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The map label for this gene is ccmA [H]

Identifier: 88606835

GI number: 88606835

Start: 132512

End: 133132

Strand: Reverse

Name: ccmA [H]

Synonym: APH_0125

Alternate gene names: 88606835

Gene position: 133132-132512 (Counterclockwise)

Preceding gene: 88607488

Following gene: 88607684

Centisome position: 9.05

GC content: 43.96

Gene sequence:

>621_bases
ATGATAGAGTGCTCTAATGTAACGTGTGTAAGGGGAGAGCGTGTTCTGTTTCGGAATCTCAGTTTTATCGCTAATCAAGG
ATCGATAACGGTTATTGCGGGAAAAAACGGGAGCGGGAAAACCTCGTTACTGCGCTCTATGGTAGGTTTAGTTCCCGTAA
GATTTGGGAAAATAACTCTGAATGGCGAGGCTATAACAATATCTAGCACGTGTATTTCTGACATAACGTACATAGGCCAT
AAGAATGCATGCCACGAGCATCTGATGGTGGTTGATATCCTTGAATTTTGGGCCAATACACGGGGTAATGATAACCTCAT
CCTTGCCGCAGTAAACTTCTTTGAGTTGCACCGCGTATTGCACACCAAGTTTAGGCACTTATCTTCAGGTTGGAAGAGAA
AAGTGGCTTTGTCTAGACTATTGATATTCAATACACACGTTTGGATGCTGGACGAGCCTTTTGCAAATTTAGACTCTGCA
TCTGTAGCAATGCTAAAGGAGCTCATTCTGACACGGGCAGAGCGAGGTGGCACCATAATACTTGCAGACCATAACCATGA
GAACACATTTTCACAAGCACAAGTAGTAAACTTAGCGCCAGAGCCTCAGACACAACCGTAA

Upstream 100 bases:

>100_bases
CCCTATATGCACTAACATATGGCCTGGAACTTGCCATTTGTTTGGAAGGATGCTAGCAAAGTACTCAGGTTGACAGCTAT
CAGTGTTTGTGGTGCTTTAA

Downstream 100 bases:

>100_bases
AAGACAGGTAAATCCGCAAGAGGAAAGTTATGGTTCCTTCAGATAGATATGAGCAGGTGCAGAAGGAGGCAAAGAAAGCG
TGTTCAACAAGGCTTTTGCG

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MIECSNVTCVRGERVLFRNLSFIANQGSITVIAGKNGSGKTSLLRSMVGLVPVRFGKITLNGEAITISSTCISDITYIGH
KNACHEHLMVVDILEFWANTRGNDNLILAAVNFFELHRVLHTKFRHLSSGWKRKVALSRLLIFNTHVWMLDEPFANLDSA
SVAMLKELILTRAERGGTIILADHNHENTFSQAQVVNLAPEPQTQP

Sequences:

>Translated_206_residues
MIECSNVTCVRGERVLFRNLSFIANQGSITVIAGKNGSGKTSLLRSMVGLVPVRFGKITLNGEAITISSTCISDITYIGH
KNACHEHLMVVDILEFWANTRGNDNLILAAVNFFELHRVLHTKFRHLSSGWKRKVALSRLLIFNTHVWMLDEPFANLDSA
SVAMLKELILTRAERGGTIILADHNHENTFSQAQVVNLAPEPQTQP
>Mature_206_residues
MIECSNVTCVRGERVLFRNLSFIANQGSITVIAGKNGSGKTSLLRSMVGLVPVRFGKITLNGEAITISSTCISDITYIGH
KNACHEHLMVVDILEFWANTRGNDNLILAAVNFFELHRVLHTKFRHLSSGWKRKVALSRLLIFNTHVWMLDEPFANLDSA
SVAMLKELILTRAERGGTIILADHNHENTFSQAQVVNLAPEPQTQP

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=183, Percent_Identity=28.4153005464481, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI150417984, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI116734710, Length=182, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI105990541, Length=176, Percent_Identity=27.8409090909091, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=189, Percent_Identity=32.8042328042328, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790467, Length=198, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082267, Length=191, Percent_Identity=27.2251308900524, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081709, Length=168, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788450, Length=206, Percent_Identity=28.1553398058252, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=167, Percent_Identity=29.3413173652695, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789593, Length=192, Percent_Identity=26.5625, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1788053, Length=207, Percent_Identity=25.1207729468599, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787370, Length=189, Percent_Identity=24.8677248677249, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573571, Length=207, Percent_Identity=28.5024154589372, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573573, Length=202, Percent_Identity=29.2079207920792, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22892; Mature: 22892

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIECSNVTCVRGERVLFRNLSFIANQGSITVIAGKNGSGKTSLLRSMVGLVPVRFGKITL
CEECCCEEEECCCEEEHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHHEEEEEEEEE
NGEAITISSTCISDITYIGHKNACHEHLMVVDILEFWANTRGNDNLILAAVNFFELHRVL
CCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
HTKFRHLSSGWKRKVALSRLLIFNTHVWMLDEPFANLDSASVAMLKELILTRAERGGTII
HHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEE
LADHNHENTFSQAQVVNLAPEPQTQP
EEECCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MIECSNVTCVRGERVLFRNLSFIANQGSITVIAGKNGSGKTSLLRSMVGLVPVRFGKITL
CEECCCEEEECCCEEEHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHHEEEEEEEEE
NGEAITISSTCISDITYIGHKNACHEHLMVVDILEFWANTRGNDNLILAAVNFFELHRVL
CCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
HTKFRHLSSGWKRKVALSRLLIFNTHVWMLDEPFANLDSASVAMLKELILTRAERGGTII
HHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEE
LADHNHENTFSQAQVVNLAPEPQTQP
EEECCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA