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The map label for this gene is gmk

Identifier: 88607024

GI number: 88607024

Start: 171559

End: 172191

Strand: Direct

Name: gmk

Synonym: APH_0170

Alternate gene names: 88607024

Gene position: 171559-172191 (Clockwise)

Preceding gene: 88607905

Following gene: 88607582

Centisome position: 11.66

GC content: 41.86

Gene sequence:

>633_bases
TTGTTGAAAAGCGTAGGTGTAATACTGGTATTATCGTCACCGTCTGGGTGCGGAAAAACAACAGTTGCCAACAAATTATT
AGAGAAGCAGAAAAACAATATAGTAAAATCCGTTTCCGTCACGACTCGCGCAGCAAGGAAAGGAGAGAAAGAAGGGAAAG
ACTACTATTTTGTAGATCGGGAAGAATTTTTAAGACTATGCAGCAACGGGGAGATAATAGAACATGCAGAAGTATTTGGT
AATTTCTACGGTGTTCCCCGCAAGAATCTAGAAGACAATGTAGATAAGGGAGTCAGCACGTTACTAGTAATTGACTGGCA
AGGAGCTTTCAAGTTCATGGAGATGATGAGAGAGCACGTAGTGAGCATATTCATAATGCCCCCTTCTATGGAAGAACTGC
GTAGGAGATTATGTGGTAGAAGAGCTGATGATTCAGAGGTTGTGGAAGCAAGGCTAAAAGGAGCAGCGTTTGAGATCAGT
CACTGCGAAGCTTACGACTACGTAATAGTAAACGAAGATATAGAGGAAACAGCAGACAGAATTAGCAATATCCTGAGGGC
AGAACAGATGAAAACTTGCAGGCAAGTTGGGCTGAGGGAATTATTAGAGAGTAGGTTCCCTATAGAAGATTAA

Upstream 100 bases:

>100_bases
TCGATATACCATAAGCAATAAAAAGAGGATGGGAACAGTACGCTGAGAAAGACCTATTTTATTGTTTAAAATCTAGTATG
TTATTGTTAAGGGGGTCTTC

Downstream 100 bases:

>100_bases
GCAATCTGTAGAATAGAATGCTGGTTGCACATTAACTGATATGTAGAACTCTATATTATTGGTCTCTGTGTTTTGCTTTT
AGTATCATAAAATGCGTATA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLKSVGVILVLSSPSGCGKTTVANKLLEKQKNNIVKSVSVTTRAARKGEKEGKDYYFVDREEFLRLCSNGEIIEHAEVFG
NFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHVVSIFIMPPSMEELRRRLCGRRADDSEVVEARLKGAAFEIS
HCEAYDYVIVNEDIEETADRISNILRAEQMKTCRQVGLRELLESRFPIED

Sequences:

>Translated_210_residues
MLKSVGVILVLSSPSGCGKTTVANKLLEKQKNNIVKSVSVTTRAARKGEKEGKDYYFVDREEFLRLCSNGEIIEHAEVFG
NFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHVVSIFIMPPSMEELRRRLCGRRADDSEVVEARLKGAAFEIS
HCEAYDYVIVNEDIEETADRISNILRAEQMKTCRQVGLRELLESRFPIED
>Mature_210_residues
MLKSVGVILVLSSPSGCGKTTVANKLLEKQKNNIVKSVSVTTRAARKGEKEGKDYYFVDREEFLRLCSNGEIIEHAEVFG
NFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHVVSIFIMPPSMEELRRRLCGRRADDSEVVEARLKGAAFEIS
HCEAYDYVIVNEDIEETADRISNILRAEQMKTCRQVGLRELLESRFPIED

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI38570142, Length=171, Percent_Identity=30.9941520467836, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=26.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=26.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=26.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=26.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI21361598, Length=191, Percent_Identity=23.5602094240838, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI186700627, Length=169, Percent_Identity=24.8520710059172, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=202, Percent_Identity=42.5742574257426, Blast_Score=166, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI193203132, Length=193, Percent_Identity=33.160621761658, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508835, Length=193, Percent_Identity=33.160621761658, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988041, Length=169, Percent_Identity=24.8520710059172, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=177, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=37.1584699453552, Blast_Score=122, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21356141, Length=190, Percent_Identity=32.1052631578947, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI85816106, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI85816281, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551002, Length=211, Percent_Identity=26.0663507109005, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_ANAPZ (Q2GLF7)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504794.1
- PDB:   3LNC
- PDBsum:   3LNC
- ProteinModelPortal:   Q2GLF7
- SMR:   Q2GLF7
- STRING:   Q2GLF7
- GeneID:   3930277
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0170
- NMPDR:   fig|212042.5.peg.165
- TIGR:   APH_0170
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q2GLF7
- ProtClustDB:   PRK00300
- BioCyc:   APHA212042:APH_0170-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23929; Mature: 23929

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSVGVILVLSSPSGCGKTTVANKLLEKQKNNIVKSVSVTTRAARKGEKEGKDYYFVDR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECH
EEFLRLCSNGEIIEHAEVFGNFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHV
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
VSIFIMPPSMEELRRRLCGRRADDSEVVEARLKGAAFEISHCEAYDYVIVNEDIEETADR
HEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCEEEEEEECCCHHHHHHH
ISNILRAEQMKTCRQVGLRELLESRFPIED
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLKSVGVILVLSSPSGCGKTTVANKLLEKQKNNIVKSVSVTTRAARKGEKEGKDYYFVDR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECH
EEFLRLCSNGEIIEHAEVFGNFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHV
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
VSIFIMPPSMEELRRRLCGRRADDSEVVEARLKGAAFEISHCEAYDYVIVNEDIEETADR
HEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCEEEEEEECCCHHHHHHH
ISNILRAEQMKTCRQVGLRELLESRFPIED
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA