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The map label for this gene is ctaD [H]

Identifier: 88658568

GI number: 88658568

Start: 1028969

End: 1030525

Strand: Direct

Name: ctaD [H]

Synonym: ECH_1003

Alternate gene names: 88658568

Gene position: 1028969-1030525 (Clockwise)

Preceding gene: 88658348

Following gene: 88658064

Centisome position: 87.48

GC content: 35.9

Gene sequence:

>1557_bases
ATGAGTAGTGAACATACACCACAGGGGATAAGACGTTGGTTGTTTTCAACAAATCACAAAGATATAGGTACATTATATAT
CATTTTTTCCATTATTGGTGGACTTGTAGGTGGTATAATGTCTCTTGTACTGAGATTACAACTAGCACATATTAACGTAT
TACATGATAACTATCAATTATATAATGTTATTGTAACAGGGCATGCATTAATTATGGTGTTTTTTATGATCATGCCAGCT
TTAACTGGAGGATTTGGTAATTGGTTCGTACCATTGCTTATAGGAGCCCCAGACATGGCATTCCCACGTCTTAATAATGT
AAGCTTCTGGCTGTTGGTTGCCTCACTAATTCTATTATGTATATCTGTCTTGATAGGAGAAGGTGCAGGTACAGGGTGGA
CATTATACCCACCATTATCATATATCGGGTCTCATCCAAGTGCTTCCGTAGATATAGCAATATTCGCTATACATGTTGCT
GGAGCTTCATCAATTGTAGGAGCAATAAATTTCATTGTGACAATATTCAACATGCGAGCTCATGGCATGACATTGTTAAA
AATGCCACTATTCGTCTGGACAATATTATTAACATCTTTTATGTTAATAGTGACAATCCCAGTTTTAGGGGGCGCAGTAA
CAATGCTATTAACAGACAGAAATTTTGGCACAAGTTTTTTTGACCCTGCTGGTGGAGGTGATCCTTTATTATTCCAACAT
CTATTTTGGTTCTTTGGACACCCAGAAGTGTATATAATCATATTCCCAGCATTTGGAATAATAAGCCAAATTGTATCCAC
TTTTTCTCATAAAGCAGTTTTTGGATACTTAGGTATGGTATTAGCATTAGTTGGCATTGCAGCTGTAGGTGCAGTAGTAT
GGGCACATCACATGTTTACTGTTGGATTAAGCGCAGAGATTATGACATATTTCAGTGTTACTACCATGTTAATAGGTGTG
TTAACAGGAGTTAAAGTATTCAGCTGGATTGCAACTATGTGGGGAGGACAAATAGAATTTAAAACTCCTATGCTATTTTC
AATTGGATTTATCTTCGTATTTGTAGTAGGAGGAGTTACTGGTATTGTAATTTCACACGGTGGTATAGATAAAGCACTGC
ACGACACATACTATGTAGTTGCACATTTCCATTATGTAATGTCAATCGCTGCATTGTTTGCTGCCTTTGCTGCTTTCTAT
TACTGGATAGGTAAAATATCAGGTAAGCAATATAACGAATGTTTAGGTAAAATACATTTCTGGTTAACTTTTATTGGAAC
TAATATTACATTTTTACCTCAACACTTTTTAGGTGTAGCAGGCATGCCAAGACGGATCCCAGATTACCCAGATGCTTTTA
TTCCATGGAATTATATATCATCAGTAGGAGCATTGATATCATTCATATCAGCCTTATTTTTTGTTTACATAATTATTTCA
ACATTAAGAAATGGAAAAAAATGTCCTAGCAATCCATGGGGAGGAGATACATTAGAATGGACAATACCATCACCAGCACC
TTTCCATACCTTTGAAGAAATACCAAAGGTTGATTAA

Upstream 100 bases:

>100_bases
GAAGACTGCATGGATTTATGCCAATAGTAATAGTTGCTGTTGAAAAAGAACAATTTGACGAATGGATACAAAAAAAGACA
CTTGAATTATAGAGGCATGC

Downstream 100 bases:

>100_bases
GCATGAGTTCTAAATGTGAAAGTGTTAAACCACAGCTTGTAAATGAAGTATTAGGCTATTGGGATCTACTCAAACCAAAA
ATCATGTATTTAGTAGTTCT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSSEHTPQGIRRWLFSTNHKDIGTLYIIFSIIGGLVGGIMSLVLRLQLAHINVLHDNYQLYNVIVTGHALIMVFFMIMPA
LTGGFGNWFVPLLIGAPDMAFPRLNNVSFWLLVASLILLCISVLIGEGAGTGWTLYPPLSYIGSHPSASVDIAIFAIHVA
GASSIVGAINFIVTIFNMRAHGMTLLKMPLFVWTILLTSFMLIVTIPVLGGAVTMLLTDRNFGTSFFDPAGGGDPLLFQH
LFWFFGHPEVYIIIFPAFGIISQIVSTFSHKAVFGYLGMVLALVGIAAVGAVVWAHHMFTVGLSAEIMTYFSVTTMLIGV
LTGVKVFSWIATMWGGQIEFKTPMLFSIGFIFVFVVGGVTGIVISHGGIDKALHDTYYVVAHFHYVMSIAALFAAFAAFY
YWIGKISGKQYNECLGKIHFWLTFIGTNITFLPQHFLGVAGMPRRIPDYPDAFIPWNYISSVGALISFISALFFVYIIIS
TLRNGKKCPSNPWGGDTLEWTIPSPAPFHTFEEIPKVD

Sequences:

>Translated_518_residues
MSSEHTPQGIRRWLFSTNHKDIGTLYIIFSIIGGLVGGIMSLVLRLQLAHINVLHDNYQLYNVIVTGHALIMVFFMIMPA
LTGGFGNWFVPLLIGAPDMAFPRLNNVSFWLLVASLILLCISVLIGEGAGTGWTLYPPLSYIGSHPSASVDIAIFAIHVA
GASSIVGAINFIVTIFNMRAHGMTLLKMPLFVWTILLTSFMLIVTIPVLGGAVTMLLTDRNFGTSFFDPAGGGDPLLFQH
LFWFFGHPEVYIIIFPAFGIISQIVSTFSHKAVFGYLGMVLALVGIAAVGAVVWAHHMFTVGLSAEIMTYFSVTTMLIGV
LTGVKVFSWIATMWGGQIEFKTPMLFSIGFIFVFVVGGVTGIVISHGGIDKALHDTYYVVAHFHYVMSIAALFAAFAAFY
YWIGKISGKQYNECLGKIHFWLTFIGTNITFLPQHFLGVAGMPRRIPDYPDAFIPWNYISSVGALISFISALFFVYIIIS
TLRNGKKCPSNPWGGDTLEWTIPSPAPFHTFEEIPKVD
>Mature_517_residues
SSEHTPQGIRRWLFSTNHKDIGTLYIIFSIIGGLVGGIMSLVLRLQLAHINVLHDNYQLYNVIVTGHALIMVFFMIMPAL
TGGFGNWFVPLLIGAPDMAFPRLNNVSFWLLVASLILLCISVLIGEGAGTGWTLYPPLSYIGSHPSASVDIAIFAIHVAG
ASSIVGAINFIVTIFNMRAHGMTLLKMPLFVWTILLTSFMLIVTIPVLGGAVTMLLTDRNFGTSFFDPAGGGDPLLFQHL
FWFFGHPEVYIIIFPAFGIISQIVSTFSHKAVFGYLGMVLALVGIAAVGAVVWAHHMFTVGLSAEIMTYFSVTTMLIGVL
TGVKVFSWIATMWGGQIEFKTPMLFSIGFIFVFVVGGVTGIVISHGGIDKALHDTYYVVAHFHYVMSIAALFAAFAAFYY
WIGKISGKQYNECLGKIHFWLTFIGTNITFLPQHFLGVAGMPRRIPDYPDAFIPWNYISSVGALISFISALFFVYIIIST
LRNGKKCPSNPWGGDTLEWTIPSPAPFHTFEEIPKVD

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=504, Percent_Identity=55.3571428571429, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=41.4396887159533, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6226519, Length=527, Percent_Identity=52.7514231499051, Blast_Score=574, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=57.2755417956656, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=54.4354838709677, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6226521, Length=67, Percent_Identity=50.7462686567164, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6226522, Length=80, Percent_Identity=47.5, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 56952; Mature: 56821

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEHTPQGIRRWLFSTNHKDIGTLYIIFSIIGGLVGGIMSLVLRLQLAHINVLHDNYQL
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEE
YNVIVTGHALIMVFFMIMPALTGGFGNWFVPLLIGAPDMAFPRLNNVSFWLLVASLILLC
EEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ISVLIGEGAGTGWTLYPPLSYIGSHPSASVDIAIFAIHVAGASSIVGAINFIVTIFNMRA
HHHHHCCCCCCCCEECCCHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
HGMTLLKMPLFVWTILLTSFMLIVTIPVLGGAVTMLLTDRNFGTSFFDPAGGGDPLLFQH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHH
LFWFFGHPEVYIIIFPAFGIISQIVSTFSHKAVFGYLGMVLALVGIAAVGAVVWAHHMFT
HHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLSAEIMTYFSVTTMLIGVLTGVKVFSWIATMWGGQIEFKTPMLFSIGFIFVFVVGGVT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHH
GIVISHGGIDKALHDTYYVVAHFHYVMSIAALFAAFAAFYYWIGKISGKQYNECLGKIHF
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
WLTFIGTNITFLPQHFLGVAGMPRRIPDYPDAFIPWNYISSVGALISFISALFFVYIIIS
HHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TLRNGKKCPSNPWGGDTLEWTIPSPAPFHTFEEIPKVD
HHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
SSEHTPQGIRRWLFSTNHKDIGTLYIIFSIIGGLVGGIMSLVLRLQLAHINVLHDNYQL
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEE
YNVIVTGHALIMVFFMIMPALTGGFGNWFVPLLIGAPDMAFPRLNNVSFWLLVASLILLC
EEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ISVLIGEGAGTGWTLYPPLSYIGSHPSASVDIAIFAIHVAGASSIVGAINFIVTIFNMRA
HHHHHCCCCCCCCEECCCHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
HGMTLLKMPLFVWTILLTSFMLIVTIPVLGGAVTMLLTDRNFGTSFFDPAGGGDPLLFQH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHH
LFWFFGHPEVYIIIFPAFGIISQIVSTFSHKAVFGYLGMVLALVGIAAVGAVVWAHHMFT
HHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLSAEIMTYFSVTTMLIGVLTGVKVFSWIATMWGGQIEFKTPMLFSIGFIFVFVVGGVT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHH
GIVISHGGIDKALHDTYYVVAHFHYVMSIAALFAAFAAFYYWIGKISGKQYNECLGKIHF
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
WLTFIGTNITFLPQHFLGVAGMPRRIPDYPDAFIPWNYISSVGALISFISALFFVYIIIS
HHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TLRNGKKCPSNPWGGDTLEWTIPSPAPFHTFEEIPKVD
HHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]