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The map label for this gene is ctaB

Identifier: 87198937

GI number: 87198937

Start: 969351

End: 970265

Strand: Direct

Name: ctaB

Synonym: Saro_0915

Alternate gene names: 87198937

Gene position: 969351-970265 (Clockwise)

Preceding gene: 87198936

Following gene: 87198938

Centisome position: 27.22

GC content: 66.23

Gene sequence:

>915_bases
ATGGATTCTGCCAAGCCCCTTGCCCTTCCCGCCGACTGGCGCGATTTCTTTGCGCTGACCAAGCCGCGCGTGATGACGCT
GGTGATCTTCACCGGCCTGTGCGGGCTTCTGGCGGCGCCGGGCACCATTCATCCGGTGATCGCCTTCACCGCCATCCTGT
GCATCGCGGTGGGGGCAGGCGGCGCGGCCGCGCTCAACCAGTGGTGGGAAGCCGACATCGACGCCGGGATGAAGCGCACG
GCGCAGCGGCCGCTGCCCGCGGGCCGGATGGACCGCACATCCGCGCGCGACTTCGGCTTTGCGCTTGCGGGCGGCTCGGT
CTTCGTGATGGGCCTTGGGGTGGGCTGGCTCGCGGCGGTGATCCTGGCCTTCTCGATCTTCTATTATAGCTGGATCTATA
CTGTCTGGCTGAAGCCCCGCACGCCGCAGAACATCGTGATCGGCGGCGGCGCGGGTGCGTTCCCGCCGATGATCGGGTGG
GTGGCCGTGACCGGCGACATCACGCTGATGCCGGTACTGCTGTTCCTGATCATCTTCATGTGGACGCCGCCGCACTTCTG
GGCACTCGCCCTGTTCGTGCAGACCGACTACGCCAAGGTGGGCATTCCGATGATGCCGGTCGTCGCGGGCGAGCGGTCGA
CGCGCAAGCAGATCCTCGCCTACTCGATCCTGCTTCTGCCGCTGACGCTGGTTCCCTGGTGGATCGGCGGGGCAGGCGCG
GTCTATGGCTGGTCGGCGCTCGTGCTGGGCCTGGTCTTCGTCGCCCTTTCGGTGAAGGTCGGGCTGCGGCGCTCGGTACC
GAACGACGGCATGCTGCCGGAAAAGCGGCTGTTCGGCTATTCGGTGCTTTATCTCTTCGTTCTCTTCGGCATGCTGGTGG
GGGACCGGCTCGCCACTGTACAAGGCTGGCAGTAA

Upstream 100 bases:

>100_bases
CGCTCTTCCGGTGAAACCGTTGCCGGGAATCCTGCACTGCAACACCTCGTCCCCTTTCGCTTCCATCCCGGTTCAAGCGC
GCGTATAGGCGCGGCCAGTC

Downstream 100 bases:

>100_bases
AATGACGGAACCCCAGAACCACGAGAACATGACCGCCGAGCAGACCGACCTGTACCGCGCCCGCCAGCGCGGGCGGAACA
AGGTGCTGGGCATCGTGCTG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDSAKPLALPADWRDFFALTKPRVMTLVIFTGLCGLLAAPGTIHPVIAFTAILCIAVGAGGAAALNQWWEADIDAGMKRT
AQRPLPAGRMDRTSARDFGFALAGGSVFVMGLGVGWLAAVILAFSIFYYSWIYTVWLKPRTPQNIVIGGGAGAFPPMIGW
VAVTGDITLMPVLLFLIIFMWTPPHFWALALFVQTDYAKVGIPMMPVVAGERSTRKQILAYSILLLPLTLVPWWIGGAGA
VYGWSALVLGLVFVALSVKVGLRRSVPNDGMLPEKRLFGYSVLYLFVLFGMLVGDRLATVQGWQ

Sequences:

>Translated_304_residues
MDSAKPLALPADWRDFFALTKPRVMTLVIFTGLCGLLAAPGTIHPVIAFTAILCIAVGAGGAAALNQWWEADIDAGMKRT
AQRPLPAGRMDRTSARDFGFALAGGSVFVMGLGVGWLAAVILAFSIFYYSWIYTVWLKPRTPQNIVIGGGAGAFPPMIGW
VAVTGDITLMPVLLFLIIFMWTPPHFWALALFVQTDYAKVGIPMMPVVAGERSTRKQILAYSILLLPLTLVPWWIGGAGA
VYGWSALVLGLVFVALSVKVGLRRSVPNDGMLPEKRLFGYSVLYLFVLFGMLVGDRLATVQGWQ
>Mature_304_residues
MDSAKPLALPADWRDFFALTKPRVMTLVIFTGLCGLLAAPGTIHPVIAFTAILCIAVGAGGAAALNQWWEADIDAGMKRT
AQRPLPAGRMDRTSARDFGFALAGGSVFVMGLGVGWLAAVILAFSIFYYSWIYTVWLKPRTPQNIVIGGGAGAFPPMIGW
VAVTGDITLMPVLLFLIIFMWTPPHFWALALFVQTDYAKVGIPMMPVVAGERSTRKQILAYSILLLPLTLVPWWIGGAGA
VYGWSALVLGLVFVALSVKVGLRRSVPNDGMLPEKRLFGYSVLYLFVLFGMLVGDRLATVQGWQ

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=191, Percent_Identity=34.0314136125654, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786631, Length=290, Percent_Identity=28.2758620689655, Blast_Score=95, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71998235, Length=224, Percent_Identity=32.5892857142857, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=221, Percent_Identity=30.316742081448, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921064, Length=293, Percent_Identity=25.938566552901, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_NOVAD (Q2G9W3)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496194.1
- STRING:   Q2G9W3
- GeneID:   3918001
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0915
- NMPDR:   fig|48935.1.peg.918
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEGW
- PhylomeDB:   Q2G9W3
- ProtClustDB:   PRK04375
- BioCyc:   NARO279238:SARO_0915-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32951; Mature: 32951

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14c627c8)-; HASH(0x142cca6c)-; HASH(0x14d63e9c)-; HASH(0x1457798c)-; HASH(0x13af2154)-; HASH(0x145a5eec)-; HASH(0x14954620)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSAKPLALPADWRDFFALTKPRVMTLVIFTGLCGLLAAPGTIHPVIAFTAILCIAVGAG
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
GAAALNQWWEADIDAGMKRTAQRPLPAGRMDRTSARDFGFALAGGSVFVMGLGVGWLAAV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCEEEECCCEEEEHHHHHHHHHH
ILAFSIFYYSWIYTVWLKPRTPQNIVIGGGAGAFPPMIGWVAVTGDITLMPVLLFLIIFM
HHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCHHHHHEEEECCHHHHHHHHHHHHHH
WTPPHFWALALFVQTDYAKVGIPMMPVVAGERSTRKQILAYSILLLPLTLVPWWIGGAGA
CCCHHHHHHHHHHHCCHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VYGWSALVLGLVFVALSVKVGLRRSVPNDGMLPEKRLFGYSVLYLFVLFGMLVGDRLATV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHC
QGWQ
CCCH
>Mature Secondary Structure
MDSAKPLALPADWRDFFALTKPRVMTLVIFTGLCGLLAAPGTIHPVIAFTAILCIAVGAG
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
GAAALNQWWEADIDAGMKRTAQRPLPAGRMDRTSARDFGFALAGGSVFVMGLGVGWLAAV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCEEEECCCEEEEHHHHHHHHHH
ILAFSIFYYSWIYTVWLKPRTPQNIVIGGGAGAFPPMIGWVAVTGDITLMPVLLFLIIFM
HHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCHHHHHEEEECCHHHHHHHHHHHHHH
WTPPHFWALALFVQTDYAKVGIPMMPVVAGERSTRKQILAYSILLLPLTLVPWWIGGAGA
CCCHHHHHHHHHHHCCHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VYGWSALVLGLVFVALSVKVGLRRSVPNDGMLPEKRLFGYSVLYLFVLFGMLVGDRLATV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHC
QGWQ
CCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA