Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 86749925

GI number: 86749925

Start: 3198258

End: 3199469

Strand: Direct

Name: moeA [H]

Synonym: RPB_2808

Alternate gene names: 86749925

Gene position: 3198258-3199469 (Clockwise)

Preceding gene: 86749923

Following gene: 86749926

Centisome position: 59.99

GC content: 71.53

Gene sequence:

>1212_bases
ATGGCGCTGATGCCGGTCGCTGATGCCCTTGCCGCCGTGCTGGATGGCGCCGCCGGGCTGCCCGAGGAGATGGTGGCGCT
CGACGACGCACATGGCCGCGTGCTGGCGCGCGACCTGGCGGCGCTGCGGACGCAGCCGCCGCAGCCGATGTCGGCGATGG
ACGGCTATGCGGTGCGCGCTGCCGATGTCGCGGTTGCGCCGGCGCGCCTCACCGTAATCGGCGAGATCGCCGCGGGTCGG
CCGGCCGAGCAATCGATCGGCCCGGGGCAAGCGCTGCGGATCTTCACCGGCGGCGTGATCCCCGACGGCGCCGATACCGT
GGTGATCCAGGAAGACACGGTCCGCGATAGCGATCAGGTGACGGTTACCGAAGCCACCCGGCCCGGCCGCCACATCCGCC
CCGCCGGGATCGACTTCACCGCCGGCGAAGTGTTGCTGCGCGCGGGCGATCGGCTCAGCGACCGCGACCTCGCACTCGCC
GCCGGCATGAACCACCCCATGCTGCCGGTGCATCGCCGGCCGCGCGTCGCCATGCTCGCCACCGGCGACGAGCTGGTGAT
GCCGGGCGCGGCACTCGGCCCCGGCCAGATCGTCTATTCCAACGGCTATGCGCTGCGGGCCTTGGCGCGCAGCGAGGGCG
CCGAGGTGATCGACCTCGGCATCGCCGCCGATACCATCGAGGCCACCCGCGCGGCGATCGCGCGTGCGCGCGACCTCGGG
GTCGACCTGCTGGTCACCACTGGCGGCGCCTCGGCCGGGGACCACGATCTGGTCAAGTCGTCGCTGGAAGCCGAGGGCAC
CGACATTGCGTTCTGGAAGATCGCGATGCGGCCGGGCAAGCCGATGATGCACGGCCGGCTCGGCCCGATGCGGGTGATCG
GCCTGCCCGGCAATCCGGTATCCTCCTATGTCTGCGCCTTCCTGTTCATGGTGCCGCTGATCCGGGCGCTTTGCGGGATC
CGCGAATCGATGCACCGCCGCCAGCCGGCGCTGCTCGGCGCCGCCCTTACCGCCAACGACCAGCGCGAGGACTATCTGCG
CGCCCGTCTGGCGCTGCGCGACGACGGACAATGGCTGGCGACGCCGGTCGACCGCCAGGATTCGTCGCTGCTGGCGCGGC
TATCTGCAGCGCAGGCGCTGATCGTTCGCCCGCCGTTCGCGCCGGCGGCCGCGGCTGGCTCGCAATGTCTCATCCTTAAG
CTTCCGGAATAG

Upstream 100 bases:

>100_bases
TCTTGCGCAAGCGTCGCGAGGCACCTAAAGCCGTTTTCATGACACGCCACCCTCGCCTTGCCGGACCGGATCGGTCCGCC
GCCAGCCCCGGAGCGAACCG

Downstream 100 bases:

>100_bases
CGATCTGCGCATTTGTTGACCTCAAATTAAGAGGTTGCGGAACACATACTGAACATATAGTGTCCGTTCATGATTTGTTT
CGAGTAGTTGCGCCTCGCCC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MALMPVADALAAVLDGAAGLPEEMVALDDAHGRVLARDLAALRTQPPQPMSAMDGYAVRAADVAVAPARLTVIGEIAAGR
PAEQSIGPGQALRIFTGGVIPDGADTVVIQEDTVRDSDQVTVTEATRPGRHIRPAGIDFTAGEVLLRAGDRLSDRDLALA
AGMNHPMLPVHRRPRVAMLATGDELVMPGAALGPGQIVYSNGYALRALARSEGAEVIDLGIAADTIEATRAAIARARDLG
VDLLVTTGGASAGDHDLVKSSLEAEGTDIAFWKIAMRPGKPMMHGRLGPMRVIGLPGNPVSSYVCAFLFMVPLIRALCGI
RESMHRRQPALLGAALTANDQREDYLRARLALRDDGQWLATPVDRQDSSLLARLSAAQALIVRPPFAPAAAAGSQCLILK
LPE

Sequences:

>Translated_403_residues
MALMPVADALAAVLDGAAGLPEEMVALDDAHGRVLARDLAALRTQPPQPMSAMDGYAVRAADVAVAPARLTVIGEIAAGR
PAEQSIGPGQALRIFTGGVIPDGADTVVIQEDTVRDSDQVTVTEATRPGRHIRPAGIDFTAGEVLLRAGDRLSDRDLALA
AGMNHPMLPVHRRPRVAMLATGDELVMPGAALGPGQIVYSNGYALRALARSEGAEVIDLGIAADTIEATRAAIARARDLG
VDLLVTTGGASAGDHDLVKSSLEAEGTDIAFWKIAMRPGKPMMHGRLGPMRVIGLPGNPVSSYVCAFLFMVPLIRALCGI
RESMHRRQPALLGAALTANDQREDYLRARLALRDDGQWLATPVDRQDSSLLARLSAAQALIVRPPFAPAAAAGSQCLILK
LPE
>Mature_402_residues
ALMPVADALAAVLDGAAGLPEEMVALDDAHGRVLARDLAALRTQPPQPMSAMDGYAVRAADVAVAPARLTVIGEIAAGRP
AEQSIGPGQALRIFTGGVIPDGADTVVIQEDTVRDSDQVTVTEATRPGRHIRPAGIDFTAGEVLLRAGDRLSDRDLALAA
GMNHPMLPVHRRPRVAMLATGDELVMPGAALGPGQIVYSNGYALRALARSEGAEVIDLGIAADTIEATRAAIARARDLGV
DLLVTTGGASAGDHDLVKSSLEAEGTDIAFWKIAMRPGKPMMHGRLGPMRVIGLPGNPVSSYVCAFLFMVPLIRALCGIR
ESMHRRQPALLGAALTANDQREDYLRARLALRDDGQWLATPVDRQDSSLLARLSAAQALIVRPPFAPAAAAGSQCLILKL
PE

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=405, Percent_Identity=36.0493827160494, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI66932975, Length=405, Percent_Identity=36.0493827160494, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=37.9581151832461, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI25147659, Length=377, Percent_Identity=32.0954907161804, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=344, Percent_Identity=27.6162790697674, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17136978, Length=350, Percent_Identity=30, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24638841, Length=350, Percent_Identity=30, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42293; Mature: 42162

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALMPVADALAAVLDGAAGLPEEMVALDDAHGRVLARDLAALRTQPPQPMSAMDGYAVRA
CCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHHCCCCCCHHHCCCCEEEE
ADVAVAPARLTVIGEIAAGRPAEQSIGPGQALRIFTGGVIPDGADTVVIQEDTVRDSDQV
ECEEECCEEEEEEEEHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCE
TVTEATRPGRHIRPAGIDFTAGEVLLRAGDRLSDRDLALAAGMNHPMLPVHRRPRVAMLA
EEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEE
TGDELVMPGAALGPGQIVYSNGYALRALARSEGAEVIDLGIAADTIEATRAAIARARDLG
CCCCEECCCCCCCCCEEEEECCEEEEEEHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
VDLLVTTGGASAGDHDLVKSSLEAEGTDIAFWKIAMRPGKPMMHGRLGPMRVIGLPGNPV
EEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCCHH
SSYVCAFLFMVPLIRALCGIRESMHRRQPALLGAALTANDQREDYLRARLALRDDGQWLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHEECCCCCEEE
TPVDRQDSSLLARLSAAQALIVRPPFAPAAAAGSQCLILKLPE
CCCCCCHHHHHHHHHHCCEEEECCCCCCHHCCCCCEEEEECCC
>Mature Secondary Structure 
ALMPVADALAAVLDGAAGLPEEMVALDDAHGRVLARDLAALRTQPPQPMSAMDGYAVRA
CCCCHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHHCCCCCCHHHCCCCEEEE
ADVAVAPARLTVIGEIAAGRPAEQSIGPGQALRIFTGGVIPDGADTVVIQEDTVRDSDQV
ECEEECCEEEEEEEEHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCE
TVTEATRPGRHIRPAGIDFTAGEVLLRAGDRLSDRDLALAAGMNHPMLPVHRRPRVAMLA
EEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEE
TGDELVMPGAALGPGQIVYSNGYALRALARSEGAEVIDLGIAADTIEATRAAIARARDLG
CCCCEECCCCCCCCCEEEEECCEEEEEEHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
VDLLVTTGGASAGDHDLVKSSLEAEGTDIAFWKIAMRPGKPMMHGRLGPMRVIGLPGNPV
EEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCCHH
SSYVCAFLFMVPLIRALCGIRESMHRRQPALLGAALTANDQREDYLRARLALRDDGQWLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHEECCCCCEEE
TPVDRQDSSLLARLSAAQALIVRPPFAPAAAAGSQCLILKLPE
CCCCCCHHHHHHHHHHCCEEEECCCCCCHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]