clockwise)

Preceding gene: 89255956

Following gene: 89255958

Centisome position: 28.22

GC content: 32.75

Gene sequence:

>864_bases
ATGGAAATCTTAAACTATATTTTAAACTTGAGCTTTACTTTTTGGCTTTTATTCTTAACCATTGCCAGTGGTTTAATTTA
TATTATTGATTTTGTGTTCTTCCAAAAATCAAGATTAGCAGCATATACAGATGAATTAAAAGGTCTTTCTAAGAAGCAAA
AACGTCAGTTCTATAAAGATAGAGGATTAAAAGCACCTTTTATTGCTGATCAGGCGAGATCTTTATTTAGTGTATTTTTT
GTAGTTTTTCTACTTAGAACCTTCTTGATTGGTAATTTTTTAATTCCAACTGCATCAATGACACCAACACTTCCAGTTGG
TGATTTTATTTTTGTCAATAAAACTGCTTATGGTATCAGAGCACCATTTACCAATGAGACTTTAATAAAAGTTGGTGAAC
CCAAAAGAGGTGATATTGTAGTATTTCATTTTCCAGTTAATCCTAATGTTGATTTTGTAAAACGAGTGATCGGTTTGCCT
GGCGATGTAATTTCGTATAAAGACAAAATGTTGACAATAAATGGTAAAAAACTTGAATATACTAATTGTAATCGTGATGC
AATGAACTATTATAATCAGTCTTTAGCTGCTGGTAGTGGCGATACAGTATGTACGGAAAACCTTGATGGAGTTAAACATG
AGGTTGATTGGATAGAGTCTATAAAGGGAACTGATTTTGAAAACCTTAAAGTCCCAGCAGGTCAATACTTTGTCATGGGA
GATAATCGTGATAATAGTGAAGATAGTCGTTATTGGGGTTTTGTACCTGACAAAGATCTAGTTGGTAAAGCAAAAGTTGT
TTGGATGAGCTGGGATAAGATAGATAAAAAGGTTCGCTGGGATGAAATTGGTAAGGTCTTTTAA

Upstream 100 bases:

>100_bases
ATGCATAATTTAAGAAAGAAAATTAACATTCCTAATTTTATACAGACTATTAGAGGTGTTGGTTACTTTGTACAAAAGGA
TAAAGTAATTAAGTAACTTC

Downstream 100 bases:

>100_bases
TTAAAAATGGTTCCTGAATATTCACGATTTTATAACATTCTTGGATATAATTTCAAAGATTATACTCTTCTCATAAGAGC
CTTAACTCATCGAAGTAAGA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MEILNYILNLSFTFWLLFLTIASGLIYIIDFVFFQKSRLAAYTDELKGLSKKQKRQFYKDRGLKAPFIADQARSLFSVFF
VVFLLRTFLIGNFLIPTASMTPTLPVGDFIFVNKTAYGIRAPFTNETLIKVGEPKRGDIVVFHFPVNPNVDFVKRVIGLP
GDVISYKDKMLTINGKKLEYTNCNRDAMNYYNQSLAAGSGDTVCTENLDGVKHEVDWIESIKGTDFENLKVPAGQYFVMG
DNRDNSEDSRYWGFVPDKDLVGKAKVVWMSWDKIDKKVRWDEIGKVF

Sequences:

>Translated_287_residues
MEILNYILNLSFTFWLLFLTIASGLIYIIDFVFFQKSRLAAYTDELKGLSKKQKRQFYKDRGLKAPFIADQARSLFSVFF
VVFLLRTFLIGNFLIPTASMTPTLPVGDFIFVNKTAYGIRAPFTNETLIKVGEPKRGDIVVFHFPVNPNVDFVKRVIGLP
GDVISYKDKMLTINGKKLEYTNCNRDAMNYYNQSLAAGSGDTVCTENLDGVKHEVDWIESIKGTDFENLKVPAGQYFVMG
DNRDNSEDSRYWGFVPDKDLVGKAKVVWMSWDKIDKKVRWDEIGKVF
>Mature_287_residues
MEILNYILNLSFTFWLLFLTIASGLIYIIDFVFFQKSRLAAYTDELKGLSKKQKRQFYKDRGLKAPFIADQARSLFSVFF
VVFLLRTFLIGNFLIPTASMTPTLPVGDFIFVNKTAYGIRAPFTNETLIKVGEPKRGDIVVFHFPVNPNVDFVKRVIGLP
GDVISYKDKMLTINGKKLEYTNCNRDAMNYYNQSLAAGSGDTVCTENLDGVKHEVDWIESIKGTDFENLKVPAGQYFVMG
DNRDNSEDSRYWGFVPDKDLVGKAKVVWMSWDKIDKKVRWDEIGKVF

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=320, Percent_Identity=34.6875, Blast_Score=176, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 32866; Mature: 32866

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3 ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILNYILNLSFTFWLLFLTIASGLIYIIDFVFFQKSRLAAYTDELKGLSKKQKRQFYKD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RGLKAPFIADQARSLFSVFFVVFLLRTFLIGNFLIPTASMTPTLPVGDFIFVNKTAYGIR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEECCCCEEE
APFTNETLIKVGEPKRGDIVVFHFPVNPNVDFVKRVIGLPGDVISYKDKMLTINGKKLEY
CCCCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCEEEE
TNCNRDAMNYYNQSLAAGSGDTVCTENLDGVKHEVDWIESIKGTDFENLKVPAGQYFVMG
CCCCHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCEECCCCCEEEEE
DNRDNSEDSRYWGFVPDKDLVGKAKVVWMSWDKIDKKVRWDEIGKVF
CCCCCCCCCCEECCCCCCCCCCCEEEEEEEHHHHHHHCCHHHHCCCC
>Mature Secondary Structure
MEILNYILNLSFTFWLLFLTIASGLIYIIDFVFFQKSRLAAYTDELKGLSKKQKRQFYKD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RGLKAPFIADQARSLFSVFFVVFLLRTFLIGNFLIPTASMTPTLPVGDFIFVNKTAYGIR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEECCCCEEE
APFTNETLIKVGEPKRGDIVVFHFPVNPNVDFVKRVIGLPGDVISYKDKMLTINGKKLEY
CCCCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCEEEE
TNCNRDAMNYYNQSLAAGSGDTVCTENLDGVKHEVDWIESIKGTDFENLKVPAGQYFVMG
CCCCHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCEECCCCCEEEEE
DNRDNSEDSRYWGFVPDKDLVGKAKVVWMSWDKIDKKVRWDEIGKVF
CCCCCCCCCCEECCCCCCCCCCCEEEEEEEHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]