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The map label for this gene is purC [H]

Identifier: 88607055

GI number: 88607055

Start: 127341

End: 128075

Strand: Reverse

Name: purC [H]

Synonym: APH_0119

Alternate gene names: 88607055

Gene position: 128075-127341 (Counterclockwise)

Preceding gene: 88607760

Following gene: 88607609

Centisome position: 8.7

GC content: 40.82

Gene sequence:

>735_bases
ATGGAAAATACACGAGAAGTTCTATATGAGGGTAAGGCCAAGATTATTCTGCGCCACCCGGAAAATGAAAGGGCGGTGAT
ACAGCATTTTAAAGATACTCTTACAGCGTTCAATGCACAAAGAAAGAGTGAGATACAGGGAAAAGGTGCATTAACTAACA
GAATAAGTTCTCTTCTGATGGAACACCTTGAAGCGAGTGGCATACGTACACACTTTTTGTCATTTTTGAATGACAAAGAA
CAGTTGGTCAGCAAGTTGAACATGATTCCTCTAGAAGTGGTAGTTAGAAATATCGCAGCTGGAAGCATGTGTAAAAAGTT
CGGAATTCCTAAGGGTAAGGTTCTGGCTGAACCCATAGTGGAGTTCTATTATAAAAACGACGAACTGTCAGACCCGATGA
TAGCAGAGGATCATGCAACTTGCTTTGGTCTTGCTTCAAAAAGCGAGCTCGCACGCATGCGGGAAATAGCACTGCAAGCT
AATAATATTCTGAGTGCACTCTTTTCCGAAGTTAAGATCTTACTCGTGGATTTTAAGCTGGAATTTGGTAAAGATTCGCA
TTCTGAGCAGGAAATTGTTCTAGGAGACGAAATTAGCCCTGATACTTGTAGGCTTTGGGATACATCTACCCTTACGGTGC
TGGATAAAGATCTGTACAGGTTCGACATAGGCAACATAGAAGATGGGTACAAAGAAGTTTTACAAAGGCTAGAACAGCAC
TTTAAAAACAAATAA

Upstream 100 bases:

>100_bases
AAACTTGTTTTTATGGTGTCCCGAAGACAGCAAATGTGTACATTTTTTTTGCAAAATTATCTACCAAATTGGTACAATGC
TGCAAAGTAAGAGGAACACA

Downstream 100 bases:

>100_bases
AAGACCAACCTGCGCTAAGTTTTGTAAGGCGGTATTGCGTGATAACCCGGAAGGTCTAGCAATAGACGTGGAGTTTTCAT
GTACCGCATCTAACATACTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MENTREVLYEGKAKIILRHPENERAVIQHFKDTLTAFNAQRKSEIQGKGALTNRISSLLMEHLEASGIRTHFLSFLNDKE
QLVSKLNMIPLEVVVRNIAAGSMCKKFGIPKGKVLAEPIVEFYYKNDELSDPMIAEDHATCFGLASKSELARMREIALQA
NNILSALFSEVKILLVDFKLEFGKDSHSEQEIVLGDEISPDTCRLWDTSTLTVLDKDLYRFDIGNIEDGYKEVLQRLEQH
FKNK

Sequences:

>Translated_244_residues
MENTREVLYEGKAKIILRHPENERAVIQHFKDTLTAFNAQRKSEIQGKGALTNRISSLLMEHLEASGIRTHFLSFLNDKE
QLVSKLNMIPLEVVVRNIAAGSMCKKFGIPKGKVLAEPIVEFYYKNDELSDPMIAEDHATCFGLASKSELARMREIALQA
NNILSALFSEVKILLVDFKLEFGKDSHSEQEIVLGDEISPDTCRLWDTSTLTVLDKDLYRFDIGNIEDGYKEVLQRLEQH
FKNK
>Mature_244_residues
MENTREVLYEGKAKIILRHPENERAVIQHFKDTLTAFNAQRKSEIQGKGALTNRISSLLMEHLEASGIRTHFLSFLNDKE
QLVSKLNMIPLEVVVRNIAAGSMCKKFGIPKGKVLAEPIVEFYYKNDELSDPMIAEDHATCFGLASKSELARMREIALQA
NNILSALFSEVKILLVDFKLEFGKDSHSEQEIVLGDEISPDTCRLWDTSTLTVLDKDLYRFDIGNIEDGYKEVLQRLEQH
FKNK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=248, Percent_Identity=32.6612903225806, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI5453539, Length=248, Percent_Identity=32.6612903225806, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI119220559, Length=255, Percent_Identity=31.3725490196078, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1788820, Length=230, Percent_Identity=42.1739130434783, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=32.2869955156951, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=29.5546558704453, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI18860083, Length=223, Percent_Identity=30.4932735426009, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27801; Mature: 27801

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTREVLYEGKAKIILRHPENERAVIQHFKDTLTAFNAQRKSEIQGKGALTNRISSLLM
CCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EHLEASGIRTHFLSFLNDKEQLVSKLNMIPLEVVVRNIAAGSMCKKFGIPKGKVLAEPIV
HHHHHCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EFYYKNDELSDPMIAEDHATCFGLASKSELARMREIALQANNILSALFSEVKILLVDFKL
HHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
EFGKDSHSEQEIVLGDEISPDTCRLWDTSTLTVLDKDLYRFDIGNIEDGYKEVLQRLEQH
ECCCCCCCCCEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FKNK
HCCC
>Mature Secondary Structure
MENTREVLYEGKAKIILRHPENERAVIQHFKDTLTAFNAQRKSEIQGKGALTNRISSLLM
CCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EHLEASGIRTHFLSFLNDKEQLVSKLNMIPLEVVVRNIAAGSMCKKFGIPKGKVLAEPIV
HHHHHCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EFYYKNDELSDPMIAEDHATCFGLASKSELARMREIALQANNILSALFSEVKILLVDFKL
HHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
EFGKDSHSEQEIVLGDEISPDTCRLWDTSTLTVLDKDLYRFDIGNIEDGYKEVLQRLEQH
ECCCCCCCCCEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FKNK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA