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The map label for this gene is accC [H]

Identifier: 87199877

GI number: 87199877

Start: 1960982

End: 1962316

Strand: Reverse

Name: accC [H]

Synonym: Saro_1860

Alternate gene names: 87199877

Gene position: 1962316-1960982 (Counterclockwise)

Preceding gene: 87199878

Following gene: 87199876

Centisome position: 55.1

GC content: 68.99

Gene sequence:

>1335_bases
ATGATCCGCAAGCTGTTCATCGCCAATCGCGGAGAGATCGCTCTCCGCGTGATCCGCACCGCGCGCGCCATGGGGATCGA
AACCGTCCTTGGCGCATCCGAGGCCGATGCCTCCTCGCTCCCGGCCAAGCTTGCCGACCACGTTGCGATCGTCGGCCCCG
GCCCCTCGTCGCAGGGCTATCTGTCGATTGAACGCGTCGTCGATGCAGCGGTCAGGTCCGGCTGCGACGCGGTCCACCCG
GGCTATGGCTTCCTTTCCGAAAACGCCGGTTTCGCCCGTGCGGTCGCTGCCGCCGGCATCCGCTTCGTCGGGCCGGACAT
CGCGACGCTCGAAGGCATGGGCGACAAGCTCGCTGCCCGCGCTCTCGCGGTCGAGGCGGGCCTGCCCGTCCTCCCCGGCG
GCGAGGCCGCGACCCGCGCCGATGTCCACGCCCGCGCCACGGAGACCGGCTACCCGCTCCTGCTCAAGGCGGTTGCGGGC
GGCGGCGGCAAGGGCATGCGCCGGGTTGACCGACCCGAAGACCTCGATGCCGCGCTCGACATGGCCCAGGCCGAAGCGCA
GGCCGCGTTCGGCAACGGCGCGGTCTATGTCGAACGCTTCGTCGCGCGCGGACGCCATGTTGAAGTCCAGCTTCTTGGCG
ACGGAACCAACGCCATCCATCTCGGCACGCGCGACTGCTCGATCCAGCGCCGATTCCAGAAGCTCGTCGAGGAAGCACCC
GCTCCCGCCATGCCGCTCGCCTCGCGCGAGGGCATCGAACAGGCCGCGGTCCGCCTCGCCCGTCATCTCGGCTATCGCGG
CGCCGGCACTGCCGAGTTCCTCGTCGATGCCGAGGACTTCTCGTTCTATTTCCTCGAACTCAACGCGCGCATCCAGGTTG
AGCATCCGGTGACCGAGGCGATCACCGGCGTCGACCTCGTCGAGCAACAGCTTCTTGTCGCCATGGGCAAGCCCCTGTCG
CTGACCCAGGCGATGGTCCGCCCCAACGGGCATGCCATCGAGGTGCGCATAAACGCCGAAGATCCCGACGCGGACTTCCG
CCCCTCCCCCGGCCGCGCAACCCGCGCCGCCTGGCCCGCAGGCGAAGGCGTCCGGGTAGACACCCACATCGGCCTCGGGG
GTGAAGTGCCGCCGTTCTACGATTCGCTCATGGGCAAGCTCATCGTCCACGGCGCAACCCGCGAACAGGCGGTCGAGCGC
CTTCGCAAGGCTCTGGATTCACTGCACATCGAAGGCCTGCCGACCACCGCACCGCTCCACCGCCGCATCGTCCTCGACCC
GCGCTTCGTCGCCGGCGGGGTCGACACCGGCTTCCTGACAGGACTTGCCCAATGA

Upstream 100 bases:

>100_bases
AACCCGGTCCATGCCGGGCGCAGCGGCACGGTCGGCGCGATGCTGGTCCCCAACGGAACGCTTGTCGCCAAGGGCGAAGC
GCTGGTCCGGCTGACCTGAC

Downstream 100 bases:

>100_bases
CCGAGATCCGTCTCGTCGACGTCACCATGCGCGATGGCAACCAGAGCCTTTGGGGTGCCACCGGCCTCAACACCGCGCAC
ATGCTCCAGGCGGCGGCGCT

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIRKLFIANRGEIALRVIRTARAMGIETVLGASEADASSLPAKLADHVAIVGPGPSSQGYLSIERVVDAAVRSGCDAVHP
GYGFLSENAGFARAVAAAGIRFVGPDIATLEGMGDKLAARALAVEAGLPVLPGGEAATRADVHARATETGYPLLLKAVAG
GGGKGMRRVDRPEDLDAALDMAQAEAQAAFGNGAVYVERFVARGRHVEVQLLGDGTNAIHLGTRDCSIQRRFQKLVEEAP
APAMPLASREGIEQAAVRLARHLGYRGAGTAEFLVDAEDFSFYFLELNARIQVEHPVTEAITGVDLVEQQLLVAMGKPLS
LTQAMVRPNGHAIEVRINAEDPDADFRPSPGRATRAAWPAGEGVRVDTHIGLGGEVPPFYDSLMGKLIVHGATREQAVER
LRKALDSLHIEGLPTTAPLHRRIVLDPRFVAGGVDTGFLTGLAQ

Sequences:

>Translated_444_residues
MIRKLFIANRGEIALRVIRTARAMGIETVLGASEADASSLPAKLADHVAIVGPGPSSQGYLSIERVVDAAVRSGCDAVHP
GYGFLSENAGFARAVAAAGIRFVGPDIATLEGMGDKLAARALAVEAGLPVLPGGEAATRADVHARATETGYPLLLKAVAG
GGGKGMRRVDRPEDLDAALDMAQAEAQAAFGNGAVYVERFVARGRHVEVQLLGDGTNAIHLGTRDCSIQRRFQKLVEEAP
APAMPLASREGIEQAAVRLARHLGYRGAGTAEFLVDAEDFSFYFLELNARIQVEHPVTEAITGVDLVEQQLLVAMGKPLS
LTQAMVRPNGHAIEVRINAEDPDADFRPSPGRATRAAWPAGEGVRVDTHIGLGGEVPPFYDSLMGKLIVHGATREQAVER
LRKALDSLHIEGLPTTAPLHRRIVLDPRFVAGGVDTGFLTGLAQ
>Mature_444_residues
MIRKLFIANRGEIALRVIRTARAMGIETVLGASEADASSLPAKLADHVAIVGPGPSSQGYLSIERVVDAAVRSGCDAVHP
GYGFLSENAGFARAVAAAGIRFVGPDIATLEGMGDKLAARALAVEAGLPVLPGGEAATRADVHARATETGYPLLLKAVAG
GGGKGMRRVDRPEDLDAALDMAQAEAQAAFGNGAVYVERFVARGRHVEVQLLGDGTNAIHLGTRDCSIQRRFQKLVEEAP
APAMPLASREGIEQAAVRLARHLGYRGAGTAEFLVDAEDFSFYFLELNARIQVEHPVTEAITGVDLVEQQLLVAMGKPLS
LTQAMVRPNGHAIEVRINAEDPDADFRPSPGRATRAAWPAGEGVRVDTHIGLGGEVPPFYDSLMGKLIVHGATREQAVER
LRKALDSLHIEGLPTTAPLHRRIVLDPRFVAGGVDTGFLTGLAQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=45.4954954954955, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=45.4954954954955, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=45.4954954954955, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=44.3438914027149, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=44.3946188340807, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=44.3946188340807, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=44.3946188340807, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI38679974, Length=505, Percent_Identity=33.6633663366337, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI38679971, Length=505, Percent_Identity=33.6633663366337, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI38679960, Length=505, Percent_Identity=33.6633663366337, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI38679977, Length=505, Percent_Identity=33.6633663366337, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679967, Length=505, Percent_Identity=33.6633663366337, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=33.399209486166, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI18105007, Length=285, Percent_Identity=24.9122807017544, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=48.9841986455982, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.0588235294118, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=46.031746031746, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=45.7399103139013, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=29.5634920634921, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=29.3650793650794, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=28.3950617283951, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=437, Percent_Identity=41.1899313501144, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=40.4867256637168, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=41.3716814159292, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6323863, Length=471, Percent_Identity=33.3333333333333, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=31.9688109161793, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=45.4751131221719, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=45.7399103139013, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=404, Percent_Identity=44.3069306930693, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=34, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=34, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=34, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=34, Blast_Score=253, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 46930; Mature: 46930

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKLFIANRGEIALRVIRTARAMGIETVLGASEADASSLPAKLADHVAIVGPGPSSQGY
CCCEEEECCCCHHHHHHHHHHHHHCHHHHHCCCCCCHHHCCHHHHCCEEEECCCCCCCCC
LSIERVVDAAVRSGCDAVHPGYGFLSENAGFARAVAAAGIRFVGPDIATLEGMGDKLAAR
CHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCHHHHHCCCHHHHHH
ALAVEAGLPVLPGGEAATRADVHARATETGYPLLLKAVAGGGGKGMRRVDRPEDLDAALD
HHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHH
MAQAEAQAAFGNGAVYVERFVARGRHVEVQLLGDGTNAIHLGTRDCSIQRRFQKLVEEAP
HHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCC
APAMPLASREGIEQAAVRLARHLGYRGAGTAEFLVDAEDFSFYFLELNARIQVEHPVTEA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCHHHH
ITGVDLVEQQLLVAMGKPLSLTQAMVRPNGHAIEVRINAEDPDADFRPSPGRATRAAWPA
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
GEGVRVDTHIGLGGEVPPFYDSLMGKLIVHGATREQAVERLRKALDSLHIEGLPTTAPLH
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
RRIVLDPRFVAGGVDTGFLTGLAQ
CEEEECCCEEECCCCHHHHHCCCC
>Mature Secondary Structure
MIRKLFIANRGEIALRVIRTARAMGIETVLGASEADASSLPAKLADHVAIVGPGPSSQGY
CCCEEEECCCCHHHHHHHHHHHHHCHHHHHCCCCCCHHHCCHHHHCCEEEECCCCCCCCC
LSIERVVDAAVRSGCDAVHPGYGFLSENAGFARAVAAAGIRFVGPDIATLEGMGDKLAAR
CHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCHHHHHCCCHHHHHH
ALAVEAGLPVLPGGEAATRADVHARATETGYPLLLKAVAGGGGKGMRRVDRPEDLDAALD
HHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHH
MAQAEAQAAFGNGAVYVERFVARGRHVEVQLLGDGTNAIHLGTRDCSIQRRFQKLVEEAP
HHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCC
APAMPLASREGIEQAAVRLARHLGYRGAGTAEFLVDAEDFSFYFLELNARIQVEHPVTEA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCHHHH
ITGVDLVEQQLLVAMGKPLSLTQAMVRPNGHAIEVRINAEDPDADFRPSPGRATRAAWPA
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
GEGVRVDTHIGLGGEVPPFYDSLMGKLIVHGATREQAVERLRKALDSLHIEGLPTTAPLH
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
RRIVLDPRFVAGGVDTGFLTGLAQ
CEEEECCCEEECCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]