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The map label for this gene is gppA [H]

Identifier: 89054471

GI number: 89054471

Start: 1975655

End: 1976836

Strand: Direct

Name: gppA [H]

Synonym: Jann_1980

Alternate gene names: 89054471

Gene position: 1975655-1976836 (Clockwise)

Preceding gene: 89054464

Following gene: 89054472

Centisome position: 45.75

GC content: 64.38

Gene sequence:

>1182_bases
ATGTCGCCCAAGCGCCCCGGCTCAGACGGCCCGTTCCCCAGACCCGTCGCACCTGTGGCCCCCAAGGGCGAGCCCGGTGG
TGTCCCGCCTGTTGAACGCCGCCCGCCGCACAGAAAAGACCCGAGCGCTGGTCCGGATCCAGACGATCTTTATGCCGCGC
TCGATCTGGGTACGAATTCGTGCCGTATGCTGATTGCGCAGCCCAAGGGCAGCCAGCTTCATGTGGTGGATTCCTTCTCG
AAGTCCGTGCAGCTGGGCCAGGGTTTGGAAGCCTCAGGCCGGATGAGCCGCGCGTCGATGGCGCGCGCTGTGGGGGCGCT
GAAGATCTGTCAGAAAAAACTGAGCAAGCACCGTGTGGAGCGGGCGCGCCTTGTGGCCACGGAAGCCTGCCGCCGTGCGA
CCAATGCGGGGGAATTCATCTCTCTGGTCAAGCGGGAGACCGGGCTGGAGCTGGAGATCATCAAGCCGGAGGAAGAGGCG
CAGCTGGCCGTTGTGTCCTGCGCGCCGCTGGTCTCCACCCGGACCGAGCAGCTATTGGTGGTGGACATCGGCGGCGGGTC
CACGGAACTGGTGTGGATCGACCTGTCCCGCGTACCCAAGCTGGAACGCCCCAAGGCGATCATGCGCCTGCATCAGGGGT
TTGACTACGACGACAGCATTTTCCCGCGTGCGAAGGTGGTGGACTGGATCTCCATCCCGTTGGGCGTCGCGACCCTGAAG
GATATGTATGACGATGTCGCCGATGACGGCGCGCGGTTCGCGCTGATGTCGTGGTTTTTCGAGGAGCAATTGGCCGAGTT
CTCCCCATACACCGATGCGGCGGAACAAACGCTGGAGGGGTTCCAGATCATCGGCACCAGTGGAACAGTCACCACGGTGG
CCGCGTCGCATCTGGGCCTGCGCCGCTATGATCGGAACAAGGTGGACGGCTTGCGGATGACCTCGACCCAGATCGACACG
GTGATCAACGGATACCTGGCCCTGGGCCCCGACGGGCGTCGCCGTGACCCAAGGATTGGGCGGGACCGGCAGACGCTGAT
CATGTCGGGTGCTGCGATTTTGCAGGCGCTGTTGCGCGCCTGGCCGACCGACAGGCTGAGCGTCGCGGATCGGGGGCTTC
GGGAGGGGCTTTTGTATGCGCAGATGAGCCGTGACGGGGTTCTGGAGGATGGTCCGTACTGA

Upstream 100 bases:

>100_bases
CGCTCATCATCATCATGAGCCGCAGCCCGGTCTGGGGCATTGTGAGCGGCCCCCTTCCGCGTTAGGCTGAGCCGCAACTC
TTATAGGAAAGGTCCGCGCC

Downstream 100 bases:

>100_bases
GGATTTGCGCTGACTGCGTCATCGCCGGGGGCAAATTTTTGAAGGAAAAATTTGCGGGCGCGTGTTGCGGATCTTGGGCA
AAGGCCTCATCTGCTGCGCG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSPKRPGSDGPFPRPVAPVAPKGEPGGVPPVERRPPHRKDPSAGPDPDDLYAALDLGTNSCRMLIAQPKGSQLHVVDSFS
KSVQLGQGLEASGRMSRASMARAVGALKICQKKLSKHRVERARLVATEACRRATNAGEFISLVKRETGLELEIIKPEEEA
QLAVVSCAPLVSTRTEQLLVVDIGGGSTELVWIDLSRVPKLERPKAIMRLHQGFDYDDSIFPRAKVVDWISIPLGVATLK
DMYDDVADDGARFALMSWFFEEQLAEFSPYTDAAEQTLEGFQIIGTSGTVTTVAASHLGLRRYDRNKVDGLRMTSTQIDT
VINGYLALGPDGRRRDPRIGRDRQTLIMSGAAILQALLRAWPTDRLSVADRGLREGLLYAQMSRDGVLEDGPY

Sequences:

>Translated_393_residues
MSPKRPGSDGPFPRPVAPVAPKGEPGGVPPVERRPPHRKDPSAGPDPDDLYAALDLGTNSCRMLIAQPKGSQLHVVDSFS
KSVQLGQGLEASGRMSRASMARAVGALKICQKKLSKHRVERARLVATEACRRATNAGEFISLVKRETGLELEIIKPEEEA
QLAVVSCAPLVSTRTEQLLVVDIGGGSTELVWIDLSRVPKLERPKAIMRLHQGFDYDDSIFPRAKVVDWISIPLGVATLK
DMYDDVADDGARFALMSWFFEEQLAEFSPYTDAAEQTLEGFQIIGTSGTVTTVAASHLGLRRYDRNKVDGLRMTSTQIDT
VINGYLALGPDGRRRDPRIGRDRQTLIMSGAAILQALLRAWPTDRLSVADRGLREGLLYAQMSRDGVLEDGPY
>Mature_392_residues
SPKRPGSDGPFPRPVAPVAPKGEPGGVPPVERRPPHRKDPSAGPDPDDLYAALDLGTNSCRMLIAQPKGSQLHVVDSFSK
SVQLGQGLEASGRMSRASMARAVGALKICQKKLSKHRVERARLVATEACRRATNAGEFISLVKRETGLELEIIKPEEEAQ
LAVVSCAPLVSTRTEQLLVVDIGGGSTELVWIDLSRVPKLERPKAIMRLHQGFDYDDSIFPRAKVVDWISIPLGVATLKD
MYDDVADDGARFALMSWFFEEQLAEFSPYTDAAEQTLEGFQIIGTSGTVTTVAASHLGLRRYDRNKVDGLRMTSTQIDTV
INGYLALGPDGRRRDPRIGRDRQTLIMSGAAILQALLRAWPTDRLSVADRGLREGLLYAQMSRDGVLEDGPY

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=335, Percent_Identity=27.4626865671642, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788848, Length=353, Percent_Identity=25.2124645892351, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 42984; Mature: 42852

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKRPGSDGPFPRPVAPVAPKGEPGGVPPVERRPPHRKDPSAGPDPDDLYAALDLGTNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEECCCCC
CRMLIAQPKGSQLHVVDSFSKSVQLGQGLEASGRMSRASMARAVGALKICQKKLSKHRVE
EEEEEECCCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RARLVATEACRRATNAGEFISLVKRETGLELEIIKPEEEAQLAVVSCAPLVSTRTEQLLV
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEHHHHHHCCCCEEEE
VDIGGGSTELVWIDLSRVPKLERPKAIMRLHQGFDYDDSIFPRAKVVDWISIPLGVATLK
EEECCCCEEEEEEEHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHH
DMYDDVADDGARFALMSWFFEEQLAEFSPYTDAAEQTLEGFQIIGTSGTVTTVAASHLGL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHH
RRYDRNKVDGLRMTSTQIDTVINGYLALGPDGRRRDPRIGRDRQTLIMSGAAILQALLRA
HHHCCCCCCCEEECHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WPTDRLSVADRGLREGLLYAQMSRDGVLEDGPY
CCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure 
SPKRPGSDGPFPRPVAPVAPKGEPGGVPPVERRPPHRKDPSAGPDPDDLYAALDLGTNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEECCCCC
CRMLIAQPKGSQLHVVDSFSKSVQLGQGLEASGRMSRASMARAVGALKICQKKLSKHRVE
EEEEEECCCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RARLVATEACRRATNAGEFISLVKRETGLELEIIKPEEEAQLAVVSCAPLVSTRTEQLLV
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEHHHHHHCCCCEEEE
VDIGGGSTELVWIDLSRVPKLERPKAIMRLHQGFDYDDSIFPRAKVVDWISIPLGVATLK
EEECCCCEEEEEEEHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHH
DMYDDVADDGARFALMSWFFEEQLAEFSPYTDAAEQTLEGFQIIGTSGTVTTVAASHLGL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHH
RRYDRNKVDGLRMTSTQIDTVINGYLALGPDGRRRDPRIGRDRQTLIMSGAAILQALLRA
HHHCCCCCCCEEECHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WPTDRLSVADRGLREGLLYAQMSRDGVLEDGPY
CCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA