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The map label for this gene is msrA2 [H]

Identifier: 89054633

GI number: 89054633

Start: 2150255

End: 2150764

Strand: Reverse

Name: msrA2 [H]

Synonym: Jann_2142

Alternate gene names: 89054633

Gene position: 2150764-2150255 (Counterclockwise)

Preceding gene: 89054634

Following gene: 89054623

Centisome position: 49.81

GC content: 59.41

Gene sequence:

>510_bases
ATGACGGAACGTGCAGTTTTGGCGGGCGGTTGCTTTTGGGGCATGCAGGATCTGATCCGCAAAATGCCCGGAGTTGAGGC
CACGCGCGTGGGTTACACGGGCGGTGATGTGCCCAATGCCACCTATCGCAATCACGGCACCCATGCGGAGGGGATCGAGA
TCCTGTTTGATCCGGCCCGCATCAGCTATCGCCAGATTCTGGAGTTCTTTTTCCAGATCCACGATCCGACCACACCAAAC
CGCCAGGGCAATGACCGGGGCATGAGCTACCGCAGCGCCATCTATTATGTGGACGATGCGCAAAAAGCTGTTGCCGAGGA
TACGATTGCCGATGTGAACGCGTCCGGTCTTTGGCCCGGTGCCGTGGTGACCGAGGTGGAGCCCGCGGGTCCGTTCTGGG
ACGCCGAGCCCGAGCATCAGGATTATCTGGAGCGTATTCCTAACGGGTATACCTGCCATTTCGTGCGCCCGGACTGGGTG
CTTCCGAAACGATCAACCGCAGCGGAGTAA

Upstream 100 bases:

>100_bases
TGCGGTATTGCATCAACTCCGCCTCACTGCGGTTCGTGCATCGCGACGACATGGAAAACGAAGGCTATGGGGCGTATGTT
GATCAAGTGGAGGACGTGGC

Downstream 100 bases:

>100_bases
CCTATGGCCATTCGACTGATCGCCACCGCAATCCTGATGGGCGCGTCCTATTTCGCCGGCAAAGCGGCCGCGAAACGGGA
AGAGACGGAGAGCGGTGAAG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MTERAVLAGGCFWGMQDLIRKMPGVEATRVGYTGGDVPNATYRNHGTHAEGIEILFDPARISYRQILEFFFQIHDPTTPN
RQGNDRGMSYRSAIYYVDDAQKAVAEDTIADVNASGLWPGAVVTEVEPAGPFWDAEPEHQDYLERIPNGYTCHFVRPDWV
LPKRSTAAE

Sequences:

>Translated_169_residues
MTERAVLAGGCFWGMQDLIRKMPGVEATRVGYTGGDVPNATYRNHGTHAEGIEILFDPARISYRQILEFFFQIHDPTTPN
RQGNDRGMSYRSAIYYVDDAQKAVAEDTIADVNASGLWPGAVVTEVEPAGPFWDAEPEHQDYLERIPNGYTCHFVRPDWV
LPKRSTAAE
>Mature_168_residues
TERAVLAGGCFWGMQDLIRKMPGVEATRVGYTGGDVPNATYRNHGTHAEGIEILFDPARISYRQILEFFFQIHDPTTPNR
QGNDRGMSYRSAIYYVDDAQKAVAEDTIADVNASGLWPGAVVTEVEPAGPFWDAEPEHQDYLERIPNGYTCHFVRPDWVL
PKRSTAAE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=36.9426751592357, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=36.9426751592357, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=37.3831775700935, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=44.078947368421, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=41.958041958042, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=35.7575757575758, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24664627, Length=140, Percent_Identity=36.4285714285714, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553131, Length=135, Percent_Identity=37.037037037037, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=35.2112676056338, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18935; Mature: 18804

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERAVLAGGCFWGMQDLIRKMPGVEATRVGYTGGDVPNATYRNHGTHAEGIEILFDPAR
CCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCHH
ISYRQILEFFFQIHDPTTPNRQGNDRGMSYRSAIYYVDDAQKAVAEDTIADVNASGLWPG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCC
AVVTEVEPAGPFWDAEPEHQDYLERIPNGYTCHFVRPDWVLPKRSTAAE
CEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TERAVLAGGCFWGMQDLIRKMPGVEATRVGYTGGDVPNATYRNHGTHAEGIEILFDPAR
CCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCHH
ISYRQILEFFFQIHDPTTPNRQGNDRGMSYRSAIYYVDDAQKAVAEDTIADVNASGLWPG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCC
AVVTEVEPAGPFWDAEPEHQDYLERIPNGYTCHFVRPDWVLPKRSTAAE
CEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]