Click here to switch to the map view.

The map label for this gene is tlyC [H]

Identifier: 88607215

GI number: 88607215

Start: 20942

End: 21811

Strand: Direct

Name: tlyC [H]

Synonym: APH_0021

Alternate gene names: 88607215

Gene position: 20942-21811 (Clockwise)

Preceding gene: 88607750

Following gene: 88607173

Centisome position: 1.42

GC content: 38.85

Gene sequence:

>870_bases
ATGGGTGCTGGAGTTTTTGAAGAAGATGAGGGAAGTAACCTGACTTTCTTCAATCGCTGGAAAGCGCGTCTCTACTCTTT
TATCTTTAACAACTTTCCTGGATTTAAAGACTTTGCGAAAGATGCGGTGTTTCGTAGAAACATATTTGGCTTCAATTGTT
TCAACATAATGGGTAATTTGGTAAGTTTTGATGATTGCTCACTTCAGGAAATAATGGTGCAAAGGTCGGAAATTAGGGCT
TTTGCCATAGATGACAGTGACTTAGTTAATAGTGTCCTTAAAAGCCAACATACAAGAGTCCCTGTATATAAAGACAATCT
GGATAATATTGTCGGGTTTATTCACATTAGAGATATTCTGATGAAGGGTGGTTCAGATTTTAATGTGAAAGACGTTATAC
GCGATGTTATTTATGTTCCACATTCTATGAAGGCGGTCAGCCTATTTGTTAAAATGCAGTCTTCTAGAGTTCACATGGCT
ATTGTGCTTGACGAGTATGGTAGTACTGATGGTCTTGTAACAATGGAAGATATAATAGAACCTATAGTAGGTGATATCGA
ATACGAAAACGATGAGACTGCTATTCCTGATATTGTAAACATTTCAGACAATACAATTGAGGTGAATGCCAGAGTTTTGG
TTCGAACCTTGGAGCGCACTTTGGGAGTGGTGTTAAGAGACTCGTCTGCTGAAGAAGATTATGACACTGTAGGGGGGCTT
ATTTTCGCTATGGTAGGCAGGGTACCAGTTGTAGATGAGGTTTTCCAACATAAAAGTGGTGCGGTCTTTACAATAAAAGA
GGCTGATAATCGCTGCATATATAGGGTTATTATTGATCTATCAGGCGTGAATAGGAATACTGCTTGCTGA

Upstream 100 bases:

>100_bases
ACATTTATTCACACAGTTATCCAGTAACTTTGTATGGAAAATAAAATTTAGCTGCGTATACTCTTGGTTCTGATCAAGTG
ATTTACCGGTTGCACAGAAT

Downstream 100 bases:

>100_bases
TTGCGACATTGTAAAGTCAAGACAGCAGTGTTCTTTTTGTCTATGCTGTGTTGTGCTCTTTTTTACAGGAATCTTGCTTT
ATTCGAGATATTAGCGCATG

Product: putative hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MGAGVFEEDEGSNLTFFNRWKARLYSFIFNNFPGFKDFAKDAVFRRNIFGFNCFNIMGNLVSFDDCSLQEIMVQRSEIRA
FAIDDSDLVNSVLKSQHTRVPVYKDNLDNIVGFIHIRDILMKGGSDFNVKDVIRDVIYVPHSMKAVSLFVKMQSSRVHMA
IVLDEYGSTDGLVTMEDIIEPIVGDIEYENDETAIPDIVNISDNTIEVNARVLVRTLERTLGVVLRDSSAEEDYDTVGGL
IFAMVGRVPVVDEVFQHKSGAVFTIKEADNRCIYRVIIDLSGVNRNTAC

Sequences:

>Translated_289_residues
MGAGVFEEDEGSNLTFFNRWKARLYSFIFNNFPGFKDFAKDAVFRRNIFGFNCFNIMGNLVSFDDCSLQEIMVQRSEIRA
FAIDDSDLVNSVLKSQHTRVPVYKDNLDNIVGFIHIRDILMKGGSDFNVKDVIRDVIYVPHSMKAVSLFVKMQSSRVHMA
IVLDEYGSTDGLVTMEDIIEPIVGDIEYENDETAIPDIVNISDNTIEVNARVLVRTLERTLGVVLRDSSAEEDYDTVGGL
IFAMVGRVPVVDEVFQHKSGAVFTIKEADNRCIYRVIIDLSGVNRNTAC
>Mature_288_residues
GAGVFEEDEGSNLTFFNRWKARLYSFIFNNFPGFKDFAKDAVFRRNIFGFNCFNIMGNLVSFDDCSLQEIMVQRSEIRAF
AIDDSDLVNSVLKSQHTRVPVYKDNLDNIVGFIHIRDILMKGGSDFNVKDVIRDVIYVPHSMKAVSLFVKMQSSRVHMAI
VLDEYGSTDGLVTMEDIIEPIVGDIEYENDETAIPDIVNISDNTIEVNARVLVRTLERTLGVVLRDSSAEEDYDTVGGLI
FAMVGRVPVVDEVFQHKSGAVFTIKEADNRCIYRVIIDLSGVNRNTAC

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=208, Percent_Identity=33.6538461538462, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1786879, Length=262, Percent_Identity=29.7709923664122, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI145693175, Length=221, Percent_Identity=27.6018099547511, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082033, Length=241, Percent_Identity=24.0663900414938, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788119, Length=216, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 32580; Mature: 32449

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGVFEEDEGSNLTFFNRWKARLYSFIFNNFPGFKDFAKDAVFRRNIFGFNCFNIMGNL
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEHHHHHCCC
VSFDDCSLQEIMVQRSEIRAFAIDDSDLVNSVLKSQHTRVPVYKDNLDNIVGFIHIRDIL
CCCCCCCHHHHHHHHHHCEEEEECCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHH
MKGGSDFNVKDVIRDVIYVPHSMKAVSLFVKMQSSRVHMAIVLDEYGSTDGLVTMEDIIE
HCCCCCCCHHHHHHHHHHCCCCHHHHHHHEEECCCCEEEEEEEECCCCCCCEEEHHHHHH
PIVGDIEYENDETAIPDIVNISDNTIEVNARVLVRTLERTLGVVLRDSSAEEDYDTVGGL
HHHCCCEECCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHH
IFAMVGRVPVVDEVFQHKSGAVFTIKEADNRCIYRVIIDLSGVNRNTAC
HHHHHCCCCHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
GAGVFEEDEGSNLTFFNRWKARLYSFIFNNFPGFKDFAKDAVFRRNIFGFNCFNIMGNL
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEHHHHHCCC
VSFDDCSLQEIMVQRSEIRAFAIDDSDLVNSVLKSQHTRVPVYKDNLDNIVGFIHIRDIL
CCCCCCCHHHHHHHHHHCEEEEECCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHH
MKGGSDFNVKDVIRDVIYVPHSMKAVSLFVKMQSSRVHMAIVLDEYGSTDGLVTMEDIIE
HCCCCCCCHHHHHHHHHHCCCCHHHHHHHEEECCCCEEEEEEEECCCCCCCEEEHHHHHH
PIVGDIEYENDETAIPDIVNISDNTIEVNARVLVRTLERTLGVVLRDSSAEEDYDTVGGL
HHHCCCEECCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHH
IFAMVGRVPVVDEVFQHKSGAVFTIKEADNRCIYRVIIDLSGVNRNTAC
HHHHHCCCCHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA