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The map label for this gene is ywlC [H]

Identifier: 88658214

GI number: 88658214

Start: 816944

End: 817528

Strand: Direct

Name: ywlC [H]

Synonym: ECH_0802

Alternate gene names: 88658214

Gene position: 816944-817528 (Clockwise)

Preceding gene: 88658068

Following gene: 88658108

Centisome position: 69.45

GC content: 30.6

Gene sequence:

>585_bases
ATGATCTCAGAAGCAGTACAAGCATTAAAAAATAAACACTTAATATTATTTCCCACTGAAACTGTTTACGCACTAGCTGG
AAGTGCATACAGCATTGAAGCAGTACAAAAAATATATCAGATAAAAGGTAGATCATACAATAAACCCTTATCTTTACTAC
TTAGCAATATTGATAAAATTAAACAATTTTCCACTTTAACAGAACACACTTTTAAAATAATACAAAAACTTTCTCCTGGA
CCTGTAACTTTTGTATTACCAATTCATAATTATAACAAACTACCTAGACAATTCTTTAATGACACTATTGGAATCAGAAT
ACCAGATCACCCTATAGCTCTAGAAATATTAAGTAATTTCGATAATCCTGTTGTAGGAACAAGCGTTAACATTTCTGGAC
AACCTAGTGTCACTGCCTCACATCAAGTTCAAGAAACAATTAAGCAGCACATTTCAGTAATAATAGAAGATGACAGCTTA
GTAAATGGTATTGAATCAACAGTAATCGACTTAACATCATATAAAATATTAAGAACAGGAGCAGTATCAGAAAAGAAAAT
CCAGGATATAATACATAGTATATAG

Upstream 100 bases:

>100_bases
TTGTTAACCAAAAAGATCACTTTATAATTTTAATCATAGCTCTATCATTAAAATTATATTTGTACTATTTATATATACTG
ACAATTAACTTATATATAAA

Downstream 100 bases:

>100_bases
ATTAACGCATAAACTTTATAGTAAAACATAAAAGTTCATAAAAAAATATTCATACCATACTGATCAATATATATTAAAAA
ACTTATATAAATAACCTTAT

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MISEAVQALKNKHLILFPTETVYALAGSAYSIEAVQKIYQIKGRSYNKPLSLLLSNIDKIKQFSTLTEHTFKIIQKLSPG
PVTFVLPIHNYNKLPRQFFNDTIGIRIPDHPIALEILSNFDNPVVGTSVNISGQPSVTASHQVQETIKQHISVIIEDDSL
VNGIESTVIDLTSYKILRTGAVSEKKIQDIIHSI

Sequences:

>Translated_194_residues
MISEAVQALKNKHLILFPTETVYALAGSAYSIEAVQKIYQIKGRSYNKPLSLLLSNIDKIKQFSTLTEHTFKIIQKLSPG
PVTFVLPIHNYNKLPRQFFNDTIGIRIPDHPIALEILSNFDNPVVGTSVNISGQPSVTASHQVQETIKQHISVIIEDDSL
VNGIESTVIDLTSYKILRTGAVSEKKIQDIIHSI
>Mature_194_residues
MISEAVQALKNKHLILFPTETVYALAGSAYSIEAVQKIYQIKGRSYNKPLSLLLSNIDKIKQFSTLTEHTFKIIQKLSPG
PVTFVLPIHNYNKLPRQFFNDTIGIRIPDHPIALEILSNFDNPVVGTSVNISGQPSVTASHQVQETIKQHISVIIEDDSL
VNGIESTVIDLTSYKILRTGAVSEKKIQDIIHSI

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=194, Percent_Identity=29.8969072164948, Blast_Score=84, Evalue=9e-17,
Organism=Escherichia coli, GI2367210, Length=158, Percent_Identity=29.1139240506329, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI87081864, Length=177, Percent_Identity=24.8587570621469, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=195, Percent_Identity=27.6923076923077, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321269, Length=204, Percent_Identity=30.3921568627451, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI78707274, Length=189, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 21574; Mature: 21574

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEAVQALKNKHLILFPTETVYALAGSAYSIEAVQKIYQIKGRSYNKPLSLLLSNIDKI
CHHHHHHHHHCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KQFSTLTEHTFKIIQKLSPGPVTFVLPIHNYNKLPRQFFNDTIGIRIPDHPIALEILSNF
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCCHHHHHHHCC
DNPVVGTSVNISGQPSVTASHQVQETIKQHISVIIEDDSLVNGIESTVIDLTSYKILRTG
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHCC
AVSEKKIQDIIHSI
CCCHHHHHHHHHCC
>Mature Secondary Structure
MISEAVQALKNKHLILFPTETVYALAGSAYSIEAVQKIYQIKGRSYNKPLSLLLSNIDKI
CHHHHHHHHHCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KQFSTLTEHTFKIIQKLSPGPVTFVLPIHNYNKLPRQFFNDTIGIRIPDHPIALEILSNF
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCCHHHHHHHCC
DNPVVGTSVNISGQPSVTASHQVQETIKQHISVIIEDDSLVNGIESTVIDLTSYKILRTG
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHCC
AVSEKKIQDIIHSI
CCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]