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The map label for this gene is adk [H]

Identifier: 88607898

GI number: 88607898

Start: 284986

End: 285636

Strand: Direct

Name: adk [H]

Synonym: APH_0300

Alternate gene names: 88607898

Gene position: 284986-285636 (Clockwise)

Preceding gene: 88607078

Following gene: 88607193

Centisome position: 19.37

GC content: 43.78

Gene sequence:

>651_bases
ATGGAAAAAGAACAGGTAAATTTACTTATTTTTGGTGCTCCTGGTTCTGGAAAGGGGACGCAAGCGCGTTTGCTGGGTGA
ATATCTGAAGGGGCTTGAAGTTATCTCCATGGGAGATTTGTTGAGGGCTGAAGTTGCTTCTAAGACTGTGATAGGGGCAG
AAGTAGAAGCGATAATGCAAGAGGGAAGGCTTGTAGGAGATCCTTTAGTTTGCGAGATGATATTTAGGAAATTAAGGGGG
TTTTCTGCAGGTTTCTTATTGGATGGTTTTCCAAGGAATTTACCTCAAGCGGAATTTCTCACTGCAGTGATGCAGTTATT
GAATCGCAAGATAGATGCGGTTTTAAAGTTAGAGGTAGATGCTGCAGTTGTTGAGAATAGGCTGCAAGGTCGCCTGGTAT
GTAAGGGATGTGGTGCTGTATCCAATGCTGTGTTTAATCATGGTGCGTGTCAAGCGTGCGGCTGTGAGGAGTATGTTCGC
AGGAATGACGATTCGTTGAATGTTATTAGGCGAAGGCTCATGGATTATGATAGGGAAGTTACGGTGTTGGAAGGATACTA
TCAGGACAAGGTGATTAGGATAAATGGAGACAGAACTGTGGAAGAAATTCACGGGGATGTGAAGCATGTGCTAGATCGTC
TAAATAACTAG

Upstream 100 bases:

>100_bases
GCTTCTTGATTATTGTCAATGTCATTAATGATACGTTTTCTCAGGTACAGACTCAGATATATTCTGGAAGGTATAGTGCG
TTGATGAAGAAGTCAGAGCT

Downstream 100 bases:

>100_bases
TTGACGGTATGTGGAGCATTTGCTATATAGGGGTTTATTGGTGTTTTTGTTAGGGGTTTTTGGTGGCGCGTATAGGTGGG
GTTAACGTACCTGTAGATAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MEKEQVNLLIFGAPGSGKGTQARLLGEYLKGLEVISMGDLLRAEVASKTVIGAEVEAIMQEGRLVGDPLVCEMIFRKLRG
FSAGFLLDGFPRNLPQAEFLTAVMQLLNRKIDAVLKLEVDAAVVENRLQGRLVCKGCGAVSNAVFNHGACQACGCEEYVR
RNDDSLNVIRRRLMDYDREVTVLEGYYQDKVIRINGDRTVEEIHGDVKHVLDRLNN

Sequences:

>Translated_216_residues
MEKEQVNLLIFGAPGSGKGTQARLLGEYLKGLEVISMGDLLRAEVASKTVIGAEVEAIMQEGRLVGDPLVCEMIFRKLRG
FSAGFLLDGFPRNLPQAEFLTAVMQLLNRKIDAVLKLEVDAAVVENRLQGRLVCKGCGAVSNAVFNHGACQACGCEEYVR
RNDDSLNVIRRRLMDYDREVTVLEGYYQDKVIRINGDRTVEEIHGDVKHVLDRLNN
>Mature_216_residues
MEKEQVNLLIFGAPGSGKGTQARLLGEYLKGLEVISMGDLLRAEVASKTVIGAEVEAIMQEGRLVGDPLVCEMIFRKLRG
FSAGFLLDGFPRNLPQAEFLTAVMQLLNRKIDAVLKLEVDAAVVENRLQGRLVCKGCGAVSNAVFNHGACQACGCEEYVR
RNDDSLNVIRRRLMDYDREVTVLEGYYQDKVIRINGDRTVEEIHGDVKHVLDRLNN

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=33.0143540669856, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=33.0143540669856, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=34.5744680851064, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI310110345, Length=194, Percent_Identity=31.4432989690722, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI53832003, Length=194, Percent_Identity=31.4432989690722, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI8051579, Length=194, Percent_Identity=31.4432989690722, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI53832001, Length=194, Percent_Identity=31.4432989690722, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4502011, Length=214, Percent_Identity=29.4392523364486, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI28144897, Length=211, Percent_Identity=27.4881516587678, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI28144899, Length=211, Percent_Identity=27.4881516587678, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=33.9449541284404, Blast_Score=120, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=32.7102803738318, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17567503, Length=218, Percent_Identity=33.0275229357798, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=30, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=191, Percent_Identity=32.4607329842932, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=32.972972972973, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI22026816, Length=187, Percent_Identity=36.8983957219251, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=34.6733668341709, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=34.6733668341709, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24663208, Length=210, Percent_Identity=30.952380952381, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647141, Length=210, Percent_Identity=30.952380952381, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23981; Mature: 23981

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEQVNLLIFGAPGSGKGTQARLLGEYLKGLEVISMGDLLRAEVASKTVIGAEVEAIMQ
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGRLVGDPLVCEMIFRKLRGFSAGFLLDGFPRNLPQAEFLTAVMQLLNRKIDAVLKLEVD
CCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEHH
AAVVENRLQGRLVCKGCGAVSNAVFNHGACQACGCEEYVRRNDDSLNVIRRRLMDYDREV
HHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCE
TVLEGYYQDKVIRINGDRTVEEIHGDVKHVLDRLNN
EEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKEQVNLLIFGAPGSGKGTQARLLGEYLKGLEVISMGDLLRAEVASKTVIGAEVEAIMQ
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGRLVGDPLVCEMIFRKLRGFSAGFLLDGFPRNLPQAEFLTAVMQLLNRKIDAVLKLEVD
CCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEHH
AAVVENRLQGRLVCKGCGAVSNAVFNHGACQACGCEEYVRRNDDSLNVIRRRLMDYDREV
HHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCE
TVLEGYYQDKVIRINGDRTVEEIHGDVKHVLDRLNN
EEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA