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The map label for this gene is thrC [H]

Identifier: 87198943

GI number: 87198943

Start: 973079

End: 974500

Strand: Direct

Name: thrC [H]

Synonym: Saro_0921

Alternate gene names: 87198943

Gene position: 973079-974500 (Clockwise)

Preceding gene: 87198942

Following gene: 87198944

Centisome position: 27.32

GC content: 66.95

Gene sequence:

>1422_bases
ATGAAGTACGTCAGCACCCGGGGGCAGGCACCCTCGCTCGATTTCCAGGGCGTCACGCTCGCAGGCCTCGCTTCGGATGG
CGGGCTCTACGTGCCCGAGAGCTGGCCGCAGTTCTCGCACGACGAGATCGCCGCGATGGCCGGGCTGCCCTATGCCAGGC
TGGCGCAGAAGATCATGCAGCCCTACGTCGGCGATTGCCTGACGCCGGAGCGCCTGCTGGAGCTGTGCGAACAAGCCTAT
GGCCGTTTCGCGCACGCTGCCGTGACGCCGCTCAAGCAGCTCGACGAGACGCAGTGGGTGCTCGAACTGTTCCATGGGCC
GACGCTGGCTTTCAAGGACGTCGCGCTCCAGTTGCTTGGCCTGCTGTTCGAGGAATTCCTTGCGCGTCCGAGAGAGGATG
GGGGCGACGAGCACATCACCATCGTCGGGGCGACTTCGGGTGACACCGGGTCTGCCGCCATCGATGCGGTGGCGGGTCGC
GCCAAGGTCGATATCTTCATGCTCCACCCGCATGGCCGGGTATCCGATGTGCAGCGCCGCCAGATGACCACGGTCATCGC
GCCCAACGTCCACAACATCGCCATCGACGGCAGCTTCGACGATGCCCAGGCGATGGTGAAGCGCATGTTCAACGACAGCG
CGATGACCGGCCGCTTCGGCATCGCCGCCGTCAACTCGATCAACTGGGCGCGCCTGATGGCGCAGGTGGTCTACTACTTC
TACGCCGCGCTCCAGCTTGGCGCGCCGCACCGCAAGGTTGCCTTCTCGGTGCCGACCGGCAACTTCGGGGATGTCTTCGC
AGGCTACGTCGCGGCGAAGATGGGCCTTCCGATCGAGCGGCTGATCGTGGCCACCAACGTCAACGACATCCTCCACCGCG
CGCTTTCGGCAGGCGATTATTCGGCCAGCACCGTAACGCCGACCGCCGCGCCATCGATGGACATCCAGGTTTCCTCGAAC
TTCGAGCGCCTGCTGTTCGACGGCTGCGGTCGCGACGCATCGGCGCTTGCCGCGCAGATGAAGCATTTCGAAGTGACCAA
GGCGATGCAGCTCACGAATGCGCAGCGCGAATCGGCGGCCGCGCTGTTCAGCTCCGCTCGCGCCGATGCGGGCGACATGG
CCAATGCCATGCGCTGGGCGTTCGAGGCGACGGGCGAAGTGCTCGACCCGCACACCGCGATTGGCCTTCACGCGGCACGC
GCGGCCGAAGGCATCCCTGCGGGCGTTCCGATCGTGACGCTGGCGACGGCCCATCCGGCAAAGTTCGTCGACGCGGTCGA
GCGCGCCACCGGCGTTCGCCCGGGCCTGCCCGCCCGCGTGGGCGACCTGTTCGAGCGCGAAGAGCGCTGCGACCGCCTGC
CCGGCAACTACGAAGCGGTTGCCGCCTACGTCGCCGAGCGCGCGACTCCGAAGCATGGCTGA

Upstream 100 bases:

>100_bases
GCTGAAACAAGTTCAGCATGACGAGGTTTGTGGCATCGAGGATCCGCCTCGGTCCAGAATCCTTGCCCTTTGCCCGCATG
GCCGCTAACCGCGCAAACCC

Downstream 100 bases:

>100_bases
ACTGGACCTCCAGCCCAAGCTGATGGTCGGCCAGGGCTGGGCGGACTTCGCCCTGCTCGATTCCGGCCAGGGCCGAAAGC
TGGAGCAATATGGCCCGCAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKYVSTRGQAPSLDFQGVTLAGLASDGGLYVPESWPQFSHDEIAAMAGLPYARLAQKIMQPYVGDCLTPERLLELCEQAY
GRFAHAAVTPLKQLDETQWVLELFHGPTLAFKDVALQLLGLLFEEFLARPREDGGDEHITIVGATSGDTGSAAIDAVAGR
AKVDIFMLHPHGRVSDVQRRQMTTVIAPNVHNIAIDGSFDDAQAMVKRMFNDSAMTGRFGIAAVNSINWARLMAQVVYYF
YAALQLGAPHRKVAFSVPTGNFGDVFAGYVAAKMGLPIERLIVATNVNDILHRALSAGDYSASTVTPTAAPSMDIQVSSN
FERLLFDGCGRDASALAAQMKHFEVTKAMQLTNAQRESAAALFSSARADAGDMANAMRWAFEATGEVLDPHTAIGLHAAR
AAEGIPAGVPIVTLATAHPAKFVDAVERATGVRPGLPARVGDLFEREERCDRLPGNYEAVAAYVAERATPKHG

Sequences:

>Translated_473_residues
MKYVSTRGQAPSLDFQGVTLAGLASDGGLYVPESWPQFSHDEIAAMAGLPYARLAQKIMQPYVGDCLTPERLLELCEQAY
GRFAHAAVTPLKQLDETQWVLELFHGPTLAFKDVALQLLGLLFEEFLARPREDGGDEHITIVGATSGDTGSAAIDAVAGR
AKVDIFMLHPHGRVSDVQRRQMTTVIAPNVHNIAIDGSFDDAQAMVKRMFNDSAMTGRFGIAAVNSINWARLMAQVVYYF
YAALQLGAPHRKVAFSVPTGNFGDVFAGYVAAKMGLPIERLIVATNVNDILHRALSAGDYSASTVTPTAAPSMDIQVSSN
FERLLFDGCGRDASALAAQMKHFEVTKAMQLTNAQRESAAALFSSARADAGDMANAMRWAFEATGEVLDPHTAIGLHAAR
AAEGIPAGVPIVTLATAHPAKFVDAVERATGVRPGLPARVGDLFEREERCDRLPGNYEAVAAYVAERATPKHG
>Mature_473_residues
MKYVSTRGQAPSLDFQGVTLAGLASDGGLYVPESWPQFSHDEIAAMAGLPYARLAQKIMQPYVGDCLTPERLLELCEQAY
GRFAHAAVTPLKQLDETQWVLELFHGPTLAFKDVALQLLGLLFEEFLARPREDGGDEHITIVGATSGDTGSAAIDAVAGR
AKVDIFMLHPHGRVSDVQRRQMTTVIAPNVHNIAIDGSFDDAQAMVKRMFNDSAMTGRFGIAAVNSINWARLMAQVVYYF
YAALQLGAPHRKVAFSVPTGNFGDVFAGYVAAKMGLPIERLIVATNVNDILHRALSAGDYSASTVTPTAAPSMDIQVSSN
FERLLFDGCGRDASALAAQMKHFEVTKAMQLTNAQRESAAALFSSARADAGDMANAMRWAFEATGEVLDPHTAIGLHAAR
AAEGIPAGVPIVTLATAHPAKFVDAVERATGVRPGLPARVGDLFEREERCDRLPGNYEAVAAYVAERATPKHG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=459, Percent_Identity=37.4727668845316, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI153792148, Length=467, Percent_Identity=32.5481798715203, Blast_Score=225, Evalue=6e-59,
Organism=Escherichia coli, GI1786185, Length=461, Percent_Identity=32.7548806941432, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319901, Length=455, Percent_Identity=42.1978021978022, Blast_Score=337, Evalue=2e-93,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50800; Mature: 50800

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVSTRGQAPSLDFQGVTLAGLASDGGLYVPESWPQFSHDEIAAMAGLPYARLAQKIMQ
CCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
PYVGDCLTPERLLELCEQAYGRFAHAAVTPLKQLDETQWVLELFHGPTLAFKDVALQLLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LLFEEFLARPREDGGDEHITIVGATSGDTGSAAIDAVAGRAKVDIFMLHPHGRVSDVQRR
HHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHHH
QMTTVIAPNVHNIAIDGSFDDAQAMVKRMFNDSAMTGRFGIAAVNSINWARLMAQVVYYF
HHHHEECCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
YAALQLGAPHRKVAFSVPTGNFGDVFAGYVAAKMGLPIERLIVATNVNDILHRALSAGDY
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHCCCC
SASTVTPTAAPSMDIQVSSNFERLLFDGCGRDASALAAQMKHFEVTKAMQLTNAQRESAA
CCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFSSARADAGDMANAMRWAFEATGEVLDPHTAIGLHAARAAEGIPAGVPIVTLATAHPA
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHH
KFVDAVERATGVRPGLPARVGDLFEREERCDRLPGNYEAVAAYVAERATPKHG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKYVSTRGQAPSLDFQGVTLAGLASDGGLYVPESWPQFSHDEIAAMAGLPYARLAQKIMQ
CCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
PYVGDCLTPERLLELCEQAYGRFAHAAVTPLKQLDETQWVLELFHGPTLAFKDVALQLLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LLFEEFLARPREDGGDEHITIVGATSGDTGSAAIDAVAGRAKVDIFMLHPHGRVSDVQRR
HHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHHH
QMTTVIAPNVHNIAIDGSFDDAQAMVKRMFNDSAMTGRFGIAAVNSINWARLMAQVVYYF
HHHHEECCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
YAALQLGAPHRKVAFSVPTGNFGDVFAGYVAAKMGLPIERLIVATNVNDILHRALSAGDY
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHCCCC
SASTVTPTAAPSMDIQVSSNFERLLFDGCGRDASALAAQMKHFEVTKAMQLTNAQRESAA
CCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFSSARADAGDMANAMRWAFEATGEVLDPHTAIGLHAARAAEGIPAGVPIVTLATAHPA
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHH
KFVDAVERATGVRPGLPARVGDLFEREERCDRLPGNYEAVAAYVAERATPKHG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]