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The map label for this gene is phrB [H]

Identifier: 89054480

GI number: 89054480

Start: 1987997

End: 1989403

Strand: Direct

Name: phrB [H]

Synonym: Jann_1989

Alternate gene names: 89054480

Gene position: 1987997-1989403 (Clockwise)

Preceding gene: 89054479

Following gene: 89054481

Centisome position: 46.04

GC content: 63.89

Gene sequence:

>1407_bases
ATGACGACGATTTATTGGGTGCGGCGGGACTTTCGCCTGTCGGACAATCCGGCGCTGGTGGCGGCCTGCGAACGTGGCGC
TGTGGTGCCGCTGTTCATTTGCGATGAGGTGATCGAGGGCCACGGGGCAGCGCCGAAGTGGCGGCTTGGCCTTGGCGTGG
AGGCGTTCGCCGAGGCGCTGCACGCTGTCGGATCAAAGCTGATCCTGCGTCGCGGGGACGCTCTGCCGACCCTGCGGGCC
GTTATCGCCGATGTCTCTGCCAATGCTGTGCATTGGAACCGGCTCTATGACCCCGACAGCCGCAAGCGTGATGAAGCGGT
GAAAGCCGCGCTGAAAGAGGACGGGGTCGAGGCCATCAGCCACAAGGGGCACGTGCTGTTTGAGCCCTGGACGGTGGAGA
CGAAGACGGGCGGCTACTACAAGGTTTACACGCCGTTCTGGAAGATGGTGCGCGACCGTTCGCCGGGGGAGGCCTTGGCC
GCGCCCAAAATCCCCGCGCCGGACACTTGGCCTGCGTCCGATGACCTTAGCGACTGGCACCTTGGCAAGGCGATGAACCG
GGGCGCGGAGGTTGTCGCCCCGCATCTGAATGTCGGCGAACAGGCCGCGCAGGGGCGACTTGGCGCGTTCATCGGCAATG
GGATCGACGACTATGCGGATGCCCGAGACAACCTGGCGAAGAATGGCACATCGTTGCTGTCTGAAAACCTCGCCTATGGG
GAGATCAGCGCCCGCCAATGCTGGCATGCGGGTCAGCGGGCCATGGCCGACGGGAAGCCGGGCGCGGAGACGTTCTTGAA
AGAAGTGGTCTGGCGCGATTTTGCCTACCATCTGGTGCATCACACGCCCCGCATCACCACCGCCAACTGGCGGGAGGAGT
GGGAGGCGTTTCCCTGGAACACCGACCCCGACACACCGGAGGTCACGGCTTGGAAGCAGGGCCGCACCGGCATGGCCGTC
GTCGATGCCGCGATGCGCGAAATGTACGTGACTGGGCGGATGCACAACCGCGCCCGGATGTTGGTGGCGTCCTACCTGAC
CAAACACCTGATGACCGATTGGAAGATCGGGATGGATTGGTTCGAAGAGTGCCTTGTTGATTGGGACCCGGCCAGCAACG
CGATGGGGTGGCAATGGTCGGCGGGCTCCGGCCCCGACGCGACGCCGTATTTCCGCGTCTTCAATCCTGAAACTCAGGCG
GAGAAGTTCGATAAAGCAGGGCGCTACCGGATGCGCTGGTTGGCAGAAATCACCGGCAAGCCCCAAGATACCGCATCGGC
CTATTTCGACGCGGTCCCCCGCGCCTGGGGCCTTGACCCCACGATGGGCTACCCCAGTGCGCCCATCGTCACAGCCTCCG
AGGGCCGCAAACGGGCATTGGATGCCTACGAAAATCGTGGCTTCTGA

Upstream 100 bases:

>100_bases
CCATCGGGGCGTCAGAGCGGGACCTTGTGCTGATCGAGGCTCCGTAAGCTCTTGACCCCACGCGCCACGCCCTAACTACC
GGTTAACGAATGGGGCGAGC

Downstream 100 bases:

>100_bases
CGCCAATGTGTCAAAGAAATCTGACAGATCGCACGAATGTGGCTTGCCCAACCGGCACATGGCTTACATGTACGTGACTG
GATTAAAGGGAAAATCATGA

Product: deoxyribodipyrimidine photo-lyase type I

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTTIYWVRRDFRLSDNPALVAACERGAVVPLFICDEVIEGHGAAPKWRLGLGVEAFAEALHAVGSKLILRRGDALPTLRA
VIADVSANAVHWNRLYDPDSRKRDEAVKAALKEDGVEAISHKGHVLFEPWTVETKTGGYYKVYTPFWKMVRDRSPGEALA
APKIPAPDTWPASDDLSDWHLGKAMNRGAEVVAPHLNVGEQAAQGRLGAFIGNGIDDYADARDNLAKNGTSLLSENLAYG
EISARQCWHAGQRAMADGKPGAETFLKEVVWRDFAYHLVHHTPRITTANWREEWEAFPWNTDPDTPEVTAWKQGRTGMAV
VDAAMREMYVTGRMHNRARMLVASYLTKHLMTDWKIGMDWFEECLVDWDPASNAMGWQWSAGSGPDATPYFRVFNPETQA
EKFDKAGRYRMRWLAEITGKPQDTASAYFDAVPRAWGLDPTMGYPSAPIVTASEGRKRALDAYENRGF

Sequences:

>Translated_468_residues
MTTIYWVRRDFRLSDNPALVAACERGAVVPLFICDEVIEGHGAAPKWRLGLGVEAFAEALHAVGSKLILRRGDALPTLRA
VIADVSANAVHWNRLYDPDSRKRDEAVKAALKEDGVEAISHKGHVLFEPWTVETKTGGYYKVYTPFWKMVRDRSPGEALA
APKIPAPDTWPASDDLSDWHLGKAMNRGAEVVAPHLNVGEQAAQGRLGAFIGNGIDDYADARDNLAKNGTSLLSENLAYG
EISARQCWHAGQRAMADGKPGAETFLKEVVWRDFAYHLVHHTPRITTANWREEWEAFPWNTDPDTPEVTAWKQGRTGMAV
VDAAMREMYVTGRMHNRARMLVASYLTKHLMTDWKIGMDWFEECLVDWDPASNAMGWQWSAGSGPDATPYFRVFNPETQA
EKFDKAGRYRMRWLAEITGKPQDTASAYFDAVPRAWGLDPTMGYPSAPIVTASEGRKRALDAYENRGF
>Mature_467_residues
TTIYWVRRDFRLSDNPALVAACERGAVVPLFICDEVIEGHGAAPKWRLGLGVEAFAEALHAVGSKLILRRGDALPTLRAV
IADVSANAVHWNRLYDPDSRKRDEAVKAALKEDGVEAISHKGHVLFEPWTVETKTGGYYKVYTPFWKMVRDRSPGEALAA
PKIPAPDTWPASDDLSDWHLGKAMNRGAEVVAPHLNVGEQAAQGRLGAFIGNGIDDYADARDNLAKNGTSLLSENLAYGE
ISARQCWHAGQRAMADGKPGAETFLKEVVWRDFAYHLVHHTPRITTANWREEWEAFPWNTDPDTPEVTAWKQGRTGMAVV
DAAMREMYVTGRMHNRARMLVASYLTKHLMTDWKIGMDWFEECLVDWDPASNAMGWQWSAGSGPDATPYFRVFNPETQAE
KFDKAGRYRMRWLAEITGKPQDTASAYFDAVPRAWGLDPTMGYPSAPIVTASEGRKRALDAYENRGF

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=448, Percent_Identity=26.7857142857143, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI188536100, Length=443, Percent_Identity=24.3792325056433, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI188536103, Length=398, Percent_Identity=22.8643216080402, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786926, Length=484, Percent_Identity=35.5371900826446, Blast_Score=246, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324962, Length=510, Percent_Identity=26.2745098039216, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17137248, Length=497, Percent_Identity=27.1629778672032, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24585455, Length=497, Percent_Identity=27.1629778672032, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24648152, Length=472, Percent_Identity=22.4576271186441, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52283; Mature: 52152

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIYWVRRDFRLSDNPALVAACERGAVVPLFICDEVIEGHGAAPKWRLGLGVEAFAEAL
CCEEEEEEEECEECCCCCEEEEECCCCEEEHHHHHHHHHCCCCCCCEEECCCHHHHHHHH
HAVGSKLILRRGDALPTLRAVIADVSANAVHWNRLYDPDSRKRDEAVKAALKEDGVEAIS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCHHHHH
HKGHVLFEPWTVETKTGGYYKVYTPFWKMVRDRSPGEALAAPKIPAPDTWPASDDLSDWH
CCCCEEECCEEEEECCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGKAMNRGAEVVAPHLNVGEQAAQGRLGAFIGNGIDDYADARDNLAKNGTSLLSENLAYG
HHHHHCCCCEEEECCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
EISARQCWHAGQRAMADGKPGAETFLKEVVWRDFAYHLVHHTPRITTANWREEWEAFPWN
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCC
TDPDTPEVTAWKQGRTGMAVVDAAMREMYVTGRMHNRARMLVASYLTKHLMTDWKIGMDW
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
FEECLVDWDPASNAMGWQWSAGSGPDATPYFRVFNPETQAEKFDKAGRYRMRWLAEITGK
HHHHHCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHCCC
PQDTASAYFDAVPRAWGLDPTMGYPSAPIVTASEGRKRALDAYENRGF
CCHHHHHHHHHCCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TTIYWVRRDFRLSDNPALVAACERGAVVPLFICDEVIEGHGAAPKWRLGLGVEAFAEAL
CEEEEEEEECEECCCCCEEEEECCCCEEEHHHHHHHHHCCCCCCCEEECCCHHHHHHHH
HAVGSKLILRRGDALPTLRAVIADVSANAVHWNRLYDPDSRKRDEAVKAALKEDGVEAIS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCHHHHH
HKGHVLFEPWTVETKTGGYYKVYTPFWKMVRDRSPGEALAAPKIPAPDTWPASDDLSDWH
CCCCEEECCEEEEECCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGKAMNRGAEVVAPHLNVGEQAAQGRLGAFIGNGIDDYADARDNLAKNGTSLLSENLAYG
HHHHHCCCCEEEECCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
EISARQCWHAGQRAMADGKPGAETFLKEVVWRDFAYHLVHHTPRITTANWREEWEAFPWN
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCC
TDPDTPEVTAWKQGRTGMAVVDAAMREMYVTGRMHNRARMLVASYLTKHLMTDWKIGMDW
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
FEECLVDWDPASNAMGWQWSAGSGPDATPYFRVFNPETQAEKFDKAGRYRMRWLAEITGK
HHHHHCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHCCC
PQDTASAYFDAVPRAWGLDPTMGYPSAPIVTASEGRKRALDAYENRGF
CCHHHHHHHHHCCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6325460; 8905232; 9278503; 2200511; 7604260 [H]