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The map label for this gene is nadA [H]

Identifier: 88607747

GI number: 88607747

Start: 24534

End: 25499

Strand: Direct

Name: nadA [H]

Synonym: APH_0026

Alternate gene names: 88607747

Gene position: 24534-25499 (Clockwise)

Preceding gene: 88607173

Following gene: 88607776

Centisome position: 1.67

GC content: 41.41

Gene sequence:

>966_bases
ATGCTGCAGGAACATCGCGATTTATTACGCGAAATTAGGGATATAGCTAGGAAGAAGAAGGCTGTGATCCTTGCCCATTA
TTATCAAGAGGATGAAATCCAAGAGGTGGCAGATTTCGTTGGGGATTCTCTTGATTTATCGCAAAAGGCTTCGACTACAG
ACGCTGACATTATAGTGTTCTGTGGTGTTTTTTTTATGGCAGAAGTGGCGAAGATTTTGAACCCCAGCAAAAAGGTCATA
CTTCCTGACTTAAACGCAGGATGTTCGTTGGCGGATTCATGCCGAGGAGAGGATTTTAAGAAGTTCAGACAGGCTCACAG
TGACCATGTTTCCGTTACATATATAAACTCCTCAGCAGAAGTTAAGTGCTATTCAGATATAATTTGTACTTCTTCAAATG
CGGTAAGCATAATCAATAGAATACCAAAGGAGAAAAAGATATTATTTGCGCCTGATCGTTATCTTGGGGAGTTTCTCATT
TCGAAAACAGGCAGGGATATGCTTTTATGGAATGGGAGCTGTATAGTTCATGAGAGGTTTTCTGAAGAGGCTTTGGTGAA
CTTGATGGTGCGTCATAAAGATGCTCATGTTGTTGCCCATCCGGAATGTCCTGGAAATTTGCTTAGGCATGCTCACTGTG
TTGGATCTACGAAAAATCTTCTTCAATATGTCAAAGACAGGCCTGGTAATAAGTTCATTGTGTTGACGGAAGAAGGCATA
GTATACCAAATGAAGAAATCTTCTCCTGGCAGCACCTTTTATGTAGTAGGTGCTGAGCATAGTTCTGGATGTGAGTACTG
TAGCCAGTGTCCTTATATGCGATTAAACACCATGGAAAAGCTCTACAAATGCATCGCTGAGGAACTACCTGAAGTGACAT
TAGATGAAGACATAATATTTGCGGCAAGGAGATCAGTAAATGCAATGATGGACTTTTCCTTTGCGAGAGAGCCTGCGGTT
GTATAA

Upstream 100 bases:

>100_bases
TAGTTAGTTCATGGAATATAGCTTATTTAGTTATCAAAAAATAATTTTACTGATATTGTTAATAAGTTTTTCATTGATAC
TGATGTTTTAGGCAATTGTC

Downstream 100 bases:

>100_bases
TCGTTAAGTATAACTATGAGGTAGGGAAGGTTATCTATTCTTCCTTAAGATTTTCGTCGAAGAATTGATACTTTCCTGCC
ATTGACTTGTATGTATCGGC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLQEHRDLLREIRDIARKKKAVILAHYYQEDEIQEVADFVGDSLDLSQKASTTDADIIVFCGVFFMAEVAKILNPSKKVI
LPDLNAGCSLADSCRGEDFKKFRQAHSDHVSVTYINSSAEVKCYSDIICTSSNAVSIINRIPKEKKILFAPDRYLGEFLI
SKTGRDMLLWNGSCIVHERFSEEALVNLMVRHKDAHVVAHPECPGNLLRHAHCVGSTKNLLQYVKDRPGNKFIVLTEEGI
VYQMKKSSPGSTFYVVGAEHSSGCEYCSQCPYMRLNTMEKLYKCIAEELPEVTLDEDIIFAARRSVNAMMDFSFAREPAV
V

Sequences:

>Translated_321_residues
MLQEHRDLLREIRDIARKKKAVILAHYYQEDEIQEVADFVGDSLDLSQKASTTDADIIVFCGVFFMAEVAKILNPSKKVI
LPDLNAGCSLADSCRGEDFKKFRQAHSDHVSVTYINSSAEVKCYSDIICTSSNAVSIINRIPKEKKILFAPDRYLGEFLI
SKTGRDMLLWNGSCIVHERFSEEALVNLMVRHKDAHVVAHPECPGNLLRHAHCVGSTKNLLQYVKDRPGNKFIVLTEEGI
VYQMKKSSPGSTFYVVGAEHSSGCEYCSQCPYMRLNTMEKLYKCIAEELPEVTLDEDIIFAARRSVNAMMDFSFAREPAV
V
>Mature_321_residues
MLQEHRDLLREIRDIARKKKAVILAHYYQEDEIQEVADFVGDSLDLSQKASTTDADIIVFCGVFFMAEVAKILNPSKKVI
LPDLNAGCSLADSCRGEDFKKFRQAHSDHVSVTYINSSAEVKCYSDIICTSSNAVSIINRIPKEKKILFAPDRYLGEFLI
SKTGRDMLLWNGSCIVHERFSEEALVNLMVRHKDAHVVAHPECPGNLLRHAHCVGSTKNLLQYVKDRPGNKFIVLTEEGI
VYQMKKSSPGSTFYVVGAEHSSGCEYCSQCPYMRLNTMEKLYKCIAEELPEVTLDEDIIFAARRSVNAMMDFSFAREPAV
V

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=311, Percent_Identity=36.6559485530547, Blast_Score=220, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 36185; Mature: 36185

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQEHRDLLREIRDIARKKKAVILAHYYQEDEIQEVADFVGDSLDLSQKASTTDADIIVF
CCCHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
CGVFFMAEVAKILNPSKKVILPDLNAGCSLADSCRGEDFKKFRQAHSDHVSVTYINSSAE
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEEEECCCCC
VKCYSDIICTSSNAVSIINRIPKEKKILFAPDRYLGEFLISKTGRDMLLWNGSCIVHERF
EEEEEHEEECCCCHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCEEEEECCEEEEECCC
SEEALVNLMVRHKDAHVVAHPECPGNLLRHAHCVGSTKNLLQYVKDRPGNKFIVLTEEGI
CHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCE
VYQMKKSSPGSTFYVVGAEHSSGCEYCSQCPYMRLNTMEKLYKCIAEELPEVTLDEDIIF
EEEEECCCCCCEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AARRSVNAMMDFSFAREPAVV
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLQEHRDLLREIRDIARKKKAVILAHYYQEDEIQEVADFVGDSLDLSQKASTTDADIIVF
CCCHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
CGVFFMAEVAKILNPSKKVILPDLNAGCSLADSCRGEDFKKFRQAHSDHVSVTYINSSAE
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEEEECCCCC
VKCYSDIICTSSNAVSIINRIPKEKKILFAPDRYLGEFLISKTGRDMLLWNGSCIVHERF
EEEEEHEEECCCCHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCEEEEECCEEEEECCC
SEEALVNLMVRHKDAHVVAHPECPGNLLRHAHCVGSTKNLLQYVKDRPGNKFIVLTEEGI
CHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCE
VYQMKKSSPGSTFYVVGAEHSSGCEYCSQCPYMRLNTMEKLYKCIAEELPEVTLDEDIIF
EEEEECCCCCCEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AARRSVNAMMDFSFAREPAVV
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9297820 [H]