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The map label for this gene is clpP [H]

Identifier: 88658316

GI number: 88658316

Start: 928847

End: 929446

Strand: Reverse

Name: clpP [H]

Synonym: ECH_0901

Alternate gene names: 88658316

Gene position: 929446-928847 (Counterclockwise)

Preceding gene: 88657614

Following gene: 88658550

Centisome position: 79.02

GC content: 36.0

Gene sequence:

>600_bases
ATGACTTTAGTCCCCATGGTAGTTGAACAGACTAGTAGAGGCGAGCGTGCATATGATATATATTCACGATTGTTAAAGGA
AAGGATAATCTTCATAACTGGACCGATAGAAGATCAAATGGCAAGTCTAATAGTTGCGCAGCTTATATTTTTAGAATCTG
AAAATCCAGAAAAAGAAATATGTATGTATATTAATTCTCCAGGTGGTGTTGTTACAGCTGGGTTATCAATATATGACACT
ATGCAGTATATAAAACCTAAGGTTTCTACATTATGTTTAGGGCAAGCTGCTTCTATGGGATCTTTGTTATTGGCTGCTGG
AGAACCAGGAATGCGTTATGCACTTCCTAATTCTAGGATCATGATCCATCAACCTTCAGGTGGTTTCCAAGGACAAGCAA
CTGATATAGAAATACATGCTAAAGAGATCTTGGATATTAAGGGTAGGCTTAATGATATTTATGTAAAGCATACAGGAAGA
GATTTATCAGAAGTTGTTGCAAATATGGAACGCGATAATTTTATGAGAGCTGAGAAAGCTAAAGATTTTGGTATTATTGA
TAAAGTTATTGAGAAGCGTCTCGATATTGGGGTAGAGTAA

Upstream 100 bases:

>100_bases
GATATAAGCCTTATGTTTGAGAATATATAGTTGTAAAATTATATTAAATGGATTAGTTTAAGACAGCATTTATAGTGATT
GTAAAGAAAAGGAGATGGCT

Downstream 100 bases:

>100_bases
TTAAAATTGGAGAGATATGGCAGATAATGAAAAAAATTCTTGTAGCTGTTCTTTCTGCGGAAAGATTCATAGTGAAGTAC
GTAAGTTAATTGCTGGGCCA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTLVPMVVEQTSRGERAYDIYSRLLKERIIFITGPIEDQMASLIVAQLIFLESENPEKEICMYINSPGGVVTAGLSIYDT
MQYIKPKVSTLCLGQAASMGSLLLAAGEPGMRYALPNSRIMIHQPSGGFQGQATDIEIHAKEILDIKGRLNDIYVKHTGR
DLSEVVANMERDNFMRAEKAKDFGIIDKVIEKRLDIGVE

Sequences:

>Translated_199_residues
MTLVPMVVEQTSRGERAYDIYSRLLKERIIFITGPIEDQMASLIVAQLIFLESENPEKEICMYINSPGGVVTAGLSIYDT
MQYIKPKVSTLCLGQAASMGSLLLAAGEPGMRYALPNSRIMIHQPSGGFQGQATDIEIHAKEILDIKGRLNDIYVKHTGR
DLSEVVANMERDNFMRAEKAKDFGIIDKVIEKRLDIGVE
>Mature_198_residues
TLVPMVVEQTSRGERAYDIYSRLLKERIIFITGPIEDQMASLIVAQLIFLESENPEKEICMYINSPGGVVTAGLSIYDTM
QYIKPKVSTLCLGQAASMGSLLLAAGEPGMRYALPNSRIMIHQPSGGFQGQATDIEIHAKEILDIKGRLNDIYVKHTGRD
LSEVVANMERDNFMRAEKAKDFGIIDKVIEKRLDIGVE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=65.7894736842105, Blast_Score=266, Evalue=6e-72,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=65.8031088082902, Blast_Score=287, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=58.0645161290323, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=68.586387434555, Blast_Score=274, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22137; Mature: 22006

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVPMVVEQTSRGERAYDIYSRLLKERIIFITGPIEDQMASLIVAQLIFLESENPEKEI
CCCCCHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEE
CMYINSPGGVVTAGLSIYDTMQYIKPKVSTLCLGQAASMGSLLLAAGEPGMRYALPNSRI
EEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCEE
MIHQPSGGFQGQATDIEIHAKEILDIKGRLNDIYVKHTGRDLSEVVANMERDNFMRAEKA
EEECCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
KDFGIIDKVIEKRLDIGVE
CCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLVPMVVEQTSRGERAYDIYSRLLKERIIFITGPIEDQMASLIVAQLIFLESENPEKEI
CCCCHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEE
CMYINSPGGVVTAGLSIYDTMQYIKPKVSTLCLGQAASMGSLLLAAGEPGMRYALPNSRI
EEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCEE
MIHQPSGGFQGQATDIEIHAKEILDIKGRLNDIYVKHTGRDLSEVVANMERDNFMRAEKA
EEECCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
KDFGIIDKVIEKRLDIGVE
CCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA