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The map label for this gene is zwf [H]

Identifier: 89054460

GI number: 89054460

Start: 1962402

End: 1963847

Strand: Direct

Name: zwf [H]

Synonym: Jann_1969

Alternate gene names: 89054460

Gene position: 1962402-1963847 (Clockwise)

Preceding gene: 89054459

Following gene: 89054461

Centisome position: 45.45

GC content: 62.03

Gene sequence:

>1446_bases
ATGGTCTCGCGCGTCATTCCGGTCGAACCGTTTGATCTTGTCATATTTGGGGGCACGGGCGATCTGGCCCGGCGTAAAAT
CCTACCGGCGCTGTTCCGGCGGTTCAGCGATGGGCAGATGCCCGAGGGCGCGCGCATCATCGGCGCGGCACGGACCAAGC
AAAGCGGCGCGGCCTGGGCCAAATGGGTCCATGAGGCGTTGAAAGAATTCCTTACAAAAGAGGAACTGGACAAGGCGCTG
GTGAAGGCGTTTCTGGAGCGGCTCGATTATCTGGCGATTGACGCGACGGGGGACGGTGGATGGTCGGACCTGAAGGGCAA
GATGCGCGACGGCGTCACCCAGGCGTTTTACTTCTCGGTCGGTCCCAGCCTGTTCGGGGCGTTGGCAGAACGTCTCCATG
CCCACGACATCGCCCACGCCGATGCGCGCATCGTGGTCGAAAAACCGTTTGGGCGCGACCTCGCCTCGGCCCGGGAGTTG
AACGGCACCCTGGCCGCGCATTTCAACGAGACGCAGATCTACCGGATTGATCACTATCTGGGCAAGGAAACGGTCCAGAA
CCTCATGGCGATCCGCTTCGGCAATGTCCTGTTCGAGCCGCTTTGGAACGCGCAATACATTGATCACGTGCAGATCACCG
TGGCCGAAACCGTCGGCGTGGATGGGCGCGGAGCGTATTACGATAAATCGGGCGCGATGCGCGATATGGTGCAGAACCAC
CTGATGCAGCTGCTCTGCCTGACGGCGATGGAGCCGCCCAACAAGTTTGAGCCTGACGCGGTGCGCGATGAGAAGCTGAA
GGTGATCCGCGCGCTCGACCCTGTGGCACCAGCCGATATCGTGCGTGGGCAGTATCAGGGCAAGCAGGGCTCCTATCTGG
AAGATGTGGAGGATCCCGGCTCCAACACCGAAAGCTACATCGCGATGAAGCTGCACGTGGCCAACTGGCGCTGGAACGGC
ACGCCATTCTATCTGCGGACGGGCAAATGCCTGAAATCGCGCAAGTCCGAGATTGTGGTGCATTTCAAGGAAACGCCGCA
TTCGATCTTTGAGGCCGATGCGGGCAGCCACGCCAATGTTCTGTCGATCCGCCTGCAACCCGATGAGGGGATCAAGCTGC
GCGTCACGATCAAGGAGCCGGGACCCGGCGGCATGCGTTTGGTGGATGTGCCGCTCGACATGACGTTCGCGGAGGCACTG
GGGCCAGATGTGGGCCGGGTGCCGGACGCCTATGAGCGGCTGATCATGGATGTGATCCGGGGCAATCAGACCCTGTTCAT
GCGCGGCGATGAGGTGGAGGCGGCCTGGGCCTGGACCGATCCGATCATCGGCGGCTGGAAGGCGCGGAGCGAAAAGCCGG
TCGCCTATGACACCGGCTCGACCGGCCCGGAAGAGGCGCTGATGCTGCTGCACCGGGACGGCCGCAGATGGAGGGATTTG
TCATGA

Upstream 100 bases:

>100_bases
TGAAGTCGCTTGAGATGGATGCGGGTTTTGTTAGACATTCCCTCGTGGTGTCGGATAGAAGGGCGCTGTTAGCGCTAACG
TGATTTGAGGAGAACCCGCC

Downstream 100 bases:

>100_bases
GGAATTTCGTCGAATACCCCGACCAAGAAATGATGATGCTGGATCTTGCGGACCGGCTGACCGGAGAGTTGGCCGATTGC
CTGCGCCGCCACGACAGCGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MVSRVIPVEPFDLVIFGGTGDLARRKILPALFRRFSDGQMPEGARIIGAARTKQSGAAWAKWVHEALKEFLTKEELDKAL
VKAFLERLDYLAIDATGDGGWSDLKGKMRDGVTQAFYFSVGPSLFGALAERLHAHDIAHADARIVVEKPFGRDLASAREL
NGTLAAHFNETQIYRIDHYLGKETVQNLMAIRFGNVLFEPLWNAQYIDHVQITVAETVGVDGRGAYYDKSGAMRDMVQNH
LMQLLCLTAMEPPNKFEPDAVRDEKLKVIRALDPVAPADIVRGQYQGKQGSYLEDVEDPGSNTESYIAMKLHVANWRWNG
TPFYLRTGKCLKSRKSEIVVHFKETPHSIFEADAGSHANVLSIRLQPDEGIKLRVTIKEPGPGGMRLVDVPLDMTFAEAL
GPDVGRVPDAYERLIMDVIRGNQTLFMRGDEVEAAWAWTDPIIGGWKARSEKPVAYDTGSTGPEEALMLLHRDGRRWRDL
S

Sequences:

>Translated_481_residues
MVSRVIPVEPFDLVIFGGTGDLARRKILPALFRRFSDGQMPEGARIIGAARTKQSGAAWAKWVHEALKEFLTKEELDKAL
VKAFLERLDYLAIDATGDGGWSDLKGKMRDGVTQAFYFSVGPSLFGALAERLHAHDIAHADARIVVEKPFGRDLASAREL
NGTLAAHFNETQIYRIDHYLGKETVQNLMAIRFGNVLFEPLWNAQYIDHVQITVAETVGVDGRGAYYDKSGAMRDMVQNH
LMQLLCLTAMEPPNKFEPDAVRDEKLKVIRALDPVAPADIVRGQYQGKQGSYLEDVEDPGSNTESYIAMKLHVANWRWNG
TPFYLRTGKCLKSRKSEIVVHFKETPHSIFEADAGSHANVLSIRLQPDEGIKLRVTIKEPGPGGMRLVDVPLDMTFAEAL
GPDVGRVPDAYERLIMDVIRGNQTLFMRGDEVEAAWAWTDPIIGGWKARSEKPVAYDTGSTGPEEALMLLHRDGRRWRDL
S
>Mature_481_residues
MVSRVIPVEPFDLVIFGGTGDLARRKILPALFRRFSDGQMPEGARIIGAARTKQSGAAWAKWVHEALKEFLTKEELDKAL
VKAFLERLDYLAIDATGDGGWSDLKGKMRDGVTQAFYFSVGPSLFGALAERLHAHDIAHADARIVVEKPFGRDLASAREL
NGTLAAHFNETQIYRIDHYLGKETVQNLMAIRFGNVLFEPLWNAQYIDHVQITVAETVGVDGRGAYYDKSGAMRDMVQNH
LMQLLCLTAMEPPNKFEPDAVRDEKLKVIRALDPVAPADIVRGQYQGKQGSYLEDVEDPGSNTESYIAMKLHVANWRWNG
TPFYLRTGKCLKSRKSEIVVHFKETPHSIFEADAGSHANVLSIRLQPDEGIKLRVTIKEPGPGGMRLVDVPLDMTFAEAL
GPDVGRVPDAYERLIMDVIRGNQTLFMRGDEVEAAWAWTDPIIGGWKARSEKPVAYDTGSTGPEEALMLLHRDGRRWRDL
S

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=479, Percent_Identity=38.6221294363257, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI109389365, Length=479, Percent_Identity=37.7870563674322, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI52145310, Length=480, Percent_Identity=29.7916666666667, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1788158, Length=487, Percent_Identity=43.7371663244353, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=37.1134020618557, Blast_Score=325, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=35.5179704016913, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24643350, Length=472, Percent_Identity=37.0762711864407, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24643352, Length=472, Percent_Identity=37.0762711864407, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI221513548, Length=491, Percent_Identity=28.5132382892057, Blast_Score=205, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 53713; Mature: 53713

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRVIPVEPFDLVIFGGTGDLARRKILPALFRRFSDGQMPEGARIIGAARTKQSGAAWA
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHH
KWVHEALKEFLTKEELDKALVKAFLERLDYLAIDATGDGGWSDLKGKMRDGVTQAFYFSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCHHHCCHHHHHHHHC
GPSLFGALAERLHAHDIAHADARIVVEKPFGRDLASARELNGTLAAHFNETQIYRIDHYL
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCEEEEECCCCEEEEHHHHH
GKETVQNLMAIRFGNVLFEPLWNAQYIDHVQITVAETVGVDGRGAYYDKSGAMRDMVQNH
CHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEEEEECCCCCCCCEECCCCHHHHHHHHH
LMQLLCLTAMEPPNKFEPDAVRDEKLKVIRALDPVAPADIVRGQYQGKQGSYLEDVEDPG
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHCCCCC
SNTESYIAMKLHVANWRWNGTPFYLRTGKCLKSRKSEIVVHFKETPHSIFEADAGSHANV
CCCCCEEEEEEEEEEEEECCCEEEEECCHHHHCCCCEEEEEECCCCHHHHHCCCCCCCEE
LSIRLQPDEGIKLRVTIKEPGPGGMRLVDVPLDMTFAEALGPDVGRVPDAYERLIMDVIR
EEEEECCCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHC
GNQTLFMRGDEVEAAWAWTDPIIGGWKARSEKPVAYDTGSTGPEEALMLLHRDGRRWRDL
CCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCC
S
C
>Mature Secondary Structure
MVSRVIPVEPFDLVIFGGTGDLARRKILPALFRRFSDGQMPEGARIIGAARTKQSGAAWA
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHH
KWVHEALKEFLTKEELDKALVKAFLERLDYLAIDATGDGGWSDLKGKMRDGVTQAFYFSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCHHHCCHHHHHHHHC
GPSLFGALAERLHAHDIAHADARIVVEKPFGRDLASARELNGTLAAHFNETQIYRIDHYL
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCEEEEECCCCEEEEHHHHH
GKETVQNLMAIRFGNVLFEPLWNAQYIDHVQITVAETVGVDGRGAYYDKSGAMRDMVQNH
CHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEEEEECCCCCCCCEECCCCHHHHHHHHH
LMQLLCLTAMEPPNKFEPDAVRDEKLKVIRALDPVAPADIVRGQYQGKQGSYLEDVEDPG
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHCCCCC
SNTESYIAMKLHVANWRWNGTPFYLRTGKCLKSRKSEIVVHFKETPHSIFEADAGSHANV
CCCCCEEEEEEEEEEEEECCCEEEEECCHHHHCCCCEEEEEECCCCHHHHHCCCCCCCEE
LSIRLQPDEGIKLRVTIKEPGPGGMRLVDVPLDMTFAEALGPDVGRVPDAYERLIMDVIR
EEEEECCCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHC
GNQTLFMRGDEVEAAWAWTDPIIGGWKARSEKPVAYDTGSTGPEEALMLLHRDGRRWRDL
CCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]