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The map label for this gene is pyrH

Identifier: 88607790

GI number: 88607790

Start: 117715

End: 118449

Strand: Direct

Name: pyrH

Synonym: APH_0111

Alternate gene names: 88607790

Gene position: 117715-118449 (Clockwise)

Preceding gene: 88606992

Following gene: 88607028

Centisome position: 8.0

GC content: 44.9

Gene sequence:

>735_bases
ATGTCAATCGATTGTAATGTTGTGGAGAATGTGCGTTATTCTAGGGTTTTGCTGAAGGTATCGGGAGAGGCACTTGCCGG
AGAGAGAGGTTTTGGGTTCGATCAGGATGTCATAGGAAAGTTGTCGTGTGACTTGAAGAAGGTGAGAGAATCTGGGGTGG
AGCTGTGTATTGTGGTTGGTGGTGGCAATATCTTCCGTGGCTCATCTACCTCGTTTGGCTTTGAAAGAGCTAGTAATGAT
TATGTAGGTATGCTTGCTACTATGATCAATGCCTTAGCGTTGCAGAATTCACTTGAGGATATGGGGATAGCGAGTAGGGT
GCTTTCTGCTATTCCGATGACTGCTGTGTGTGAGACGTACATTAGAAGGCGTGCTATACGTCATCTAGAGAAGGGCAGAG
TGGTTATATGTGCTGCAGGGATTGGTAGCCCTTTCTTTACTACGGATACCGCTGCTGTGTTGAGAAGCATAGAGATGCGT
TGTGATGCTATATTCAAGGGCACACAGGTGGATGGTGTATATTCATCAGATCCAAAGAAGGATTGTTCTGCTACAAGATA
CGACAAAATCTCCTACCATGACTTACTTGCGTCAGATTTAAAGATAATGGATGCTGCCGCGGTGTCGCTCGCGAGGGAGA
ATTCTATTCCTATAATTGTGTTTGATCTAGGGAAAGAGAATGCTTTTTCGGAAGTGATGAAGGGAAGGGGTACGTTTACT
ACTATATCTGGATAG

Upstream 100 bases:

>100_bases
GCGCTTTGGGAGCTCCGTATCTAGCTAGATTGATTATTTAGTGTATTGTAGTATAATCAACGCTGACTGTGCCCACGGGG
GTGGAACTTACGCTTGGATT

Downstream 100 bases:

>100_bases
GAGGGGAAGTGGCTACTGGAGCGATTAGGCAATATGCTCAAGAGAGGATGGACAAGACTTATGCCATGTTCTTGAATGAC
ATATCGGGTATACGGACAGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSIDCNVVENVRYSRVLLKVSGEALAGERGFGFDQDVIGKLSCDLKKVRESGVELCIVVGGGNIFRGSSTSFGFERASND
YVGMLATMINALALQNSLEDMGIASRVLSAIPMTAVCETYIRRRAIRHLEKGRVVICAAGIGSPFFTTDTAAVLRSIEMR
CDAIFKGTQVDGVYSSDPKKDCSATRYDKISYHDLLASDLKIMDAAAVSLARENSIPIIVFDLGKENAFSEVMKGRGTFT
TISG

Sequences:

>Translated_244_residues
MSIDCNVVENVRYSRVLLKVSGEALAGERGFGFDQDVIGKLSCDLKKVRESGVELCIVVGGGNIFRGSSTSFGFERASND
YVGMLATMINALALQNSLEDMGIASRVLSAIPMTAVCETYIRRRAIRHLEKGRVVICAAGIGSPFFTTDTAAVLRSIEMR
CDAIFKGTQVDGVYSSDPKKDCSATRYDKISYHDLLASDLKIMDAAAVSLARENSIPIIVFDLGKENAFSEVMKGRGTFT
TISG
>Mature_243_residues
SIDCNVVENVRYSRVLLKVSGEALAGERGFGFDQDVIGKLSCDLKKVRESGVELCIVVGGGNIFRGSSTSFGFERASNDY
VGMLATMINALALQNSLEDMGIASRVLSAIPMTAVCETYIRRRAIRHLEKGRVVICAAGIGSPFFTTDTAAVLRSIEMRC
DAIFKGTQVDGVYSSDPKKDCSATRYDKISYHDLLASDLKIMDAAAVSLARENSIPIIVFDLGKENAFSEVMKGRGTFTT
ISG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=44.3965517241379, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_ANAPZ (Q2GLL2)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504739.1
- ProteinModelPortal:   Q2GLL2
- SMR:   Q2GLL2
- STRING:   Q2GLL2
- GeneID:   3930967
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0111
- NMPDR:   fig|212042.5.peg.108
- TIGR:   APH_0111
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q2GLL2
- BioCyc:   APHA212042:APH_0111-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26365; Mature: 26233

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: BINDING 61-61 BINDING 62-62 BINDING 66-66 BINDING 80-80 BINDING 168-168 BINDING 169-169 BINDING 174-174 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDCNVVENVRYSRVLLKVSGEALAGERGFGFDQDVIGKLSCDLKKVRESGVELCIVVG
CCCCCHHHHCCHHHEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEE
GGNIFRGSSTSFGFERASNDYVGMLATMINALALQNSLEDMGIASRVLSAIPMTAVCETY
CCCEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IRRRAIRHLEKGRVVICAAGIGSPFFTTDTAAVLRSIEMRCDAIFKGTQVDGVYSSDPKK
HHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
DCSATRYDKISYHDLLASDLKIMDAAAVSLARENSIPIIVFDLGKENAFSEVMKGRGTFT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCEE
TISG
EECC
>Mature Secondary Structure 
SIDCNVVENVRYSRVLLKVSGEALAGERGFGFDQDVIGKLSCDLKKVRESGVELCIVVG
CCCCHHHHCCHHHEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEE
GGNIFRGSSTSFGFERASNDYVGMLATMINALALQNSLEDMGIASRVLSAIPMTAVCETY
CCCEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IRRRAIRHLEKGRVVICAAGIGSPFFTTDTAAVLRSIEMRCDAIFKGTQVDGVYSSDPKK
HHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
DCSATRYDKISYHDLLASDLKIMDAAAVSLARENSIPIIVFDLGKENAFSEVMKGRGTFT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCEE
TISG
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA