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The map label for this gene is lon [H]

Identifier: 86749683

GI number: 86749683

Start: 2943967

End: 2946405

Strand: Direct

Name: lon [H]

Synonym: RPB_2565

Alternate gene names: 86749683

Gene position: 2943967-2946405 (Clockwise)

Preceding gene: 86749682

Following gene: 86749684

Centisome position: 55.22

GC content: 64.29

Gene sequence:

>2439_bases
ATGACCGCCACGAAACCAAGGCCGACCATCGTTTACGGCGAAAGCCACTCCTATCCAGTTCTTCCGCTGCGCGACATCGT
CGTGTTCCCGCACATGATCGTGCCGCTGTTCGTCGGCCGCGAGAAATCGATCCGCGCGCTCGAAGAGGTGATGAAGAACG
ACGCACTGATCATGCTCGCGACGCAGAAGAACGCGTCCGACGACGATCCGGCGCCGGGCTCGATCTACGAGATCGGCACG
CTCGCCAGCGTGCTGCAACTGCTGAAGCTGCCCGACGGCACCGTCAAGGTGCTGGTCGAAGGTCTGGCGCGCGCCCGGGT
CGAGAGCTACACCGATCGCACCGAGTACTACGAAGCGCAGGCGCAATCGATCGCCGACACCGACGCCGAGAGCGTCGAGG
CGGAAGCGCTGTCGCGCTCCGTGGTGTCCGATTTCGAGAGCTACGTGAAGCTCAACAAGAAGATCTCCGCCGAGGTCGTC
GGCGTGGTGCAGTCGATCACCGACTTCGCCAAGCTCGGCGATACCGTGGCGTCGCATCTCGCCGTCAAGATCGCCGATCG
CCAGGGCATCCTGGAGACGCTGTCCGTCACCGCGCGCCTGGAGAAGGTGCTCGGGCTGATGGAGAGCGAGATCTCGGTGC
TGCAGGTCGAGAAGCGGATCCGCTCGCGCGTCAAGCGCCAGATGGAGAAGACCCAGCGCGAGTACTATCTCAACGAGCAG
ATGAAGGCGATCCAGAAGGAACTCGGCGACGACGAGGGCCGGGACGAACTCGCCGATCTCGAAGAGAAGATCGCCAAGAC
CAAGCTGTCGAAGGAAGCCCGCGAGAAGGCGCAGCACGAGCTGAAGAAGCTGCGCCAGATGTCGCCGATGTCCGCGGAAG
CGACCGTCGTGCGCAACTATCTCGATTGGCTGCTGTCGATCCCGTGGAACAAGAAGTCCAAGGTGAAGAAGGATCTCGAG
GCGGCGCAGGCCACGCTCGATTCCGATCACTACGGGCTCGAGAAGGTCAAGGAGCGGATCGTCGAGTATCTGGCGGTGCA
GTCGCGCGCCAACAAGCTGTCGGGTCCGATCCTGTGCCTGGTCGGCCCGCCCGGCGTCGGCAAGACCTCGCTCGGCAAGT
CGATCGCGAAAGCGACCGGCCGCGAGTTCGTGCGCGTGTCGCTCGGCGGCGTGCGTGACGAGGCCGAGATCCGCGGTCAC
CGCCGCACCTATATCGGCTCGATGCCCGGCAAGATCATCCAGTCGATGCGCAAGGCCAAGACCTCGAACCCGCTGTTCCT
GCTGGACGAGATCGACAAGATGGGCGCCGATTTCCGCGGCGATCCGTCCTCGGCGCTGCTCGAGGTGCTCGACCCCGAGC
AGAACTCGACCTTCAACGACCACTATCTCGAGGTCGACTACGATCTGTCCAACGTGATGTTCATCACCACGGCGAACACC
CTGAATATCCCGGGGCCGCTGATGGACCGCATGGAGATCATCCGGATCGCGGGCTACACCGAGAACGAGAAGGTCGAGAT
CGCGCGCAAGCATCTGATCCCGCTGGCGCTGACCAAGCACGGGCTGGATTCCAAGGAGTGGTCGATCGACGACGACGCGC
TGCTCCTGATGATCCGGCGCTACACCCGCGAAGCGGGCGTGCGTAATCTCGAGCGCGAACTGTCCACGCTCGCCCGCAAG
GCGGTCAAGGACCTGATGCTCTCGAAGAAGAAGTCGGTGAAGGTCACCGAGAAGGCGATCGAGGAATATCTCGGCGTGCC
GAAATTCCGCTTCGGCGAGATCGAGCTGGAAGATCAGGTCGGTGTCGTCACGGGTCTCGCGTGGACCGATGTCGGCGGCG
AGCTGCTGACGATCGAAAGCGTGATGATGCCGGGCAAGGGCCGGATGACGGTCACCGGCAATCTGCGCGACGTGATGAAG
GAATCGATCTCGGCGGCGGCGTCCTATGTCCGCTCGCGCGCGATCACCTTCGGGATCGAGCCGCCGTTCTTCGAGCGGCG
CGACATCCACGTCCACGTGCCGGAGGGGGCGACCCCGAAGGACGGCCCGTCGGCCGGCGTGGCGATGGCGACCACCATCG
TCTCGGTGCTGACCGGGATTCCGATCCGGCGCGACATCGCCATGACCGGCGAGATCACGCTGCGCGGCAGGGTGCTGCCG
ATCGGCGGCCTGAAGGAGAAGTTGCTGGCGGCGGCTAGAGGCGGCATCAAGACGGTGCTGATCCCCGAGGACAACGCCAA
GGACCTCACCGAGATCTCGGACGCGATCAAGGGTGGCCTCAACATCATCCCGGTCGCCCGGATGGACGAGGTCATTGCCA
ACGCGCTGGTCCGTGCTCCGGTGCCGATCGTCTGGGAAGAGGAAACCGCCGCCAAGATCCCCGGCAAGCCGGAGACCTCG
GAGGCCGACGAAGCCGCTGGCGGACTCACCGCGCACTGA

Upstream 100 bases:

>100_bases
GGCCTGACCGGCCGAAACGCGCCGGTACACTCGGCACCTTGTGGTGGCTGCGCCGGGGGGCGGGCTACGAGCAAGGGGGC
ACAACGAAAAGGAACGGGCC

Downstream 100 bases:

>100_bases
GCGGTCCGAGCCCGACACCAATAGCGACGGCGCCCTGCGGGGCGCCGTTTGCGTTTGGGGAACCGGAAGTGTGTGGGGAA
GTCGGGGCTGGTGGGCGGCG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 812; Mature: 811

Protein sequence:

>812_residues
MTATKPRPTIVYGESHSYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKNDALIMLATQKNASDDDPAPGSIYEIGT
LASVLQLLKLPDGTVKVLVEGLARARVESYTDRTEYYEAQAQSIADTDAESVEAEALSRSVVSDFESYVKLNKKISAEVV
GVVQSITDFAKLGDTVASHLAVKIADRQGILETLSVTARLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
MKAIQKELGDDEGRDELADLEEKIAKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNYLDWLLSIPWNKKSKVKKDLE
AAQATLDSDHYGLEKVKERIVEYLAVQSRANKLSGPILCLVGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGH
RRTYIGSMPGKIIQSMRKAKTSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNSTFNDHYLEVDYDLSNVMFITTANT
LNIPGPLMDRMEIIRIAGYTENEKVEIARKHLIPLALTKHGLDSKEWSIDDDALLLMIRRYTREAGVRNLERELSTLARK
AVKDLMLSKKKSVKVTEKAIEEYLGVPKFRFGEIELEDQVGVVTGLAWTDVGGELLTIESVMMPGKGRMTVTGNLRDVMK
ESISAAASYVRSRAITFGIEPPFFERRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPIRRDIAMTGEITLRGRVLP
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGLNIIPVARMDEVIANALVRAPVPIVWEEETAAKIPGKPETS
EADEAAGGLTAH

Sequences:

>Translated_812_residues
MTATKPRPTIVYGESHSYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKNDALIMLATQKNASDDDPAPGSIYEIGT
LASVLQLLKLPDGTVKVLVEGLARARVESYTDRTEYYEAQAQSIADTDAESVEAEALSRSVVSDFESYVKLNKKISAEVV
GVVQSITDFAKLGDTVASHLAVKIADRQGILETLSVTARLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
MKAIQKELGDDEGRDELADLEEKIAKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNYLDWLLSIPWNKKSKVKKDLE
AAQATLDSDHYGLEKVKERIVEYLAVQSRANKLSGPILCLVGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGH
RRTYIGSMPGKIIQSMRKAKTSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNSTFNDHYLEVDYDLSNVMFITTANT
LNIPGPLMDRMEIIRIAGYTENEKVEIARKHLIPLALTKHGLDSKEWSIDDDALLLMIRRYTREAGVRNLERELSTLARK
AVKDLMLSKKKSVKVTEKAIEEYLGVPKFRFGEIELEDQVGVVTGLAWTDVGGELLTIESVMMPGKGRMTVTGNLRDVMK
ESISAAASYVRSRAITFGIEPPFFERRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPIRRDIAMTGEITLRGRVLP
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGLNIIPVARMDEVIANALVRAPVPIVWEEETAAKIPGKPETS
EADEAAGGLTAH
>Mature_811_residues
TATKPRPTIVYGESHSYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKNDALIMLATQKNASDDDPAPGSIYEIGTL
ASVLQLLKLPDGTVKVLVEGLARARVESYTDRTEYYEAQAQSIADTDAESVEAEALSRSVVSDFESYVKLNKKISAEVVG
VVQSITDFAKLGDTVASHLAVKIADRQGILETLSVTARLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQM
KAIQKELGDDEGRDELADLEEKIAKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNYLDWLLSIPWNKKSKVKKDLEA
AQATLDSDHYGLEKVKERIVEYLAVQSRANKLSGPILCLVGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHR
RTYIGSMPGKIIQSMRKAKTSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNSTFNDHYLEVDYDLSNVMFITTANTL
NIPGPLMDRMEIIRIAGYTENEKVEIARKHLIPLALTKHGLDSKEWSIDDDALLLMIRRYTREAGVRNLERELSTLARKA
VKDLMLSKKKSVKVTEKAIEEYLGVPKFRFGEIELEDQVGVVTGLAWTDVGGELLTIESVMMPGKGRMTVTGNLRDVMKE
SISAAASYVRSRAITFGIEPPFFERRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPIRRDIAMTGEITLRGRVLPI
GGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGLNIIPVARMDEVIANALVRAPVPIVWEEETAAKIPGKPETSE
ADEAAGGLTAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=660, Percent_Identity=41.6666666666667, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=46.0035523978686, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=63.6125654450262, Blast_Score=1001, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=699, Percent_Identity=40.2002861230329, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17556486, Length=795, Percent_Identity=33.7106918238994, Blast_Score=441, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=706, Percent_Identity=41.3597733711048, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=653, Percent_Identity=43.4915773353752, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=653, Percent_Identity=43.4915773353752, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89505; Mature: 89374

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATKPRPTIVYGESHSYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKNDALIMLA
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEE
TQKNASDDDPAPGSIYEIGTLASVLQLLKLPDGTVKVLVEGLARARVESYTDRTEYYEAQ
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSIADTDAESVEAEALSRSVVSDFESYVKLNKKISAEVVGVVQSITDFAKLGDTVASHL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKIADRQGILETLSVTARLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
HEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDDEGRDELADLEEKIAKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LDWLLSIPWNKKSKVKKDLEAAQATLDSDHYGLEKVKERIVEYLAVQSRANKLSGPILCL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
ECCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHC
TSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNSTFNDHYLEVDYDLSNVMFITTANT
CCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCC
LNIPGPLMDRMEIIRIAGYTENEKVEIARKHLIPLALTKHGLDSKEWSIDDDALLLMIRR
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
YTREAGVRNLERELSTLARKAVKDLMLSKKKSVKVTEKAIEEYLGVPKFRFGEIELEDQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEECCEEECCCC
GVVTGLAWTDVGGELLTIESVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAITFGIE
CEEEEEEECCCCCCEEEEHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHEEECCC
PPFFERRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPIRRDIAMTGEITLRGRVLP
CCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEEEEEEE
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGLNIIPVARMDEVIANALVRAP
CCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCC
VPIVWEEETAAKIPGKPETSEADEAAGGLTAH
CCEEECCCCCCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TATKPRPTIVYGESHSYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKNDALIMLA
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEE
TQKNASDDDPAPGSIYEIGTLASVLQLLKLPDGTVKVLVEGLARARVESYTDRTEYYEAQ
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSIADTDAESVEAEALSRSVVSDFESYVKLNKKISAEVVGVVQSITDFAKLGDTVASHL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKIADRQGILETLSVTARLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
HEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDDEGRDELADLEEKIAKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LDWLLSIPWNKKSKVKKDLEAAQATLDSDHYGLEKVKERIVEYLAVQSRANKLSGPILCL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
ECCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHC
TSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNSTFNDHYLEVDYDLSNVMFITTANT
CCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCC
LNIPGPLMDRMEIIRIAGYTENEKVEIARKHLIPLALTKHGLDSKEWSIDDDALLLMIRR
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
YTREAGVRNLERELSTLARKAVKDLMLSKKKSVKVTEKAIEEYLGVPKFRFGEIELEDQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEECCEEECCCC
GVVTGLAWTDVGGELLTIESVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAITFGIE
CEEEEEEECCCCCCEEEEHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHEEECCC
PPFFERRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPIRRDIAMTGEITLRGRVLP
CCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEEEEEEE
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGLNIIPVARMDEVIANALVRAP
CCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCC
VPIVWEEETAAKIPGKPETSEADEAAGGLTAH
CCEEECCCCCCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA