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The map label for this gene is lolC [H]

Identifier: 86749716

GI number: 86749716

Start: 2980197

End: 2981477

Strand: Direct

Name: lolC [H]

Synonym: RPB_2598

Alternate gene names: 86749716

Gene position: 2980197-2981477 (Clockwise)

Preceding gene: 86749715

Following gene: 86749717

Centisome position: 55.9

GC content: 64.17

Gene sequence:

>1281_bases
ATGGATCACAGCATGACTGAGCCAGTTCGAACTCCTCCTTTTGCGCCATTCGAATGGCTCCTGTCCGGGCGCTACCTCCG
CGCGCGCCGCCGTGAGGGGTTCATCTCGGTGATCGCCGGGTTCTCGTTTCTCGGCATCATGCTCGGCGTCGCGACGCTGA
TCATCGTGATGGCGGTGATGAACGGCTTCCGCAAGGAACTGCTCGACAAGATCCTCGGCCTCAACGGCCATCTGCTGGTG
CAGCCGCTGGAAAGCCCGCTGACCGACTGGAAAGAGGTCGCCGATCGCATCAGCGGCGTGGCGGGCATCAAGCTCGCGGC
GCCGGTGATCGACGGCCAGGCGCTGGCGTCGTCGCCGTTCAATGCCTCCGGCGTGCTGGTGCGCGGCATCCGCGCCGACG
ACCTCAACAATCTGTCGTCGATCGCCAATCACATCAAGCAGGGCACGCTCGACGGCTTCGACGAAGGGCAGGGCGTCGCG
ATCGGGCGCAGGCTCGCCGATCAATTGTCGCTGCACGCCGGCGACAGCGTCACGCTGGTGGCGCCGCGCGGCGCGGTGAC
GCCGATGGGCACCACGCCGCGGATCAAGCCGTACAAGATCGCCGCCGTGTTCGAGATCGGCATGTCGGAATACGACTCGA
CCTTCGTGTTCATGCCGCTGAAGGAGGCGCAGGCCTATTTCAACCGCAATAACGACGTCACCGCGATCGAGGTCTACACC
ACCAATCCGGACAGGATCGACGCCTTCCGCAAGAGCGTCACCGAGGCCGCAGGCCGGCCGGTGTTCCTGGTCGATTGGCG
GCAGCGCAATTCGACCTTCTTCAACGCGCTGCAGGTCGAGCGCAACGTGATGTTCCTGATCCTGACGCTGATCGTGCTGG
TGGCGGCGCTCAACATCGTCTCCGGCCTGATCATGCTGGTGAAGGACAAGGGCAGCGATATCGCCATCCTGCGCACCATG
GGGGCGACGCAAGGATCGATCATGCGGGTGTTCCTGATCACCGGCGCTGCGATCGGCGTGGTCGGCACGCTGACCGGCTT
CGTCGTCGGGCTGGTGATCTGCCTGAACATCGAATCGATCCGGCAATTCCTGTCCTGGGTGACCAATACCGAGCTGTTTT
CGCCGGAGCTGTACTTCCTGTCGAAGCTGCCGGCCGAGGTCGATTTCGCCGAGACCAGCGCGGTGGTGATCATGGCGCTG
ACGCTGTCCTTCCTGGCGACGCTATATCCGTCGTGGCGCGCGGCGCGGCTCGATCCCGTCGACGCGCTCCGCTATGAGTG
A

Upstream 100 bases:

>100_bases
AGAATATCGCGCTGGCGGAGACGGTCGCACGGCTCGCGCCGTAAGATTTATCCACTGGCGGCTCGGCTGAAATTAGCCCG
AATCGTGTGAAATTCGGAGC

Downstream 100 bases:

>100_bases
GGCCGCAATGGAGCAGGACGCAGAAGACATCCCGGTCGTCTACCTTCACGACATCAAGCGGCAATACACGCAGGGCGAAG
CCACGCTGACGATCCTCGAC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MDHSMTEPVRTPPFAPFEWLLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVMNGFRKELLDKILGLNGHLLV
QPLESPLTDWKEVADRISGVAGIKLAAPVIDGQALASSPFNASGVLVRGIRADDLNNLSSIANHIKQGTLDGFDEGQGVA
IGRRLADQLSLHAGDSVTLVAPRGAVTPMGTTPRIKPYKIAAVFEIGMSEYDSTFVFMPLKEAQAYFNRNNDVTAIEVYT
TNPDRIDAFRKSVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIVSGLIMLVKDKGSDIAILRTM
GATQGSIMRVFLITGAAIGVVGTLTGFVVGLVICLNIESIRQFLSWVTNTELFSPELYFLSKLPAEVDFAETSAVVIMAL
TLSFLATLYPSWRAARLDPVDALRYE

Sequences:

>Translated_426_residues
MDHSMTEPVRTPPFAPFEWLLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVMNGFRKELLDKILGLNGHLLV
QPLESPLTDWKEVADRISGVAGIKLAAPVIDGQALASSPFNASGVLVRGIRADDLNNLSSIANHIKQGTLDGFDEGQGVA
IGRRLADQLSLHAGDSVTLVAPRGAVTPMGTTPRIKPYKIAAVFEIGMSEYDSTFVFMPLKEAQAYFNRNNDVTAIEVYT
TNPDRIDAFRKSVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIVSGLIMLVKDKGSDIAILRTM
GATQGSIMRVFLITGAAIGVVGTLTGFVVGLVICLNIESIRQFLSWVTNTELFSPELYFLSKLPAEVDFAETSAVVIMAL
TLSFLATLYPSWRAARLDPVDALRYE
>Mature_426_residues
MDHSMTEPVRTPPFAPFEWLLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVMNGFRKELLDKILGLNGHLLV
QPLESPLTDWKEVADRISGVAGIKLAAPVIDGQALASSPFNASGVLVRGIRADDLNNLSSIANHIKQGTLDGFDEGQGVA
IGRRLADQLSLHAGDSVTLVAPRGAVTPMGTTPRIKPYKIAAVFEIGMSEYDSTFVFMPLKEAQAYFNRNNDVTAIEVYT
TNPDRIDAFRKSVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIVSGLIMLVKDKGSDIAILRTM
GATQGSIMRVFLITGAAIGVVGTLTGFVVGLVICLNIESIRQFLSWVTNTELFSPELYFLSKLPAEVDFAETSAVVIMAL
TLSFLATLYPSWRAARLDPVDALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=409, Percent_Identity=32.0293398533007, Blast_Score=208, Evalue=4e-55,
Organism=Escherichia coli, GI1787360, Length=415, Percent_Identity=27.9518072289157, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46545; Mature: 46545

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHSMTEPVRTPPFAPFEWLLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVM
CCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFRKELLDKILGLNGHLLVQPLESPLTDWKEVADRISGVAGIKLAAPVIDGQALASSPF
HHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEECCEECCHHHCCCCC
NASGVLVRGIRADDLNNLSSIANHIKQGTLDGFDEGQGVAIGRRLADQLSLHAGDSVTLV
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
APRGAVTPMGTTPRIKPYKIAAVFEIGMSEYDSTFVFMPLKEAQAYFNRNNDVTAIEVYT
ECCCCCCCCCCCCCCCCEEEEEEEECCHHCCCCEEEEEEHHHHHHHHCCCCCEEEEEEEE
TNPDRIDAFRKSVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIV
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIMLVKDKGSDIAILRTMGATQGSIMRVFLITGAAIGVVGTLTGFVVGLVICLNIESI
HHHHEEEECCCCCEEEEEECCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RQFLSWVTNTELFSPELYFLSKLPAEVDFAETSAVVIMALTLSFLATLYPSWRAARLDPV
HHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
DALRYE
HHHCCC
>Mature Secondary Structure
MDHSMTEPVRTPPFAPFEWLLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVM
CCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFRKELLDKILGLNGHLLVQPLESPLTDWKEVADRISGVAGIKLAAPVIDGQALASSPF
HHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEECCEECCHHHCCCCC
NASGVLVRGIRADDLNNLSSIANHIKQGTLDGFDEGQGVAIGRRLADQLSLHAGDSVTLV
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
APRGAVTPMGTTPRIKPYKIAAVFEIGMSEYDSTFVFMPLKEAQAYFNRNNDVTAIEVYT
ECCCCCCCCCCCCCCCCEEEEEEEECCHHCCCCEEEEEEHHHHHHHHCCCCCEEEEEEEE
TNPDRIDAFRKSVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIV
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIMLVKDKGSDIAILRTMGATQGSIMRVFLITGAAIGVVGTLTGFVVGLVICLNIESI
HHHHEEEECCCCCEEEEEECCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RQFLSWVTNTELFSPELYFLSKLPAEVDFAETSAVVIMALTLSFLATLYPSWRAARLDPV
HHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
DALRYE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]