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The map label for this gene is lktA [H]

Identifier: 89053557

GI number: 89053557

Start: 1025899

End: 1028751

Strand: Direct

Name: lktA [H]

Synonym: Jann_1066

Alternate gene names: 89053557

Gene position: 1025899-1028751 (Clockwise)

Preceding gene: 89053555

Following gene: 89053563

Centisome position: 23.76

GC content: 62.81

Gene sequence:

>2853_bases
ATGGCAACATATTTCGTCACGACATCGAATTGGAATGATCCGTCCTTCTGGTCCTCGATCAATCAATCGGGCGACGGCCA
TTCGATCGATTTCGGCAATCTACCCAGCAACTTTTCGGTGGAGTTCGACAAGGGCAGCGGTCTTGTCACGCTGTCGGACG
GGACGTCGACATTCACGATTGGGGATGCCAACCATGGTGGCAGCTCGGACGCGACCCTGGGTGGCTCCACGCAGTGGACG
TATTTCGATAATGTCGAGGGAAGCCAGGGCGATGACAGCTACACCGGTGACAACAGCGCCGACAGATATGAAGGCCAGGC
CGGCGACGACACAGTGCAGGGCGGTGGTGGCGACGACTACCTTGATGGCTGGCAGGGTGACGACAGCATCGACGGCGAGG
ACGGGGATGACTTCATCTACGGCTACGACGGGAATGATACGATCTCGGGTGGTGCGGGCAACGATACGATTGACGGAGAG
GACGGCGACGACAGCATAGACGGCGGCTCCGGCAATGACAGCCTGAGCGGAGGCGGCGGCAACGATACGATCCAGGGCGG
CGATGGCCGCGACACCATTGATGGCGGCTCTGGCAATGACAGCATTGACGGCGGTGGCGACAGCGACACGATCTCGGGCG
GCAGCGGGGCCGACACGATCGACGGGGGTGCGGGCGACGACCAGATCAGCGGGGGCGACGGGGCCGACGTGATCACAGGG
GGCACCGGCGACGACACGATTGACGGCGGCGCAGGGGCCGATGTGATCCACGGCAATGACGGTGACGACAGTCTGGACGG
CGGCACGGGCGACGACACGATCCACGGCGGCGATGGCAGCGATACCATCCTTTTGGGCGATGACGGAAATTCGGGCCGCA
CGAAGGTCAACGCCGGCGATAACCTTCAGGGGACCACCGGCCAGGATGCCTATGAATGGGCGGGCGGTGCGGGAAATTCC
GCCGTGATCCGGTTCAATTTGTCCGCGACTGCGGGCGACAGTGACGGCCTTGCCGATTACGTCGTCGTCACCAACGCAGA
TGATGCGGGCACTTTAACGATTGGCGATTTCGATATCGGCATCGACACGATCTATATCCAGGAACCGTGGGCCAATGTCA
GCAGTTCGACAGGCGATTACAACGGCACGCCGTTTGAGACCTACACGCTGACCTACGCCGATGGCGCGCAGCAGACCTTC
CGGATTTATCACGATGGCTCAACGCCGCCGAATGTGGCCGACATCTTCTCAACCGGGACGTCACCCTCCGCGGCTGTGCC
CGACGGCAACGATAGTGTCACGGGCGGAAGTGACGCTGATACGTTCGTGGTCTCGGACGGTTTCGGCAACGACACCGTTG
AGGGCGGCAGCGGCGGCACCGATTATGACACCATCGACCTCTCGTCCCTGACGGGGCCCGTCACCGTCTCCTATTCAGGA
ACCGAGGCGGGCACGATCACCGACGGCACCAATACGATCACCTTCTCGGATATCGAGCATCTGACCCTTTCAGATCAGGC
CGATGTCGTGAACGCGACCAGCGCGACCGAGAGGATTTCCATCGACCTAGGGGCCGGGGATGACAGCCTCACCGACGGGG
ACGGCGACGATTCAATTATCGCGGGCGACGGTGACGATTTCATCATGGCCAATGATGGCAATGATACCATCGAAGGCGGC
GCAGGCGACGACGATATTGAGGGCGGCGGCGGCGCGGACAGCATCGACGGCGGCGACGGCAACGATTTCATCGCGGGCTA
CGATGTCGCGGGCCTTGCGGCCAACAGCGAGCGCGTCAACACCGATGACGGCGCGAACGATACCTTGTCGGGCGGCGCGG
GCGAAGACACGCTTCTGGGCGGTGCGGGCGATGATGACCTGGACGGCGGCGCGGACAACGACACCCTGAAGGGTGGCACC
GGCAATGACAGCCTCACGGGCGGCGATGGCGATGATACCTTCGTCTATAATGTGGGCGATGGCCTTGATACGATCACCGA
TTTCAATGCGGGCAACAGCGGTGATCTGGGTGACGGCGACCCCACGAACAACGATTTCATCGACCTCAGCGCCTACTACG
ATTCGATCCGGGAATTGCGCGCTGACTTTGAGGATGACGGCATCCTCAACCAATCCAACGACACGGGGCCGGGGGCTGCC
GATTACTCCGACAACACGCAGATGGCTGACGGGGAGGGGATCGCGTTCCAGAACGCGTCCCGCAACAGCTTCTCCGCCGA
TTCCACCGGTGTGGTCTGCTTCACCCGCGGCACGGCCATCCGCACCCCGCGCGGGGAGGTCCTGATCGAAGATCTCCGTG
TCGGTGATCTGGTGGATACGCTCGATAATGGCCCGCAACGGCTCGTCTGGATCGGCACGCGAGAGGTCAGTGTCGCGCAG
CTGACGATCTATCCCAACCTGCGCCCGATCCGCATTCAACGGGGCGTCCTGGGCAACACGCGCAAGATGCTGGTGTCGCG
TCAGCACGGCATGCTTCTGGGGCAGGATCACTTCGCCCGCGCCGTTCACCTGAGCAAATGCATGCGCGGCGTGGGGCTGC
TGCGCCCCGAGGAGGGCGTGACCTACATCCACCTGTTGTTCGAGAGCCATCAGGTCGTCTTCGCCGAAGGAATTGCGAGC
GAGAGCTTCTACCCCGGCCCCCAGGCATTGGCGATGATGGACGCGGCGGGTCGCGCGGCCCTGGCCACGCATCTGCCGAC
ACTGAACACCGACGCCCCCACGCTTATGAACGCCCATATCGCCTACGGCCCGCCCGTCCGCGCGTTTCTGGCCAAGCAAG
AGGTGGCGGAGTGGACGCTGCGCGACAGGCCACAATTTGCGTTGGCGGGGTAG

Upstream 100 bases:

>100_bases
TACAATTTTAACTAAGTCTTCCGCAGATTCATGGCGCGCCCACAGCAAGCCTTAACATCAGGCGGATATCTCAGGGGCCT
TCGCGCGCAAGGGGCCCGAC

Downstream 100 bases:

>100_bases
CACGGGGCCATGGGGCATGGGCCGGTTGGTCGCGCGCTGAGATCAGCGGCAAGCACGGCGGTTCGGGACGCTGCGCGGCC
TAGTCGCGGGCCGTGCCCTC

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 950; Mature: 949

Protein sequence:

>950_residues
MATYFVTTSNWNDPSFWSSINQSGDGHSIDFGNLPSNFSVEFDKGSGLVTLSDGTSTFTIGDANHGGSSDATLGGSTQWT
YFDNVEGSQGDDSYTGDNSADRYEGQAGDDTVQGGGGDDYLDGWQGDDSIDGEDGDDFIYGYDGNDTISGGAGNDTIDGE
DGDDSIDGGSGNDSLSGGGGNDTIQGGDGRDTIDGGSGNDSIDGGGDSDTISGGSGADTIDGGAGDDQISGGDGADVITG
GTGDDTIDGGAGADVIHGNDGDDSLDGGTGDDTIHGGDGSDTILLGDDGNSGRTKVNAGDNLQGTTGQDAYEWAGGAGNS
AVIRFNLSATAGDSDGLADYVVVTNADDAGTLTIGDFDIGIDTIYIQEPWANVSSSTGDYNGTPFETYTLTYADGAQQTF
RIYHDGSTPPNVADIFSTGTSPSAAVPDGNDSVTGGSDADTFVVSDGFGNDTVEGGSGGTDYDTIDLSSLTGPVTVSYSG
TEAGTITDGTNTITFSDIEHLTLSDQADVVNATSATERISIDLGAGDDSLTDGDGDDSIIAGDGDDFIMANDGNDTIEGG
AGDDDIEGGGGADSIDGGDGNDFIAGYDVAGLAANSERVNTDDGANDTLSGGAGEDTLLGGAGDDDLDGGADNDTLKGGT
GNDSLTGGDGDDTFVYNVGDGLDTITDFNAGNSGDLGDGDPTNNDFIDLSAYYDSIRELRADFEDDGILNQSNDTGPGAA
DYSDNTQMADGEGIAFQNASRNSFSADSTGVVCFTRGTAIRTPRGEVLIEDLRVGDLVDTLDNGPQRLVWIGTREVSVAQ
LTIYPNLRPIRIQRGVLGNTRKMLVSRQHGMLLGQDHFARAVHLSKCMRGVGLLRPEEGVTYIHLLFESHQVVFAEGIAS
ESFYPGPQALAMMDAAGRAALATHLPTLNTDAPTLMNAHIAYGPPVRAFLAKQEVAEWTLRDRPQFALAG

Sequences:

>Translated_950_residues
MATYFVTTSNWNDPSFWSSINQSGDGHSIDFGNLPSNFSVEFDKGSGLVTLSDGTSTFTIGDANHGGSSDATLGGSTQWT
YFDNVEGSQGDDSYTGDNSADRYEGQAGDDTVQGGGGDDYLDGWQGDDSIDGEDGDDFIYGYDGNDTISGGAGNDTIDGE
DGDDSIDGGSGNDSLSGGGGNDTIQGGDGRDTIDGGSGNDSIDGGGDSDTISGGSGADTIDGGAGDDQISGGDGADVITG
GTGDDTIDGGAGADVIHGNDGDDSLDGGTGDDTIHGGDGSDTILLGDDGNSGRTKVNAGDNLQGTTGQDAYEWAGGAGNS
AVIRFNLSATAGDSDGLADYVVVTNADDAGTLTIGDFDIGIDTIYIQEPWANVSSSTGDYNGTPFETYTLTYADGAQQTF
RIYHDGSTPPNVADIFSTGTSPSAAVPDGNDSVTGGSDADTFVVSDGFGNDTVEGGSGGTDYDTIDLSSLTGPVTVSYSG
TEAGTITDGTNTITFSDIEHLTLSDQADVVNATSATERISIDLGAGDDSLTDGDGDDSIIAGDGDDFIMANDGNDTIEGG
AGDDDIEGGGGADSIDGGDGNDFIAGYDVAGLAANSERVNTDDGANDTLSGGAGEDTLLGGAGDDDLDGGADNDTLKGGT
GNDSLTGGDGDDTFVYNVGDGLDTITDFNAGNSGDLGDGDPTNNDFIDLSAYYDSIRELRADFEDDGILNQSNDTGPGAA
DYSDNTQMADGEGIAFQNASRNSFSADSTGVVCFTRGTAIRTPRGEVLIEDLRVGDLVDTLDNGPQRLVWIGTREVSVAQ
LTIYPNLRPIRIQRGVLGNTRKMLVSRQHGMLLGQDHFARAVHLSKCMRGVGLLRPEEGVTYIHLLFESHQVVFAEGIAS
ESFYPGPQALAMMDAAGRAALATHLPTLNTDAPTLMNAHIAYGPPVRAFLAKQEVAEWTLRDRPQFALAG
>Mature_949_residues
ATYFVTTSNWNDPSFWSSINQSGDGHSIDFGNLPSNFSVEFDKGSGLVTLSDGTSTFTIGDANHGGSSDATLGGSTQWTY
FDNVEGSQGDDSYTGDNSADRYEGQAGDDTVQGGGGDDYLDGWQGDDSIDGEDGDDFIYGYDGNDTISGGAGNDTIDGED
GDDSIDGGSGNDSLSGGGGNDTIQGGDGRDTIDGGSGNDSIDGGGDSDTISGGSGADTIDGGAGDDQISGGDGADVITGG
TGDDTIDGGAGADVIHGNDGDDSLDGGTGDDTIHGGDGSDTILLGDDGNSGRTKVNAGDNLQGTTGQDAYEWAGGAGNSA
VIRFNLSATAGDSDGLADYVVVTNADDAGTLTIGDFDIGIDTIYIQEPWANVSSSTGDYNGTPFETYTLTYADGAQQTFR
IYHDGSTPPNVADIFSTGTSPSAAVPDGNDSVTGGSDADTFVVSDGFGNDTVEGGSGGTDYDTIDLSSLTGPVTVSYSGT
EAGTITDGTNTITFSDIEHLTLSDQADVVNATSATERISIDLGAGDDSLTDGDGDDSIIAGDGDDFIMANDGNDTIEGGA
GDDDIEGGGGADSIDGGDGNDFIAGYDVAGLAANSERVNTDDGANDTLSGGAGEDTLLGGAGDDDLDGGADNDTLKGGTG
NDSLTGGDGDDTFVYNVGDGLDTITDFNAGNSGDLGDGDPTNNDFIDLSAYYDSIRELRADFEDDGILNQSNDTGPGAAD
YSDNTQMADGEGIAFQNASRNSFSADSTGVVCFTRGTAIRTPRGEVLIEDLRVGDLVDTLDNGPQRLVWIGTREVSVAQL
TIYPNLRPIRIQRGVLGNTRKMLVSRQHGMLLGQDHFARAVHLSKCMRGVGLLRPEEGVTYIHLLFESHQVVFAEGIASE
SFYPGPQALAMMDAAGRAALATHLPTLNTDAPTLMNAHIAYGPPVRAFLAKQEVAEWTLRDRPQFALAG

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 96958; Mature: 96827

Theoretical pI: Translated: 3.50; Mature: 3.50

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYFVTTSNWNDPSFWSSINQSGDGHSIDFGNLPSNFSVEFDKGSGLVTLSDGTSTFTI
CEEEEEEECCCCCHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCCCEEEECCCCEEEEE
GDANHGGSSDATLGGSTQWTYFDNVEGSQGDDSYTGDNSADRYEGQAGDDTVQGGGGDDY
ECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCC
LDGWQGDDSIDGEDGDDFIYGYDGNDTISGGAGNDTIDGEDGDDSIDGGSGNDSLSGGGG
CCCCCCCCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NDTIQGGDGRDTIDGGSGNDSIDGGGDSDTISGGSGADTIDGGAGDDQISGGDGADVITG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
GTGDDTIDGGAGADVIHGNDGDDSLDGGTGDDTIHGGDGSDTILLGDDGNSGRTKVNAGD
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCCCCEEECCCC
NLQGTTGQDAYEWAGGAGNSAVIRFNLSATAGDSDGLADYVVVTNADDAGTLTIGDFDIG
CCCCCCCCCHHHHCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECCCCCCEEEEECEECC
IDTIYIQEPWANVSSSTGDYNGTPFETYTLTYADGAQQTFRIYHDGSTPPNVADIFSTGT
EEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHCCC
SPSAAVPDGNDSVTGGSDADTFVVSDGFGNDTVEGGSGGTDYDTIDLSSLTGPVTVSYSG
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECC
TEAGTITDGTNTITFSDIEHLTLSDQADVVNATSATERISIDLGAGDDSLTDGDGDDSII
CCCCEEECCCCEEEECCCEEEEECCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCCEE
AGDGDDFIMANDGNDTIEGGAGDDDIEGGGGADSIDGGDGNDFIAGYDVAGLAANSERVN
ECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCC
TDDGANDTLSGGAGEDTLLGGAGDDDLDGGADNDTLKGGTGNDSLTGGDGDDTFVYNVGD
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GLDTITDFNAGNSGDLGDGDPTNNDFIDLSAYYDSIRELRADFEDDGILNQSNDTGPGAA
CCCHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DYSDNTQMADGEGIAFQNASRNSFSADSTGVVCFTRGTAIRTPRGEVLIEDLRVGDLVDT
CCCCCCEECCCCCEEEECCCCCCCCCCCCCEEEEECCCEEECCCCCEEEECCCHHHHHHH
LDNGPQRLVWIGTREVSVAQLTIYPNLRPIRIQRGVLGNTRKMLVSRQHGMLLGQDHFAR
HCCCCCEEEEEECCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCEEECCHHHHH
AVHLSKCMRGVGLLRPEEGVTYIHLLFESHQVVFAEGIASESFYPGPQALAMMDAAGRAA
HHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHCCCEE
LATHLPTLNTDAPTLMNAHIAYGPPVRAFLAKQEVAEWTLRDRPQFALAG
HHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCC
>Mature Secondary Structure 
ATYFVTTSNWNDPSFWSSINQSGDGHSIDFGNLPSNFSVEFDKGSGLVTLSDGTSTFTI
EEEEEEECCCCCHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCCCEEEECCCCEEEEE
GDANHGGSSDATLGGSTQWTYFDNVEGSQGDDSYTGDNSADRYEGQAGDDTVQGGGGDDY
ECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCC
LDGWQGDDSIDGEDGDDFIYGYDGNDTISGGAGNDTIDGEDGDDSIDGGSGNDSLSGGGG
CCCCCCCCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NDTIQGGDGRDTIDGGSGNDSIDGGGDSDTISGGSGADTIDGGAGDDQISGGDGADVITG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
GTGDDTIDGGAGADVIHGNDGDDSLDGGTGDDTIHGGDGSDTILLGDDGNSGRTKVNAGD
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCCCCEEECCCC
NLQGTTGQDAYEWAGGAGNSAVIRFNLSATAGDSDGLADYVVVTNADDAGTLTIGDFDIG
CCCCCCCCCHHHHCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECCCCCCEEEEECEECC
IDTIYIQEPWANVSSSTGDYNGTPFETYTLTYADGAQQTFRIYHDGSTPPNVADIFSTGT
EEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHCCC
SPSAAVPDGNDSVTGGSDADTFVVSDGFGNDTVEGGSGGTDYDTIDLSSLTGPVTVSYSG
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECC
TEAGTITDGTNTITFSDIEHLTLSDQADVVNATSATERISIDLGAGDDSLTDGDGDDSII
CCCCEEECCCCEEEECCCEEEEECCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCCEE
AGDGDDFIMANDGNDTIEGGAGDDDIEGGGGADSIDGGDGNDFIAGYDVAGLAANSERVN
ECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCC
TDDGANDTLSGGAGEDTLLGGAGDDDLDGGADNDTLKGGTGNDSLTGGDGDDTFVYNVGD
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GLDTITDFNAGNSGDLGDGDPTNNDFIDLSAYYDSIRELRADFEDDGILNQSNDTGPGAA
CCCHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DYSDNTQMADGEGIAFQNASRNSFSADSTGVVCFTRGTAIRTPRGEVLIEDLRVGDLVDT
CCCCCCEECCCCCEEEECCCCCCCCCCCCCEEEEECCCEEECCCCCEEEECCCHHHHHHH
LDNGPQRLVWIGTREVSVAQLTIYPNLRPIRIQRGVLGNTRKMLVSRQHGMLLGQDHFAR
HCCCCCEEEEEECCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCEEECCHHHHH
AVHLSKCMRGVGLLRPEEGVTYIHLLFESHQVVFAEGIASESFYPGPQALAMMDAAGRAA
HHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHCCCEE
LATHLPTLNTDAPTLMNAHIAYGPPVRAFLAKQEVAEWTLRDRPQFALAG
HHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]