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The map label for this gene is pepE [H]

Identifier: 87198463

GI number: 87198463

Start: 477544

End: 479349

Strand: Direct

Name: pepE [H]

Synonym: Saro_0438

Alternate gene names: 87198463

Gene position: 477544-479349 (Clockwise)

Preceding gene: 87198460

Following gene: 87198464

Centisome position: 13.41

GC content: 68.33

Gene sequence:

>1806_bases
ATGCTTATGCACACCCACGAAGCCCGCCTCGACGCCTTGCGAAAGCAGCTGGCGAAGGACGGCCTGGACGGCTTCGTCAT
CCCGATTTCCGACGAACACATGAGCGAGTATGTCGGCGCCTACGCCCAGCGGCTGGAATGGCTGACCGGGTTCGGCGGTT
CGGCCGGGACTGCCGTCGTCCTTGCGAACGAAGCCGCGATCTTCGTCGACGGGCGCTACACCCTGCAGGTACGCGATCAG
GTCGACGGTTCGCTGTGGTCGTACCAGTCGGTGCCGCAGACCAGCGTCGCTGCCTGGCTTGGCGAACATGCGCCCAAAGG
CGCGCGCATCGGCTATGATGCGTGGCTCCATTCCAAGGGCTGGGCGCAAGCCGCGCAGAAGGCCCTTGCAGATCGCGGGG
CGACGCTCGTGCCCGTGTCCGCCAATCCGGTCGACGCGGTGTGGCAGGACCGCCCGGCGCCCTCGCTCGCACCCGCCATT
CCCCACGCGGACGAACACGCGGGCAAGTCCGCCAGCGAGAAGCGCGCCGAAGTTGCCGAATGGCTGGCCGCCAGGGGGCT
GGACGCCGCTGTCGTCACCGCGCTCGATTCGGTGGCATGGCTGCTCAACATCCGGGGCAGCGACGTGGACCGCACGCCGG
TGGCACTGTCCTTCGTACTTGCCCATGCCGATGGCACCGCCGACCTGTTCATCGCGCCGGAAAAGGTCACGCCTGCGCTC
CTCGCGCATCTCGGCAATGCCGTGCGCGTGCAGCCGCGCGAGGCTTTCGTGCCTGCGCTCAGGGCGCTCGCGGGGCGCAA
GGTCGCGGTAGATCCAGAGCGGGCGGTGGCGGCGATCTTCCATGCACTCGAAGATTCCGGCGCCGAGATCGTTGCCGAGA
CGGACCCGGTCGTCTTGCCCAAGGCCCTGAAGAATCCGGTCGAGCAGGCTGGGCACCGCGCCGCGCAGGCCCGCGATGGC
GCGGCGATCGCCCGCTTCCTGCGCTGGGTGGCCGTCGAGGCGCCGAAGGGCGGGGTGACCGAACTCTCGGCCGCCAACCG
CCTCCAGGCCTTTCGCGCGGAAGGCGGGCTGCTCAGGGACCTGTCTTTCGACACGATCTCGGGCGCGGGACCGAACGGCG
CCGTCGTTCACTACCGGGTGAGCGAGGAAACGAGCCGCGTACTCGAGCCGAACAGTGTCTACCTCGTCGATTCGGGCGGT
CAGTACGTCGATGGCACCACCGACATCACCCGCACCGTGTGGATCGGTCCGGGCGAGCCGCCTGCGCTGGTGAAGGACCG
CTTCACCCGGGTTCTCAAGGGCCACATCGCGCTTGCGCGGGCGGTGTTCCCCAAGGGCACCGCGGGCAGCCAGCTCGACA
GCTTCGCGCGCCAGTTCCTGTGGGCGGCAGGCCTCGATTATGCCCACGGCACCGGCCACGGCGTCGGCAGCTTCCTCGCC
GTCCACGAGGGGCCGCAGCGCATCGCCAAGGCATCCGGAGGCCAGGCGGGCACCGGGCAGGAACTCATGCCAGGCATGAT
CCTGTCGAATGAGCCTGGCTATTACAAAACCGGAGAATACGGCATCCGCATCGAGAATCTCGTGCTCGTGGAGCGGCGCG
AAATCGAAGGCGCGGAAGGCGAGTTCTACGGTTTCGAGACACTGACCTTTGCGCCCATAGACCGGGCTCTGGTCGACGTG
GCGCTGCTTTCGGGCGAAGAGCGCGAGTGGCTGAACGCCTATCACGCGAGCGTCCGCGCTGTCCTTGCGCCCCAGCTCGG
CGGCGAGGATCGCGAGTGGCTGGTCCGGGCCTGCGCCCCCTTGTGA

Upstream 100 bases:

>100_bases
TTCCTTGCCGCGACGGGAGGAGTGGCAAGAGTCATTCGCTGCATCTATGTTGCCCGCATGACGCCCGCAAGGCGGGCCTA
TCCCATTCAGGACACACCCC

Downstream 100 bases:

>100_bases
CGGGATATTTGTTCACCTATTGTTCCGAAATCGACTCACGCAAAGGAAATCGGACATGATCGGCTACGTCACCGTTGGGA
CGAATGACCTCGAACGCTCC

Product: peptidase M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MLMHTHEARLDALRKQLAKDGLDGFVIPISDEHMSEYVGAYAQRLEWLTGFGGSAGTAVVLANEAAIFVDGRYTLQVRDQ
VDGSLWSYQSVPQTSVAAWLGEHAPKGARIGYDAWLHSKGWAQAAQKALADRGATLVPVSANPVDAVWQDRPAPSLAPAI
PHADEHAGKSASEKRAEVAEWLAARGLDAAVVTALDSVAWLLNIRGSDVDRTPVALSFVLAHADGTADLFIAPEKVTPAL
LAHLGNAVRVQPREAFVPALRALAGRKVAVDPERAVAAIFHALEDSGAEIVAETDPVVLPKALKNPVEQAGHRAAQARDG
AAIARFLRWVAVEAPKGGVTELSAANRLQAFRAEGGLLRDLSFDTISGAGPNGAVVHYRVSEETSRVLEPNSVYLVDSGG
QYVDGTTDITRTVWIGPGEPPALVKDRFTRVLKGHIALARAVFPKGTAGSQLDSFARQFLWAAGLDYAHGTGHGVGSFLA
VHEGPQRIAKASGGQAGTGQELMPGMILSNEPGYYKTGEYGIRIENLVLVERREIEGAEGEFYGFETLTFAPIDRALVDV
ALLSGEEREWLNAYHASVRAVLAPQLGGEDREWLVRACAPL

Sequences:

>Translated_601_residues
MLMHTHEARLDALRKQLAKDGLDGFVIPISDEHMSEYVGAYAQRLEWLTGFGGSAGTAVVLANEAAIFVDGRYTLQVRDQ
VDGSLWSYQSVPQTSVAAWLGEHAPKGARIGYDAWLHSKGWAQAAQKALADRGATLVPVSANPVDAVWQDRPAPSLAPAI
PHADEHAGKSASEKRAEVAEWLAARGLDAAVVTALDSVAWLLNIRGSDVDRTPVALSFVLAHADGTADLFIAPEKVTPAL
LAHLGNAVRVQPREAFVPALRALAGRKVAVDPERAVAAIFHALEDSGAEIVAETDPVVLPKALKNPVEQAGHRAAQARDG
AAIARFLRWVAVEAPKGGVTELSAANRLQAFRAEGGLLRDLSFDTISGAGPNGAVVHYRVSEETSRVLEPNSVYLVDSGG
QYVDGTTDITRTVWIGPGEPPALVKDRFTRVLKGHIALARAVFPKGTAGSQLDSFARQFLWAAGLDYAHGTGHGVGSFLA
VHEGPQRIAKASGGQAGTGQELMPGMILSNEPGYYKTGEYGIRIENLVLVERREIEGAEGEFYGFETLTFAPIDRALVDV
ALLSGEEREWLNAYHASVRAVLAPQLGGEDREWLVRACAPL
>Mature_601_residues
MLMHTHEARLDALRKQLAKDGLDGFVIPISDEHMSEYVGAYAQRLEWLTGFGGSAGTAVVLANEAAIFVDGRYTLQVRDQ
VDGSLWSYQSVPQTSVAAWLGEHAPKGARIGYDAWLHSKGWAQAAQKALADRGATLVPVSANPVDAVWQDRPAPSLAPAI
PHADEHAGKSASEKRAEVAEWLAARGLDAAVVTALDSVAWLLNIRGSDVDRTPVALSFVLAHADGTADLFIAPEKVTPAL
LAHLGNAVRVQPREAFVPALRALAGRKVAVDPERAVAAIFHALEDSGAEIVAETDPVVLPKALKNPVEQAGHRAAQARDG
AAIARFLRWVAVEAPKGGVTELSAANRLQAFRAEGGLLRDLSFDTISGAGPNGAVVHYRVSEETSRVLEPNSVYLVDSGG
QYVDGTTDITRTVWIGPGEPPALVKDRFTRVLKGHIALARAVFPKGTAGSQLDSFARQFLWAAGLDYAHGTGHGVGSFLA
VHEGPQRIAKASGGQAGTGQELMPGMILSNEPGYYKTGEYGIRIENLVLVERREIEGAEGEFYGFETLTFAPIDRALVDV
ALLSGEEREWLNAYHASVRAVLAPQLGGEDREWLVRACAPL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=603, Percent_Identity=39.9668325041459, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI93141226, Length=609, Percent_Identity=37.1100164203612, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI264681565, Length=603, Percent_Identity=37.9767827529022, Blast_Score=383, Evalue=1e-106,
Organism=Escherichia coli, GI1788728, Length=252, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509539, Length=597, Percent_Identity=37.3534338358459, Blast_Score=348, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI25149105, Length=604, Percent_Identity=30.9602649006623, Blast_Score=269, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322999, Length=659, Percent_Identity=32.7769347496206, Blast_Score=318, Evalue=2e-87,
Organism=Drosophila melanogaster, GI17137632, Length=620, Percent_Identity=35.6451612903226, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI161078230, Length=608, Percent_Identity=31.7434210526316, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI21357287, Length=608, Percent_Identity=31.7434210526316, Blast_Score=279, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 64175; Mature: 64175

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMHTHEARLDALRKQLAKDGLDGFVIPISDEHMSEYVGAYAQRLEWLTGFGGSAGTAVV
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LANEAAIFVDGRYTLQVRDQVDGSLWSYQSVPQTSVAAWLGEHAPKGARIGYDAWLHSKG
EECCEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCH
WAQAAQKALADRGATLVPVSANPVDAVWQDRPAPSLAPAIPHADEHAGKSASEKRAEVAE
HHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHH
WLAARGLDAAVVTALDSVAWLLNIRGSDVDRTPVALSFVLAHADGTADLFIAPEKVTPAL
HHHHCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHH
LAHLGNAVRVQPREAFVPALRALAGRKVAVDPERAVAAIFHALEDSGAEIVAETDPVVLP
HHHCCCCEEECHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCEEEECCCCEECC
KALKNPVEQAGHRAAQARDGAAIARFLRWVAVEAPKGGVTELSAANRLQAFRAEGGLLRD
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCEEEE
LSFDTISGAGPNGAVVHYRVSEETSRVLEPNSVYLVDSGGQYVDGTTDITRTVWIGPGEP
CCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCEEEECCCCCEECCCCCCEEEEEECCCCC
PALVKDRFTRVLKGHIALARAVFPKGTAGSQLDSFARQFLWAAGLDYAHGTGHGVGSFLA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHE
VHEGPQRIAKASGGQAGTGQELMPGMILSNEPGYYKTGEYGIRIENLVLVERREIEGAEG
ECCCHHHHHHCCCCCCCCCCHHCCCEEECCCCCCEECCCCCEEEEEEEEEEHHHCCCCCC
EFYGFETLTFAPIDRALVDVALLSGEEREWLNAYHASVRAVLAPQLGGEDREWLVRACAP
CEECEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
L
C
>Mature Secondary Structure
MLMHTHEARLDALRKQLAKDGLDGFVIPISDEHMSEYVGAYAQRLEWLTGFGGSAGTAVV
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LANEAAIFVDGRYTLQVRDQVDGSLWSYQSVPQTSVAAWLGEHAPKGARIGYDAWLHSKG
EECCEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCH
WAQAAQKALADRGATLVPVSANPVDAVWQDRPAPSLAPAIPHADEHAGKSASEKRAEVAE
HHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHH
WLAARGLDAAVVTALDSVAWLLNIRGSDVDRTPVALSFVLAHADGTADLFIAPEKVTPAL
HHHHCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHH
LAHLGNAVRVQPREAFVPALRALAGRKVAVDPERAVAAIFHALEDSGAEIVAETDPVVLP
HHHCCCCEEECHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCEEEECCCCEECC
KALKNPVEQAGHRAAQARDGAAIARFLRWVAVEAPKGGVTELSAANRLQAFRAEGGLLRD
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCEEEE
LSFDTISGAGPNGAVVHYRVSEETSRVLEPNSVYLVDSGGQYVDGTTDITRTVWIGPGEP
CCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCEEEECCCCCEECCCCCCEEEEEECCCCC
PALVKDRFTRVLKGHIALARAVFPKGTAGSQLDSFARQFLWAAGLDYAHGTGHGVGSFLA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHE
VHEGPQRIAKASGGQAGTGQELMPGMILSNEPGYYKTGEYGIRIENLVLVERREIEGAEG
ECCCHHHHHHCCCCCCCCCCHHCCCEEECCCCCCEECCCCCEEEEEEEEEEHHHCCCCCC
EFYGFETLTFAPIDRALVDVALLSGEEREWLNAYHASVRAVLAPQLGGEDREWLVRACAP
CEECEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]