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The map label for this gene is pqqL [C]

Identifier: 88658542

GI number: 88658542

Start: 1084236

End: 1085555

Strand: Direct

Name: pqqL [C]

Synonym: ECH_1057

Alternate gene names: 88658542

Gene position: 1084236-1085555 (Clockwise)

Preceding gene: 88657923

Following gene: 88658196

Centisome position: 92.18

GC content: 31.82

Gene sequence:

>1320_bases
ATGGTTAAATTTTTTACTTGTTTTTTTACAATCTTCTTCACAATAGCTAATCATGCTTTATCTTTTAACATTAAAGTTAC
ACATGAAAAGCTAGATAATGGCATGGAAGTATATGTTATCCCTAATCATCGCGCACCCGCAGTTATGCATATGGTATTAT
ATAAAGTTGGTGGGACTGATGATCCAGTAGGTTATTCTGGACTTGCACATTTTTTTGAACATTTAATGTTCAGTGGTACA
GAAAAATTCCCTAATCTTATAACTACTCTAAGTGATATAGGCGGAAACTTCAATGCAAGTACATCTGAATTTTGCACTAT
ATATTATGAACTAATACCAAAACAACATTTATCTCTTGCAATGGATATTGAATCAGACAGAATGCAAAATTTTAAAATTA
CTGATAAGGCATTAATAAGAGAGCAAAAGGTAGTATTAGAAGAAAGAAAAATGAGAGTTGAAAGTCAGGCAAAAAACATA
CTGCAAGAAGAGATGGAAAACACATTCTATTATAATGGATATGGTAGACCAGTAGTAGGGTGGGAACATGAAATCAGCAA
TTACAATAGAGAAGTTGCTGAAGCATTTTATAAACTTCACTACAGCCCTAACAACGCTATATTAGTTGTAACTGGAGATG
TCGATCCACAGGAAACAATCAACCTTGCACAACAGTACTATGGGAAGATAGAACCTAATCACAAAAAATCCACACGTGTT
TTTAGAGCAGAACCTTCACACAAAGCAAACATTACATTAACATTAGAAGATAGTTCAGTAGAAATCCCAGAATTATTTTT
AATGTATCAAATACCAAGCGGTATCGCAAATAAAAACTATATACTCAATATGATGGCAGCAGAAATACTTGGTAACGGTA
AATTCAGTTTGCTTTACAATGATCTAGTAATGAATAACTCAATAGTCACATCAATAGGCACCAATTATAACTATTTAACT
GATAGTGATAACTACCTCTTTATAGAAGCCGTACCTAAAGATGGGATCTCTACAGAAACTGTAGAAAAAGAAATCCACAA
ATGTATAAATAGTTATCTTGAAAATGGCATTTCACCAGAATATTTAGAAAGTGCAAAACAAAAAGTAAAAGCACACTTAA
CTTATTCTCTTGATGGATTAAGCTTTATATCATATTTCTACGGCATGAACTTAATTCTAGGAGTACCATTATCAGAAATT
AACAATATTTACGATACAATAGATAAAATAAAGATTGAGGATATTGATTCCACTATGGAAAACATCTTCTTAAAGAACGT
AAGATTAGCTGGACATTTATTACCTAAATTGGGAGAATAG

Upstream 100 bases:

>100_bases
AATTAATGATTTGATAATAAAAAGACAATAACCTTAATTCATTTGATATTCTCAAATTATACATATAAACTATCAATCAA
ATAATCGTAAGGTTACAGTA

Downstream 100 bases:

>100_bases
TTATGAGGAATACATTATTCTACATAATAACATTGATTTTTTTTGCATATAATGCATATGCAGATGATATTAATATCAAC
ATAAAGGAAGCCACTATTAA

Product: M16 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MVKFFTCFFTIFFTIANHALSFNIKVTHEKLDNGMEVYVIPNHRAPAVMHMVLYKVGGTDDPVGYSGLAHFFEHLMFSGT
EKFPNLITTLSDIGGNFNASTSEFCTIYYELIPKQHLSLAMDIESDRMQNFKITDKALIREQKVVLEERKMRVESQAKNI
LQEEMENTFYYNGYGRPVVGWEHEISNYNREVAEAFYKLHYSPNNAILVVTGDVDPQETINLAQQYYGKIEPNHKKSTRV
FRAEPSHKANITLTLEDSSVEIPELFLMYQIPSGIANKNYILNMMAAEILGNGKFSLLYNDLVMNNSIVTSIGTNYNYLT
DSDNYLFIEAVPKDGISTETVEKEIHKCINSYLENGISPEYLESAKQKVKAHLTYSLDGLSFISYFYGMNLILGVPLSEI
NNIYDTIDKIKIEDIDSTMENIFLKNVRLAGHLLPKLGE

Sequences:

>Translated_439_residues
MVKFFTCFFTIFFTIANHALSFNIKVTHEKLDNGMEVYVIPNHRAPAVMHMVLYKVGGTDDPVGYSGLAHFFEHLMFSGT
EKFPNLITTLSDIGGNFNASTSEFCTIYYELIPKQHLSLAMDIESDRMQNFKITDKALIREQKVVLEERKMRVESQAKNI
LQEEMENTFYYNGYGRPVVGWEHEISNYNREVAEAFYKLHYSPNNAILVVTGDVDPQETINLAQQYYGKIEPNHKKSTRV
FRAEPSHKANITLTLEDSSVEIPELFLMYQIPSGIANKNYILNMMAAEILGNGKFSLLYNDLVMNNSIVTSIGTNYNYLT
DSDNYLFIEAVPKDGISTETVEKEIHKCINSYLENGISPEYLESAKQKVKAHLTYSLDGLSFISYFYGMNLILGVPLSEI
NNIYDTIDKIKIEDIDSTMENIFLKNVRLAGHLLPKLGE
>Mature_439_residues
MVKFFTCFFTIFFTIANHALSFNIKVTHEKLDNGMEVYVIPNHRAPAVMHMVLYKVGGTDDPVGYSGLAHFFEHLMFSGT
EKFPNLITTLSDIGGNFNASTSEFCTIYYELIPKQHLSLAMDIESDRMQNFKITDKALIREQKVVLEERKMRVESQAKNI
LQEEMENTFYYNGYGRPVVGWEHEISNYNREVAEAFYKLHYSPNNAILVVTGDVDPQETINLAQQYYGKIEPNHKKSTRV
FRAEPSHKANITLTLEDSSVEIPELFLMYQIPSGIANKNYILNMMAAEILGNGKFSLLYNDLVMNNSIVTSIGTNYNYLT
DSDNYLFIEAVPKDGISTETVEKEIHKCINSYLENGISPEYLESAKQKVKAHLTYSLDGLSFISYFYGMNLILGVPLSEI
NNIYDTIDKIKIEDIDSTMENIFLKNVRLAGHLLPKLGE

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=365, Percent_Identity=22.7397260273973, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI46593007, Length=215, Percent_Identity=25.1162790697674, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787770, Length=272, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI2367164, Length=125, Percent_Identity=32.8, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71999683, Length=380, Percent_Identity=21.0526315789474, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=419, Percent_Identity=23.6276849642005, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21357875, Length=297, Percent_Identity=24.2424242424242, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646943, Length=297, Percent_Identity=24.2424242424242, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667786, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 50071; Mature: 50071

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKFFTCFFTIFFTIANHALSFNIKVTHEKLDNGMEVYVIPNHRAPAVMHMVLYKVGGTD
CCHHHHHHHHHHHHHHHHEEEEEEEEEHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCC
DPVGYSGLAHFFEHLMFSGTEKFPNLITTLSDIGGNFNASTSEFCTIYYELIPKQHLSLA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEE
MDIESDRMQNFKITDKALIREQKVVLEERKMRVESQAKNILQEEMENTFYYNGYGRPVVG
EECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
WEHEISNYNREVAEAFYKLHYSPNNAILVVTGDVDPQETINLAQQYYGKIEPNHKKSTRV
CHHHHHHCCHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEE
FRAEPSHKANITLTLEDSSVEIPELFLMYQIPSGIANKNYILNMMAAEILGNGKFSLLYN
EECCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
DLVMNNSIVTSIGTNYNYLTDSDNYLFIEAVPKDGISTETVEKEIHKCINSYLENGISPE
HHHCCCCEEEECCCCCCEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
YLESAKQKVKAHLTYSLDGLSFISYFYGMNLILGVPLSEINNIYDTIDKIKIEDIDSTME
HHHHHHHHHHHHEEEECCHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHEEEHHHHHHHH
NIFLKNVRLAGHLLPKLGE
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVKFFTCFFTIFFTIANHALSFNIKVTHEKLDNGMEVYVIPNHRAPAVMHMVLYKVGGTD
CCHHHHHHHHHHHHHHHHEEEEEEEEEHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCC
DPVGYSGLAHFFEHLMFSGTEKFPNLITTLSDIGGNFNASTSEFCTIYYELIPKQHLSLA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEE
MDIESDRMQNFKITDKALIREQKVVLEERKMRVESQAKNILQEEMENTFYYNGYGRPVVG
EECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
WEHEISNYNREVAEAFYKLHYSPNNAILVVTGDVDPQETINLAQQYYGKIEPNHKKSTRV
CHHHHHHCCHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEE
FRAEPSHKANITLTLEDSSVEIPELFLMYQIPSGIANKNYILNMMAAEILGNGKFSLLYN
EECCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
DLVMNNSIVTSIGTNYNYLTDSDNYLFIEAVPKDGISTETVEKEIHKCINSYLENGISPE
HHHCCCCEEEECCCCCCEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
YLESAKQKVKAHLTYSLDGLSFISYFYGMNLILGVPLSEINNIYDTIDKIKIEDIDSTME
HHHHHHHHHHHHEEEECCHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHEEEHHHHHHHH
NIFLKNVRLAGHLLPKLGE
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]