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The map label for this gene is grxC [H]

Identifier: 88658049

GI number: 88658049

Start: 1089785

End: 1090030

Strand: Direct

Name: grxC [H]

Synonym: ECH_1062

Alternate gene names: 88658049

Gene position: 1089785-1090030 (Clockwise)

Preceding gene: 88657825

Following gene: 88657866

Centisome position: 92.65

GC content: 30.49

Gene sequence:

>246_bases
GTGATAAAAGTGAAAATATATACTAAAGACTTCTGCCCTTATTGTACTAAAGCAAAGGCTTTATTCAACAAAAAAAACAT
TCCTTTTGAAGAAATTGACATTACAGGCAACAATTCTTTGCTAGAACAAATGATACAACAATCAAACGGCATGAAGACTG
TACCCCAAATATTTATTAATGATCAACATATAGGTGGCTGTGATGATTTATATAAACTGTATGAGTCAGGTAAACTAGAA
TTATAG

Upstream 100 bases:

>100_bases
CATATATTATTTTCATAATAAAATTTTATAAAATTCCTATATTTACTTTTTGCTATTACTATGATATCCAGAAATTCAGT
TAATCATAGGATACATTATA

Downstream 100 bases:

>100_bases
TAACAGCTGTACATATCTGTTTTTTAGCTAACATTCCTCCTCTATACAAATCAACTTGAAGAAATTGACATTACAGGCAA
CAATTCTTTGCTAGAACAAA

Product: glutaredoxin 3

Products: NA

Alternate protein names: Grx3 [H]

Number of amino acids: Translated: 81; Mature: 81

Protein sequence:

>81_residues
MIKVKIYTKDFCPYCTKAKALFNKKNIPFEEIDITGNNSLLEQMIQQSNGMKTVPQIFINDQHIGGCDDLYKLYESGKLE
L

Sequences:

>Translated_81_residues
MIKVKIYTKDFCPYCTKAKALFNKKNIPFEEIDITGNNSLLEQMIQQSNGMKTVPQIFINDQHIGGCDDLYKLYESGKLE
L
>Mature_81_residues
MIKVKIYTKDFCPYCTKAKALFNKKNIPFEEIDITGNNSLLEQMIQQSNGMKTVPQIFINDQHIGGCDDLYKLYESGKLE
L

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI291045268, Length=80, Percent_Identity=33.75, Blast_Score=66, Evalue=6e-12,
Organism=Homo sapiens, GI291045266, Length=80, Percent_Identity=33.75, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI169646776, Length=82, Percent_Identity=39.0243902439024, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI4504025, Length=82, Percent_Identity=39.0243902439024, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1790039, Length=80, Percent_Identity=56.25, Blast_Score=96, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320720, Length=83, Percent_Identity=37.3493975903614, Blast_Score=60, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24666486, Length=80, Percent_Identity=37.5, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922712, Length=80, Percent_Identity=36.25, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011900
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9321; Mature: 9321

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVKIYTKDFCPYCTKAKALFNKKNIPFEEIDITGNNSLLEQMIQQSNGMKTVPQIFIN
CEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEC
DQHIGGCDDLYKLYESGKLEL
CCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKVKIYTKDFCPYCTKAKALFNKKNIPFEEIDITGNNSLLEQMIQQSNGMKTVPQIFIN
CEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEC
DQHIGGCDDLYKLYESGKLEL
CCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]