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The map label for this gene is nqo3 [H]

Identifier: 89053674

GI number: 89053674

Start: 1144969

End: 1146987

Strand: Direct

Name: nqo3 [H]

Synonym: Jann_1183

Alternate gene names: 89053674

Gene position: 1144969-1146987 (Clockwise)

Preceding gene: 89053673

Following gene: 89053675

Centisome position: 26.52

GC content: 65.03

Gene sequence:

>2019_bases
ATGACCGACCTGCGCACGATCATCATCGACGACAACGAGGTCGAGGTTGATCCCGCCATGACCCTGATCCAGGCCTGTGA
GCAGGCCGGGATCGAGATCCCACGGTTCTGTTATCATGAGCGTCTGACCATCGCGGGCAATTGCCGCATGTGTCTGGTCG
AAGTCGTGGGCGGGCCGCCGAAACCTGCGGCAAGCTGCGCGATGCAGGTGAAGGATCTGCGCCCCGGCCCCGAGGGCGCG
CCGCCGGTGATCAAGACGAACTCGCCCATGGTCAAGAAGGCCCGCGAGGGGGTGATGGAGTTTCTGCTGATCAACCATCC
GCTGGATTGCCCGATCTGCGATCAGGGCGGCGAGTGCGATTTGCAGGATCAGGCGATGGCGTATGGCGTGGATTTCTCGC
GCTTCCGCGAGCCCAAGCGCGCCGTGGATAACCTGGAACTTGGCCCGCTGGTCGGCACCGCGATGACGCGCTGCATTTCC
TGCACCCGCTGCGTGCGGTTTATCACTGAGGTCGCGGGCATGCCCGAGATGGGCCAGACCGGCCGGGGCGAGGATGCGGA
GATCACCTCCTATCTGGGGGCAACGCTGGAATCAGAGATGCAGGGCAATATCGTGGATCTGTGCCCCGTCGGCGCGCTGA
CCAACAAGCCCTACAGCTTCACGGCACGCCCGTGGGAGTTGACGAAGACGGAAAGCATCGACGTGATGGATGCGCTTGGC
TCCAACATCCGGGTGGACACCAAGGGCCGCGAAGTGATGCGCATCCTACCGCGCAACCATGACGGCGTGAATGAGGAATG
GCTGAGCGACAAGTCCCGCTATATCTGGGACGGGTTGAAGCGCCAGCGTCTGGACCAGCCCTATATCCGTGAAAACGGCA
AGCTGCGCCCGGCCAGCTGGGGCGAGGCGATGGGCCTTGCGGCGTCGGAGATCAAGGGGGCCACGAAGCTGGCCGGGTTG
GTGGGCGATCTGGCCTCCACCGAGGCGGCGTTTGCGTTGAAATCCCTGGTCGAGGGGCAGGGCGGTGTCGTGGAATGCCG
CACCGACGGCGCGAAGCTGCCCGCCGGCAACCGCGCGGCCTACGTTGGCACCGCAAGCATCGAGGATATCGATGCGGCTG
AATATATCCAGCTGATCGGCACCAATCCCCGCGCCGAGGCTCCGGTCCTGAACGCCCGTCTGCGCAAGGCGTGGCTGCGG
GGCGCAAAGATCGGGCTGGTGGGCGAGGCCGTGGACCTGACCTATGAGTATGCCCATGTCGGCACCGGGTTCCCGGCGCT
GCGGACCCTTGCGGATCAGCAATATGATCAGGTGCTTGAGGCCAGTTCTCTGGTGATCGTGGGTCAGGGCGCTTTGACTG
GCGAGGGCGGGGCGGATGCACTGGCGCTTGCGATGCGAATGGCCGAACGGTCCCGGTCGGGTTTGCTTGTCCTGCATACG
GCGGCGGGCCGCGTGGGTGCCATGGATGTGGGGGCGACCAACTCCGATGGGATGGCCACCGTGCAGGATGCGGATGTGAT
TTACAACATGGGTGCGGATGAGGTGGAGGTCTCCACCGGGTCTTTTGTCATTTACCAAGGCTCCCACGGGGATCGGGGTG
CGCACCGCGCGGATGTGATCCTGCCGGGCGCGGCCTACACCGAGGAGACCGGCATCTTCGTGAACACCGAAGGCCGCCCG
CAAATGGCGCAGCGCGCGGGCTTCCCCCCGGGTGATGCGCGCGAGAACTGGGCGATCCTGCGGGCCCTGTCGGCGGAGGT
CGGCGCGACGTTGCCGTTTGATACCATTGCGGCGCTGCGCAAGGCGATGATGGCAGAGGCGCCGCATCTGAAGATGATCG
ACGAGGTGGCCGAGAATGAAGGCGAGGCGCTGGAGATCACGGATTTGGGGCAGGGGGATTTCACCAATGCGGTCAGCGAT
CACTACCTGACCAATCCGATCGCGCGGGCCTCGGGGCTGATGGCGGAGCTGAGCGCGGGCGCGAAGGCGCGTGGCCAGTC
CAGGATCGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
TTACCGCAGGGACGCCGATTGGCAGATTGCTGCGGTCGCGTTAGAAGCGGGGTCAGACGGTGGCGCGCGCCTGCGCCAAT
GACATGAGGGACCGACCGCC

Downstream 100 bases:

>100_bases
GGGGGATGCGGGTCGCTCCGCTCCGCTCAGCCCGCTTTTCCACCCTGGCGGGTGTCAGCGCGGCATGTCTGATCGGGTGT
CTGCCCGCCACCGAGGGGCC

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MTDLRTIIIDDNEVEVDPAMTLIQACEQAGIEIPRFCYHERLTIAGNCRMCLVEVVGGPPKPAASCAMQVKDLRPGPEGA
PPVIKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDFSRFREPKRAVDNLELGPLVGTAMTRCIS
CTRCVRFITEVAGMPEMGQTGRGEDAEITSYLGATLESEMQGNIVDLCPVGALTNKPYSFTARPWELTKTESIDVMDALG
SNIRVDTKGREVMRILPRNHDGVNEEWLSDKSRYIWDGLKRQRLDQPYIRENGKLRPASWGEAMGLAASEIKGATKLAGL
VGDLASTEAAFALKSLVEGQGGVVECRTDGAKLPAGNRAAYVGTASIEDIDAAEYIQLIGTNPRAEAPVLNARLRKAWLR
GAKIGLVGEAVDLTYEYAHVGTGFPALRTLADQQYDQVLEASSLVIVGQGALTGEGGADALALAMRMAERSRSGLLVLHT
AAGRVGAMDVGATNSDGMATVQDADVIYNMGADEVEVSTGSFVIYQGSHGDRGAHRADVILPGAAYTEETGIFVNTEGRP
QMAQRAGFPPGDARENWAILRALSAEVGATLPFDTIAALRKAMMAEAPHLKMIDEVAENEGEALEITDLGQGDFTNAVSD
HYLTNPIARASGLMAELSAGAKARGQSRIAAE

Sequences:

>Translated_672_residues
MTDLRTIIIDDNEVEVDPAMTLIQACEQAGIEIPRFCYHERLTIAGNCRMCLVEVVGGPPKPAASCAMQVKDLRPGPEGA
PPVIKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDFSRFREPKRAVDNLELGPLVGTAMTRCIS
CTRCVRFITEVAGMPEMGQTGRGEDAEITSYLGATLESEMQGNIVDLCPVGALTNKPYSFTARPWELTKTESIDVMDALG
SNIRVDTKGREVMRILPRNHDGVNEEWLSDKSRYIWDGLKRQRLDQPYIRENGKLRPASWGEAMGLAASEIKGATKLAGL
VGDLASTEAAFALKSLVEGQGGVVECRTDGAKLPAGNRAAYVGTASIEDIDAAEYIQLIGTNPRAEAPVLNARLRKAWLR
GAKIGLVGEAVDLTYEYAHVGTGFPALRTLADQQYDQVLEASSLVIVGQGALTGEGGADALALAMRMAERSRSGLLVLHT
AAGRVGAMDVGATNSDGMATVQDADVIYNMGADEVEVSTGSFVIYQGSHGDRGAHRADVILPGAAYTEETGIFVNTEGRP
QMAQRAGFPPGDARENWAILRALSAEVGATLPFDTIAALRKAMMAEAPHLKMIDEVAENEGEALEITDLGQGDFTNAVSD
HYLTNPIARASGLMAELSAGAKARGQSRIAAE
>Mature_671_residues
TDLRTIIIDDNEVEVDPAMTLIQACEQAGIEIPRFCYHERLTIAGNCRMCLVEVVGGPPKPAASCAMQVKDLRPGPEGAP
PVIKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDFSRFREPKRAVDNLELGPLVGTAMTRCISC
TRCVRFITEVAGMPEMGQTGRGEDAEITSYLGATLESEMQGNIVDLCPVGALTNKPYSFTARPWELTKTESIDVMDALGS
NIRVDTKGREVMRILPRNHDGVNEEWLSDKSRYIWDGLKRQRLDQPYIRENGKLRPASWGEAMGLAASEIKGATKLAGLV
GDLASTEAAFALKSLVEGQGGVVECRTDGAKLPAGNRAAYVGTASIEDIDAAEYIQLIGTNPRAEAPVLNARLRKAWLRG
AKIGLVGEAVDLTYEYAHVGTGFPALRTLADQQYDQVLEASSLVIVGQGALTGEGGADALALAMRMAERSRSGLLVLHTA
AGRVGAMDVGATNSDGMATVQDADVIYNMGADEVEVSTGSFVIYQGSHGDRGAHRADVILPGAAYTEETGIFVNTEGRPQ
MAQRAGFPPGDARENWAILRALSAEVGATLPFDTIAALRKAMMAEAPHLKMIDEVAENEGEALEITDLGQGDFTNAVSDH
YLTNPIARASGLMAELSAGAKARGQSRIAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=707, Percent_Identity=45.968882602546, Blast_Score=588, Evalue=1e-168,
Organism=Escherichia coli, GI145693161, Length=336, Percent_Identity=34.2261904761905, Blast_Score=201, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17565758, Length=687, Percent_Identity=46.5793304221252, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32566231, Length=584, Percent_Identity=48.6301369863014, Blast_Score=522, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI193209088, Length=283, Percent_Identity=55.4770318021201, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24640559, Length=680, Percent_Identity=47.3529411764706, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640557, Length=680, Percent_Identity=47.3529411764706, Blast_Score=573, Evalue=1e-163,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71884; Mature: 71753

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLRTIIIDDNEVEVDPAMTLIQACEQAGIEIPRFCYHERLTIAGNCRMCLVEVVGGPP
CCCCEEEEECCCCEECCHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEECCCCC
KPAASCAMQVKDLRPGPEGAPPVIKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECD
CHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
LQDQAMAYGVDFSRFREPKRAVDNLELGPLVGTAMTRCISCTRCVRFITEVAGMPEMGQT
CCCCHHHCCCCHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRGEDAEITSYLGATLESEMQGNIVDLCPVGALTNKPYSFTARPWELTKTESIDVMDALG
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCC
SNIRVDTKGREVMRILPRNHDGVNEEWLSDKSRYIWDGLKRQRLDQPYIRENGKLRPASW
CCEEEECCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCCC
GEAMGLAASEIKGATKLAGLVGDLASTEAAFALKSLVEGQGGVVECRTDGAKLPAGNRAA
CHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEE
YVGTASIEDIDAAEYIQLIGTNPRAEAPVLNARLRKAWLRGAKIGLVGEAVDLTYEYAHV
EEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECHHHEEEEEHHC
GTGFPALRTLADQQYDQVLEASSLVIVGQGALTGEGGADALALAMRMAERSRSGLLVLHT
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEE
AAGRVGAMDVGATNSDGMATVQDADVIYNMGADEVEVSTGSFVIYQGSHGDRGAHRADVI
CCCCCCEEECCCCCCCCCEEEECCCEEEECCCCEEEECCCCEEEEECCCCCCCCCCCCEE
LPGAAYTEETGIFVNTEGRPQMAQRAGFPPGDARENWAILRALSAEVGATLPFDTIAALR
ECCCCCCCCCCEEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
KAMMAEAPHLKMIDEVAENEGEALEITDLGQGDFTNAVSDHYLTNPIARASGLMAELSAG
HHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCC
AKARGQSRIAAE
CCCCCCCCCCCC
>Mature Secondary Structure 
TDLRTIIIDDNEVEVDPAMTLIQACEQAGIEIPRFCYHERLTIAGNCRMCLVEVVGGPP
CCCEEEEECCCCEECCHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEECCCCC
KPAASCAMQVKDLRPGPEGAPPVIKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECD
CHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
LQDQAMAYGVDFSRFREPKRAVDNLELGPLVGTAMTRCISCTRCVRFITEVAGMPEMGQT
CCCCHHHCCCCHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRGEDAEITSYLGATLESEMQGNIVDLCPVGALTNKPYSFTARPWELTKTESIDVMDALG
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCC
SNIRVDTKGREVMRILPRNHDGVNEEWLSDKSRYIWDGLKRQRLDQPYIRENGKLRPASW
CCEEEECCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCCC
GEAMGLAASEIKGATKLAGLVGDLASTEAAFALKSLVEGQGGVVECRTDGAKLPAGNRAA
CHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEE
YVGTASIEDIDAAEYIQLIGTNPRAEAPVLNARLRKAWLRGAKIGLVGEAVDLTYEYAHV
EEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECHHHEEEEEHHC
GTGFPALRTLADQQYDQVLEASSLVIVGQGALTGEGGADALALAMRMAERSRSGLLVLHT
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEE
AAGRVGAMDVGATNSDGMATVQDADVIYNMGADEVEVSTGSFVIYQGSHGDRGAHRADVI
CCCCCCEEECCCCCCCCCEEEECCCEEEECCCCEEEECCCCEEEEECCCCCCCCCCCCEE
LPGAAYTEETGIFVNTEGRPQMAQRAGFPPGDARENWAILRALSAEVGATLPFDTIAALR
ECCCCCCCCCCEEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
KAMMAEAPHLKMIDEVAENEGEALEITDLGQGDFTNAVSDHYLTNPIARASGLMAELSAG
HHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCC
AKARGQSRIAAE
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]