Click here to switch to the map view.

The map label for this gene is fkpA [H]

Identifier: 87199011

GI number: 87199011

Start: 1030696

End: 1031259

Strand: Direct

Name: fkpA [H]

Synonym: Saro_0989

Alternate gene names: 87199011

Gene position: 1030696-1031259 (Clockwise)

Preceding gene: 87198998

Following gene: 87199012

Centisome position: 28.94

GC content: 68.79

Gene sequence:

>564_bases
ATGACCAACTTCGCCCTGGCGCTTTGCCGCATCGCTCCCGTCCTCGTCCTCTCGGCCGCGGTGCCGGCCATTTCGGCTGC
TCCCGCCAAGGCGCCCGTGGCCTCGGCCCAGGCCATCCCGTTGCCGCTGAACCCCGTGATCGCGGGACCGCAGCGGCTGT
GCACCGCCAAGACCGCGAGCGGACTGGGCACGATGGGGCTGAAGGCCGTGGAAGGCGCGAAGCCCGCCAAGGGCGACTAC
GTGCTGGTCAACTACATCGGTTATCTTGCGACGAACGGCGAAGTGTTCGACCAGGGCATGCAGGCCGCCTTCCCGGTGGA
AGGCGTGATCCCGGGTTTTTCCGAAGGGCTCCAGATGATGGCCAAGGGAAGCACGTGGCGCTTCTGCGTTCCGTCCCCGC
TTGGGTATGGCGCGGAAGCTTCGGGGCCGATCCCGGCCAACTCGGACCTCGTCTTCCAGGTCGAACTCGTCGACTTCAAG
ACCGCCGCCGAAGTGGAGGCCATGCGGGCCGCCGCCGCCTCGGCCCAGCCCGGTGCCGAAGCGCAGCCTGCCACCCCGCG
CTGA

Upstream 100 bases:

>100_bases
GTGGACGAAAGTCGCTGGTTTGCGTGATGCGGTACGCATTTCCCGAATTTTTGTTGCAGTCCGCATGGCGCGGGAACCTG
CGTCCGACTAATGACGGGTC

Downstream 100 bases:

>100_bases
TCCAGCCGGAACTGGCAGGTCTATTCACTGGTCCTTCATCGGAAGGCTTCCTATAGTCGGGCGATGCGAATTCGTACCAC
GCGCGCCCGGCGCATAGGCC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTNFALALCRIAPVLVLSAAVPAISAAPAKAPVASAQAIPLPLNPVIAGPQRLCTAKTASGLGTMGLKAVEGAKPAKGDY
VLVNYIGYLATNGEVFDQGMQAAFPVEGVIPGFSEGLQMMAKGSTWRFCVPSPLGYGAEASGPIPANSDLVFQVELVDFK
TAAEVEAMRAAAASAQPGAEAQPATPR

Sequences:

>Translated_187_residues
MTNFALALCRIAPVLVLSAAVPAISAAPAKAPVASAQAIPLPLNPVIAGPQRLCTAKTASGLGTMGLKAVEGAKPAKGDY
VLVNYIGYLATNGEVFDQGMQAAFPVEGVIPGFSEGLQMMAKGSTWRFCVPSPLGYGAEASGPIPANSDLVFQVELVDFK
TAAEVEAMRAAAASAQPGAEAQPATPR
>Mature_186_residues
TNFALALCRIAPVLVLSAAVPAISAAPAKAPVASAQAIPLPLNPVIAGPQRLCTAKTASGLGTMGLKAVEGAKPAKGDYV
LVNYIGYLATNGEVFDQGMQAAFPVEGVIPGFSEGLQMMAKGSTWRFCVPSPLGYGAEASGPIPANSDLVFQVELVDFKT
AAEVEAMRAAAASAQPGAEAQPATPR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=107, Percent_Identity=45.7943925233645, Blast_Score=81, Evalue=3e-17,
Organism=Escherichia coli, GI1789745, Length=114, Percent_Identity=39.4736842105263, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18983; Mature: 18852

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFALALCRIAPVLVLSAAVPAISAAPAKAPVASAQAIPLPLNPVIAGPQRLCTAKTAS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
GLGTMGLKAVEGAKPAKGDYVLVNYIGYLATNGEVFDQGMQAAFPVEGVIPGFSEGLQMM
CCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHH
AKGSTWRFCVPSPLGYGAEASGPIPANSDLVFQVELVDFKTAAEVEAMRAAAASAQPGAE
HCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
AQPATPR
CCCCCCC
>Mature Secondary Structure 
TNFALALCRIAPVLVLSAAVPAISAAPAKAPVASAQAIPLPLNPVIAGPQRLCTAKTAS
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
GLGTMGLKAVEGAKPAKGDYVLVNYIGYLATNGEVFDQGMQAAFPVEGVIPGFSEGLQMM
CCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHH
AKGSTWRFCVPSPLGYGAEASGPIPANSDLVFQVELVDFKTAAEVEAMRAAAASAQPGAE
HCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
AQPATPR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]