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The map label for this gene is nrdA [H]

Identifier: 88606797

GI number: 88606797

Start: 314089

End: 315900

Strand: Direct

Name: nrdA [H]

Synonym: APH_0331

Alternate gene names: 88606797

Gene position: 314089-315900 (Clockwise)

Preceding gene: 88606854

Following gene: 88607507

Centisome position: 21.35

GC content: 44.26

Gene sequence:

>1812_bases
ATGGTAGTTGGGGTATATAACGTGTCGCAGATTGTTATAGATTACACTCGTGATGATAACCTTACGAATTTTGGCAAGGC
TGTTTTGTCAGATCGGTATTTATTAGAGAAGGAAGATTATCAGCAGCTTTTTGTGCGGGTGGCGCAGTATTACTCGGATG
ATAGCCAGCATGCTCAGAGGTTATACGATTACATGAGTAAACTTTGGTTTATGCCGGCCACTCCGATATTGAGTAATGGT
GGCACTAGTAGGGGGTTGCCTATATCGTGTTTCTTGAATGAGACAGAAGACAGTCTTGCGGGAATATTGAATTTGTGGAA
CGAGAATGTATGGTTGGCCTCTCGTGGTGGTGGAATAGGCAGCTATTGGGGTAATTTGCGTTCTATAGGTGAAAGAGTTC
GGGGAAGTGGTAAGACTTCGGGCATAATCCCTTTCATCGTTGTACAGAATGCGTTAACTCTTGCTATTAGCCAGGGTTCT
TTGCGTCGTGGTAGTTCGGCCGTATACCTTCCTGTGTGGCATCCTGAGATAGAGGAGTTCTTGGATATAAGACGGCCAAC
AGGGGGAGATCCCAACAGAAAGGCTTTGAATATTCATCATGGTGTGTTGTTGTCTGATGAATTTATGGAAGCTGTGGAGC
ATGATAAGACGTGGGATTTGCTTAGTCCTAAGGATAAGTGCGTGATTTCCACGGTAAAAGCTCGGGATTTGTGGATCAAG
ATATTGACGACTAGGGTAGAGACGGGAGAGCCTTATATAATTTTTGTAGATGCAGTTAATAGGTGCAAGCCCGAGATATA
CAAAAAGCTAGGCTTAGACGTGAAGATGTCGAACCTATGTACGGAGATTACTCTTACTACGGGTGAAGATCATTTAAAGA
AATCCAGGACAGCGGTGTGTTGCTTATCTTCGCTGAACCTGGAATATTATGATATGTGGTGTGGCAATCCTCAGTTTATA
GAGGATGTTATGCGGTTTTTGGATAATGTACTGACAGATTTTGTGCAGAAAGCACCTACAGAGCTGGAGAGGGCTAGGTA
TTCTGCAATGCGGGAGCGTAGTATTGGCATAGGTGTAATGGGCTTTCACTCGTTTCTACAGAGCAAAATGGTACCTTTTG
AGTCTTTTGCTGCAACTATGTGGAATAAGAAGATCTTTTCGTATTTAAAAAGCCAGGCTGATGCCGTTTCACGCAAGTTG
GCTCTTGAAAAGGGGGCGTGTCCTGATGCTCAAGATGCAAACGAGATGGAGAGGTTTGTGCACAAACTTTCTGTGGCGCC
TACTGCGTCTATATCTATCATAGCTGGTAACACTTCGCCTGGTATAGAGCCGTATGCGGCCAATGTGTTTACCCACAAGA
CTCTTACTGGTTCGTTCATAGTGCGCAATAAGTTTCTACAGGAATTACTGAAATCTAAGGGTAAAGATGATGATCAGGTT
TGGTCGTCGATATCCACGAATGAAGGGTCTGTGCAGCATTTAGACTTTCTCACTGACCACGAGAAGCTTGTTTTTAAGAC
GGCGTATGAGTTGGATCAGCGTTGGGTTATAGAGCATAGTGGCGATAGGACGCCATATATATGTCAGGCGCAGTCAGTGA
ACATATTCCTTCCGGCTGGTGTACACAAGAGATATCTGCATAAGGTGCATTTCTTAGCGTGGAAGAAGGGTCTGAAGAGC
TTGTATTATATGAGGTCTAAGTCAGTTCAAAGGGCAGATAAGGTTTCTCATGAAGTGAATGGAGCTGCAGCGGTGGTGCC
TCGTAAGCAGCTAACTAATTTCAGCTACGATGAGTGTTTGTCCTGTCAGTAA

Upstream 100 bases:

>100_bases
CCTTTTTTTCTATGCATACTGTATATCGTGCTAAATTTCTGATATAGATACTGTATGTGTTATACGAAGGAATTGAGACC
CAGATTTTGTCTCAGTGATA

Downstream 100 bases:

>100_bases
CGCTGGGGTATTGCGTGAAGAGCGGTGACTAGGCGAGAGTGGGAACTTTATTTACGGCTATAAGGTGATGCTGTGCGAGA
GTATTAGGGAGCTTTTCTCG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MVVGVYNVSQIVIDYTRDDNLTNFGKAVLSDRYLLEKEDYQQLFVRVAQYYSDDSQHAQRLYDYMSKLWFMPATPILSNG
GTSRGLPISCFLNETEDSLAGILNLWNENVWLASRGGGIGSYWGNLRSIGERVRGSGKTSGIIPFIVVQNALTLAISQGS
LRRGSSAVYLPVWHPEIEEFLDIRRPTGGDPNRKALNIHHGVLLSDEFMEAVEHDKTWDLLSPKDKCVISTVKARDLWIK
ILTTRVETGEPYIIFVDAVNRCKPEIYKKLGLDVKMSNLCTEITLTTGEDHLKKSRTAVCCLSSLNLEYYDMWCGNPQFI
EDVMRFLDNVLTDFVQKAPTELERARYSAMRERSIGIGVMGFHSFLQSKMVPFESFAATMWNKKIFSYLKSQADAVSRKL
ALEKGACPDAQDANEMERFVHKLSVAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQELLKSKGKDDDQV
WSSISTNEGSVQHLDFLTDHEKLVFKTAYELDQRWVIEHSGDRTPYICQAQSVNIFLPAGVHKRYLHKVHFLAWKKGLKS
LYYMRSKSVQRADKVSHEVNGAAAVVPRKQLTNFSYDECLSCQ

Sequences:

>Translated_603_residues
MVVGVYNVSQIVIDYTRDDNLTNFGKAVLSDRYLLEKEDYQQLFVRVAQYYSDDSQHAQRLYDYMSKLWFMPATPILSNG
GTSRGLPISCFLNETEDSLAGILNLWNENVWLASRGGGIGSYWGNLRSIGERVRGSGKTSGIIPFIVVQNALTLAISQGS
LRRGSSAVYLPVWHPEIEEFLDIRRPTGGDPNRKALNIHHGVLLSDEFMEAVEHDKTWDLLSPKDKCVISTVKARDLWIK
ILTTRVETGEPYIIFVDAVNRCKPEIYKKLGLDVKMSNLCTEITLTTGEDHLKKSRTAVCCLSSLNLEYYDMWCGNPQFI
EDVMRFLDNVLTDFVQKAPTELERARYSAMRERSIGIGVMGFHSFLQSKMVPFESFAATMWNKKIFSYLKSQADAVSRKL
ALEKGACPDAQDANEMERFVHKLSVAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQELLKSKGKDDDQV
WSSISTNEGSVQHLDFLTDHEKLVFKTAYELDQRWVIEHSGDRTPYICQAQSVNIFLPAGVHKRYLHKVHFLAWKKGLKS
LYYMRSKSVQRADKVSHEVNGAAAVVPRKQLTNFSYDECLSCQ
>Mature_603_residues
MVVGVYNVSQIVIDYTRDDNLTNFGKAVLSDRYLLEKEDYQQLFVRVAQYYSDDSQHAQRLYDYMSKLWFMPATPILSNG
GTSRGLPISCFLNETEDSLAGILNLWNENVWLASRGGGIGSYWGNLRSIGERVRGSGKTSGIIPFIVVQNALTLAISQGS
LRRGSSAVYLPVWHPEIEEFLDIRRPTGGDPNRKALNIHHGVLLSDEFMEAVEHDKTWDLLSPKDKCVISTVKARDLWIK
ILTTRVETGEPYIIFVDAVNRCKPEIYKKLGLDVKMSNLCTEITLTTGEDHLKKSRTAVCCLSSLNLEYYDMWCGNPQFI
EDVMRFLDNVLTDFVQKAPTELERARYSAMRERSIGIGVMGFHSFLQSKMVPFESFAATMWNKKIFSYLKSQADAVSRKL
ALEKGACPDAQDANEMERFVHKLSVAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQELLKSKGKDDDQV
WSSISTNEGSVQHLDFLTDHEKLVFKTAYELDQRWVIEHSGDRTPYICQAQSVNIFLPAGVHKRYLHKVHFLAWKKGLKS
LYYMRSKSVQRADKVSHEVNGAAAVVPRKQLTNFSYDECLSCQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=619, Percent_Identity=30.6946688206785, Blast_Score=249, Evalue=4e-66,
Organism=Escherichia coli, GI1789030, Length=415, Percent_Identity=29.3975903614458, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI2367133, Length=439, Percent_Identity=28.0182232346241, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17555242, Length=664, Percent_Identity=31.9277108433735, Blast_Score=265, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6320914, Length=638, Percent_Identity=31.1912225705329, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322123, Length=644, Percent_Identity=29.8136645962733, Blast_Score=242, Evalue=1e-64,
Organism=Drosophila melanogaster, GI17352481, Length=639, Percent_Identity=30.5164319248826, Blast_Score=244, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 68219; Mature: 68219

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVGVYNVSQIVIDYTRDDNLTNFGKAVLSDRYLLEKEDYQQLFVRVAQYYSDDSQHAQR
CEEEEEEHEEEEEEECCCCCCHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHHHHHH
LYDYMSKLWFMPATPILSNGGTSRGLPISCFLNETEDSLAGILNLWNENVWLASRGGGIG
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCH
SYWGNLRSIGERVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSAVYLPVWHPEIEEF
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCHHHH
LDIRRPTGGDPNRKALNIHHGVLLSDEFMEAVEHDKTWDLLSPKDKCVISTVKARDLWIK
HHHCCCCCCCCCCCEEEEECCEEECHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHE
ILTTRVETGEPYIIFVDAVNRCKPEIYKKLGLDVKMSNLCTEITLTTGEDHLKKSRTAVC
EEHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCEECCCCEEEEEEECCHHHHHHHHHHHH
CLSSLNLEYYDMWCGNPQFIEDVMRFLDNVLTDFVQKAPTELERARYSAMRERSIGIGVM
HHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEHH
GFHSFLQSKMVPFESFAATMWNKKIFSYLKSQADAVSRKLALEKGACPDAQDANEMERFV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
HKLSVAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQELLKSKGKDDDQV
HHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHH
WSSISTNEGSVQHLDFLTDHEKLVFKTAYELDQRWVIEHSGDRTPYICQAQSVNIFLPAG
HHHCCCCCCCEEHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCEEEEECCC
VHKRYLHKVHFLAWKKGLKSLYYMRSKSVQRADKVSHEVNGAAAVVPRKQLTNFSYDECL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCCHHHHC
SCQ
CCC
>Mature Secondary Structure
MVVGVYNVSQIVIDYTRDDNLTNFGKAVLSDRYLLEKEDYQQLFVRVAQYYSDDSQHAQR
CEEEEEEHEEEEEEECCCCCCHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHHHHHH
LYDYMSKLWFMPATPILSNGGTSRGLPISCFLNETEDSLAGILNLWNENVWLASRGGGIG
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCH
SYWGNLRSIGERVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSAVYLPVWHPEIEEF
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCHHHH
LDIRRPTGGDPNRKALNIHHGVLLSDEFMEAVEHDKTWDLLSPKDKCVISTVKARDLWIK
HHHCCCCCCCCCCCEEEEECCEEECHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHE
ILTTRVETGEPYIIFVDAVNRCKPEIYKKLGLDVKMSNLCTEITLTTGEDHLKKSRTAVC
EEHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCEECCCCEEEEEEECCHHHHHHHHHHHH
CLSSLNLEYYDMWCGNPQFIEDVMRFLDNVLTDFVQKAPTELERARYSAMRERSIGIGVM
HHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEHH
GFHSFLQSKMVPFESFAATMWNKKIFSYLKSQADAVSRKLALEKGACPDAQDANEMERFV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
HKLSVAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQELLKSKGKDDDQV
HHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHH
WSSISTNEGSVQHLDFLTDHEKLVFKTAYELDQRWVIEHSGDRTPYICQAQSVNIFLPAG
HHHCCCCCCCEEHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCEEEEECCC
VHKRYLHKVHFLAWKKGLKSLYYMRSKSVQRADKVSHEVNGAAAVVPRKQLTNFSYDECL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCCHHHHC
SCQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]