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The map label for this gene is pgi

Identifier: 89054462

GI number: 89054462

Start: 1964524

End: 1966137

Strand: Direct

Name: pgi

Synonym: Jann_1971

Alternate gene names: 89054462

Gene position: 1964524-1966137 (Clockwise)

Preceding gene: 89054461

Following gene: 89054464

Centisome position: 45.5

GC content: 62.89

Gene sequence:

>1614_bases
ATGGGTGAGATCTGGTCAGAGCTGAAGGCGCATCATTCCGCCAAATCGCGGCGCAAGATGTTGGATTTGTTCGAGAAAGG
TAACAGAGTTCAGGCGTTTTCAGCGACGGTAGACGGCCTCTACTTTGACTTTTCCAAGACCAATCTGGACGATGGCGCGC
TGTCTTTGCTGTTGGAACTGGCGCGCGTGAAGGGTGTCGAATCCCGCCGTGCGGCGATGTTTGCTGGCGACAAGATCAAT
GAGACCGAAGGGCGCGCGGTCCTTCACACGGCGCTGCGCGCGCCTGCGGGGCCGATCAAGGTCGATGGCCAAGACATCAT
GCCCGGCGTGTTGGAGACCCGCGCCCGGTGCTTTACCTTCGCCCAACAGGTGCGCGACGGCAGCTTCACGGCGCAGGGGG
GCCGCATCACGGATGTGGTCAATATCGGCATCGGCGGCTCGGACCTTGGGCCTGCCATGGCAACCCTGGCCCTTGCGCCC
TATCACGATGGCCCGCGTCTGCACTATGTCTCGAACGTCGATGGCGCGGACATGAACGGCGCCCTGCAAGGGATTGATCC
CAAAACGACTTTGGTGATTGTGGCCTCGAAAACCTTCACCACGATCGAGACGATGACCAACGCCCAGACGGCGCGGGACT
GGATGGCGCAGGACGTCGCTGATCCGTCGGCGCAGTTCGTCGCGCTCAGTTCCTCCACCGAGAAGGCCGGCGCGTTTGGC
ATCCCGCCCGAGCGGACGTTCGGGTTCGAGGATTGGGTCGGCGGGCGCTACTCCCTGTGGGGACCGATTGGGCTGGGTCT
GATGATTGCCATCGGCCCGGAGGCGTTTCAGCAATTCCTTGATGGGGCCGCCACGATGGACCGGCACTTTCAGGAGGCCG
ATCTGGCCGACAACCTGCCCGTTCTTCTGGCGCTGGTGGGGATGTGGCACAATCAGGTGGAAGGCCACGCGACCCGCGCC
GTTTTGCCCTACGACAACCGTCTGTCGCGCTTGCCCGCCTACCTTCAGCAGCTTGAGATGGAGAGCAACGGCAAGTCCGT
CGCGATGGATGGCAGCGCGTTGCAGCAGAATTCCGGCCCGGTGGTCTGGGGAGAGCCGGGCACCAACGGCCAGCACGCGT
TCTATCAGTTGATCCATCAGGGCACCCGTGTGGTGCCGTGTGAATTCCTCGTGGCCGCCAAGGGGCACGAGCCGGATCTG
ACCCACCATCACCGGCTATTGGTCGCCAATTGCCTGGCGCAGTCCGAGGCGCTGATGCGCGGCAGATCCATGGAAGAGGC
ACGCGCGCTCATGGCCGCCAAGGGCCTTGAAGGTGCAGAGCTGGAGCGTCAGGCCGCCCACCGTGTGTTCCCGGGCAACA
GGCCCTCCACAACGCTGCTCTATGATCAACTCACGCCATTCACCCTCGGCCAGATCATCGCGCTTTATGAGCATCGGGTG
TTTGTGGAAGGGGTCATTCTGGGGATCAATTCCTTCGACCAATGGGGCGTGGAGTTGGGCAAAGAGCTGGCCACTGCGCT
GGAGCCGGTTCTGACCGGTAAGGATGACGGCGCTGGCAAGGACGGCTCGACCCTCGCGCTGGTGGATGCGGTGAAGGCGG
TTGGGGGCATCTAG

Upstream 100 bases:

>100_bases
AGCGTGCAGCACTCGAACGCGCCCTGCATTTGCCCCCGGAAGACGCGCCGATCAGCGCGGTTCTGGCGGGCGCAACAGTC
CATTGGGCGGAGTAGGCGAT

Downstream 100 bases:

>100_bases
CCCGCCGCCAACACACCGTCTTCGGTCACGAAGGACGCGCGGCCTGCCTCCGGGATCGGGTAGCGGCCCGACCCGTCGCG
GTTGAGCAACACCACGACCG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MGEIWSELKAHHSAKSRRKMLDLFEKGNRVQAFSATVDGLYFDFSKTNLDDGALSLLLELARVKGVESRRAAMFAGDKIN
ETEGRAVLHTALRAPAGPIKVDGQDIMPGVLETRARCFTFAQQVRDGSFTAQGGRITDVVNIGIGGSDLGPAMATLALAP
YHDGPRLHYVSNVDGADMNGALQGIDPKTTLVIVASKTFTTIETMTNAQTARDWMAQDVADPSAQFVALSSSTEKAGAFG
IPPERTFGFEDWVGGRYSLWGPIGLGLMIAIGPEAFQQFLDGAATMDRHFQEADLADNLPVLLALVGMWHNQVEGHATRA
VLPYDNRLSRLPAYLQQLEMESNGKSVAMDGSALQQNSGPVVWGEPGTNGQHAFYQLIHQGTRVVPCEFLVAAKGHEPDL
THHHRLLVANCLAQSEALMRGRSMEEARALMAAKGLEGAELERQAAHRVFPGNRPSTTLLYDQLTPFTLGQIIALYEHRV
FVEGVILGINSFDQWGVELGKELATALEPVLTGKDDGAGKDGSTLALVDAVKAVGGI

Sequences:

>Translated_537_residues
MGEIWSELKAHHSAKSRRKMLDLFEKGNRVQAFSATVDGLYFDFSKTNLDDGALSLLLELARVKGVESRRAAMFAGDKIN
ETEGRAVLHTALRAPAGPIKVDGQDIMPGVLETRARCFTFAQQVRDGSFTAQGGRITDVVNIGIGGSDLGPAMATLALAP
YHDGPRLHYVSNVDGADMNGALQGIDPKTTLVIVASKTFTTIETMTNAQTARDWMAQDVADPSAQFVALSSSTEKAGAFG
IPPERTFGFEDWVGGRYSLWGPIGLGLMIAIGPEAFQQFLDGAATMDRHFQEADLADNLPVLLALVGMWHNQVEGHATRA
VLPYDNRLSRLPAYLQQLEMESNGKSVAMDGSALQQNSGPVVWGEPGTNGQHAFYQLIHQGTRVVPCEFLVAAKGHEPDL
THHHRLLVANCLAQSEALMRGRSMEEARALMAAKGLEGAELERQAAHRVFPGNRPSTTLLYDQLTPFTLGQIIALYEHRV
FVEGVILGINSFDQWGVELGKELATALEPVLTGKDDGAGKDGSTLALVDAVKAVGGI
>Mature_536_residues
GEIWSELKAHHSAKSRRKMLDLFEKGNRVQAFSATVDGLYFDFSKTNLDDGALSLLLELARVKGVESRRAAMFAGDKINE
TEGRAVLHTALRAPAGPIKVDGQDIMPGVLETRARCFTFAQQVRDGSFTAQGGRITDVVNIGIGGSDLGPAMATLALAPY
HDGPRLHYVSNVDGADMNGALQGIDPKTTLVIVASKTFTTIETMTNAQTARDWMAQDVADPSAQFVALSSSTEKAGAFGI
PPERTFGFEDWVGGRYSLWGPIGLGLMIAIGPEAFQQFLDGAATMDRHFQEADLADNLPVLLALVGMWHNQVEGHATRAV
LPYDNRLSRLPAYLQQLEMESNGKSVAMDGSALQQNSGPVVWGEPGTNGQHAFYQLIHQGTRVVPCEFLVAAKGHEPDLT
HHHRLLVANCLAQSEALMRGRSMEEARALMAAKGLEGAELERQAAHRVFPGNRPSTTLLYDQLTPFTLGQIIALYEHRVF
VEGVILGINSFDQWGVELGKELATALEPVLTGKDDGAGKDGSTLALVDAVKAVGGI

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=535, Percent_Identity=49.9065420560748, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI296080693, Length=534, Percent_Identity=46.8164794007491, Blast_Score=492, Evalue=1e-139,
Organism=Escherichia coli, GI1790457, Length=539, Percent_Identity=47.6808905380334, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71996708, Length=538, Percent_Identity=48.5130111524164, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71996703, Length=538, Percent_Identity=48.5130111524164, Blast_Score=508, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319673, Length=545, Percent_Identity=44.4036697247706, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24651916, Length=542, Percent_Identity=48.8929889298893, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651914, Length=542, Percent_Identity=48.8929889298893, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17737445, Length=542, Percent_Identity=48.8929889298893, Blast_Score=517, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_JANSC (Q28QX4)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509913.1
- HSSP:   Q3TEE7
- ProteinModelPortal:   Q28QX4
- SMR:   Q28QX4
- STRING:   Q28QX4
- GeneID:   3934422
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1971
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   LGKGVYQ
- PhylomeDB:   Q28QX4
- ProtClustDB:   PRK00179
- BioCyc:   JSP290400:JANN_1971-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57868; Mature: 57737

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 341-341 ACT_SITE 372-372 ACT_SITE 501-501

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEIWSELKAHHSAKSRRKMLDLFEKGNRVQAFSATVDGLYFDFSKTNLDDGALSLLLEL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEECCCCCCCHHHHHHHHHH
ARVKGVESRRAAMFAGDKINETEGRAVLHTALRAPAGPIKVDGQDIMPGVLETRARCFTF
HHHCCCCHHHHHHEECCCCCCCCCHHHHHHHHHCCCCCEEECCHHHCCHHHHHHHHHHHH
AQQVRDGSFTAQGGRITDVVNIGIGGSDLGPAMATLALAPYHDGPRLHYVSNVDGADMNG
HHHHCCCCEEECCCEEEEEEEECCCCCCHHHHHHHHEECCCCCCCCEEEECCCCCCCCCC
ALQGIDPKTTLVIVASKTFTTIETMTNAQTARDWMAQDVADPSAQFVALSSSTEKAGAFG
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
IPPERTFGFEDWVGGRYSLWGPIGLGLMIAIGPEAFQQFLDGAATMDRHFQEADLADNLP
CCCCCCCCHHHCCCCCEEECCCCCCCEEEEECHHHHHHHHCCHHHHHHHHHHCCCCCCHH
VLLALVGMWHNQVEGHATRAVLPYDNRLSRLPAYLQQLEMESNGKSVAMDGSALQQNSGP
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCC
VVWGEPGTNGQHAFYQLIHQGTRVVPCEFLVAAKGHEPDLTHHHRLLVANCLAQSEALMR
EEECCCCCCCHHHHHHHHHCCCEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
GRSMEEARALMAAKGLEGAELERQAAHRVFPGNRPSTTLLYDQLTPFTLGQIIALYEHRV
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
FVEGVILGINSFDQWGVELGKELATALEPVLTGKDDGAGKDGSTLALVDAVKAVGGI
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCC
>Mature Secondary Structure 
GEIWSELKAHHSAKSRRKMLDLFEKGNRVQAFSATVDGLYFDFSKTNLDDGALSLLLEL
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEECCCCCCCHHHHHHHHHH
ARVKGVESRRAAMFAGDKINETEGRAVLHTALRAPAGPIKVDGQDIMPGVLETRARCFTF
HHHCCCCHHHHHHEECCCCCCCCCHHHHHHHHHCCCCCEEECCHHHCCHHHHHHHHHHHH
AQQVRDGSFTAQGGRITDVVNIGIGGSDLGPAMATLALAPYHDGPRLHYVSNVDGADMNG
HHHHCCCCEEECCCEEEEEEEECCCCCCHHHHHHHHEECCCCCCCCEEEECCCCCCCCCC
ALQGIDPKTTLVIVASKTFTTIETMTNAQTARDWMAQDVADPSAQFVALSSSTEKAGAFG
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
IPPERTFGFEDWVGGRYSLWGPIGLGLMIAIGPEAFQQFLDGAATMDRHFQEADLADNLP
CCCCCCCCHHHCCCCCEEECCCCCCCEEEEECHHHHHHHHCCHHHHHHHHHHCCCCCCHH
VLLALVGMWHNQVEGHATRAVLPYDNRLSRLPAYLQQLEMESNGKSVAMDGSALQQNSGP
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCC
VVWGEPGTNGQHAFYQLIHQGTRVVPCEFLVAAKGHEPDLTHHHRLLVANCLAQSEALMR
EEECCCCCCCHHHHHHHHHCCCEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
GRSMEEARALMAAKGLEGAELERQAAHRVFPGNRPSTTLLYDQLTPFTLGQIIALYEHRV
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
FVEGVILGINSFDQWGVELGKELATALEPVLTGKDDGAGKDGSTLALVDAVKAVGGI
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA