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The map label for this gene is parC [H]

Identifier: 86749737

GI number: 86749737

Start: 3001661

End: 3003922

Strand: Direct

Name: parC [H]

Synonym: RPB_2620

Alternate gene names: 86749737

Gene position: 3001661-3003922 (Clockwise)

Preceding gene: 86749736

Following gene: 86749741

Centisome position: 56.3

GC content: 64.41

Gene sequence:

>2262_bases
ATGGGAAAAAGACTGATTCCGCCGGAGCCGGCCGAGATTCACGAAGTGCAGCTTCGTGAAGCGCTGGAAGAGCGTTACCT
CGCTTATGCGCTCTCGACCATCATGCATCGCGCCTTGCCTGACGCTCGCGACGGGCTGAAGCCGGTGCATCGGCGTATTC
TTTATGGCATGCGGCTGTTGCGGCTCGACCCCGGCACGCCGTTCAAGAAGTCGGCCAAGATCGTCGGCGACGTGATGGGC
TCGTTCCATCCGCACGGCGACCAGTCGATCTACGACGCGCTGGTGCGCCTCGCGCAGGACTTCTCCTCGCGCTATCCGCT
GGTCGACGGCCAGGGAAACTTCGGCAATATCGACGGCGATAATCCGGCCGCCTATCGCTACACCGAAGCGCGCATGACCG
ATGTCGCGCGGCTCTTGCTCGATGGTATCGACGAGGACGGCGTCGCGTTTCGGCCCAACTACGACGGCCAGGCCAAAGAG
CCGGTGGTGCTGCCCGGCGGCTTTCCGAACCTGCTTGCCAACGGCGCGCAGGGCATCGCGGTCGGCATGGCCACCGCGAT
CCCGCCGCACAACGCCGCCGAACTCTGCGACGCCGCGCTGCATCTGATCGACAAGCCGGACGCCAAGACGAAGGCGCTGC
TGCGCTTCGTCAAGGGCCCGGACTTCCCGACTGGCGGCATCGTCATCGATTCCAAGGAGAGCATCGCCGAGGCCTATACG
ACGGGCCGCGGCGCGTTCCGCACCCGCGCCAAATGGATGCAGGAGGAGGGCGCACGCGGCACCTGGGTCGTGGTCGTCAC
CGAAATTCCGTGGCTGGTGCAGAAGTCCCGGCTGATCGAGAAGATCGCCGAACTGTTGAACGAGAAGAAGCTGCCGCTGG
TCGGCGACATCCGCGACGAATCCGCCGAAGACGTGCGCGTCGTGATCGAGCCGAAGTCGCGCGCCGTCGATCCGGCGCTG
ATGATGGAATCGCTGTTCCGGCTGACCGAGCTGGAAAGCCGGATCCCGCTCAATCTCAACGTGCTGGTGAAGGGTCGCAT
CCCCAAGGTGCTCGGCCTCGCCGAATGTCTGCGCGAATGGCTCGACCATCTGCGCGACGTGCTGCTGCGGCGCTCGAACT
ACCGCAAGGCGCAGATCGAGCATCGGCTCGAAGTGCTCGGCGGCTATCTGATCGCGTATCTAAACATCGACAAGGTGATC
AAGATCATCCGCACCGAGGACGAGCCGAAACCCGTCCTGATGAAGGCCTTCAACCTCACCGATGTGCAGGCCGAAGCGAT
CCTCAACATGCGGCTGCGCAGCTTGCGCAAGCTCGAGGAATTCGAGATCCGCACCGAGGACAAGAATCTGCGCGCCGAGC
TGAAGGGCATCAACGCGATTCTGAAATCCGAGACCGAGCAGTGGGCCAAGGTCGGCGAGCAGGTGCGCAAGGTGCGCGAG
ATGTTCGGGCCGAAGACACCGCTCGGCAAGCGCCGCACCCAATTCGCCGACGCGCCCGAGCACGATCTCGCCGCGATCGA
GGAAGCCTTCGTCGAGCGCGAGCCGGTCACCGTGGTGATCTCCGACAAGGGCTGGGTGCGCACCCTGAAGGGCCACGTCG
CCGATCTGTCCGGTCTGAACTTCAAGCAGGACGACAAGCTCGATAGGGCGTTCTTCGCCGAGACCACGTCGAAGCTGCTG
CTGCTCGCCACCAATGGGCGGTTCTACTCGCTCGAGGTCGCCAAGCTGCCCGGCGGCCGCGGCCATGGCGAGCCGATCCG
CATGTTCATCGACATGGAGCAGGACGCCGCCATCGTCGCGATGTTCGTGCACAAGGGCGGTCGCAAATTCCTGATCGCCA
GTCATGACGGCCAGGGATTCGTCGTCGGCGAGGACGATTGCGTCGGCACCACCCGCAAGGGCAAGCAGATCATCAATGTC
GAGATGCCGAACGAGGCGAGGGCGCTGACCGTCGTCGGCGACGGCTCGGACAACGTCGCGGTGATCGGCGACAACCGCAA
GATGCTGATCTTCCCGCTCGACCAGGTGCCGGAGATGGCGCGCGGCCGCGGCGTGCGGCTGCAGAAATACAAGGACGGCG
GGCTGTCCGACATCGTCACCTTCGTGGCCAAGGAAGGTCTGAGCTGGCGCGACTCCGCCGGCCGCGAGTTCAGCGCGACG
ATGAAGGAACTGGCCGAATGGCGCGGCAATCGCGCCGATGCCGGCCGAATGCCGCCGAAGGGTTTTCCGAAGTCGAACAA
ATTCGGCCGCGGCATCGAGTGA

Upstream 100 bases:

>100_bases
GCTTCGACGCGGCAGAGGCGACAGCGCCGGTGTCGAGCGGCGAGACTGCGTATCCCCTCTAGAACTTGCCGGAAACCCAG
CCAAAGGCTAACCCGTCGCC

Downstream 100 bases:

>100_bases
TCGCGCGCCGCGCGCCGGTTCGCCTGACCATGGATCTGTAGCGGCGGCGACGAGCCGCTCGCTCCGCCGCAGCGTTCCGG
TTCGATCTCGGCAAAGCTGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MGKRLIPPEPAEIHEVQLREALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPGTPFKKSAKIVGDVMG
SFHPHGDQSIYDALVRLAQDFSSRYPLVDGQGNFGNIDGDNPAAYRYTEARMTDVARLLLDGIDEDGVAFRPNYDGQAKE
PVVLPGGFPNLLANGAQGIAVGMATAIPPHNAAELCDAALHLIDKPDAKTKALLRFVKGPDFPTGGIVIDSKESIAEAYT
TGRGAFRTRAKWMQEEGARGTWVVVVTEIPWLVQKSRLIEKIAELLNEKKLPLVGDIRDESAEDVRVVIEPKSRAVDPAL
MMESLFRLTELESRIPLNLNVLVKGRIPKVLGLAECLREWLDHLRDVLLRRSNYRKAQIEHRLEVLGGYLIAYLNIDKVI
KIIRTEDEPKPVLMKAFNLTDVQAEAILNMRLRSLRKLEEFEIRTEDKNLRAELKGINAILKSETEQWAKVGEQVRKVRE
MFGPKTPLGKRRTQFADAPEHDLAAIEEAFVEREPVTVVISDKGWVRTLKGHVADLSGLNFKQDDKLDRAFFAETTSKLL
LLATNGRFYSLEVAKLPGGRGHGEPIRMFIDMEQDAAIVAMFVHKGGRKFLIASHDGQGFVVGEDDCVGTTRKGKQIINV
EMPNEARALTVVGDGSDNVAVIGDNRKMLIFPLDQVPEMARGRGVRLQKYKDGGLSDIVTFVAKEGLSWRDSAGREFSAT
MKELAEWRGNRADAGRMPPKGFPKSNKFGRGIE

Sequences:

>Translated_753_residues
MGKRLIPPEPAEIHEVQLREALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPGTPFKKSAKIVGDVMG
SFHPHGDQSIYDALVRLAQDFSSRYPLVDGQGNFGNIDGDNPAAYRYTEARMTDVARLLLDGIDEDGVAFRPNYDGQAKE
PVVLPGGFPNLLANGAQGIAVGMATAIPPHNAAELCDAALHLIDKPDAKTKALLRFVKGPDFPTGGIVIDSKESIAEAYT
TGRGAFRTRAKWMQEEGARGTWVVVVTEIPWLVQKSRLIEKIAELLNEKKLPLVGDIRDESAEDVRVVIEPKSRAVDPAL
MMESLFRLTELESRIPLNLNVLVKGRIPKVLGLAECLREWLDHLRDVLLRRSNYRKAQIEHRLEVLGGYLIAYLNIDKVI
KIIRTEDEPKPVLMKAFNLTDVQAEAILNMRLRSLRKLEEFEIRTEDKNLRAELKGINAILKSETEQWAKVGEQVRKVRE
MFGPKTPLGKRRTQFADAPEHDLAAIEEAFVEREPVTVVISDKGWVRTLKGHVADLSGLNFKQDDKLDRAFFAETTSKLL
LLATNGRFYSLEVAKLPGGRGHGEPIRMFIDMEQDAAIVAMFVHKGGRKFLIASHDGQGFVVGEDDCVGTTRKGKQIINV
EMPNEARALTVVGDGSDNVAVIGDNRKMLIFPLDQVPEMARGRGVRLQKYKDGGLSDIVTFVAKEGLSWRDSAGREFSAT
MKELAEWRGNRADAGRMPPKGFPKSNKFGRGIE
>Mature_752_residues
GKRLIPPEPAEIHEVQLREALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPGTPFKKSAKIVGDVMGS
FHPHGDQSIYDALVRLAQDFSSRYPLVDGQGNFGNIDGDNPAAYRYTEARMTDVARLLLDGIDEDGVAFRPNYDGQAKEP
VVLPGGFPNLLANGAQGIAVGMATAIPPHNAAELCDAALHLIDKPDAKTKALLRFVKGPDFPTGGIVIDSKESIAEAYTT
GRGAFRTRAKWMQEEGARGTWVVVVTEIPWLVQKSRLIEKIAELLNEKKLPLVGDIRDESAEDVRVVIEPKSRAVDPALM
MESLFRLTELESRIPLNLNVLVKGRIPKVLGLAECLREWLDHLRDVLLRRSNYRKAQIEHRLEVLGGYLIAYLNIDKVIK
IIRTEDEPKPVLMKAFNLTDVQAEAILNMRLRSLRKLEEFEIRTEDKNLRAELKGINAILKSETEQWAKVGEQVRKVREM
FGPKTPLGKRRTQFADAPEHDLAAIEEAFVEREPVTVVISDKGWVRTLKGHVADLSGLNFKQDDKLDRAFFAETTSKLLL
LATNGRFYSLEVAKLPGGRGHGEPIRMFIDMEQDAAIVAMFVHKGGRKFLIASHDGQGFVVGEDDCVGTTRKGKQIINVE
MPNEARALTVVGDGSDNVAVIGDNRKMLIFPLDQVPEMARGRGVRLQKYKDGGLSDIVTFVAKEGLSWRDSAGREFSATM
KELAEWRGNRADAGRMPPKGFPKSNKFGRGIE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=406, Percent_Identity=25.8620689655172, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19913408, Length=181, Percent_Identity=31.4917127071823, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789396, Length=678, Percent_Identity=42.9203539823009, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1788562, Length=659, Percent_Identity=38.9984825493171, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI212645845, Length=391, Percent_Identity=23.2736572890026, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=447, Percent_Identity=24.3847874720358, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=172, Percent_Identity=32.5581395348837, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=384, Percent_Identity=25.5208333333333, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136538, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83976; Mature: 83845

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRLIPPEPAEIHEVQLREALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHEE
RLDPGTPFKKSAKIVGDVMGSFHPHGDQSIYDALVRLAQDFSSRYPLVDGQGNFGNIDGD
EECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC
NPAAYRYTEARMTDVARLLLDGIDEDGVAFRPNYDGQAKEPVVLPGGFPNLLANGAQGIA
CCCEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEECCCCCHHHHHCCCCCEE
VGMATAIPPHNAAELCDAALHLIDKPDAKTKALLRFVKGPDFPTGGIVIDSKESIAEAYT
EEHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGRGAFRTRAKWMQEEGARGTWVVVVTEIPWLVQKSRLIEKIAELLNEKKLPLVGDIRDE
CCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDVRVVIEPKSRAVDPALMMESLFRLTELESRIPLNLNVLVKGRIPKVLGLAECLREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
LDHLRDVLLRRSNYRKAQIEHRLEVLGGYLIAYLNIDKVIKIIRTEDEPKPVLMKAFNLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCCCCEEEECCCC
DVQAEAILNMRLRSLRKLEEFEIRTEDKNLRAELKGINAILKSETEQWAKVGEQVRKVRE
HHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFGPKTPLGKRRTQFADAPEHDLAAIEEAFVEREPVTVVISDKGWVRTLKGHVADLSGLN
HHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCC
FKQDDKLDRAFFAETTSKLLLLATNGRFYSLEVAKLPGGRGHGEPIRMFIDMEQDAAIVA
CCCCCCHHHHHHHHCCCCEEEEEECCEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEE
MFVHKGGRKFLIASHDGQGFVVGEDDCVGTTRKGKQIINVEMPNEARALTVVGDGSDNVA
EEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEE
VIGDNRKMLIFPLDQVPEMARGRGVRLQKYKDGGLSDIVTFVAKEGLSWRDSAGREFSAT
EEECCCEEEEEECHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
MKELAEWRGNRADAGRMPPKGFPKSNKFGRGIE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKRLIPPEPAEIHEVQLREALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHEE
RLDPGTPFKKSAKIVGDVMGSFHPHGDQSIYDALVRLAQDFSSRYPLVDGQGNFGNIDGD
EECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC
NPAAYRYTEARMTDVARLLLDGIDEDGVAFRPNYDGQAKEPVVLPGGFPNLLANGAQGIA
CCCEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEECCCCCHHHHHCCCCCEE
VGMATAIPPHNAAELCDAALHLIDKPDAKTKALLRFVKGPDFPTGGIVIDSKESIAEAYT
EEHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGRGAFRTRAKWMQEEGARGTWVVVVTEIPWLVQKSRLIEKIAELLNEKKLPLVGDIRDE
CCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDVRVVIEPKSRAVDPALMMESLFRLTELESRIPLNLNVLVKGRIPKVLGLAECLREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
LDHLRDVLLRRSNYRKAQIEHRLEVLGGYLIAYLNIDKVIKIIRTEDEPKPVLMKAFNLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCCCCEEEECCCC
DVQAEAILNMRLRSLRKLEEFEIRTEDKNLRAELKGINAILKSETEQWAKVGEQVRKVRE
HHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFGPKTPLGKRRTQFADAPEHDLAAIEEAFVEREPVTVVISDKGWVRTLKGHVADLSGLN
HHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCC
FKQDDKLDRAFFAETTSKLLLLATNGRFYSLEVAKLPGGRGHGEPIRMFIDMEQDAAIVA
CCCCCCHHHHHHHHCCCCEEEEEECCEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEE
MFVHKGGRKFLIASHDGQGFVVGEDDCVGTTRKGKQIINVEMPNEARALTVVGDGSDNVA
EEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEE
VIGDNRKMLIFPLDQVPEMARGRGVRLQKYKDGGLSDIVTFVAKEGLSWRDSAGREFSAT
EEECCCEEEEEECHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
MKELAEWRGNRADAGRMPPKGFPKSNKFGRGIE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]