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The map label for this gene is rnc

Identifier: 88658070

GI number: 88658070

Start: 1082503

End: 1083183

Strand: Direct

Name: rnc

Synonym: ECH_1054

Alternate gene names: 88658070

Gene position: 1082503-1083183 (Clockwise)

Preceding gene: 88658500

Following gene: 88657923

Centisome position: 92.03

GC content: 32.89

Gene sequence:

>681_bases
ATGATAGAAAGTATATCAAAAATCATAAAATATAACTTTAAAAATCCCCAATTATTAAATGAGGCATTGACACATCCTAG
TCTAGTATCAAAAGATACCTTAAAATTTAACTATGAAAGACTAGAATTCCTAGGGGATGCAGTATTAAACATAGTAATAT
CCGAAATGCTATTCAATATTTTCCCTAAAGATACAGAAGGTAACCTCGCTAAAAAGAAGACAGCATTAGTTTGTGGCAAT
AAGTTAGTAGAAGTTGCACAGTCTATAAATCTCGGACAATTTATCATGATGTCAGATGGTGAAAGAGCGTGTGGTGGTAT
AAATAATTTCCGTAATTTAGAAAATGCATTAGAAGCTTTAATAGGTGCAATATACCTTGACGGAGGATTTACAGCAGCAC
AAGACTTTATATACTTATTTTGGGAACATTCTGCAACACATATGAATGTCCCTCCACAAGATGCAAAAACTATACTGCAA
GAATTGGTACAAGGAAAAAGGTTACCAGCTCCTGCATATCACACCATAGATAAATCTGGACCAGATCACAACCCTACATT
TACAGTAGAAGTAAGAATTCCATCATATCAAGCAATACAAGCAACTGGTCATAATAAAAAACTCGCTGAACAAAAAGCAG
CAAGTTTAATGTTAAATCAAATTCATAACAAAACAAAATGA

Upstream 100 bases:

>100_bases
TTCTATAACTTATATTAAGTTTTACAACATTCAAAATAATATTACTATAAAGGATACAGAATTTAAACATAGTACATCTT
ACTACAATTAAAATAAAATC

Downstream 100 bases:

>100_bases
CACCAAGAATAAAAAATACTATTTACATATTAATAACAATAATATTATCCATGGTATGTTTAGTATATGCTTCTGTACCA
TTATATAGCATATTTTGTAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MIESISKIIKYNFKNPQLLNEALTHPSLVSKDTLKFNYERLEFLGDAVLNIVISEMLFNIFPKDTEGNLAKKKTALVCGN
KLVEVAQSINLGQFIMMSDGERACGGINNFRNLENALEALIGAIYLDGGFTAAQDFIYLFWEHSATHMNVPPQDAKTILQ
ELVQGKRLPAPAYHTIDKSGPDHNPTFTVEVRIPSYQAIQATGHNKKLAEQKAASLMLNQIHNKTK

Sequences:

>Translated_226_residues
MIESISKIIKYNFKNPQLLNEALTHPSLVSKDTLKFNYERLEFLGDAVLNIVISEMLFNIFPKDTEGNLAKKKTALVCGN
KLVEVAQSINLGQFIMMSDGERACGGINNFRNLENALEALIGAIYLDGGFTAAQDFIYLFWEHSATHMNVPPQDAKTILQ
ELVQGKRLPAPAYHTIDKSGPDHNPTFTVEVRIPSYQAIQATGHNKKLAEQKAASLMLNQIHNKTK
>Mature_226_residues
MIESISKIIKYNFKNPQLLNEALTHPSLVSKDTLKFNYERLEFLGDAVLNIVISEMLFNIFPKDTEGNLAKKKTALVCGN
KLVEVAQSINLGQFIMMSDGERACGGINNFRNLENALEALIGAIYLDGGFTAAQDFIYLFWEHSATHMNVPPQDAKTILQ
ELVQGKRLPAPAYHTIDKSGPDHNPTFTVEVRIPSYQAIQATGHNKKLAEQKAASLMLNQIHNKTK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=99, Percent_Identity=38.3838383838384, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI155030234, Length=99, Percent_Identity=38.3838383838384, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=33.6492890995261, Blast_Score=127, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193202651, Length=214, Percent_Identity=28.0373831775701, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506883, Length=214, Percent_Identity=28.0373831775701, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137682, Length=219, Percent_Identity=28.7671232876712, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_EHRCR (Q2GFE4)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507839.1
- HSSP:   Q9X0I6
- ProteinModelPortal:   Q2GFE4
- SMR:   Q2GFE4
- STRING:   Q2GFE4
- GeneID:   3927257
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_1054
- TIGR:   ECH_1054
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q2GFE4
- ProtClustDB:   PRK00102
- BioCyc:   ECHA205920:ECH_1054-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25200; Mature: 25200

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESISKIIKYNFKNPQLLNEALTHPSLVSKDTLKFNYERLEFLGDAVLNIVISEMLFNI
CHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPKDTEGNLAKKKTALVCGNKLVEVAQSINLGQFIMMSDGERACGGINNFRNLENALEAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHH
IGAIYLDGGFTAAQDFIYLFWEHSATHMNVPPQDAKTILQELVQGKRLPAPAYHTIDKSG
HHHHHCCCCCHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCC
PDHNPTFTVEVRIPSYQAIQATGHNKKLAEQKAASLMLNQIHNKTK
CCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIESISKIIKYNFKNPQLLNEALTHPSLVSKDTLKFNYERLEFLGDAVLNIVISEMLFNI
CHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPKDTEGNLAKKKTALVCGNKLVEVAQSINLGQFIMMSDGERACGGINNFRNLENALEAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHH
IGAIYLDGGFTAAQDFIYLFWEHSATHMNVPPQDAKTILQELVQGKRLPAPAYHTIDKSG
HHHHHCCCCCHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCC
PDHNPTFTVEVRIPSYQAIQATGHNKKLAEQKAASLMLNQIHNKTK
CCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA