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The map label for this gene is atpB [H]

Identifier: 89053258

GI number: 89053258

Start: 728398

End: 729246

Strand: Direct

Name: atpB [H]

Synonym: Jann_0767

Alternate gene names: 89053258

Gene position: 728398-729246 (Clockwise)

Preceding gene: 89053257

Following gene: 89053259

Centisome position: 16.87

GC content: 62.31

Gene sequence:

>849_bases
ATGGCGACTGACAGCACCAACACTCAGACCGGCGGCGGATCAAACCGCATGGTGGCCTACGTTCTGATCGGCCTCGCCGT
CCTTGGGTTCATCGCAGCCTACATGGATGACTATGCGGGCGGTCTTGCGATCCACCCGATGGATCAGTTCGAGATCAAGC
CGCTGTTCGGCTATGGTGAGGTCGGGTTCTTCACGATCACCAATTCCACCCTCTGGATGGGCCTCGCCGTGCTGGCCGTG
ATCGCGCTGATGGTCTGGGGCACACGTGGTCGCGCCGTGATCCCGTCGCGTAGCCAGTCGATGGCCGAGTTGGCCTATGG
CTTCGTGCGCCAGATGGTCGAGGACGTGGCAGGCAAGGACGCGCTGCCCTACTTCCCCTACATCTTCACGCTGTTTCTCT
ACATCCTCTGCGCCAATTTCCTGGGCCTGATCCCGTCCAGCTTCACGACAACCTCGCACATCGCCGTGACGGCCGTGCTG
GCGCTTGCCGTGTTCATTACCGTCACAATCGTCGGCTTCGTGAAAAACGGGGCCGGGTTCCTGAGCCTGTTTTGGGTCTC
CTCCGCGCCGCTGGTGTTGCGCCCGATCCTCGCGGTGATCGAGATCATTTCCTACTTCGTGCGCCCCGTCAGCCACTCCG
TCCGACTTGCGGGCGTGATGTTGGCTGGCCACGCGGTCCTCAAGGTGTTCGCCGGGTTCGCGGGCGCCATGGGCCTCGCC
AGCATCGCGCCGATCCTGGGCGTTGTGGCGATCTACGGCCTCGAAGTGCTCGTGTCGGCCATCCAGGCCTACGTGTTCAC
CATTCTGACATGTGTCTACCTGAAGGACGCACTGCACCCCGCTCACTAA

Upstream 100 bases:

>100_bases
AAGACCATGATCGGCTCGGCGAAAGAGGTCCAGCAAGACGCGCTGGAGCGCGAAGAGATCAAGACGCGCGAAAGCGCCGG
ACAGGAAACGGGGACGCAGG

Downstream 100 bases:

>100_bases
TTTCGACCCGGGCTGACCTGTCCGGCTAGAGGTAACTTCCAATCGGGCCAGAGCCCGGAAATCTAAAGAAACGTAAGGAG
ATACATCATGGAAGGCGATA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MATDSTNTQTGGGSNRMVAYVLIGLAVLGFIAAYMDDYAGGLAIHPMDQFEIKPLFGYGEVGFFTITNSTLWMGLAVLAV
IALMVWGTRGRAVIPSRSQSMAELAYGFVRQMVEDVAGKDALPYFPYIFTLFLYILCANFLGLIPSSFTTTSHIAVTAVL
ALAVFITVTIVGFVKNGAGFLSLFWVSSAPLVLRPILAVIEIISYFVRPVSHSVRLAGVMLAGHAVLKVFAGFAGAMGLA
SIAPILGVVAIYGLEVLVSAIQAYVFTILTCVYLKDALHPAH

Sequences:

>Translated_282_residues
MATDSTNTQTGGGSNRMVAYVLIGLAVLGFIAAYMDDYAGGLAIHPMDQFEIKPLFGYGEVGFFTITNSTLWMGLAVLAV
IALMVWGTRGRAVIPSRSQSMAELAYGFVRQMVEDVAGKDALPYFPYIFTLFLYILCANFLGLIPSSFTTTSHIAVTAVL
ALAVFITVTIVGFVKNGAGFLSLFWVSSAPLVLRPILAVIEIISYFVRPVSHSVRLAGVMLAGHAVLKVFAGFAGAMGLA
SIAPILGVVAIYGLEVLVSAIQAYVFTILTCVYLKDALHPAH
>Mature_281_residues
ATDSTNTQTGGGSNRMVAYVLIGLAVLGFIAAYMDDYAGGLAIHPMDQFEIKPLFGYGEVGFFTITNSTLWMGLAVLAVI
ALMVWGTRGRAVIPSRSQSMAELAYGFVRQMVEDVAGKDALPYFPYIFTLFLYILCANFLGLIPSSFTTTSHIAVTAVLA
LAVFITVTIVGFVKNGAGFLSLFWVSSAPLVLRPILAVIEIISYFVRPVSHSVRLAGVMLAGHAVLKVFAGFAGAMGLAS
IAPILGVVAIYGLEVLVSAIQAYVFTILTCVYLKDALHPAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=151, Percent_Identity=31.7880794701987, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6226527, Length=246, Percent_Identity=34.5528455284553, Blast_Score=139, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 30060; Mature: 29929

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDSTNTQTGGGSNRMVAYVLIGLAVLGFIAAYMDDYAGGLAIHPMDQFEIKPLFGYGE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEECCCC
VGFFTITNSTLWMGLAVLAVIALMVWGTRGRAVIPSRSQSMAELAYGFVRQMVEDVAGKD
EEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCC
ALPYFPYIFTLFLYILCANFLGLIPSSFTTTSHIAVTAVLALAVFITVTIVGFVKNGAGF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LSLFWVSSAPLVLRPILAVIEIISYFVRPVSHSVRLAGVMLAGHAVLKVFAGFAGAMGLA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIAPILGVVAIYGLEVLVSAIQAYVFTILTCVYLKDALHPAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATDSTNTQTGGGSNRMVAYVLIGLAVLGFIAAYMDDYAGGLAIHPMDQFEIKPLFGYGE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEECCCC
VGFFTITNSTLWMGLAVLAVIALMVWGTRGRAVIPSRSQSMAELAYGFVRQMVEDVAGKD
EEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCC
ALPYFPYIFTLFLYILCANFLGLIPSSFTTTSHIAVTAVLALAVFITVTIVGFVKNGAGF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LSLFWVSSAPLVLRPILAVIEIISYFVRPVSHSVRLAGVMLAGHAVLKVFAGFAGAMGLA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIAPILGVVAIYGLEVLVSAIQAYVFTILTCVYLKDALHPAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA