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The map label for this gene is bhbA [H]

Identifier: 87198833

GI number: 87198833

Start: 862984

End: 865128

Strand: Direct

Name: bhbA [H]

Synonym: Saro_0811

Alternate gene names: 87198833

Gene position: 862984-865128 (Clockwise)

Preceding gene: 87198832

Following gene: 87198834

Centisome position: 24.23

GC content: 65.78

Gene sequence:

>2145_bases
ATGAGCGAGAAGACACTGGCAGATTGGCAGGCCGCCGCCGCCAAGGAAGTGAAGGGAAAGGACCTGACCTGGCAGACGCC
CGAGGGCATCGCCGTCAAGCCGCTCTACACCGCCGACGACGTCACCGCCGATCCGGGGCTGCCCGGCTTCGCGCCGTTCA
CGCGCGGCGTTCGGGCCTCGATGTATGCGGGGCGGCCATGGACGATCCGCCAGTACGCCGGCTTTTCGACCGCCGAGGAA
TCCAACGCATTCTATCGCCGCAACCTTGCCGCCGGGCAGAAGGGCCTGTCGGTCGCGTTCGACCTTGCGACGCACCGCGG
CTATGACTCCGACCACCCGCGCGTCGTGGGCGATGTCGGCAAGGCGGGCGTGGCCATCGACAGCGTCGAGGACATGAAGA
TCCTGTTCGACGGCATCCCGCTCGACCAGATGTCGGTCTCGATGACCATGAACGGCGCGGTGATCCCGATCCTGGCGTTC
TTCATCGTCGCGGGCGAGGAGCAGGGCGTCGACCGCAAGCTGCTCGACGGGACCATCCAGAACGACATCCTCAAGGAGTT
CATGGTCCGCAACACCTACATCTACCCGCCCGAGCCGAGCATGCGGATCATCTCGGACATCTTCGGCTACACCAGCCGCG
AGATGCCGAAGTTCAACTCGATCTCGATTTCCGGCTATCACATGCAGGAAGCCGGGGCGACGCAGGTGCAGGAACTCGCG
TTCACCATCGCCGACGGCATGGAGTACGTGAAGTACGGCGTGGCCTCGGGCCTCGACATCGACAAGTTTGCCGGCCGCCT
GTCGTTCTTCTTCGCCATCGGCATGAACTTCTTCATGGAAGTGGCCAAGCTGCGCGCCGCGCGCGTGCTGTGGCACCGCG
TGATGACGAAGCTGGGCGCGCAGGACGAGCGTTCGAAGATGCTGCGCACGCACTGCCAGACCTCGGGCGTGAGCCTGCAG
GAGCAGGACCCCTACAACAACGTCATCCGCACCACGATCGAGGCGATGGCCGCAATGCTGGGCGGCACCCAGTCGCTCCA
CACCAACGCGCTCGACGAAGCCATTGCGCTGCCCACCGACTTTTCCGCCCGTATTGCGCGCAACACGCAGATCGTGATCC
AGGAAGAGACGGGCATGTGCAACGTGGTCGATCCGCTCGGCGGGTCGTACTACATCGAGGCGCTGACGCAGGAACTGGTC
GACAAGGCCTGGGAGATCATCGAGCGTGTCGAAGCTGAAGGCGGCATGGCCAAGGCCGTGGCGGCGGGCTGGCCCAAGGC
GATGATCGAGGAAGCCGCCGCTGGCCGGCAGGCCCGCGTCGACAGGGGCGAGGACGTGATCGTCGGCGTCAACAAGTACC
GGCTTGCCAGCGAGGACAAGCTCGAAACGCTTGAAGTGGACAACCACGTTGTCCGCGAGGCGCAGATCGCCCGGATCAAG
CGCGTGCGCGAAACCCGCGACGAGACCAAGTGCCGCGCAGCGCTCAATGCCCTTACCGAAGGTGCAAAGACCGGCGGCAA
CCTGCTTGAGCTAGCTGTCGAAGCCGCTCGCCACCGTGCGACGCTGGGCGAGATTTCCGACGCGATGGAAGTCGTGTTCG
GCCGCCACGGTACGTTCCCGACGCCGGTGAAGGGCGTCTACGGTTCGGCATATGCCGGAGACAGCCGCTACCAGCAGGTT
CTCGATGGCGTCGAGGCCGTGACGCGCCGCCTCGGCCGCAAGCCCCGCATGCTCGTCGCCAAGATGGGGCAGGACGGGCA
CGATCGCGGTGCCAACGTGATCGCGTCGGCCTTTGGCGACATGGGCTTCGAGGTGACTAGCGGCCCGCTGTTCCAGACTC
CCGAGGAGGCCGCTGCGCTGGCGCTGGAGAAGGACGTCGACGCCGTCGGAGCATCCTCGCTTGCCGCCGGTCACAAGACG
CTGATCCCCGAACTGATCGGCCATCTCAAGGCGGCCGGCCGCCCCGACATCAAGGTCGTGGCGGGCGGGGTGATCCCGCC
GCAGGACTACGACTTCCTGCGCGAAGCCGGGGTGCAGGGGATCTACGGCCCGGGCTCGAACGTGGTCGAATGCGCCGCCG
ACATGCTGCGCCTGCTTGGCCACAACATGCCGCCCGCAGGGGAGGAGCTCGAAAATGCCCAATAA

Upstream 100 bases:

>100_bases
ACCCTGAACGTGTTTCAGGGTCCATCGTGCGACCGGCACGGCGGTTCGAATGGCGAAATGGATGCTGAAACAAGTTCAGC
ATGACGTGTGAGATGGCAAG

Downstream 100 bases:

>100_bases
AGCAGATGTTTTGCGTCAAATCGCAGAATGCGACCAGCTCGGGGTACCCGCGTTCCTTGCAAAATACGCTAATGGACGTG
GCTCTCGAACAACTTGGATT

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MSEKTLADWQAAAAKEVKGKDLTWQTPEGIAVKPLYTADDVTADPGLPGFAPFTRGVRASMYAGRPWTIRQYAGFSTAEE
SNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDGIPLDQMSVSMTMNGAVIPILAF
FIVAGEEQGVDRKLLDGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQELA
FTIADGMEYVKYGVASGLDIDKFAGRLSFFFAIGMNFFMEVAKLRAARVLWHRVMTKLGAQDERSKMLRTHCQTSGVSLQ
EQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTDFSARIARNTQIVIQEETGMCNVVDPLGGSYYIEALTQELV
DKAWEIIERVEAEGGMAKAVAAGWPKAMIEEAAAGRQARVDRGEDVIVGVNKYRLASEDKLETLEVDNHVVREAQIARIK
RVRETRDETKCRAALNALTEGAKTGGNLLELAVEAARHRATLGEISDAMEVVFGRHGTFPTPVKGVYGSAYAGDSRYQQV
LDGVEAVTRRLGRKPRMLVAKMGQDGHDRGANVIASAFGDMGFEVTSGPLFQTPEEAAALALEKDVDAVGASSLAAGHKT
LIPELIGHLKAAGRPDIKVVAGGVIPPQDYDFLREAGVQGIYGPGSNVVECAADMLRLLGHNMPPAGEELENAQ

Sequences:

>Translated_714_residues
MSEKTLADWQAAAAKEVKGKDLTWQTPEGIAVKPLYTADDVTADPGLPGFAPFTRGVRASMYAGRPWTIRQYAGFSTAEE
SNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDGIPLDQMSVSMTMNGAVIPILAF
FIVAGEEQGVDRKLLDGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQELA
FTIADGMEYVKYGVASGLDIDKFAGRLSFFFAIGMNFFMEVAKLRAARVLWHRVMTKLGAQDERSKMLRTHCQTSGVSLQ
EQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTDFSARIARNTQIVIQEETGMCNVVDPLGGSYYIEALTQELV
DKAWEIIERVEAEGGMAKAVAAGWPKAMIEEAAAGRQARVDRGEDVIVGVNKYRLASEDKLETLEVDNHVVREAQIARIK
RVRETRDETKCRAALNALTEGAKTGGNLLELAVEAARHRATLGEISDAMEVVFGRHGTFPTPVKGVYGSAYAGDSRYQQV
LDGVEAVTRRLGRKPRMLVAKMGQDGHDRGANVIASAFGDMGFEVTSGPLFQTPEEAAALALEKDVDAVGASSLAAGHKT
LIPELIGHLKAAGRPDIKVVAGGVIPPQDYDFLREAGVQGIYGPGSNVVECAADMLRLLGHNMPPAGEELENAQ
>Mature_713_residues
SEKTLADWQAAAAKEVKGKDLTWQTPEGIAVKPLYTADDVTADPGLPGFAPFTRGVRASMYAGRPWTIRQYAGFSTAEES
NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDGIPLDQMSVSMTMNGAVIPILAFF
IVAGEEQGVDRKLLDGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQELAF
TIADGMEYVKYGVASGLDIDKFAGRLSFFFAIGMNFFMEVAKLRAARVLWHRVMTKLGAQDERSKMLRTHCQTSGVSLQE
QDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTDFSARIARNTQIVIQEETGMCNVVDPLGGSYYIEALTQELVD
KAWEIIERVEAEGGMAKAVAAGWPKAMIEEAAAGRQARVDRGEDVIVGVNKYRLASEDKLETLEVDNHVVREAQIARIKR
VRETRDETKCRAALNALTEGAKTGGNLLELAVEAARHRATLGEISDAMEVVFGRHGTFPTPVKGVYGSAYAGDSRYQQVL
DGVEAVTRRLGRKPRMLVAKMGQDGHDRGANVIASAFGDMGFEVTSGPLFQTPEEAAALALEKDVDAVGASSLAAGHKTL
IPELIGHLKAAGRPDIKVVAGGVIPPQDYDFLREAGVQGIYGPGSNVVECAADMLRLLGHNMPPAGEELENAQ

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=695, Percent_Identity=62.158273381295, Blast_Score=887, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=707, Percent_Identity=64.0735502121641, Blast_Score=898, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=706, Percent_Identity=64.8725212464589, Blast_Score=934, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77435; Mature: 77304

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTLADWQAAAAKEVKGKDLTWQTPEGIAVKPLYTADDVTADPGLPGFAPFTRGVRAS
CCCCCHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCHHH
MYAGRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVG
HCCCCCEEEHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEEEECCC
KAGVAIDSVEDMKILFDGIPLDQMSVSMTMNGAVIPILAFFIVAGEEQGVDRKLLDGTIQ
CCCEEECCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
NDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQELA
HHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECEEECCCCHHHHHHHH
FTIADGMEYVKYGVASGLDIDKFAGRLSFFFAIGMNFFMEVAKLRAARVLWHRVMTKLGA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDERSKMLRTHCQTSGVSLQEQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTD
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
FSARIARNTQIVIQEETGMCNVVDPLGGSYYIEALTQELVDKAWEIIERVEAEGGMAKAV
CHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAGWPKAMIEEAAAGRQARVDRGEDVIVGVNKYRLASEDKLETLEVDNHVVREAQIARIK
HHCCHHHHHHHHHCCCHHCCCCCCEEEEECCHHCCCCCCCCCEEECCHHHHHHHHHHHHH
RVRETRDETKCRAALNALTEGAKTGGNLLELAVEAARHRATLGEISDAMEVVFGRHGTFP
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPVKGVYGSAYAGDSRYQQVLDGVEAVTRRLGRKPRMLVAKMGQDGHDRGANVIASAFGD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHC
MGFEVTSGPLFQTPEEAAALALEKDVDAVGASSLAAGHKTLIPELIGHLKAAGRPDIKVV
CCCEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEE
AGGVIPPQDYDFLREAGVQGIYGPGSNVVECAADMLRLLGHNMPPAGEELENAQ
ECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEKTLADWQAAAAKEVKGKDLTWQTPEGIAVKPLYTADDVTADPGLPGFAPFTRGVRAS
CCCCHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCHHH
MYAGRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVG
HCCCCCEEEHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEEEECCC
KAGVAIDSVEDMKILFDGIPLDQMSVSMTMNGAVIPILAFFIVAGEEQGVDRKLLDGTIQ
CCCEEECCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
NDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQELA
HHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECEEECCCCHHHHHHHH
FTIADGMEYVKYGVASGLDIDKFAGRLSFFFAIGMNFFMEVAKLRAARVLWHRVMTKLGA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDERSKMLRTHCQTSGVSLQEQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTD
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
FSARIARNTQIVIQEETGMCNVVDPLGGSYYIEALTQELVDKAWEIIERVEAEGGMAKAV
CHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAGWPKAMIEEAAAGRQARVDRGEDVIVGVNKYRLASEDKLETLEVDNHVVREAQIARIK
HHCCHHHHHHHHHCCCHHCCCCCCEEEEECCHHCCCCCCCCCEEECCHHHHHHHHHHHHH
RVRETRDETKCRAALNALTEGAKTGGNLLELAVEAARHRATLGEISDAMEVVFGRHGTFP
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPVKGVYGSAYAGDSRYQQVLDGVEAVTRRLGRKPRMLVAKMGQDGHDRGANVIASAFGD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHC
MGFEVTSGPLFQTPEEAAALALEKDVDAVGASSLAAGHKTLIPELIGHLKAAGRPDIKVV
CCCEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEE
AGGVIPPQDYDFLREAGVQGIYGPGSNVVECAADMLRLLGHNMPPAGEELENAQ
ECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]