Click here to switch to the map view.

The map label for this gene is hisC

Identifier: 87198719

GI number: 87198719

Start: 734586

End: 735704

Strand: Direct

Name: hisC

Synonym: Saro_0695

Alternate gene names: 87198719

Gene position: 734586-735704 (Clockwise)

Preceding gene: 87198718

Following gene: 87198720

Centisome position: 20.63

GC content: 65.15

Gene sequence:

>1119_bases
ATGGCAAACGCTCCGCAACTCCCGGCATCTCCTCAGCCCAAGGACTGGATCCTCGGCATTCACGCCTATGTCCCCGGCAA
GTCGACCGGCAAGGACGGGCAGGTGCTGACCAAGCTGTCGGCGAACGAAAATCCGCTCGGGACAAGCGCCGCCGCGCTCG
AAGCGCGGGCACATGCGGGCGATCCGGCGCGCTATCCTGATCCTGACAGCAAGGATCTTCGCGCCGCCATCGGCGAAGTC
CACGGCATCGATCCATCCCGGATCGTCATGGGCACCGGTTCTGACGAACTGCTCAACCTGGCCGCGCAGGCCTATGCCGG
CCCCGGCGATGAAGTGCTCTACGTGCGCTACGGCTTCTCGGTCTACGACATCGCCGCGCGCCGCTGCGGGGCAGTGCCTG
TCGTTGCGCCCGACGCCGATTACGGCACCGATGTCGATGCGCTGCTCGCCTGCGTGACCGAGCGTACGCGCGTCGTCTTC
CTTGCCAATCCGAACAACCCGACTGGAAGCTGGTTGCCCCGCGAAGAGGTTGCGCGGCTCCACGCGGGTCTGCGCTCCGA
CATCCTGCTGGTACTCGACGGTGCCTACGCCGAGTACCTTGATCCGGCGAACGATGATGGCGCCCTCGACCTGGCGGTCA
CCGCCTGCAACGTTCTGGTCACGCGCACGTTTTCAAAGATATACGGCCTTGCCGGGGAGCGTATTGGCTGGGGCACCGGC
CATCCGGCCATTGTCGATATGCTCAATCGGATTCGCGGTCCTTTCAACATCTCGCTGACCGGACAGGCTGCAGGCCTTGC
CGCTGTTCGCGATCAGGCCTTTGTTGAAGCCTCGCGCCGCCACAACGCACATCAGCGCACGCGGTTCGTCGGCAAGCTCG
AAGCCCTCGGCAATCACGGCGTCCGCCCGTTGCCCAGCCAGGCGAACTTCGTGCTGATCCTGTTCGAGGGCAAGGTGACT
GCCGAAGACGTTTACCTCGGCCTCATGGACTACGGCTACATCACCCGCTGGCTGCCGGGGCAGGGCCTGCCCCAGGCGCT
GCGCATCACCATAGGCACCGAGGCGCAGATGGACGAGATCGCCGATGCCATCCGCCGGATGTGCGAGGCTGCACGGTGA

Upstream 100 bases:

>100_bases
AGACTGAAGGCCGGAAGCGCTAGCCCGCTTCCGGCCCTTTTTTGGTGAGGCCGGTGCCATTGCCTTGCCGGGAACCCCCA
CAAACTCTAAGGCGCGGGCC

Downstream 100 bases:

>100_bases
CGGGCGCTTCGTTCGGACAGGTTACCATCGTGGGCCTGGGCCTGCTTGGCGGGTCGATCGGACATGCGGTGCAGGCTTAC
CTGCCAGGCACGACGGTAGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MANAPQLPASPQPKDWILGIHAYVPGKSTGKDGQVLTKLSANENPLGTSAAALEARAHAGDPARYPDPDSKDLRAAIGEV
HGIDPSRIVMGTGSDELLNLAAQAYAGPGDEVLYVRYGFSVYDIAARRCGAVPVVAPDADYGTDVDALLACVTERTRVVF
LANPNNPTGSWLPREEVARLHAGLRSDILLVLDGAYAEYLDPANDDGALDLAVTACNVLVTRTFSKIYGLAGERIGWGTG
HPAIVDMLNRIRGPFNISLTGQAAGLAAVRDQAFVEASRRHNAHQRTRFVGKLEALGNHGVRPLPSQANFVLILFEGKVT
AEDVYLGLMDYGYITRWLPGQGLPQALRITIGTEAQMDEIADAIRRMCEAAR

Sequences:

>Translated_372_residues
MANAPQLPASPQPKDWILGIHAYVPGKSTGKDGQVLTKLSANENPLGTSAAALEARAHAGDPARYPDPDSKDLRAAIGEV
HGIDPSRIVMGTGSDELLNLAAQAYAGPGDEVLYVRYGFSVYDIAARRCGAVPVVAPDADYGTDVDALLACVTERTRVVF
LANPNNPTGSWLPREEVARLHAGLRSDILLVLDGAYAEYLDPANDDGALDLAVTACNVLVTRTFSKIYGLAGERIGWGTG
HPAIVDMLNRIRGPFNISLTGQAAGLAAVRDQAFVEASRRHNAHQRTRFVGKLEALGNHGVRPLPSQANFVLILFEGKVT
AEDVYLGLMDYGYITRWLPGQGLPQALRITIGTEAQMDEIADAIRRMCEAAR
>Mature_371_residues
ANAPQLPASPQPKDWILGIHAYVPGKSTGKDGQVLTKLSANENPLGTSAAALEARAHAGDPARYPDPDSKDLRAAIGEVH
GIDPSRIVMGTGSDELLNLAAQAYAGPGDEVLYVRYGFSVYDIAARRCGAVPVVAPDADYGTDVDALLACVTERTRVVFL
ANPNNPTGSWLPREEVARLHAGLRSDILLVLDGAYAEYLDPANDDGALDLAVTACNVLVTRTFSKIYGLAGERIGWGTGH
PAIVDMLNRIRGPFNISLTGQAAGLAAVRDQAFVEASRRHNAHQRTRFVGKLEALGNHGVRPLPSQANFVLILFEGKVTA
EDVYLGLMDYGYITRWLPGQGLPQALRITIGTEAQMDEIADAIRRMCEAAR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=25.2100840336134, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=347, Percent_Identity=26.5129682997118, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_NOVAD (Q2GAI1)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_495976.1
- ProteinModelPortal:   Q2GAI1
- SMR:   Q2GAI1
- STRING:   Q2GAI1
- GeneID:   3918518
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0695
- NMPDR:   fig|48935.1.peg.1934
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   YDIAARR
- ProtClustDB:   PRK02731
- BioCyc:   NARO279238:SARO_0695-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39832; Mature: 39700

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAPQLPASPQPKDWILGIHAYVPGKSTGKDGQVLTKLSANENPLGTSAAALEARAHAG
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCC
DPARYPDPDSKDLRAAIGEVHGIDPSRIVMGTGSDELLNLAAQAYAGPGDEVLYVRYGFS
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCH
VYDIAARRCGAVPVVAPDADYGTDVDALLACVTERTRVVFLANPNNPTGSWLPREEVARL
HHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHH
HAGLRSDILLVLDGAYAEYLDPANDDGALDLAVTACNVLVTRTFSKIYGLAGERIGWGTG
HCCCCCCEEEEEECCHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
HPAIVDMLNRIRGPFNISLTGQAAGLAAVRDQAFVEASRRHNAHQRTRFVGKLEALGNHG
CHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
VRPLPSQANFVLILFEGKVTAEDVYLGLMDYGYITRWLPGQGLPQALRITIGTEAQMDEI
CCCCCCCCCEEEEEEECCEEHHHHEEHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHH
ADAIRRMCEAAR
HHHHHHHHHHCC
>Mature Secondary Structure 
ANAPQLPASPQPKDWILGIHAYVPGKSTGKDGQVLTKLSANENPLGTSAAALEARAHAG
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCC
DPARYPDPDSKDLRAAIGEVHGIDPSRIVMGTGSDELLNLAAQAYAGPGDEVLYVRYGFS
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCH
VYDIAARRCGAVPVVAPDADYGTDVDALLACVTERTRVVFLANPNNPTGSWLPREEVARL
HHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHH
HAGLRSDILLVLDGAYAEYLDPANDDGALDLAVTACNVLVTRTFSKIYGLAGERIGWGTG
HCCCCCCEEEEEECCHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
HPAIVDMLNRIRGPFNISLTGQAAGLAAVRDQAFVEASRRHNAHQRTRFVGKLEALGNHG
CHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
VRPLPSQANFVLILFEGKVTAEDVYLGLMDYGYITRWLPGQGLPQALRITIGTEAQMDEI
CCCCCCCCCEEEEEEECCEEHHHHEEHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHH
ADAIRRMCEAAR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA