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The map label for this gene is guaA

Identifier: 89054712

GI number: 89054712

Start: 2226150

End: 2227757

Strand: Reverse

Name: guaA

Synonym: Jann_2221

Alternate gene names: 89054712

Gene position: 2227757-2226150 (Counterclockwise)

Preceding gene: 89054713

Following gene: 89054711

Centisome position: 51.59

GC content: 62.13

Gene sequence:

>1608_bases
ATGAACACTGCCGCCGTCCCAACTGCCGATGAACTTGGCCCCGCCCATCACGAACGCCTGTTGATCATCGACTTCGGGTC
GCAGGTCACGCAACTAATTGCCCGCCGCCTGCGCGAATTGAACGTCTATTGCGAAATCCACCCCTACCAGAACGTCGATG
ACGCCTTTATCGGGGACTTTGCCCCCAAGGCGATCATCTTCTCGGGCGGGCCGGATTCGGTCACACGGGATGGCTCTCCC
CGCCCTCCACAGGCGGCCTATGCGGCGGGCGTGCCGATCCTGGGGATCTGCTATGGGCAGCAAGTCATGATGCAGGACCT
CGGCGGAGAGGTGCATGGCGGCAAGATCTCGGGCGGCGGAGGCACGGCAGAGTTCGGACGGGCCTTTGTGGAACCCACGG
GCGCATTGGCGTTGTTGCAGGGCTGGTTTGCGGATGGCAAGGAACAGGTCTGGATGAGCCACGGCGACCACGTCGCGAAA
CTGGCGCCCGGATTTGAGGTCTACGGCACCTCCCCCAACGCGCCCTATGCGATCACGGCGGATCTTGAGCGGAATTTCTT
CGCCGTCCAGTTCCATCCCGAGGTCCATCACACCCCGCGCGGCGCCATGCTGTATGAGAATTTTGTGAAACTAGCGGGTT
TCTCCGGCGACTGGACCATGGGTGCCTACCGCGAACAGGCGGTGGAGGCGATCCGTGCGCAGGTGGGCGATGCAAAGGTC
ATCTGCGCGCTGTCGGGCGGGGTCGATTCGTCGGTGACCGCAGCGCTTCTACACGAGGCCATCGGCGATCAGCTGACCTG
CGTCTTCGTGGATCACGGCTTGTTGCGCCTGAATGAGGGGGCAGAGGTCGTGGAGATGTTCCGCGATCACATGAACCTCC
ACGTGATCCATGCCGAGGAGCAGGACCTGTTTCTGGGCGAGCTGGACGGCGTGTCCGACCCGGAAACCAAGCGCAAGATT
ATCGGACGCTTGTTCATCGATGTGTTCCAGAAATATGCGGGCCAGATCGAGGGCGCGGATTTCCTCGCCCAGGGCACGCT
TTACCCGGATGTCATTGAAAGCGTGAGCTTTTCCGGCGGTCCCAGCGTAACGATCAAGTCGCACCATAACGTCGGTGGCC
TGCCCGAGAAGATGGGTTTGACGCTGGTGGAACCCCTGCGCGAATTGTTCAAGGATGAGGTCCGCGCCCTGGGTCGTGAG
TTGGGCCTGCCCGCCCATTTCATCGCCCGCCACCCCTTTCCCGGCCCCGGCCTCGCCATCCGTTGCCCGGGTGAGATCAC
GCGCGCGAAACTGGATATCCTGCGCCAGGCCGACGCGGTCTACATCGACCAGATCCGCCGCCACGGCCTTTATGATGAGA
TCTGGCAGGCCTTCGTCGCGATTCTGCCGGTGCGCACCGTCGGTGTTATGGGCGATGGCCGCACCTATGATTACGCCTGT
GCCCTGCGCGCCGTGACCTCCGTCGATGGGATGACGGCCGACTACTACCCGTTCAGCCACGATTTTCTGGGTGAAACGGC
GACCCGCATTATTAATGAGGTGCCCGGTATCAACCGCGTGACCTATGACATCACCTCCAAACCGCCGGGCACCATTGAGT
GGGAGTGA

Upstream 100 bases:

>100_bases
AGACATGGACGAGTTGCGCGCGGCGTTGGCGAAGGCCGGCGTGACCTGAACCGTCACGCCGCTCTTGCACGGAAAGCCCC
GTGGCCGTACTCCGTCTTCC

Downstream 100 bases:

>100_bases
CCGTTATCACGCTAGAGCACTCCGCAGCCCTCTGACTTCCGCTCTAAGAAACTGTTTCTAAAGCTCATGCTGGTCGCTGG
GCATGCCATTCCATCCGTTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MNTAAVPTADELGPAHHERLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVDDAFIGDFAPKAIIFSGGPDSVTRDGSP
RPPQAAYAAGVPILGICYGQQVMMQDLGGEVHGGKISGGGGTAEFGRAFVEPTGALALLQGWFADGKEQVWMSHGDHVAK
LAPGFEVYGTSPNAPYAITADLERNFFAVQFHPEVHHTPRGAMLYENFVKLAGFSGDWTMGAYREQAVEAIRAQVGDAKV
ICALSGGVDSSVTAALLHEAIGDQLTCVFVDHGLLRLNEGAEVVEMFRDHMNLHVIHAEEQDLFLGELDGVSDPETKRKI
IGRLFIDVFQKYAGQIEGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLTLVEPLRELFKDEVRALGRE
LGLPAHFIARHPFPGPGLAIRCPGEITRAKLDILRQADAVYIDQIRRHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYAC
ALRAVTSVDGMTADYYPFSHDFLGETATRIINEVPGINRVTYDITSKPPGTIEWE

Sequences:

>Translated_535_residues
MNTAAVPTADELGPAHHERLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVDDAFIGDFAPKAIIFSGGPDSVTRDGSP
RPPQAAYAAGVPILGICYGQQVMMQDLGGEVHGGKISGGGGTAEFGRAFVEPTGALALLQGWFADGKEQVWMSHGDHVAK
LAPGFEVYGTSPNAPYAITADLERNFFAVQFHPEVHHTPRGAMLYENFVKLAGFSGDWTMGAYREQAVEAIRAQVGDAKV
ICALSGGVDSSVTAALLHEAIGDQLTCVFVDHGLLRLNEGAEVVEMFRDHMNLHVIHAEEQDLFLGELDGVSDPETKRKI
IGRLFIDVFQKYAGQIEGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLTLVEPLRELFKDEVRALGRE
LGLPAHFIARHPFPGPGLAIRCPGEITRAKLDILRQADAVYIDQIRRHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYAC
ALRAVTSVDGMTADYYPFSHDFLGETATRIINEVPGINRVTYDITSKPPGTIEWE
>Mature_535_residues
MNTAAVPTADELGPAHHERLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVDDAFIGDFAPKAIIFSGGPDSVTRDGSP
RPPQAAYAAGVPILGICYGQQVMMQDLGGEVHGGKISGGGGTAEFGRAFVEPTGALALLQGWFADGKEQVWMSHGDHVAK
LAPGFEVYGTSPNAPYAITADLERNFFAVQFHPEVHHTPRGAMLYENFVKLAGFSGDWTMGAYREQAVEAIRAQVGDAKV
ICALSGGVDSSVTAALLHEAIGDQLTCVFVDHGLLRLNEGAEVVEMFRDHMNLHVIHAEEQDLFLGELDGVSDPETKRKI
IGRLFIDVFQKYAGQIEGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLTLVEPLRELFKDEVRALGRE
LGLPAHFIARHPFPGPGLAIRCPGEITRAKLDILRQADAVYIDQIRRHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYAC
ALRAVTSVDGMTADYYPFSHDFLGETATRIINEVPGINRVTYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=564, Percent_Identity=34.7517730496454, Blast_Score=266, Evalue=4e-71,
Organism=Escherichia coli, GI1788854, Length=527, Percent_Identity=53.8899430740038, Blast_Score=564, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=35.6896551724138, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=35.6896551724138, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=35.6896551724138, Blast_Score=277, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=48.9563567362429, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=32.5581395348837, Blast_Score=248, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58279; Mature: 58279

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAAVPTADELGPAHHERLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVDDAFIGDF
CCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHCCC
APKAIIFSGGPDSVTRDGSPRPPQAAYAAGVPILGICYGQQVMMQDLGGEVHGGKISGGG
CCCEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEEHHCHHHHHHHCCCCCCCCEECCCC
GTAEFGRAFVEPTGALALLQGWFADGKEQVWMSHGDHVAKLAPGFEVYGTSPNAPYAITA
CCHHHHHHHHCCCHHHHHHHHHHCCCCHHEECCCCCCHHHHCCCCEEECCCCCCCEEEEE
DLERNFFAVQFHPEVHHTPRGAMLYENFVKLAGFSGDWTMGAYREQAVEAIRAQVGDAKV
ECCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
ICALSGGVDSSVTAALLHEAIGDQLTCVFVDHGLLRLNEGAEVVEMFRDHMNLHVIHAEE
EEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHCCCEEEEEECC
QDLFLGELDGVSDPETKRKIIGRLFIDVFQKYAGQIEGADFLAQGTLYPDVIESVSFSGG
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHCCCCCC
PSVTIKSHHNVGGLPEKMGLTLVEPLRELFKDEVRALGRELGLPAHFIARHPFPGPGLAI
CEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEE
RCPGEITRAKLDILRQADAVYIDQIRRHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYAC
ECCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHH
ALRAVTSVDGMTADYYPFSHDFLGETATRIINEVPGINRVTYDITSKPPGTIEWE
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNTAAVPTADELGPAHHERLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVDDAFIGDF
CCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHCCC
APKAIIFSGGPDSVTRDGSPRPPQAAYAAGVPILGICYGQQVMMQDLGGEVHGGKISGGG
CCCEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEEHHCHHHHHHHCCCCCCCCEECCCC
GTAEFGRAFVEPTGALALLQGWFADGKEQVWMSHGDHVAKLAPGFEVYGTSPNAPYAITA
CCHHHHHHHHCCCHHHHHHHHHHCCCCHHEECCCCCCHHHHCCCCEEECCCCCCCEEEEE
DLERNFFAVQFHPEVHHTPRGAMLYENFVKLAGFSGDWTMGAYREQAVEAIRAQVGDAKV
ECCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
ICALSGGVDSSVTAALLHEAIGDQLTCVFVDHGLLRLNEGAEVVEMFRDHMNLHVIHAEE
EEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHCCCEEEEEECC
QDLFLGELDGVSDPETKRKIIGRLFIDVFQKYAGQIEGADFLAQGTLYPDVIESVSFSGG
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHCCCCCC
PSVTIKSHHNVGGLPEKMGLTLVEPLRELFKDEVRALGRELGLPAHFIARHPFPGPGLAI
CEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEE
RCPGEITRAKLDILRQADAVYIDQIRRHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYAC
ECCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHH
ALRAVTSVDGMTADYYPFSHDFLGETATRIINEVPGINRVTYDITSKPPGTIEWE
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA