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The map label for this gene is hbdA [H]

Identifier: 87198578

GI number: 87198578

Start: 604391

End: 605263

Strand: Direct

Name: hbdA [H]

Synonym: Saro_0554

Alternate gene names: 87198578

Gene position: 604391-605263 (Clockwise)

Preceding gene: 87198577

Following gene: 87198579

Centisome position: 16.97

GC content: 63.23

Gene sequence:

>873_bases
ATGATCAAGACGGTAGCTGTCATCGGCGCGGGCCAGATGGGTTCGGGCATTGCGCAGGTTTCGGCGCAGGCGGGCATGAA
GGTCCTGCTCGGCGACGTCTCGATCGAGCTGGCGGACAAGGCCAGGGACAAGATCGCCAAGGGTCTTTCCAAGCTGGTCG
AGAAGGGCAAGGTCGATGCCACGCTCGCCGCGTCGACGGTCGCCAACCTTCACACCTTCTCCGATCATGCCGCGCTGGCC
GAGGCCGACCTCGTCATCGAGGCCGCGACCGAGCGCGAGGACATCAAGCACAAGATCTTCGAATCGGCAGGCAGGCACTT
GGCCGCCCATGCGATCATGGCGTCGAACACGTCTTCGATCCCGATCACCCGCATGGCCGTCTCCTCGCCCGATCCGGAGC
GCTTCATCGGCATCCACTTCTTCAACCCGGTTCCGCTGATGAAGCTGGTCGAGGTGATCCCTGGTCTTGCGACGTCGGTC
CCGACGATCGAAGCGGTGCGTGATTACGTGGCGAACATCGGCAAGGAAATCGTGCTTTCGCAGGACGAGCCCGGCTTCAT
CGTCAACCGCATCTTCGTGCCGTTCATCAACGAGGCGGCCTTCGTGCTGGGCAGCGGCACCGGGTCGATCGTGGATATCG
ACAAAGGCGTCAAGCTGGGCCTCAACCATCCGATGGGCCCGCTCGAACTGGCGGACTTCATCGGGCTCGATACCCTGCTC
GAGATCATGAAGATCTACCTCGCCTCGACCGGCGACCCGAAGTACCGCCCGGCCCCGCTGCTGCAGAAGTACGTCGAGGC
GGGCTGGCTCGGCCGCAAGACCGGCCGTGGCTTTTACGATTACTCGGGCGAGGTGCCTGTTCCCACTCGTTGA

Upstream 100 bases:

>100_bases
CTATGGGTGCCCGGCGCCTCTCGCTAGGGGCAGGTGGACTTGGGTTTCCGCGCCCGCTAGGCACCCTCCCGATTCAACAT
ATCGGCGAGGGAAGTTCACC

Downstream 100 bases:

>100_bases
GGCGGATCAAGGAACGGCAGGCGTGTAGCGGCGTAGTCTCCTTACAAGGAGACACGCCGTGAACGACCCCGAACGACCCG
ATCCCGCCAGTGCCCCCGAG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MIKTVAVIGAGQMGSGIAQVSAQAGMKVLLGDVSIELADKARDKIAKGLSKLVEKGKVDATLAASTVANLHTFSDHAALA
EADLVIEAATEREDIKHKIFESAGRHLAAHAIMASNTSSIPITRMAVSSPDPERFIGIHFFNPVPLMKLVEVIPGLATSV
PTIEAVRDYVANIGKEIVLSQDEPGFIVNRIFVPFINEAAFVLGSGTGSIVDIDKGVKLGLNHPMGPLELADFIGLDTLL
EIMKIYLASTGDPKYRPAPLLQKYVEAGWLGRKTGRGFYDYSGEVPVPTR

Sequences:

>Translated_290_residues
MIKTVAVIGAGQMGSGIAQVSAQAGMKVLLGDVSIELADKARDKIAKGLSKLVEKGKVDATLAASTVANLHTFSDHAALA
EADLVIEAATEREDIKHKIFESAGRHLAAHAIMASNTSSIPITRMAVSSPDPERFIGIHFFNPVPLMKLVEVIPGLATSV
PTIEAVRDYVANIGKEIVLSQDEPGFIVNRIFVPFINEAAFVLGSGTGSIVDIDKGVKLGLNHPMGPLELADFIGLDTLL
EIMKIYLASTGDPKYRPAPLLQKYVEAGWLGRKTGRGFYDYSGEVPVPTR
>Mature_290_residues
MIKTVAVIGAGQMGSGIAQVSAQAGMKVLLGDVSIELADKARDKIAKGLSKLVEKGKVDATLAASTVANLHTFSDHAALA
EADLVIEAATEREDIKHKIFESAGRHLAAHAIMASNTSSIPITRMAVSSPDPERFIGIHFFNPVPLMKLVEVIPGLATSV
PTIEAVRDYVANIGKEIVLSQDEPGFIVNRIFVPFINEAAFVLGSGTGSIVDIDKGVKLGLNHPMGPLELADFIGLDTLL
EIMKIYLASTGDPKYRPAPLLQKYVEAGWLGRKTGRGFYDYSGEVPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=41.3194444444444, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=39.5424836601307, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI20127408, Length=289, Percent_Identity=34.2560553633218, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=31.1643835616438, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=31.1643835616438, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI115430219, Length=232, Percent_Identity=25.8620689655172, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=41.1971830985916, Blast_Score=210, Evalue=9e-56,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=35.4961832061069, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1790281, Length=285, Percent_Identity=35.0877192982456, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=43.4027777777778, Blast_Score=224, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=41.4634146341463, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=39.0243902439024, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=34.6289752650177, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=34.6289752650177, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=34.6289752650177, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=32.5088339222615, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=30.2816901408451, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=287, Percent_Identity=28.2229965156794, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=34.0350877192982, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=34.0350877192982, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=34.0350877192982, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI20129993, Length=235, Percent_Identity=26.8085106382979, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45549573, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30928; Mature: 30928

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTVAVIGAGQMGSGIAQVSAQAGMKVLLGDVSIELADKARDKIAKGLSKLVEKGKVDA
CCEEEEEEECCCCCCHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCH
TLAASTVANLHTFSDHAALAEADLVIEAATEREDIKHKIFESAGRHLAAHAIMASNTSSI
HHHHHHHHHHHHCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCHHHHHHHHEECCCCCC
PITRMAVSSPDPERFIGIHFFNPVPLMKLVEVIPGLATSVPTIEAVRDYVANIGKEIVLS
CEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCEEEEC
QDEPGFIVNRIFVPFINEAAFVLGSGTGSIVDIDKGVKLGLNHPMGPLELADFIGLDTLL
CCCCCCEEHHHHHHHHCCEEEEEECCCCCEEECCCCCEECCCCCCCHHHHHHHHCHHHHH
EIMKIYLASTGDPKYRPAPLLQKYVEAGWLGRKTGRGFYDYSGEVPVPTR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKTVAVIGAGQMGSGIAQVSAQAGMKVLLGDVSIELADKARDKIAKGLSKLVEKGKVDA
CCEEEEEEECCCCCCHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCH
TLAASTVANLHTFSDHAALAEADLVIEAATEREDIKHKIFESAGRHLAAHAIMASNTSSI
HHHHHHHHHHHHCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCHHHHHHHHEECCCCCC
PITRMAVSSPDPERFIGIHFFNPVPLMKLVEVIPGLATSVPTIEAVRDYVANIGKEIVLS
CEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCEEEEC
QDEPGFIVNRIFVPFINEAAFVLGSGTGSIVDIDKGVKLGLNHPMGPLELADFIGLDTLL
CCCCCCEEHHHHHHHHCCEEEEEECCCCCEEECCCCCEECCCCCCCHHHHHHHHCHHHHH
EIMKIYLASTGDPKYRPAPLLQKYVEAGWLGRKTGRGFYDYSGEVPVPTR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]