Click here to switch to the map view.

The map label for this gene is purL [H]

Identifier: 86750823

GI number: 86750823

Start: 4249971

End: 4252181

Strand: Reverse

Name: purL [H]

Synonym: RPB_3713

Alternate gene names: 86750823

Gene position: 4252181-4249971 (Counterclockwise)

Preceding gene: 86750824

Following gene: 86750820

Centisome position: 79.75

GC content: 66.67

Gene sequence:

>2211_bases
ATGTCCGCTCCAGAGCCGAAAATCACCCCGGAATTGATCGCCAGCCATGGCCTCAAGCCGGACGAATATCAGCGGATTCT
CGACCTGATCGGGCGCGAGCCGACGTTCACCGAGCTCGGCATCTTTTCGGCGATGTGGAACGAGCATTGCTCGTACAAAT
CCTCGCGGATCCATCTGAAGGGGCTGCCCACCAAGGCGCCGTGGGTGCTGCAGGGGCCGGGCGAGAACGCCGGCGTGATC
GACATCGGCGACAACCAGGCCGTGGTCTTCAAGATGGAGAGCCACAACCACCCGAGCTATATCGAGCCGTATCAGGGCGC
CACCACCGGCGTCGGCGGCATCCTGCGCGACGTCTTCACCATGGGCGCGCGGCCGATCGCCTGCCTCAATGCGCTCTCCT
TCGGCGATCCGAGCCATCCCAAGACCCGCCACCTCGTCTCGGGCGTCGTCGCCGGCGTCGGCGGCTACGGCAATTCGTTC
GGCGTGCCCACCGTCGGCGGCCAGACCCGGTTTCACACCCGCTATGACGGCAACATCCTGGTCAACGCGATGGCGGTCGG
CCTCGCGGATTCCGACAAGATCTTCCTCGCCGCGGCGAGCGGCGTCGGCATGCCGATCGTCTATCTCGGTTCCAAGACCG
GCCGCGACGGCATGGGCGGCGCCACCATGGCGTCGGCCGAGTTCGACGAGGGCTCGGAAGAGAAGCGTCCGACCGTGCAG
GTCGGCGATCCCTTCGCCGAGAAGCTGCTGCTGGAAGCCTGTCTGGAGATCATGGCCAAGGATTGCGTGATCGCGATCCA
GGACATGGGCGCGGCCGGCCTGACCTGCTCGGCGGTGGAAATGGGCGCCAAGGGCGACCTCGGCGTCGATCTCGATCTCG
ACGCGGTGCCGACCCGCGAGACCGGCATGACCGCCTACGAGATGATGCTCTCCGAGAGCCAGGAGCGGATGCTCATGGTG
TTGAAGCCGGAGAAGGAAAAGGAAGCCGAAGAGATCTTCAGGAAGTGGGGCCTCGACTTCGCGATCGTCGGCTACACCAC
GCCGACCAAGCGCTTCGTGGTCAAGCACGGCGGCGCGGTGAAGGCCGATCTGCCGATCAAGGAACTCGGCGACGAGGCGC
CGCTGTACGACCGCCCGCACGTGCCGTCGCCGAAGCTGCCCGTCATCCACGCCCGCGAGGTCAATGCGCCGATGCCGGTG
CCCGAGGCGCTGGAGAAGCTGCTGGCGACTCCGGACCTGTGCAGCAAGCGCTGGGTCTGGGAGCAATACGACCACGTCAT
CGGCGGCAACACGCTGCAGCGCCCCGGCGGCGACGCCGCGGTGGTGCGCGTCGAGGACGGGCCGAAGGGGCTGGCGCTCA
CCGTCGACGTCACGCCGCGTTATTGCGAGGCCGACCCTTACGAGGGCGGCAAGCAGGCGGTGGCGGAGGCCTATCGCAAC
ATCACCGCGGTCGGCGGCAAGCCGCTGGCGATCACCGATAACCTCAATTTCGGCAATCCGGAGCGGCCCGAGATCATGGG
CCAGCTGGTCGGCTGCCTGAAGGGCATCTCGGAAGCCTGCATCGCGCTGGATTCGCCGATCGTGTCCGGCAACGTCTCGC
TCTACAACGAGACCTCGGGCCGCGGCATCCTGCCGACGCCCTCGATCGGCGGCGTCGGCCTGCTCGACGATTTCACCAAA
TCGGCGACGCTCGCCTTCAAGGCCGAGGGCGAGGCGATCCTGCTGATCGGCGAGACCCATGGCTGGCTCGGTCAATCCGT
GTATTTGCGCGACGTCTGCGGCCGCGAAGAGGGCGCGCCGCCCCCGGTCGATCTGGCCTGCGAGAAGCGCCACGGCGACG
TCGTCCGCGGCATGATCCACGCCGGCACCGCGACCGCCGTGCACGATTTATCCGACGGTGGCTTGTTAGTTGCGCTCGCC
GAAATGGCGATCAGCGGCAATATCGGCGCGTCGCTCGATGCGCCGCCGGATTCGACCGTCGCGCACGCTTGGTGGTTCGG
CGAGGACCAGGGCCGCTATCTCGTCACCGTGAAGGAAGACGATCTGCTGACCGTGCTGTCGAAGCTGAAGAGCGTCGGCG
TGCCCTGCACGCAGATCGGCACCACCGGCGGCCACACGCTGAAGATCGACGGCGAACGCGCGATCGACGTGAAGGCGCTA
CGCCACGCCCACGAGCACTGGCTGCCGGATTATATGGCGGGGAAGAACTAA

Upstream 100 bases:

>100_bases
CATCCCCAGCCGCGCAGAAAACCCTTTCCCGCGTCCCCCGATCTTTCTAAACAACAGCCACGCGCGGGCCCCTCCCGCGC
GACGACAGGATTGCGCCGAA

Downstream 100 bases:

>100_bases
GCTTCGCCGGCGCGAGGCCCTGCGGCCTGACGCCGTCATCCTGAGGCGCGCACTGCGCGCTTCGCAGCTTGCCCCAACGC
CGTCATCCTGAGGCGCGAGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 736; Mature: 735

Protein sequence:

>736_residues
MSAPEPKITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVLQGPGENAGVI
DIGDNQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSF
GVPTVGGQTRFHTRYDGNILVNAMAVGLADSDKIFLAAASGVGMPIVYLGSKTGRDGMGGATMASAEFDEGSEEKRPTVQ
VGDPFAEKLLLEACLEIMAKDCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDAVPTRETGMTAYEMMLSESQERMLMV
LKPEKEKEAEEIFRKWGLDFAIVGYTTPTKRFVVKHGGAVKADLPIKELGDEAPLYDRPHVPSPKLPVIHAREVNAPMPV
PEALEKLLATPDLCSKRWVWEQYDHVIGGNTLQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPYEGGKQAVAEAYRN
ITAVGGKPLAITDNLNFGNPERPEIMGQLVGCLKGISEACIALDSPIVSGNVSLYNETSGRGILPTPSIGGVGLLDDFTK
SATLAFKAEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLACEKRHGDVVRGMIHAGTATAVHDLSDGGLLVALA
EMAISGNIGASLDAPPDSTVAHAWWFGEDQGRYLVTVKEDDLLTVLSKLKSVGVPCTQIGTTGGHTLKIDGERAIDVKAL
RHAHEHWLPDYMAGKN

Sequences:

>Translated_736_residues
MSAPEPKITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVLQGPGENAGVI
DIGDNQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSF
GVPTVGGQTRFHTRYDGNILVNAMAVGLADSDKIFLAAASGVGMPIVYLGSKTGRDGMGGATMASAEFDEGSEEKRPTVQ
VGDPFAEKLLLEACLEIMAKDCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDAVPTRETGMTAYEMMLSESQERMLMV
LKPEKEKEAEEIFRKWGLDFAIVGYTTPTKRFVVKHGGAVKADLPIKELGDEAPLYDRPHVPSPKLPVIHAREVNAPMPV
PEALEKLLATPDLCSKRWVWEQYDHVIGGNTLQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPYEGGKQAVAEAYRN
ITAVGGKPLAITDNLNFGNPERPEIMGQLVGCLKGISEACIALDSPIVSGNVSLYNETSGRGILPTPSIGGVGLLDDFTK
SATLAFKAEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLACEKRHGDVVRGMIHAGTATAVHDLSDGGLLVALA
EMAISGNIGASLDAPPDSTVAHAWWFGEDQGRYLVTVKEDDLLTVLSKLKSVGVPCTQIGTTGGHTLKIDGERAIDVKAL
RHAHEHWLPDYMAGKN
>Mature_735_residues
SAPEPKITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSRIHLKGLPTKAPWVLQGPGENAGVID
IGDNQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSFG
VPTVGGQTRFHTRYDGNILVNAMAVGLADSDKIFLAAASGVGMPIVYLGSKTGRDGMGGATMASAEFDEGSEEKRPTVQV
GDPFAEKLLLEACLEIMAKDCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDAVPTRETGMTAYEMMLSESQERMLMVL
KPEKEKEAEEIFRKWGLDFAIVGYTTPTKRFVVKHGGAVKADLPIKELGDEAPLYDRPHVPSPKLPVIHAREVNAPMPVP
EALEKLLATPDLCSKRWVWEQYDHVIGGNTLQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPYEGGKQAVAEAYRNI
TAVGGKPLAITDNLNFGNPERPEIMGQLVGCLKGISEACIALDSPIVSGNVSLYNETSGRGILPTPSIGGVGLLDDFTKS
ATLAFKAEGEAILLIGETHGWLGQSVYLRDVCGREEGAPPPVDLACEKRHGDVVRGMIHAGTATAVHDLSDGGLLVALAE
MAISGNIGASLDAPPDSTVAHAWWFGEDQGRYLVTVKEDDLLTVLSKLKSVGVPCTQIGTTGGHTLKIDGERAIDVKALR
HAHEHWLPDYMAGKN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=698, Percent_Identity=25.5014326647564, Blast_Score=120, Evalue=5e-27,
Organism=Escherichia coli, GI48994899, Length=773, Percent_Identity=24.7089262613195, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17553022, Length=439, Percent_Identity=24.373576309795, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321498, Length=739, Percent_Identity=23.5453315290934, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 78475; Mature: 78344

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPEPKITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSRIHLK
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
GLPTKAPWVLQGPGENAGVIDIGDNQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFT
ECCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
MGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSFGVPTVGGQTRFHTRYDGNIL
HCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEE
VNAMAVGLADSDKIFLAAASGVGMPIVYLGSKTGRDGMGGATMASAEFDEGSEEKRPTVQ
EEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
VGDPFAEKLLLEACLEIMAKDCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDAVPTRE
ECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEHHEECCCCCCCCEEECCCCCCCCC
TGMTAYEMMLSESQERMLMVLKPEKEKEAEEIFRKWGLDFAIVGYTTPTKRFVVKHGGAV
CCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCEE
KADLPIKELGDEAPLYDRPHVPSPKLPVIHAREVNAPMPVPEALEKLLATPDLCSKRWVW
EECCCHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHCCCHH
EQYDHVIGGNTLQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPYEGGKQAVAEAYRN
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHC
ITAVGGKPLAITDNLNFGNPERPEIMGQLVGCLKGISEACIALDSPIVSGNVSLYNETSG
EEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECCCC
RGILPTPSIGGVGLLDDFTKSATLAFKAEGEAILLIGETHGWLGQSVYLRDVCGREEGAP
CCCCCCCCCCCCCHHHHHCCCEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCCCCCC
PPVDLACEKRHGDVVRGMIHAGTATAVHDLSDGGLLVALAEMAISGNIGASLDAPPDSTV
CCCCEEECCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEHHHHCCCCCCCCCCCCCCCE
AHAWWFGEDQGRYLVTVKEDDLLTVLSKLKSVGVPCTQIGTTGGHTLKIDGERAIDVKAL
EEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCCCHHHHHH
RHAHEHWLPDYMAGKN
HHHHHHCCCHHHCCCC
>Mature Secondary Structure 
SAPEPKITPELIASHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSRIHLK
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
GLPTKAPWVLQGPGENAGVIDIGDNQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFT
ECCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
MGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSFGVPTVGGQTRFHTRYDGNIL
HCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEE
VNAMAVGLADSDKIFLAAASGVGMPIVYLGSKTGRDGMGGATMASAEFDEGSEEKRPTVQ
EEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
VGDPFAEKLLLEACLEIMAKDCVIAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDAVPTRE
ECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEHHEECCCCCCCCEEECCCCCCCCC
TGMTAYEMMLSESQERMLMVLKPEKEKEAEEIFRKWGLDFAIVGYTTPTKRFVVKHGGAV
CCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCEE
KADLPIKELGDEAPLYDRPHVPSPKLPVIHAREVNAPMPVPEALEKLLATPDLCSKRWVW
EECCCHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHCCCHH
EQYDHVIGGNTLQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPYEGGKQAVAEAYRN
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHC
ITAVGGKPLAITDNLNFGNPERPEIMGQLVGCLKGISEACIALDSPIVSGNVSLYNETSG
EEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECCCC
RGILPTPSIGGVGLLDDFTKSATLAFKAEGEAILLIGETHGWLGQSVYLRDVCGREEGAP
CCCCCCCCCCCCCHHHHHCCCEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCCCCCC
PPVDLACEKRHGDVVRGMIHAGTATAVHDLSDGGLLVALAEMAISGNIGASLDAPPDSTV
CCCCEEECCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEHHHHCCCCCCCCCCCCCCCE
AHAWWFGEDQGRYLVTVKEDDLLTVLSKLKSVGVPCTQIGTTGGHTLKIDGERAIDVKAL
EEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCCCHHHHHH
RHAHEHWLPDYMAGKN
HHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA