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The map label for this gene is serA [H]

Identifier: 86749669

GI number: 86749669

Start: 2925184

End: 2926173

Strand: Direct

Name: serA [H]

Synonym: RPB_2550

Alternate gene names: 86749669

Gene position: 2925184-2926173 (Clockwise)

Preceding gene: 86749668

Following gene: 86749670

Centisome position: 54.86

GC content: 66.67

Gene sequence:

>990_bases
ATGACGACCAACAACAAGAAACTGCTGGTGACGGAATCGCTGTCGGAACGGGGAAGGGCGCTGTTCGCCGAGCGCGCCGA
CATCGAGGTGGTCGAATTCGACAACATGATCTCGGCCGCCGATTTCAACGCCTTGCTGCGGCATCACGCGCCGGTGCACG
GCGTCGCGCTCGGGGCGACGCGGTTCGGCGAGCCCGAACTCGATTCGTCGCAGGACATGAAAGTGGTGGCGCGGATCGGC
GTCGGCTACGACGCCATCGACGTGCCCGCGTTGTCGAAACGCAAGGTCCCGCTGATGGTCGCCGGCACCGCGAATTCCCC
CTCGGTCGCCGAACAGGCGCTGTTCATGATGCTGACGTTGGCGAAGCGCGGCGTCGAACTGCACGCGCTGGTGAAGACCG
GCGCCTGGGCGACGCGGCTGGCGCTGCTGCCGTTCGACCTGTTCGGCAAGACCGTGCTGATCGTCGGCTTCGGCCGGATC
GGCACCCGCACAGCCAAGCGCTGTCTCGCGATGGAAATGACCGTGCTGGTGTACGATCCCTACGTTCCCGCCGCGGCGAT
CGAAGCGGCCGGCTGCGAGCCCGTGGCCGATCTCGACGCCGCGCTGCCGGGTGCCGACTTCATCAGCCTGCATTGCCCGA
AGACGGCCGAGACCACCGGGCTGATCAACGCTGGCCGGCTGTCGAAGATGAAGCCGACCGCCTATCTGATCAACACCGCG
CGCGGCGGCATTGTGGTCGAGTCTGCGTTGTACGACGCGCTGGTCGCGGGCAGGCTCGCCGGCGCCGGGCTGGACGTGTT
CGAGGTCGAGCCGCCGCCGCTCGGTCACAAATTATTCGATCTGCCCAATGTGATCATCGCCCCGCACGTCGCCGGCGTCA
CCCGCGAGGCGCTCGACCGGATGGGCGAGCAGACCGCCCGCAACATGCTGAGCGCGCTCGATGGCGCTCCGATCGCGGCG
AATGTCATCAATCAGGACGTGCTCAGTTAG

Upstream 100 bases:

>100_bases
TGTTGCGTTTGGCGGTGGACCTCAACAATATGCACCTGATAGACGAGGGGACCGGCCTCGTGATCTGAAGGCCGGACAGA
GAGACGTCCACGGGGCCGGA

Downstream 100 bases:

>100_bases
TTGTTAGTCCATTGCGCCAATTCCGTCATTGCGAGGAGCGTAGCGACGAAGCAATCCAGCTCCGTGCACTGCGCCTCTGG
ATTGCTTCGCTTCGCTCGCA

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTTNNKKLLVTESLSERGRALFAERADIEVVEFDNMISAADFNALLRHHAPVHGVALGATRFGEPELDSSQDMKVVARIG
VGYDAIDVPALSKRKVPLMVAGTANSPSVAEQALFMMLTLAKRGVELHALVKTGAWATRLALLPFDLFGKTVLIVGFGRI
GTRTAKRCLAMEMTVLVYDPYVPAAAIEAAGCEPVADLDAALPGADFISLHCPKTAETTGLINAGRLSKMKPTAYLINTA
RGGIVVESALYDALVAGRLAGAGLDVFEVEPPPLGHKLFDLPNVIIAPHVAGVTREALDRMGEQTARNMLSALDGAPIAA
NVINQDVLS

Sequences:

>Translated_329_residues
MTTNNKKLLVTESLSERGRALFAERADIEVVEFDNMISAADFNALLRHHAPVHGVALGATRFGEPELDSSQDMKVVARIG
VGYDAIDVPALSKRKVPLMVAGTANSPSVAEQALFMMLTLAKRGVELHALVKTGAWATRLALLPFDLFGKTVLIVGFGRI
GTRTAKRCLAMEMTVLVYDPYVPAAAIEAAGCEPVADLDAALPGADFISLHCPKTAETTGLINAGRLSKMKPTAYLINTA
RGGIVVESALYDALVAGRLAGAGLDVFEVEPPPLGHKLFDLPNVIIAPHVAGVTREALDRMGEQTARNMLSALDGAPIAA
NVINQDVLS
>Mature_328_residues
TTNNKKLLVTESLSERGRALFAERADIEVVEFDNMISAADFNALLRHHAPVHGVALGATRFGEPELDSSQDMKVVARIGV
GYDAIDVPALSKRKVPLMVAGTANSPSVAEQALFMMLTLAKRGVELHALVKTGAWATRLALLPFDLFGKTVLIVGFGRIG
TRTAKRCLAMEMTVLVYDPYVPAAAIEAAGCEPVADLDAALPGADFISLHCPKTAETTGLINAGRLSKMKPTAYLINTAR
GGIVVESALYDALVAGRLAGAGLDVFEVEPPPLGHKLFDLPNVIIAPHVAGVTREALDRMGEQTARNMLSALDGAPIAAN
VINQDVLS

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=326, Percent_Identity=33.1288343558282, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=32.967032967033, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=32.967032967033, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI6912396, Length=326, Percent_Identity=33.1288343558282, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=31.9066147859922, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=31.9066147859922, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=31.9066147859922, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI87082289, Length=264, Percent_Identity=35.6060606060606, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789279, Length=259, Percent_Identity=32.046332046332, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=29.3893129770992, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081824, Length=241, Percent_Identity=30.2904564315353, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=247, Percent_Identity=38.8663967611336, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=299, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=324, Percent_Identity=30.5555555555556, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=324, Percent_Identity=29.9382716049383, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=31.0344827586207, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=259, Percent_Identity=32.4324324324324, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=187, Percent_Identity=32.620320855615, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=148, Percent_Identity=31.7567567567568, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=266, Percent_Identity=36.0902255639098, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28571528, Length=256, Percent_Identity=37.5, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI45552429, Length=273, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45551003, Length=273, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585514, Length=273, Percent_Identity=32.6007326007326, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574282, Length=273, Percent_Identity=32.6007326007326, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574284, Length=273, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=249, Percent_Identity=33.7349397590361, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24646446, Length=316, Percent_Identity=30.0632911392405, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=316, Percent_Identity=30.0632911392405, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=316, Percent_Identity=30.0632911392405, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=316, Percent_Identity=30.0632911392405, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=31.6176470588235, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24585516, Length=249, Percent_Identity=27.3092369477912, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34845; Mature: 34714

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNNKKLLVTESLSERGRALFAERADIEVVEFDNMISAADFNALLRHHAPVHGVALGAT
CCCCCCEEEEECCHHHCCCEEEHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCC
RFGEPELDSSQDMKVVARIGVGYDAIDVPALSKRKVPLMVAGTANSPSVAEQALFMMLTL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
AKRGVELHALVKTGAWATRLALLPFDLFGKTVLIVGFGRIGTRTAKRCLAMEMTVLVYDP
HHCCCEEEEEECCCCHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHHHHHHEEEEEEECC
YVPAAAIEAAGCEPVADLDAALPGADFISLHCPKTAETTGLINAGRLSKMKPTAYLINTA
CCCHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECC
RGGIVVESALYDALVAGRLAGAGLDVFEVEPPPLGHKLFDLPNVIIAPHVAGVTREALDR
CCCEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCCEEECCCHHHHHHHHHHH
MGEQTARNMLSALDGAPIAANVINQDVLS
HHHHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTNNKKLLVTESLSERGRALFAERADIEVVEFDNMISAADFNALLRHHAPVHGVALGAT
CCCCCEEEEECCHHHCCCEEEHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCC
RFGEPELDSSQDMKVVARIGVGYDAIDVPALSKRKVPLMVAGTANSPSVAEQALFMMLTL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
AKRGVELHALVKTGAWATRLALLPFDLFGKTVLIVGFGRIGTRTAKRCLAMEMTVLVYDP
HHCCCEEEEEECCCCHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHHHHHHEEEEEEECC
YVPAAAIEAAGCEPVADLDAALPGADFISLHCPKTAETTGLINAGRLSKMKPTAYLINTA
CCCHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECC
RGGIVVESALYDALVAGRLAGAGLDVFEVEPPPLGHKLFDLPNVIIAPHVAGVTREALDR
CCCEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCCEEECCCHHHHHHHHHHH
MGEQTARNMLSALDGAPIAANVINQDVLS
HHHHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]