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The map label for this gene is guaB [H]

Identifier: 89054473

GI number: 89054473

Start: 1977804

End: 1979252

Strand: Direct

Name: guaB [H]

Synonym: Jann_1982

Alternate gene names: 89054473

Gene position: 1977804-1979252 (Clockwise)

Preceding gene: 89054472

Following gene: 89054474

Centisome position: 45.8

GC content: 64.39

Gene sequence:

>1449_bases
ATGGAGATTCGCGAGGCCCTCACCTTTGATGACGTTCTGCTGGTTCCCGGCAAATCCTCGGTGCTGCCGTCGGACGCCGA
CACGCGGACGCGGGTGACCAAGAGCATCGCGTTGAATATTCCGCTGCTCAGCTCGGCCATGGACACGGTGACGGAGGGGC
GCATGGCGATTGCCATGGCGCAGGCGGGCGGGATGGGGGTGATCCACCGCAATCTGGATGTGGACCAACAGGCGCGCGAA
GTGCGGCGGGTAAAGCGGTTCGAGAGCGGGATTGTGTACAACCCCGTGACGTTGACCCCGGACCAGACGCTGGCGGATGC
GAAGTCGCTGATGGAACGCTACGGATTTTCGGGCTTTCCCGTCGTGGACGAGACGCGCCGCGTGTTGGGCATTGTCACCA
ATCGCGACATGCGGTTCGCGGCCGATGACGCAACGCCGGTGCAGGCGATGATGACGGCCGATGACCTGGCGATCCTGCGC
GAGCCTGCCGACCGGGACGAGGCGATCAGCCTGATGAAGGCGCGTCGGATCGAAAAGCTGCTGATCACCGACGGGCAGGG
CGCGTTGACGGGACTTTTGACGTTGAAAGACACGGAGCAGGCGGTGCTGAACCCGATGGCCTGCAAGGACCCGCTGGGGC
GGTTGCGGGTGGCGGCTGCCACGACCGTGGGCGATGCGGGCTTTGAGCGGTCTCAGGCACTGATCGACGCGGGCTGTGAC
CTGATCGTCATCGACACGGCCCATGGCCATTCGGAGGGCGTGGCGACAGCGGTCGAGCGGGTGAAATCCCTGTCCAATGA
GGTGCAAGTCGTCGCGGGCAATGTCGCGACCGGAGAGGCCACGCGCGCGTTGATCGACGCTGGTGCTGACGCGGTGAAAG
TGGGGATCGGACCGGGCTCCATCTGCACGACGCGTATCGTGGCAGGCGTGGGCGTGCCGCAGCTGACGGCGATTTCCGAT
TGTGCGGACGCCGCGGGCGACACGCCGGTTATCGCGGATGGCGGCATCAAATTTTCAGGCGACTTCGCCAAGGCGATTGC
TGCGGGCGCCCATTGCGCCATGGTCGGGTCGATGATTGCCGGAACGGACGAGTCGCCCGGCGAGGTGATCCTCTACCAGG
GCCGTTCGTTCAAATCCTATCGTGGCATGGGGTCCCTTGGGGCCATGGCGCGCGGATCGGCGGATCGGTATTTCCAGAAG
GACGCGGCCAGCGACAAACTGGTGCCCGAAGGGATCGAGGGGCAGGTGCCTTACAAAGGCTCGGCAGGGGCCGTCGTGCA
TCAGTTGATCGGGGGCCTGCGCGCCGCCATGGGCTACACCGGCAGTGCAACGGTCGACGAGATGCGGACGAAATGCCAGT
TCGTGCGGATCACCGGATCGGGTCTGAAAGAAAGCCATGTGCATGATGTGCAGATCACTCGCGAAAGCCCAAATTATCGT
GCGGGATGA

Upstream 100 bases:

>100_bases
TCGGGACGAGGCCTGAGGCACACCAGATTTAGGGCTTGCCCCGCTGGCGTCCCCATGGGATAGCGACGTGCCAACCGATC
CCCCTCCAAGGAGCACCCAG

Downstream 100 bases:

>100_bases
ATATCTTGTACGCCGACATTAAAGTGATACCTTAGGATGCAACCTGCCGCGCGCTATGCCGCCGCAATCGAGGTATTGGA
CGCTTGGTGCGATGGCTTGG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MEIREALTFDDVLLVPGKSSVLPSDADTRTRVTKSIALNIPLLSSAMDTVTEGRMAIAMAQAGGMGVIHRNLDVDQQARE
VRRVKRFESGIVYNPVTLTPDQTLADAKSLMERYGFSGFPVVDETRRVLGIVTNRDMRFAADDATPVQAMMTADDLAILR
EPADRDEAISLMKARRIEKLLITDGQGALTGLLTLKDTEQAVLNPMACKDPLGRLRVAAATTVGDAGFERSQALIDAGCD
LIVIDTAHGHSEGVATAVERVKSLSNEVQVVAGNVATGEATRALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAISD
CADAAGDTPVIADGGIKFSGDFAKAIAAGAHCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSLGAMARGSADRYFQK
DAASDKLVPEGIEGQVPYKGSAGAVVHQLIGGLRAAMGYTGSATVDEMRTKCQFVRITGSGLKESHVHDVQITRESPNYR
AG

Sequences:

>Translated_482_residues
MEIREALTFDDVLLVPGKSSVLPSDADTRTRVTKSIALNIPLLSSAMDTVTEGRMAIAMAQAGGMGVIHRNLDVDQQARE
VRRVKRFESGIVYNPVTLTPDQTLADAKSLMERYGFSGFPVVDETRRVLGIVTNRDMRFAADDATPVQAMMTADDLAILR
EPADRDEAISLMKARRIEKLLITDGQGALTGLLTLKDTEQAVLNPMACKDPLGRLRVAAATTVGDAGFERSQALIDAGCD
LIVIDTAHGHSEGVATAVERVKSLSNEVQVVAGNVATGEATRALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAISD
CADAAGDTPVIADGGIKFSGDFAKAIAAGAHCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSLGAMARGSADRYFQK
DAASDKLVPEGIEGQVPYKGSAGAVVHQLIGGLRAAMGYTGSATVDEMRTKCQFVRITGSGLKESHVHDVQITRESPNYR
AG
>Mature_482_residues
MEIREALTFDDVLLVPGKSSVLPSDADTRTRVTKSIALNIPLLSSAMDTVTEGRMAIAMAQAGGMGVIHRNLDVDQQARE
VRRVKRFESGIVYNPVTLTPDQTLADAKSLMERYGFSGFPVVDETRRVLGIVTNRDMRFAADDATPVQAMMTADDLAILR
EPADRDEAISLMKARRIEKLLITDGQGALTGLLTLKDTEQAVLNPMACKDPLGRLRVAAATTVGDAGFERSQALIDAGCD
LIVIDTAHGHSEGVATAVERVKSLSNEVQVVAGNVATGEATRALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAISD
CADAAGDTPVIADGGIKFSGDFAKAIAAGAHCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSLGAMARGSADRYFQK
DAASDKLVPEGIEGQVPYKGSAGAVVHQLIGGLRAAMGYTGSATVDEMRTKCQFVRITGSGLKESHVHDVQITRESPNYR
AG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=36.4389233954451, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI217035146, Length=483, Percent_Identity=36.4389233954451, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI156616279, Length=483, Percent_Identity=36.4389233954451, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI34328930, Length=483, Percent_Identity=36.4389233954451, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI34328928, Length=483, Percent_Identity=36.4389233954451, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI217035152, Length=477, Percent_Identity=36.4779874213836, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI217035148, Length=483, Percent_Identity=35.6107660455487, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=33.9583333333333, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI50541954, Length=260, Percent_Identity=37.3076923076923, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541952, Length=260, Percent_Identity=37.3076923076923, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541948, Length=260, Percent_Identity=37.3076923076923, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541956, Length=257, Percent_Identity=37.7431906614786, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI156104880, Length=257, Percent_Identity=37.3540856031128, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=58.7136929460581, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1786293, Length=262, Percent_Identity=36.6412213740458, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=505, Percent_Identity=35.6435643564356, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=37.793427230047, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=39.3305439330544, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=493, Percent_Identity=36.9168356997972, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6323464, Length=493, Percent_Identity=37.3225152129817, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=35.6701030927835, Blast_Score=293, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319352, Length=348, Percent_Identity=36.7816091954023, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=36.2068965517241, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=35.8333333333333, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=35.8333333333333, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=35.6164383561644, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 50639; Mature: 50639

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIREALTFDDVLLVPGKSSVLPSDADTRTRVTKSIALNIPLLSSAMDTVTEGRMAIAMA
CCHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHEEEECCCHHHHHHHHHHCCCEEEEEE
QAGGMGVIHRNLDVDQQAREVRRVKRFESGIVYNPVTLTPDQTLADAKSLMERYGFSGFP
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEECCEEECCCHHHHHHHHHHHHCCCCCCC
VVDETRRVLGIVTNRDMRFAADDATPVQAMMTADDLAILREPADRDEAISLMKARRIEKL
CHHHHHHHEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEE
LITDGQGALTGLLTLKDTEQAVLNPMACKDPLGRLRVAAATTVGDAGFERSQALIDAGCD
EEECCCCCEEEEEEECCCHHHHCCCHHHCCCHHHEEEEEEEECCCCCCHHHHHHHHCCCC
LIVIDTAHGHSEGVATAVERVKSLSNEVQVVAGNVATGEATRALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCH
ICTTRIVAGVGVPQLTAISDCADAAGDTPVIADGGIKFSGDFAKAIAAGAHCAMVGSMIA
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHHC
GTDESPGEVILYQGRSFKSYRGMGSLGAMARGSADRYFQKDAASDKLVPEGIEGQVPYKG
CCCCCCCCEEEECCCCCHHHCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
SAGAVVHQLIGGLRAAMGYTGSATVDEMRTKCQFVRITGSGLKESHVHDVQITRESPNYR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEEECCCCCC
AG
CC
>Mature Secondary Structure
MEIREALTFDDVLLVPGKSSVLPSDADTRTRVTKSIALNIPLLSSAMDTVTEGRMAIAMA
CCHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHEEEECCCHHHHHHHHHHCCCEEEEEE
QAGGMGVIHRNLDVDQQAREVRRVKRFESGIVYNPVTLTPDQTLADAKSLMERYGFSGFP
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEECCEEECCCHHHHHHHHHHHHCCCCCCC
VVDETRRVLGIVTNRDMRFAADDATPVQAMMTADDLAILREPADRDEAISLMKARRIEKL
CHHHHHHHEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEE
LITDGQGALTGLLTLKDTEQAVLNPMACKDPLGRLRVAAATTVGDAGFERSQALIDAGCD
EEECCCCCEEEEEEECCCHHHHCCCHHHCCCHHHEEEEEEEECCCCCCHHHHHHHHCCCC
LIVIDTAHGHSEGVATAVERVKSLSNEVQVVAGNVATGEATRALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCH
ICTTRIVAGVGVPQLTAISDCADAAGDTPVIADGGIKFSGDFAKAIAAGAHCAMVGSMIA
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHHC
GTDESPGEVILYQGRSFKSYRGMGSLGAMARGSADRYFQKDAASDKLVPEGIEGQVPYKG
CCCCCCCCEEEECCCCCHHHCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
SAGAVVHQLIGGLRAAMGYTGSATVDEMRTKCQFVRITGSGLKESHVHDVQITRESPNYR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEEECCCCCC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]