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The map label for this gene is tkt [H]

Identifier: 88607696

GI number: 88607696

Start: 324440

End: 326419

Strand: Direct

Name: tkt [H]

Synonym: APH_0340

Alternate gene names: 88607696

Gene position: 324440-326419 (Clockwise)

Preceding gene: 88607311

Following gene: 88607513

Centisome position: 22.05

GC content: 43.54

Gene sequence:

>1980_bases
GTGCAGTATTCTACTCAGCTAACTGAGATGGCAAGTGCCATTAGGCTATTATCTGTTGATGCAATTCAGAATGCTGCTTC
AGGTCATCCTGGTATGCCCTTAGGTATGGCTGATGTAGCTGCTGTATTGTTTTCTAAATTTTTGAGATTCAGTGTACAAA
ACCCAAACTGGATCAATCGGGATAGACTGGTCATGTCTAATGGACATGGTTCCATGCTTATTTACTCCATACTCCATTTA
TTAGGGTACATCAGCATAGATGATATAAAGAAATTCAGGCAGTTGCATTCCATAACTCCTGGTCATCCTGAATATGGGTG
TACACCTGGTATAGAAGCTACTACTGGTCCTTTGGGTCAGGGATTGGGTTGTGCTGTTGGAATGGCTATTGCTGAACGGA
TGCTTGCGCAGAGATTTGGCGGTGATCTAATTGATCATTACACTTACGTCATGGCCGGGGATGGGTGCTTGATGGAGGGT
ATTAGTCATGAAGCAGCTTCCTTAGCGGGGCATTTGGGTCTGGGTAAGCTTATAGTTCTATTTGATGACAATGGTATCTC
TATAGATGGAAAGATTAGCCTTGCCTCTTCTGATAACGTAGCTGCGAGATTTGCATCATATGGCTGGGATGTCTGGGAAG
TAGATGGGCATGATTTTGGTCATGTATATGCTGCTATCGCCTCCGCTAGGGAGACTAATAGGCCATCTATAATAGCATGC
AAGACTATTATAGGGAAGTTTATGCGCTCTAAAGAGAATACTTCTGCAGCGCATAGTTGGCCTTTTACGCCTGCTGATGC
TCAAGAAGTTAGAGAGTCTCTAGGGCAGGGAGAAAGTAAGGCTTTTGAGGTAAGTACAGATGCTTCTGCTTTGTGGAAAG
AAGTTAGGGAAAGAGCGGAGTTGGAGTATGAGTCTTGGCTTAGCAAGTCTGAGCAATGTGACAAAATAGGCGAATTGAAT
GCTGCTACTACTAAGGGTGTACCTGAGTCTGTATTTGAAGGTTTAGATGAGCATTTTAGAGATCTAGGTTTTGCTGAAGC
TACTAGAAAGTCCTTTGGTAGAGCGCTGGAGTTTTTCTCGCAAAGGGTGAATAATCTTGTAGGGGGTTCTGCGGACTTAA
CTTCTTCTAATAATACTAAAGCTAGTTGGATGAAGCCTATTACGAAGGAAGATTTCTCTGGGTCATACATTCATTATGGT
ATAAGAGAGCATGCCATGGCCGCATGTATGAATGGAATGGCTCTTCATGCTGGGGTTATTCCTTATGGCGGAACCTTTTT
GGTGTTTTCTGATTACTGTAGGCCTGCAATACGATTATCTGCTTTAATGGCTCTTCAGGCTATTTACGTAATGACTCATG
ACTCCATAGGGGTTGGCGAGGATGGACCTACTCATCAGCCTGTGGAGCATCTTGCGTCGTTGAGAGCTATTCCAAATCTT
TATGTTTTTAGGCCGGCAGATGCTGTGGAAGTTTTGGAGTGCTGGGAAATTGCATTGAAGCTTACTAAGTCTCCATCTTT
GTTTGTGTTGTCTAGGCAAAATGTGGAACCAATGAGGTCTGAGTTGGGCCGTGAGAATCGCTCTGGGAGAGGGGCGTATA
TTCTCAGGGAGTTTGAAGGAGATCTTAGGGTTACCATTTTTGCGACAGGTACAGAGGTTGGGGTAGCAATGGCAGCTTGT
GATATCCTTCATAAGACTTATGGGGTAGGTACTAGGGTTATATCTATGCCTTGTTGGAGGTTATTTGATCAGCAAGAGAA
AAAGTACATTTCTGGGTTGTTGGATAATAATAGTCTTAAAGTAGCGGTAGAAGCGGGTAGTTCTGTTGGGTGGCATAAAT
ACATTGGTAGAGATGGCATATTTATAGGGCTTGATGAATTTGGGGCTTCTGGTAAATGTGAGGATTTATATGCGCACTTT
GGTATAACGAAGGAGAATCTGGTTTCTAAGGTGCTGGCTAGGCTGCATCCTGCTGTTTAG

Upstream 100 bases:

>100_bases
ATCACCGGACGTAGAATTGACGTAGATGCTTATAAAAACCATCTGGTAAATAGATATCTAAGCATGTGAGTGCGTTATGG
GAGATGAGAATCAAGGCGCT

Downstream 100 bases:

>100_bases
GTTCTGTGTGGATGGGAGTGTGACATGCTGAAATTTTCTATTTTTGTTTTGTTGGCATGTGGGGCTGTGATGTTATTTAG
AATCGTGAGTGCTCGCAGTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MQYSTQLTEMASAIRLLSVDAIQNAASGHPGMPLGMADVAAVLFSKFLRFSVQNPNWINRDRLVMSNGHGSMLIYSILHL
LGYISIDDIKKFRQLHSITPGHPEYGCTPGIEATTGPLGQGLGCAVGMAIAERMLAQRFGGDLIDHYTYVMAGDGCLMEG
ISHEAASLAGHLGLGKLIVLFDDNGISIDGKISLASSDNVAARFASYGWDVWEVDGHDFGHVYAAIASARETNRPSIIAC
KTIIGKFMRSKENTSAAHSWPFTPADAQEVRESLGQGESKAFEVSTDASALWKEVRERAELEYESWLSKSEQCDKIGELN
AATTKGVPESVFEGLDEHFRDLGFAEATRKSFGRALEFFSQRVNNLVGGSADLTSSNNTKASWMKPITKEDFSGSYIHYG
IREHAMAACMNGMALHAGVIPYGGTFLVFSDYCRPAIRLSALMALQAIYVMTHDSIGVGEDGPTHQPVEHLASLRAIPNL
YVFRPADAVEVLECWEIALKLTKSPSLFVLSRQNVEPMRSELGRENRSGRGAYILREFEGDLRVTIFATGTEVGVAMAAC
DILHKTYGVGTRVISMPCWRLFDQQEKKYISGLLDNNSLKVAVEAGSSVGWHKYIGRDGIFIGLDEFGASGKCEDLYAHF
GITKENLVSKVLARLHPAV

Sequences:

>Translated_659_residues
MQYSTQLTEMASAIRLLSVDAIQNAASGHPGMPLGMADVAAVLFSKFLRFSVQNPNWINRDRLVMSNGHGSMLIYSILHL
LGYISIDDIKKFRQLHSITPGHPEYGCTPGIEATTGPLGQGLGCAVGMAIAERMLAQRFGGDLIDHYTYVMAGDGCLMEG
ISHEAASLAGHLGLGKLIVLFDDNGISIDGKISLASSDNVAARFASYGWDVWEVDGHDFGHVYAAIASARETNRPSIIAC
KTIIGKFMRSKENTSAAHSWPFTPADAQEVRESLGQGESKAFEVSTDASALWKEVRERAELEYESWLSKSEQCDKIGELN
AATTKGVPESVFEGLDEHFRDLGFAEATRKSFGRALEFFSQRVNNLVGGSADLTSSNNTKASWMKPITKEDFSGSYIHYG
IREHAMAACMNGMALHAGVIPYGGTFLVFSDYCRPAIRLSALMALQAIYVMTHDSIGVGEDGPTHQPVEHLASLRAIPNL
YVFRPADAVEVLECWEIALKLTKSPSLFVLSRQNVEPMRSELGRENRSGRGAYILREFEGDLRVTIFATGTEVGVAMAAC
DILHKTYGVGTRVISMPCWRLFDQQEKKYISGLLDNNSLKVAVEAGSSVGWHKYIGRDGIFIGLDEFGASGKCEDLYAHF
GITKENLVSKVLARLHPAV
>Mature_659_residues
MQYSTQLTEMASAIRLLSVDAIQNAASGHPGMPLGMADVAAVLFSKFLRFSVQNPNWINRDRLVMSNGHGSMLIYSILHL
LGYISIDDIKKFRQLHSITPGHPEYGCTPGIEATTGPLGQGLGCAVGMAIAERMLAQRFGGDLIDHYTYVMAGDGCLMEG
ISHEAASLAGHLGLGKLIVLFDDNGISIDGKISLASSDNVAARFASYGWDVWEVDGHDFGHVYAAIASARETNRPSIIAC
KTIIGKFMRSKENTSAAHSWPFTPADAQEVRESLGQGESKAFEVSTDASALWKEVRERAELEYESWLSKSEQCDKIGELN
AATTKGVPESVFEGLDEHFRDLGFAEATRKSFGRALEFFSQRVNNLVGGSADLTSSNNTKASWMKPITKEDFSGSYIHYG
IREHAMAACMNGMALHAGVIPYGGTFLVFSDYCRPAIRLSALMALQAIYVMTHDSIGVGEDGPTHQPVEHLASLRAIPNL
YVFRPADAVEVLECWEIALKLTKSPSLFVLSRQNVEPMRSELGRENRSGRGAYILREFEGDLRVTIFATGTEVGVAMAAC
DILHKTYGVGTRVISMPCWRLFDQQEKKYISGLLDNNSLKVAVEAGSSVGWHKYIGRDGIFIGLDEFGASGKCEDLYAHF
GITKENLVSKVLARLHPAV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=664, Percent_Identity=26.0542168674699, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4507521, Length=664, Percent_Identity=26.0542168674699, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI133778974, Length=570, Percent_Identity=26.6666666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=580, Percent_Identity=23.2758620689655, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI225637461, Length=580, Percent_Identity=23.1034482758621, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI225637463, Length=476, Percent_Identity=24.3697478991597, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=46.4231354642314, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI1788808, Length=658, Percent_Identity=44.2249240121581, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17539652, Length=530, Percent_Identity=27.1698113207547, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=41.7910447761194, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319593, Length=657, Percent_Identity=41.5525114155251, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551847, Length=580, Percent_Identity=27.9310344827586, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45550715, Length=580, Percent_Identity=27.9310344827586, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24666278, Length=500, Percent_Identity=25.6, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24645119, Length=546, Percent_Identity=27.4725274725275, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71932; Mature: 71932

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYSTQLTEMASAIRLLSVDAIQNAASGHPGMPLGMADVAAVLFSKFLRFSVQNPNWINR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DRLVMSNGHGSMLIYSILHLLGYISIDDIKKFRQLHSITPGHPEYGCTPGIEATTGPLGQ
CCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GLGCAVGMAIAERMLAQRFGGDLIDHYTYVMAGDGCLMEGISHEAASLAGHLGLGKLIVL
CHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEECCCHHHHCCCHHHHHHHHCCCCCEEEEE
FDDNGISIDGKISLASSDNVAARFASYGWDVWEVDGHDFGHVYAAIASARETNRPSIIAC
ECCCCEEECCEEEECCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEH
KTIIGKFMRSKENTSAAHSWPFTPADAQEVRESLGQGESKAFEVSTDASALWKEVRERAE
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHC
LEYESWLSKSEQCDKIGELNAATTKGVPESVFEGLDEHFRDLGFAEATRKSFGRALEFFS
CCHHHHHCHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QRVNNLVGGSADLTSSNNTKASWMKPITKEDFSGSYIHYGIREHAMAACMNGMALHAGVI
HHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCEECCCC
PYGGTFLVFSDYCRPAIRLSALMALQAIYVMTHDSIGVGEDGPTHQPVEHLASLRAIPNL
CCCCEEEEEHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCE
YVFRPADAVEVLECWEIALKLTKSPSLFVLSRQNVEPMRSELGRENRSGRGAYILREFEG
EEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCEEEEEEECC
DLRVTIFATGTEVGVAMAACDILHKTYGVGTRVISMPCWRLFDQQEKKYISGLLDNNSLK
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VAVEAGSSVGWHKYIGRDGIFIGLDEFGASGKCEDLYAHFGITKENLVSKVLARLHPAV
EEEECCCCCCHHHHHCCCCEEEEHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQYSTQLTEMASAIRLLSVDAIQNAASGHPGMPLGMADVAAVLFSKFLRFSVQNPNWINR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DRLVMSNGHGSMLIYSILHLLGYISIDDIKKFRQLHSITPGHPEYGCTPGIEATTGPLGQ
CCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GLGCAVGMAIAERMLAQRFGGDLIDHYTYVMAGDGCLMEGISHEAASLAGHLGLGKLIVL
CHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEECCCHHHHCCCHHHHHHHHCCCCCEEEEE
FDDNGISIDGKISLASSDNVAARFASYGWDVWEVDGHDFGHVYAAIASARETNRPSIIAC
ECCCCEEECCEEEECCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEH
KTIIGKFMRSKENTSAAHSWPFTPADAQEVRESLGQGESKAFEVSTDASALWKEVRERAE
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHC
LEYESWLSKSEQCDKIGELNAATTKGVPESVFEGLDEHFRDLGFAEATRKSFGRALEFFS
CCHHHHHCHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QRVNNLVGGSADLTSSNNTKASWMKPITKEDFSGSYIHYGIREHAMAACMNGMALHAGVI
HHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCEECCCC
PYGGTFLVFSDYCRPAIRLSALMALQAIYVMTHDSIGVGEDGPTHQPVEHLASLRAIPNL
CCCCEEEEEHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCE
YVFRPADAVEVLECWEIALKLTKSPSLFVLSRQNVEPMRSELGRENRSGRGAYILREFEG
EEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCEEEEEEECC
DLRVTIFATGTEVGVAMAACDILHKTYGVGTRVISMPCWRLFDQQEKKYISGLLDNNSLK
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VAVEAGSSVGWHKYIGRDGIFIGLDEFGASGKCEDLYAHFGITKENLVSKVLARLHPAV
EEEECCCCCCHHHHHCCCCEEEEHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928974 [H]