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The map label for this gene is proC [H]

Identifier: 87199164

GI number: 87199164

Start: 1190387

End: 1191196

Strand: Direct

Name: proC [H]

Synonym: Saro_1142

Alternate gene names: 87199164

Gene position: 1190387-1191196 (Clockwise)

Preceding gene: 87199163

Following gene: 87199165

Centisome position: 33.42

GC content: 69.75

Gene sequence:

>810_bases
ATGACCAAGACCTTTCTCCAGTTCGGCTGCGGCAACATGGGCGGAGCCATGCTCAAGGGCTGGCTTGCCGGCGGTCTGGC
GCCGGAAACCTTCACCGTGGTCGATCCCTATCTCGAAGCGGCGCCGCACGGCGTTCGCCTGCTCGAAGCTGCGCCCGCCG
GCGAGGATGCGTTCGACATCGTCCTGCTCGGCTTCAAGCCGCAGCAGTTGCCCGACGCGGCGCAGGCCGTGCGCCCCTTC
GTCGGGCCGCGCACCCTGTTGCTGTCGATACTTGCGGGCGTCGACCTCGCCACCTTGCGCCGTACTTTCCCCGAAGCGCG
TGCAATCGTCCGCGTCATGCCCAACCTGGCCGCCGCGCTAGGCAAGTCCCCGATCGCGCTGTTCGGCGATGCGGACGAGG
CCGCCCGTGCCGAGACTGACGCGCTGATGGCACCGTTGGGGCAGGCGGAATGGCTCTCGGGCGAGGATCAGATGGACCTT
GTCACCGCGCTCGCTGGTTCGGGTCCTGCCTTCGTGTACCGCTTCATCGATGCCCTGGCCGAAGGCGCTGCCGCTCTCGG
CCTGCCGCGCGACCAGGCTGACCGCCTGGCGCTGTCGATGGTGGAGGGTTCGGCCATGCTCGCCGCCGCCTCCGAACACT
CGCCGGGTGAACTCGCGCGCCGGGTCGCCAGCCCCGGCGGGGTCACGCAGGTTGGCATCGACATCCTCGACGCCGAGCGC
CGTCTTGCGCGCCTCGTGGAGGACACCTTGCGCGGTGCGCGCGACCGCAGCGCCGAGATGACGGAGCAGGCGCGGGCGCG
TCAGCAATAA

Upstream 100 bases:

>100_bases
GCCGCCGGCGAAGCCTGAACGCGGCTTGCTGTCGCGGGCAGGTGGCGGCATTGAGCGCCCTCACGCGACTCAATCTGGCG
CGATTCAAGGGGCAGCGGCG

Downstream 100 bases:

>100_bases
TTCGTTACAATTCGTTGCCGATGGTGCGCACCGGTTTCGCTTGAAACCCGGGGCGAGAGCGCCGATATTCGTCGGACGTG
GCCATTCGGGCCGCAAAACG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTKTFLQFGCGNMGGAMLKGWLAGGLAPETFTVVDPYLEAAPHGVRLLEAAPAGEDAFDIVLLGFKPQQLPDAAQAVRPF
VGPRTLLLSILAGVDLATLRRTFPEARAIVRVMPNLAAALGKSPIALFGDADEAARAETDALMAPLGQAEWLSGEDQMDL
VTALAGSGPAFVYRFIDALAEGAAALGLPRDQADRLALSMVEGSAMLAAASEHSPGELARRVASPGGVTQVGIDILDAER
RLARLVEDTLRGARDRSAEMTEQARARQQ

Sequences:

>Translated_269_residues
MTKTFLQFGCGNMGGAMLKGWLAGGLAPETFTVVDPYLEAAPHGVRLLEAAPAGEDAFDIVLLGFKPQQLPDAAQAVRPF
VGPRTLLLSILAGVDLATLRRTFPEARAIVRVMPNLAAALGKSPIALFGDADEAARAETDALMAPLGQAEWLSGEDQMDL
VTALAGSGPAFVYRFIDALAEGAAALGLPRDQADRLALSMVEGSAMLAAASEHSPGELARRVASPGGVTQVGIDILDAER
RLARLVEDTLRGARDRSAEMTEQARARQQ
>Mature_268_residues
TKTFLQFGCGNMGGAMLKGWLAGGLAPETFTVVDPYLEAAPHGVRLLEAAPAGEDAFDIVLLGFKPQQLPDAAQAVRPFV
GPRTLLLSILAGVDLATLRRTFPEARAIVRVMPNLAAALGKSPIALFGDADEAARAETDALMAPLGQAEWLSGEDQMDLV
TALAGSGPAFVYRFIDALAEGAAALGLPRDQADRLALSMVEGSAMLAAASEHSPGELARRVASPGGVTQVGIDILDAERR
LARLVEDTLRGARDRSAEMTEQARARQQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=238, Percent_Identity=30.672268907563, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI24797095, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI24797097, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI21361454, Length=244, Percent_Identity=27.0491803278689, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786585, Length=274, Percent_Identity=31.021897810219, Blast_Score=103, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17569021, Length=212, Percent_Identity=31.6037735849057, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17540664, Length=257, Percent_Identity=27.6264591439689, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320861, Length=281, Percent_Identity=26.3345195729537, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358587, Length=234, Percent_Identity=37.1794871794872, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24648116, Length=273, Percent_Identity=30.4029304029304, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24647700, Length=141, Percent_Identity=41.8439716312057, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28272; Mature: 28141

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTFLQFGCGNMGGAMLKGWLAGGLAPETFTVVDPYLEAAPHGVRLLEAAPAGEDAFDI
CCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHCCHHHHHCCCCEEEEECCCCCCCCEEE
VLLGFKPQQLPDAAQAVRPFVGPRTLLLSILAGVDLATLRRTFPEARAIVRVMPNLAAAL
EEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GKSPIALFGDADEAARAETDALMAPLGQAEWLSGEDQMDLVTALAGSGPAFVYRFIDALA
CCCCEEEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
EGAAALGLPRDQADRLALSMVEGSAMLAAASEHSPGELARRVASPGGVTQVGIDILDAER
HCHHHHCCCCCHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
RLARLVEDTLRGARDRSAEMTEQARARQQ
HHHHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TKTFLQFGCGNMGGAMLKGWLAGGLAPETFTVVDPYLEAAPHGVRLLEAAPAGEDAFDI
CCHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHCCHHHHHCCCCEEEEECCCCCCCCEEE
VLLGFKPQQLPDAAQAVRPFVGPRTLLLSILAGVDLATLRRTFPEARAIVRVMPNLAAAL
EEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GKSPIALFGDADEAARAETDALMAPLGQAEWLSGEDQMDLVTALAGSGPAFVYRFIDALA
CCCCEEEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
EGAAALGLPRDQADRLALSMVEGSAMLAAASEHSPGELARRVASPGGVTQVGIDILDAER
HCHHHHCCCCCHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
RLARLVEDTLRGARDRSAEMTEQARARQQ
HHHHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]