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The map label for this gene is lpxH [H]

Identifier: 89255913

GI number: 89255913

Start: 490499

End: 491215

Strand: Reverse

Name: lpxH [H]

Synonym: FTL_0506

Alternate gene names: 89255913

Gene position: 491215-490499 (Counterclockwise)

Preceding gene: 89255914

Following gene: 89255904

Centisome position: 25.91

GC content: 31.1

Gene sequence:

>717_bases
ATGGCTCATAATAAAGATATTTATCTAATTTCGGATCTTCATCTAAACGCTAATCATGCTGAGATGGCTGATCTTTTTAA
AAAGTTTTTAGATAGCATTACATCTACACAAAACCAGCTTTTTATTCTTGGTGACTTTTTTGATTATTGGATCGGTGATA
ATCACAGAGATGACTTTTATCATAAAATCACAAATTGGCTAAAAGAAGCTTCAGATCAAGGTTTAGAAATATTTTTCATG
TATGGAAATCGTGATTTTTTGATTGGCAGAAAATTTGCTAAACAAAGTGGCGTGACTTTAATTAAAGATCCATACTATAT
AGATATCTCTAAGCAAAAAATACTTTTCTCGCATGGAGATCTATTTTGTACAGATGATAAGAGTTACCAAATTTACAGAA
AATGGATAGCATACAACCCTATCCTTAGATTTATTTTTAGAAGATTACCTTTATTTATTAGAGAATACACCGCGAGAAAT
GTGCGCAAAGCAAGTTATGTAAAAAACCGTAAAAATCCGAATGTTGATGTAACAACTAAAGGCATTGAAAAATATCGCAA
AGACTGTGACATTATCATTCATGGTCATACGCATAAAATGGCTGTACATATAGCTGATAACTATACTAGATATGTACTTG
GCGACTGGTTCAAAGATGGTAACTATATAAAAATCTCAAAAAATGGTGAGATTATGCAGGTTAGAACTCTAAACTAA

Upstream 100 bases:

>100_bases
CCTGTTCTAGCAGTAACTAACTTTGAAAGTATTTTTGAGTATGTCAAAGAAAATCTTGATGAAACAATGATCGATAAATT
TAAACAGTACCGTCAAAAAT

Downstream 100 bases:

>100_bases
AAACATTTTTATCAATTTAATACTTTCTAACAATTTCATCATAAAGCTCAGGGCGACGATCCCTAAATAATCCCCAATAA
AACCTTTGCTGCTGTAGTTC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MAHNKDIYLISDLHLNANHAEMADLFKKFLDSITSTQNQLFILGDFFDYWIGDNHRDDFYHKITNWLKEASDQGLEIFFM
YGNRDFLIGRKFAKQSGVTLIKDPYYIDISKQKILFSHGDLFCTDDKSYQIYRKWIAYNPILRFIFRRLPLFIREYTARN
VRKASYVKNRKNPNVDVTTKGIEKYRKDCDIIIHGHTHKMAVHIADNYTRYVLGDWFKDGNYIKISKNGEIMQVRTLN

Sequences:

>Translated_238_residues
MAHNKDIYLISDLHLNANHAEMADLFKKFLDSITSTQNQLFILGDFFDYWIGDNHRDDFYHKITNWLKEASDQGLEIFFM
YGNRDFLIGRKFAKQSGVTLIKDPYYIDISKQKILFSHGDLFCTDDKSYQIYRKWIAYNPILRFIFRRLPLFIREYTARN
VRKASYVKNRKNPNVDVTTKGIEKYRKDCDIIIHGHTHKMAVHIADNYTRYVLGDWFKDGNYIKISKNGEIMQVRTLN
>Mature_237_residues
AHNKDIYLISDLHLNANHAEMADLFKKFLDSITSTQNQLFILGDFFDYWIGDNHRDDFYHKITNWLKEASDQGLEIFFMY
GNRDFLIGRKFAKQSGVTLIKDPYYIDISKQKILFSHGDLFCTDDKSYQIYRKWIAYNPILRFIFRRLPLFIREYTARNV
RKASYVKNRKNPNVDVTTKGIEKYRKDCDIIIHGHTHKMAVHIADNYTRYVLGDWFKDGNYIKISKNGEIMQVRTLN

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=229, Percent_Identity=35.3711790393013, Blast_Score=160, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 28332; Mature: 28201

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHNKDIYLISDLHLNANHAEMADLFKKFLDSITSTQNQLFILGDFFDYWIGDNHRDDFY
CCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCCCHHHH
HKITNWLKEASDQGLEIFFMYGNRDFLIGRKFAKQSGVTLIKDPYYIDISKQKILFSHGD
HHHHHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHCCCEEEECCEEEEECCCEEEEECCC
LFCTDDKSYQIYRKWIAYNPILRFIFRRLPLFIREYTARNVRKASYVKNRKNPNVDVTTK
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
GIEKYRKDCDIIIHGHTHKMAVHIADNYTRYVLGDWFKDGNYIKISKNGEIMQVRTLN
HHHHHCCCCEEEEECCCEEEEEEEECCCEEEEEEHEECCCCEEEEECCCCEEEEEECC
>Mature Secondary Structure 
AHNKDIYLISDLHLNANHAEMADLFKKFLDSITSTQNQLFILGDFFDYWIGDNHRDDFY
CCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCCCHHHH
HKITNWLKEASDQGLEIFFMYGNRDFLIGRKFAKQSGVTLIKDPYYIDISKQKILFSHGD
HHHHHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHCCCEEEECCEEEEECCCEEEEECCC
LFCTDDKSYQIYRKWIAYNPILRFIFRRLPLFIREYTARNVRKASYVKNRKNPNVDVTTK
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
GIEKYRKDCDIIIHGHTHKMAVHIADNYTRYVLGDWFKDGNYIKISKNGEIMQVRTLN
HHHHHCCCCEEEEECCCEEEEEEEECCCEEEEEEHEECCCCEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA