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The map label for this gene is hpt [H]

Identifier: 89054721

GI number: 89054721

Start: 2235994

End: 2236533

Strand: Reverse

Name: hpt [H]

Synonym: Jann_2230

Alternate gene names: 89054721

Gene position: 2236533-2235994 (Counterclockwise)

Preceding gene: 89054723

Following gene: 89054720

Centisome position: 51.8

GC content: 58.89

Gene sequence:

>540_bases
ATGGCGCAGCAAGGCTACACGGTCGAGCAGATGATCTCGGCCAAATCCATCGCCGCGCGCATTGAAGAGCTGTGCCGAGA
GATCGAGGTCGACTATGCCGACACCTCCAAACTGGTCGTGGTGGGGCTGTTGCGCGGGTCGTTCGTGTTCATCGCCGATC
TGGTGCGGGAGCTGGACCTGCCGGTGGAGGTCGATTTTTTGGAAGCCTCCAGCTATGGCAATGAGATGGAAAGCTCCCGC
GAGGTGCGCATTCTCAAGGATTTGCGGGGCGAGATACAGGGACGTGACGTGCTGGTCGTGGAGGACATCGTCGATACCGG
CCACACGCTGACCCATGTCGTGGCCCTGCTCAATCAACGCAAGCCCAACCGGCTGAAAACAATTGCTCTTCTCAACAAGA
AGATCCGCCGCGAGGTGGAGATCGAGGCCGATTGGGTCGGATTCGAGATTCCCGACGAATTCGTCGTGGGTTATGGCATC
GACTACGCACAGCGGAACCGGAACCTGCCGTTCATTGGCAAGGTGACGATGCCAGCCTGA

Upstream 100 bases:

>100_bases
GGAATGGTTTGGCACGGGGGCCCTTTCGCCTTTTACGTTTGCGCCTCATGTCATAAAAGAAACGCGGAAATTCAAGGCAC
CACGCGGATTTGGGGGCGAA

Downstream 100 bases:

>100_bases
GGCGGTCGCGCGCCCCGCATTCGCGCAGACCCGCCCACGCATCGGCGCACCGAAGCTTCATTTGACACGGTGTCGCCGCC
CGCTAACGTGGAAGGACACG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MAQQGYTVEQMISAKSIAARIEELCREIEVDYADTSKLVVVGLLRGSFVFIADLVRELDLPVEVDFLEASSYGNEMESSR
EVRILKDLRGEIQGRDVLVVEDIVDTGHTLTHVVALLNQRKPNRLKTIALLNKKIRREVEIEADWVGFEIPDEFVVGYGI
DYAQRNRNLPFIGKVTMPA

Sequences:

>Translated_179_residues
MAQQGYTVEQMISAKSIAARIEELCREIEVDYADTSKLVVVGLLRGSFVFIADLVRELDLPVEVDFLEASSYGNEMESSR
EVRILKDLRGEIQGRDVLVVEDIVDTGHTLTHVVALLNQRKPNRLKTIALLNKKIRREVEIEADWVGFEIPDEFVVGYGI
DYAQRNRNLPFIGKVTMPA
>Mature_178_residues
AQQGYTVEQMISAKSIAARIEELCREIEVDYADTSKLVVVGLLRGSFVFIADLVRELDLPVEVDFLEASSYGNEMESSRE
VRILKDLRGEIQGRDVLVVEDIVDTGHTLTHVVALLNQRKPNRLKTIALLNKKIRREVEIEADWVGFEIPDEFVVGYGID
YAQRNRNLPFIGKVTMPA

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=163, Percent_Identity=36.8098159509202, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI9910262, Length=172, Percent_Identity=36.046511627907, Blast_Score=98, Evalue=4e-21,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=56.6473988439306, Blast_Score=196, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17510817, Length=168, Percent_Identity=36.3095238095238, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20250; Mature: 20118

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQGYTVEQMISAKSIAARIEELCREIEVDYADTSKLVVVGLLRGSFVFIADLVRELDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHHHHCCC
PVEVDFLEASSYGNEMESSREVRILKDLRGEIQGRDVLVVEDIVDTGHTLTHVVALLNQR
CEEEEEEECCCCCCHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHHHHCC
KPNRLKTIALLNKKIRREVEIEADWVGFEIPDEFVVGYGIDYAQRNRNLPFIGKVTMPA
CCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHEEECCCCHHHHCCCCCEEEEECCCC
>Mature Secondary Structure 
AQQGYTVEQMISAKSIAARIEELCREIEVDYADTSKLVVVGLLRGSFVFIADLVRELDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHHHHCCC
PVEVDFLEASSYGNEMESSREVRILKDLRGEIQGRDVLVVEDIVDTGHTLTHVVALLNQR
CEEEEEEECCCCCCHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHHHHCC
KPNRLKTIALLNKKIRREVEIEADWVGFEIPDEFVVGYGIDYAQRNRNLPFIGKVTMPA
CCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHEEECCCCHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756169 [H]