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The map label for this gene is nuoL [H]

Identifier: 88607720

GI number: 88607720

Start: 452559

End: 454436

Strand: Direct

Name: nuoL [H]

Synonym: APH_0437

Alternate gene names: 88607720

Gene position: 452559-454436 (Clockwise)

Preceding gene: 88607796

Following gene: 88607159

Centisome position: 30.76

GC content: 42.17

Gene sequence:

>1878_bases
ATGTTCAGTATAGAGTTTCTATGTGTAGTGCTTCCGCTTTTAGGTGCTCTATTGGGGTATTTGTTAAAGCATGGGAGGTT
TGTCTCTCATGTAGTGGCTTGCTCATTTATCGGCAAGTCGGCTATTTTGTCGTGGTATTTGTTCTTAGCCACCAAGCAGA
GTTATGCGGTAGATTTGCTTTCTTGGTTGGAAGTGGGTGGTGTATCGGTGCGCTGGTCAATTTACATTGATAAGTTGACT
ACTGTGATGATGATCGTAGTAACTACTGTCTCGTTTATCGTACACTTGTACTCTGTTGGGTATATGCACAAAGATAAGGG
TGCTGTGCGGTTTTTAGCATACCTCTCCATGTTTACCTTTTTCATGATGGCTTTGGTAACGAGTGGCAATTTCATGCAGC
TATTTTTTGGCTGGGAGGGAGTTGGTTTATGCTCTTATCTTCTAATAGGCTTTTGGTTCGGTAAAGATTCTGCGACCAAA
GCTGCGATGAAGGCATTCGTAGTAAATAGAGTAGGGGATTTATTTTTCCTTTGTGGGATTCTAGTTGTTTTTTATTCTTT
CCATACATTAAATTTCGATGAAATCTTTGCGAAGATTGCCGATGGTTGGGATTTGGGAGTGGTTGATGTTTGGGGCTACC
AGGTTCCGCTGAAGGATTTAGCTGTTATTCTGCTGTTTGTGGGATGTATGGGTAAATCTGCGCAATTGGGGTTACATGTA
TGGCTTCCTGACGCGATGGAAGGGCCTACTCCTGCATCTGCGCTTATACATGCTGCTACAATGGTTACCGCAGGGGTTTT
TCTTATAGCGAGGAGTTCTCCCATTGTAGAGTTGTCGCCAATAGGGCAGGAAGTCATATTGGTAGTGGGGCTAGCAACCT
GTTTGTTTGCAGCGGTAGTGGCTATATTGCAGGAAGATATTAAGAAGATAGTGGCTTATTCTACGTGTAGCCAGCTTGGG
TACATGTTTGTAGCGTGTGGAACTTCGAGCTACCATTTAGCTATATTTCATCTATTGACTCATGCGTTTTTCAAGTCGTT
GTTGTTTCTCTTAGCGGGTAATGTGATACATTCCAATAATGGGGAGCAGAGAATTGCGTATATGAGTAAAAATTGCTGGA
GAGATATACCTTTCACTTATGCCTTGATGTGGATAGGTTCTCTGGCGCTCATGGGTGTTTTTCCGTTGGCGGGGTATTAC
TCAAAGGATCTCATTATAGAGAGTAGTTATGGGCATGTAGCGGGGTTTGTTATCACGAATTTGGTAGCATGTTTGACTTC
CGCCTATTCATGTCGGTTAATGATAAGGGTGTTTCATAATTCTCATTCTGAGAGGATTCCTTCCATACATGAGTCTTCGA
AAATCATGTTGCTTCCGCTCTTGGTGCTCATGGTGGGTGCCGTATTTTCCGGTATGGTGTTCAAGAATGTGTTGGGGATA
ACAGAGGGTGCGTTTTGGTCCAATAGTTTGAGTGTCCATGCGCATGAAGGAGAGATAAGCAGGATAATAGAATTGATTCC
TACGGGCATGGTCGCGCTGGGCGTGCTGTTGTGTTATCTCTTTTGTCGTTACAAAAGCTTGATTTACTATATTCCTCATG
CATTAAAAAATGTAGTGAAGAATAAGTTTTATTTTGATGAGATATATGAGGGTGTTTTTGTAATTCCAATGCAAAAAATA
TCCGAGTTGCTTTGGCGTGCTGTTGACCAAAAAGTGATTGATTATTTTATCTTAGGTGGTATTACTAAGGCGGTTGTAAT
GTCTGCTCAGCATGGTGTAAGAATACAGAGTGGACGTGTAGTTGGCTATGCTCTTGTAATGCTGCTTGGAGTGGTATCTG
CTGCGCTGTTAGTGGTATATGGTTTTAAAACACAGTGA

Upstream 100 bases:

>100_bases
TTTGCTGTCTGTGGCTTTTTTGTGTTAAGTACGCTTGTAGTTCTTGTTATGTAAGTGTGGCTCATGTTTGTGAGCGTGTA
ATTTTGCTATAGTGGCTGTT

Downstream 100 bases:

>100_bases
TCCCTTTTATGATTCTTATCCCCGTATTAGGGGGATGCCTTATTGCTTTTTTGAGAGACTCTTCCTCTAAGTTGAGGGGC
GGGCTATTTATTTCAATTAC

Product: NADH dehydrogenase I, L subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MFSIEFLCVVLPLLGALLGYLLKHGRFVSHVVACSFIGKSAILSWYLFLATKQSYAVDLLSWLEVGGVSVRWSIYIDKLT
TVMMIVVTTVSFIVHLYSVGYMHKDKGAVRFLAYLSMFTFFMMALVTSGNFMQLFFGWEGVGLCSYLLIGFWFGKDSATK
AAMKAFVVNRVGDLFFLCGILVVFYSFHTLNFDEIFAKIADGWDLGVVDVWGYQVPLKDLAVILLFVGCMGKSAQLGLHV
WLPDAMEGPTPASALIHAATMVTAGVFLIARSSPIVELSPIGQEVILVVGLATCLFAAVVAILQEDIKKIVAYSTCSQLG
YMFVACGTSSYHLAIFHLLTHAFFKSLLFLLAGNVIHSNNGEQRIAYMSKNCWRDIPFTYALMWIGSLALMGVFPLAGYY
SKDLIIESSYGHVAGFVITNLVACLTSAYSCRLMIRVFHNSHSERIPSIHESSKIMLLPLLVLMVGAVFSGMVFKNVLGI
TEGAFWSNSLSVHAHEGEISRIIELIPTGMVALGVLLCYLFCRYKSLIYYIPHALKNVVKNKFYFDEIYEGVFVIPMQKI
SELLWRAVDQKVIDYFILGGITKAVVMSAQHGVRIQSGRVVGYALVMLLGVVSAALLVVYGFKTQ

Sequences:

>Translated_625_residues
MFSIEFLCVVLPLLGALLGYLLKHGRFVSHVVACSFIGKSAILSWYLFLATKQSYAVDLLSWLEVGGVSVRWSIYIDKLT
TVMMIVVTTVSFIVHLYSVGYMHKDKGAVRFLAYLSMFTFFMMALVTSGNFMQLFFGWEGVGLCSYLLIGFWFGKDSATK
AAMKAFVVNRVGDLFFLCGILVVFYSFHTLNFDEIFAKIADGWDLGVVDVWGYQVPLKDLAVILLFVGCMGKSAQLGLHV
WLPDAMEGPTPASALIHAATMVTAGVFLIARSSPIVELSPIGQEVILVVGLATCLFAAVVAILQEDIKKIVAYSTCSQLG
YMFVACGTSSYHLAIFHLLTHAFFKSLLFLLAGNVIHSNNGEQRIAYMSKNCWRDIPFTYALMWIGSLALMGVFPLAGYY
SKDLIIESSYGHVAGFVITNLVACLTSAYSCRLMIRVFHNSHSERIPSIHESSKIMLLPLLVLMVGAVFSGMVFKNVLGI
TEGAFWSNSLSVHAHEGEISRIIELIPTGMVALGVLLCYLFCRYKSLIYYIPHALKNVVKNKFYFDEIYEGVFVIPMQKI
SELLWRAVDQKVIDYFILGGITKAVVMSAQHGVRIQSGRVVGYALVMLLGVVSAALLVVYGFKTQ
>Mature_625_residues
MFSIEFLCVVLPLLGALLGYLLKHGRFVSHVVACSFIGKSAILSWYLFLATKQSYAVDLLSWLEVGGVSVRWSIYIDKLT
TVMMIVVTTVSFIVHLYSVGYMHKDKGAVRFLAYLSMFTFFMMALVTSGNFMQLFFGWEGVGLCSYLLIGFWFGKDSATK
AAMKAFVVNRVGDLFFLCGILVVFYSFHTLNFDEIFAKIADGWDLGVVDVWGYQVPLKDLAVILLFVGCMGKSAQLGLHV
WLPDAMEGPTPASALIHAATMVTAGVFLIARSSPIVELSPIGQEVILVVGLATCLFAAVVAILQEDIKKIVAYSTCSQLG
YMFVACGTSSYHLAIFHLLTHAFFKSLLFLLAGNVIHSNNGEQRIAYMSKNCWRDIPFTYALMWIGSLALMGVFPLAGYY
SKDLIIESSYGHVAGFVITNLVACLTSAYSCRLMIRVFHNSHSERIPSIHESSKIMLLPLLVLMVGAVFSGMVFKNVLGI
TEGAFWSNSLSVHAHEGEISRIIELIPTGMVALGVLLCYLFCRYKSLIYYIPHALKNVVKNKFYFDEIYEGVFVIPMQKI
SELLWRAVDQKVIDYFILGGITKAVVMSAQHGVRIQSGRVVGYALVMLLGVVSAALLVVYGFKTQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=475, Percent_Identity=37.8947368421053, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1788614, Length=585, Percent_Identity=37.9487179487179, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1788829, Length=436, Percent_Identity=28.4403669724771, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=28.6532951289398, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788827, Length=367, Percent_Identity=27.7929155313352, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788613, Length=338, Percent_Identity=25.7396449704142, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI145693160, Length=207, Percent_Identity=26.5700483091787, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 69164; Mature: 69164

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSIEFLCVVLPLLGALLGYLLKHGRFVSHVVACSFIGKSAILSWYLFLATKQSYAVDLL
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SWLEVGGVSVRWSIYIDKLTTVMMIVVTTVSFIVHLYSVGYMHKDKGAVRFLAYLSMFTF
HHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHH
FMMALVTSGNFMQLFFGWEGVGLCSYLLIGFWFGKDSATKAAMKAFVVNRVGDLFFLCGI
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVVFYSFHTLNFDEIFAKIADGWDLGVVDVWGYQVPLKDLAVILLFVGCMGKSAQLGLHV
HHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
WLPDAMEGPTPASALIHAATMVTAGVFLIARSSPIVELSPIGQEVILVVGLATCLFAAVV
ECCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHH
AILQEDIKKIVAYSTCSQLGYMFVACGTSSYHLAIFHLLTHAFFKSLLFLLAGNVIHSNN
HHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GEQRIAYMSKNCWRDIPFTYALMWIGSLALMGVFPLAGYYSKDLIIESSYGHVAGFVITN
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
LVACLTSAYSCRLMIRVFHNSHSERIPSIHESSKIMLLPLLVLMVGAVFSGMVFKNVLGI
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
TEGAFWSNSLSVHAHEGEISRIIELIPTGMVALGVLLCYLFCRYKSLIYYIPHALKNVVK
CCCCCCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKFYFDEIYEGVFVIPMQKISELLWRAVDQKVIDYFILGGITKAVVMSAQHGVRIQSGRV
HCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCH
VGYALVMLLGVVSAALLVVYGFKTQ
HHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFSIEFLCVVLPLLGALLGYLLKHGRFVSHVVACSFIGKSAILSWYLFLATKQSYAVDLL
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SWLEVGGVSVRWSIYIDKLTTVMMIVVTTVSFIVHLYSVGYMHKDKGAVRFLAYLSMFTF
HHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHH
FMMALVTSGNFMQLFFGWEGVGLCSYLLIGFWFGKDSATKAAMKAFVVNRVGDLFFLCGI
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVVFYSFHTLNFDEIFAKIADGWDLGVVDVWGYQVPLKDLAVILLFVGCMGKSAQLGLHV
HHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
WLPDAMEGPTPASALIHAATMVTAGVFLIARSSPIVELSPIGQEVILVVGLATCLFAAVV
ECCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHH
AILQEDIKKIVAYSTCSQLGYMFVACGTSSYHLAIFHLLTHAFFKSLLFLLAGNVIHSNN
HHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GEQRIAYMSKNCWRDIPFTYALMWIGSLALMGVFPLAGYYSKDLIIESSYGHVAGFVITN
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
LVACLTSAYSCRLMIRVFHNSHSERIPSIHESSKIMLLPLLVLMVGAVFSGMVFKNVLGI
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
TEGAFWSNSLSVHAHEGEISRIIELIPTGMVALGVLLCYLFCRYKSLIYYIPHALKNVVK
CCCCCCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKFYFDEIYEGVFVIPMQKISELLWRAVDQKVIDYFILGGITKAVVMSAQHGVRIQSGRV
HCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCH
VGYALVMLLGVVSAALLVVYGFKTQ
HHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA