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The map label for this gene is mro [H]

Identifier: 87198841

GI number: 87198841

Start: 873669

End: 874724

Strand: Direct

Name: mro [H]

Synonym: Saro_0819

Alternate gene names: 87198841

Gene position: 873669-874724 (Clockwise)

Preceding gene: 87198839

Following gene: 87198844

Centisome position: 24.53

GC content: 66.1

Gene sequence:

>1056_bases
ATGACGCGATCGGAGACCGGTTTGATTGTGGATGGCGCGCCGGTGGAATCGGTCGTCCTCGAGGCACCTTGCGGCGTTCG
GGTGGAATTGCTGAGCCTTGGCGCCACGTTGCAGCGCTTTTTCACGGCCGATACCGAGGGGCGGCTGGCAGACATCGTGC
TGGGGCACGACGACGTGCGGGCATACCTTGAGGATCGCGGGTTCCTTGGCGTTACGATTGGACGATATGCCAATCGCATC
GGTGGGGCGCGGTTTTCGCTCGACGGGGTGGAGCATCGCCTTGTCGCCAACAATGGCGCGAACACGCTGCACGGGGGCGA
GCGGGGATGGGACCAGCGCAACTGGCGCATCGTCGAAGCTTCGGGCGATGCGGTGACCTTTGCGCTGCACAGCCCGGACG
GGGACGAGGGCTTCCCGGGCGCGGTCGATGCGACGACCCGCTATCGCCTCGCCGAAGACGGTACGCTGGAGATCGCGTTC
GAGGCGCGGACGGACAGACCGACGGTCGTGGCGATGACCAACCATGCGTTGTTTCATCTCGGCGGGGGGCAAGCGAGCGG
CGCTGCGGTGGATCACGAGCTGACCATTCCGGCCAGCCGCTATGCCAGGGTCGACGCGCAGCAGATCCCGCTTCCCGGTC
TCGCCCCCGTCGAAGGCACGGTTTTCGACTTCCGTCAGGCCCGGCGCATTTCAGATGGACTGCGCGACGGTCGCGAAGAA
CAGATCCGCATCGGTCGGGGCTATGACCACAATTTTGCCATCGATGACGCGGCTGCCGAAGGGCCGCGGCTGGTGGCGCG
GCTTTCAGATCCGATTTCCGGCAGGGTTCTCGAGGTGCTGTCCACCGAGCCGGGCGTGCAGCTCTACACCGGCAACTTCC
TGCACGGCGACAGGCCGGGGAAGGGCGCAAGGCTGTATCGCATGGGCGATGGCGTGGCGCTGGAGCCGCAGAAGTTCCCC
GACACGCCCAACCGGCCCGACTTCCCTTCGGCAAGGCTCGATCCCGGCGAGGTCTATCGCCACGTCATGGTCTATCGGCC
CTCGCCGACAGGCTGA

Upstream 100 bases:

>100_bases
CAGATTGACCTTAATCGCCCGGTTAGGGAAGGGGCGATTGCCTTGGGGCGGAATTGGGAATAGCCCGCCCGCCGCACAGC
GAGCTGAAGGCGGGATGCAG

Downstream 100 bases:

>100_bases
AGCTTCAGGTAAAGAAGCGCGAGAGGAAGCTGCGGCGGCGGGGCATGCTGTCTTCCTGCCCGGTGAGCTGGAGCAGGTAG
TTCGCCAGCAGGAATGCCTG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTRSETGLIVDGAPVESVVLEAPCGVRVELLSLGATLQRFFTADTEGRLADIVLGHDDVRAYLEDRGFLGVTIGRYANRI
GGARFSLDGVEHRLVANNGANTLHGGERGWDQRNWRIVEASGDAVTFALHSPDGDEGFPGAVDATTRYRLAEDGTLEIAF
EARTDRPTVVAMTNHALFHLGGGQASGAAVDHELTIPASRYARVDAQQIPLPGLAPVEGTVFDFRQARRISDGLRDGREE
QIRIGRGYDHNFAIDDAAAEGPRLVARLSDPISGRVLEVLSTEPGVQLYTGNFLHGDRPGKGARLYRMGDGVALEPQKFP
DTPNRPDFPSARLDPGEVYRHVMVYRPSPTG

Sequences:

>Translated_351_residues
MTRSETGLIVDGAPVESVVLEAPCGVRVELLSLGATLQRFFTADTEGRLADIVLGHDDVRAYLEDRGFLGVTIGRYANRI
GGARFSLDGVEHRLVANNGANTLHGGERGWDQRNWRIVEASGDAVTFALHSPDGDEGFPGAVDATTRYRLAEDGTLEIAF
EARTDRPTVVAMTNHALFHLGGGQASGAAVDHELTIPASRYARVDAQQIPLPGLAPVEGTVFDFRQARRISDGLRDGREE
QIRIGRGYDHNFAIDDAAAEGPRLVARLSDPISGRVLEVLSTEPGVQLYTGNFLHGDRPGKGARLYRMGDGVALEPQKFP
DTPNRPDFPSARLDPGEVYRHVMVYRPSPTG
>Mature_350_residues
TRSETGLIVDGAPVESVVLEAPCGVRVELLSLGATLQRFFTADTEGRLADIVLGHDDVRAYLEDRGFLGVTIGRYANRIG
GARFSLDGVEHRLVANNGANTLHGGERGWDQRNWRIVEASGDAVTFALHSPDGDEGFPGAVDATTRYRLAEDGTLEIAFE
ARTDRPTVVAMTNHALFHLGGGQASGAAVDHELTIPASRYARVDAQQIPLPGLAPVEGTVFDFRQARRISDGLRDGREEQ
IRIGRGYDHNFAIDDAAAEGPRLVARLSDPISGRVLEVLSTEPGVQLYTGNFLHGDRPGKGARLYRMGDGVALEPQKFPD
TPNRPDFPSARLDPGEVYRHVMVYRPSPTG

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=339, Percent_Identity=39.8230088495575, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1786971, Length=349, Percent_Identity=38.9684813753582, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17557428, Length=322, Percent_Identity=31.3664596273292, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI115533334, Length=322, Percent_Identity=31.3664596273292, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319493, Length=316, Percent_Identity=28.1645569620253, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=335, Percent_Identity=27.7611940298507, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322004, Length=360, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24659048, Length=341, Percent_Identity=37.5366568914956, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24668278, Length=335, Percent_Identity=34.6268656716418, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24583720, Length=335, Percent_Identity=34.9253731343284, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24668282, Length=331, Percent_Identity=37.1601208459215, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24641876, Length=334, Percent_Identity=33.5329341317365, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38032; Mature: 37901

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSETGLIVDGAPVESVVLEAPCGVRVELLSLGATLQRFFTADTEGRLADIVLGHDDVR
CCCCCCEEEEECCCCCCEEEECCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEEECCHHHH
AYLEDRGFLGVTIGRYANRIGGARFSLDGVEHRLVANNGANTLHGGERGWDQRNWRIVEA
HHHHCCCEEEEEHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEE
SGDAVTFALHSPDGDEGFPGAVDATTRYRLAEDGTLEIAFEARTDRPTVVAMTNHALFHL
CCCEEEEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEEEECCCCCEEEEEECCEEEEE
GGGQASGAAVDHELTIPASRYARVDAQQIPLPGLAPVEGTVFDFRQARRISDGLRDGREE
CCCCCCCCEECEEEECCHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
QIRIGRGYDHNFAIDDAAAEGPRLVARLSDPISGRVLEVLSTEPGVQLYTGNFLHGDRPG
EEEEECCCCCCEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEECCEECCCCCC
KGARLYRMGDGVALEPQKFPDTPNRPDFPSARLDPGEVYRHVMVYRPSPTG
CCEEEEEECCCEEECCHHCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCC
>Mature Secondary Structure 
TRSETGLIVDGAPVESVVLEAPCGVRVELLSLGATLQRFFTADTEGRLADIVLGHDDVR
CCCCCEEEEECCCCCCEEEECCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEEECCHHHH
AYLEDRGFLGVTIGRYANRIGGARFSLDGVEHRLVANNGANTLHGGERGWDQRNWRIVEA
HHHHCCCEEEEEHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEE
SGDAVTFALHSPDGDEGFPGAVDATTRYRLAEDGTLEIAFEARTDRPTVVAMTNHALFHL
CCCEEEEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEEEECCCCCEEEEEECCEEEEE
GGGQASGAAVDHELTIPASRYARVDAQQIPLPGLAPVEGTVFDFRQARRISDGLRDGREE
CCCCCCCCEECEEEECCHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
QIRIGRGYDHNFAIDDAAAEGPRLVARLSDPISGRVLEVLSTEPGVQLYTGNFLHGDRPG
EEEEECCCCCCEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEECCEECCCCCC
KGARLYRMGDGVALEPQKFPDTPNRPDFPSARLDPGEVYRHVMVYRPSPTG
CCEEEEEECCCEEECCHHCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]