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The map label for this gene is aceA [C]

Identifier: 87199051

GI number: 87199051

Start: 1067166

End: 1068761

Strand: Direct

Name: aceA [C]

Synonym: Saro_1029

Alternate gene names: 87199051

Gene position: 1067166-1068761 (Clockwise)

Preceding gene: 87199049

Following gene: 87199052

Centisome position: 29.96

GC content: 63.35

Gene sequence:

>1596_bases
ATGACCTACCACAGCAAGATCGTCGAGGCCGGCAAGGCCATCGCGCCTTTCAGCCAGACCTGGGACGGCATCGAGCCCGA
GAGCGTGGCCCGCATGCGCCTGCAGAACCGCTTCCACACCGGCCTCGACATCGCGCGCTACACCGCGAAGATCATGCGTG
CCGACATGGCTGCTTACGATGCCGACCCGGCGAACTACACCCAGTCGCTCGGCTGCTGGCACGGTTTCATCGGCCAGCAG
AAGATGATCTCCATCAAGAAGCACTTCGGCACGACCAAGGGGCGCTACCTCTACCTTTCGGGCTGGATGGTCGCAGCGCT
GCGCAGCGAATTCGGTCCGCTGCCCGACCAGTCGATGCACGAGAAGACCAGCGTTCCCGCGCTGATCGAGGAACTCTACA
CCTTCCTCAAGCAGGCTGACGCCCGCGAACTCGGCATGCTGTTCCGCGATCTCGATGCCGCCAAGGCTGCCGGCGATGCG
GTCAACACCCACCGCCTGCTGCACAAGATCGACGAGTTCGAAACGCACGTGGTTCCGATCATCGCAGACATCGACGCAGG
TTTTGGCAATGCCGAGGCGACCTACCTGCTCGCCAAGAAGTTCATCGAAGCGGGCGCCTGCTGCATCCAGATCGAGAACC
AGGTCTCGGACGAAAAGCAGTGCGGCCACCAGGACGGCAAGGTCACCGTTCCGCACGAGGACTTCCTCGCGAAGATCCGC
GCGGTCCGTTACGCCTTCATGGAACTGGGCGTCGATGACGGCGTGATCGTTGCCCGCACCGACTCGCTGGGCGCTGGCCT
GACCAAGCAGATCGCCTTTGTGAAGGAGCCGGGTGACATCGGCGACCAGTACAACAGCTTCCTCGATTGCGAGGAAGTCG
ATGCGGCCAACCTTGGCCATGGCGATGTGCTGATCAGCCGCGACGGCAAGCTGATGCGTCCCAGGCGCCTGCCTTCGAAC
CTGTACCAGTTCCGTGCCGGGACGGGCGAAGACCGCTGCGTGCTCGATTGCATCACCTCGCTCCAGAACGGCGCGGACCT
GCTGTGGATCGAAACCGAAAAGCCGCACATCGGCCAGATCGGCGGCATGGTCGACCGCATCCGCGAAGTGATCCCGAATG
CCAAGCTGGTCTACAACAACAGCCCCTCGTTCAACTGGACGCTCAACTTCCGCCAGCAGGTCTTCGATGCCTGGCAAGCC
GAAGGCCGCGACACGAGCGCCTACGACCGTGCCAAGCTGATGAGCGTGGACTATGACGGCACCGAACTGGGCGTGGAAGC
CGACGAGCGCATCCGCACCTTCCAGCGCGATGCTGCGGCTCAGGCCGGTATCTTCCACCACCTGATCACGCTGCCGACCT
ACCACACCGCGGCGCTCAGCACGGACAACCTCGCCAAGCGCTACTTCGGCGAAGAGGGCATGCTCGGCTACGTCAAGCAG
GTCCAGCGCGAGGAAATCCGCCAGGGCATCGCTTGCGTGAAGCACCAGAACATGGCCGGCTCCGACATCGGCGACGATCA
CAAGGAATACTTCGCCGGTGAGGCCGCGCTCAAGGCGGGCGGCGCCCACAACACGATGAACCAGTTCGCCGCCTGA

Upstream 100 bases:

>100_bases
TAAAGTTTGACAACATGACCGCGCTGCATGTTCCGCAGCCACGATTCGCCAGTTATCCCAAGGCCACACGCAATGCTCAC
CACGTGAGGGAACTCGGGAA

Downstream 100 bases:

>100_bases
TAGTCAGGCAGCTAGATAATCCTCGCGGCAATCAGGCCCCGAAGATCCAAGAAGGAGACCCACAATGGCTGAACCAGCAC
GTGCCCGCGCGGTCCTCTCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTYHSKIVEAGKAIAPFSQTWDGIEPESVARMRLQNRFHTGLDIARYTAKIMRADMAAYDADPANYTQSLGCWHGFIGQQ
KMISIKKHFGTTKGRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVPALIEELYTFLKQADARELGMLFRDLDAAKAAGDA
VNTHRLLHKIDEFETHVVPIIADIDAGFGNAEATYLLAKKFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIR
AVRYAFMELGVDDGVIVARTDSLGAGLTKQIAFVKEPGDIGDQYNSFLDCEEVDAANLGHGDVLISRDGKLMRPRRLPSN
LYQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHIGQIGGMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWQA
EGRDTSAYDRAKLMSVDYDGTELGVEADERIRTFQRDAAAQAGIFHHLITLPTYHTAALSTDNLAKRYFGEEGMLGYVKQ
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGAHNTMNQFAA

Sequences:

>Translated_531_residues
MTYHSKIVEAGKAIAPFSQTWDGIEPESVARMRLQNRFHTGLDIARYTAKIMRADMAAYDADPANYTQSLGCWHGFIGQQ
KMISIKKHFGTTKGRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVPALIEELYTFLKQADARELGMLFRDLDAAKAAGDA
VNTHRLLHKIDEFETHVVPIIADIDAGFGNAEATYLLAKKFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIR
AVRYAFMELGVDDGVIVARTDSLGAGLTKQIAFVKEPGDIGDQYNSFLDCEEVDAANLGHGDVLISRDGKLMRPRRLPSN
LYQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHIGQIGGMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWQA
EGRDTSAYDRAKLMSVDYDGTELGVEADERIRTFQRDAAAQAGIFHHLITLPTYHTAALSTDNLAKRYFGEEGMLGYVKQ
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGAHNTMNQFAA
>Mature_530_residues
TYHSKIVEAGKAIAPFSQTWDGIEPESVARMRLQNRFHTGLDIARYTAKIMRADMAAYDADPANYTQSLGCWHGFIGQQK
MISIKKHFGTTKGRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVPALIEELYTFLKQADARELGMLFRDLDAAKAAGDAV
NTHRLLHKIDEFETHVVPIIADIDAGFGNAEATYLLAKKFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRA
VRYAFMELGVDDGVIVARTDSLGAGLTKQIAFVKEPGDIGDQYNSFLDCEEVDAANLGHGDVLISRDGKLMRPRRLPSNL
YQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHIGQIGGMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWQAE
GRDTSAYDRAKLMSVDYDGTELGVEADERIRTFQRDAAAQAGIFHHLITLPTYHTAALSTDNLAKRYFGEEGMLGYVKQV
QREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGAHNTMNQFAA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=413, Percent_Identity=27.6029055690073, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71982926, Length=412, Percent_Identity=27.1844660194175, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17561814, Length=412, Percent_Identity=27.1844660194175, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=175, Percent_Identity=32, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325263, Length=172, Percent_Identity=27.906976744186, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59013; Mature: 58882

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYHSKIVEAGKAIAPFSQTWDGIEPESVARMRLQNRFHTGLDIARYTAKIMRADMAAYD
CCCHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
ADPANYTQSLGCWHGFIGQQKMISIKKHFGTTKGRYLYLSGWMVAALRSEFGPLPDQSMH
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHH
EKTSVPALIEELYTFLKQADARELGMLFRDLDAAKAAGDAVNTHRLLHKIDEFETHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEE
IADIDAGFGNAEATYLLAKKFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIR
EEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCEEECCHHHHHHHHH
AVRYAFMELGVDDGVIVARTDSLGAGLTKQIAFVKEPGDIGDQYNSFLDCEEVDAANLGH
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHEEEECCCCCCHHHHHCCCHHHCCCCCCCC
GDVLISRDGKLMRPRRLPSNLYQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHIGQI
CCEEEECCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHH
GGMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWQAEGRDTSAYDRAKLMSVDYDG
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHCCCCCCCHHHHHHEEEECCCC
TELGVEADERIRTFQRDAAAQAGIFHHLITLPTYHTAALSTDNLAKRYFGEEGMLGYVKQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCHHHHHHH
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGAHNTMNQFAA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCHHHHHCC
>Mature Secondary Structure 
TYHSKIVEAGKAIAPFSQTWDGIEPESVARMRLQNRFHTGLDIARYTAKIMRADMAAYD
CCHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
ADPANYTQSLGCWHGFIGQQKMISIKKHFGTTKGRYLYLSGWMVAALRSEFGPLPDQSMH
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHH
EKTSVPALIEELYTFLKQADARELGMLFRDLDAAKAAGDAVNTHRLLHKIDEFETHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEE
IADIDAGFGNAEATYLLAKKFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIR
EEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCEEECCHHHHHHHHH
AVRYAFMELGVDDGVIVARTDSLGAGLTKQIAFVKEPGDIGDQYNSFLDCEEVDAANLGH
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHEEEECCCCCCHHHHHCCCHHHCCCCCCCC
GDVLISRDGKLMRPRRLPSNLYQFRAGTGEDRCVLDCITSLQNGADLLWIETEKPHIGQI
CCEEEECCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHH
GGMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWQAEGRDTSAYDRAKLMSVDYDG
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHCCCCCCCHHHHHHEEEECCCC
TELGVEADERIRTFQRDAAAQAGIFHHLITLPTYHTAALSTDNLAKRYFGEEGMLGYVKQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCHHHHHHH
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGAHNTMNQFAA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]