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The map label for this gene is ipdC [H]

Identifier: 86749545

GI number: 86749545

Start: 2781519

End: 2783150

Strand: Direct

Name: ipdC [H]

Synonym: RPB_2425

Alternate gene names: 86749545

Gene position: 2781519-2783150 (Clockwise)

Preceding gene: 86749540

Following gene: 86749546

Centisome position: 52.17

GC content: 67.89

Gene sequence:

>1632_bases
ATGCCGACGCTTGCGACCGCTTTGCTCGACGCTCTCAAGGATCACGGCGCCAAGGAGATCTTCGGCATCCCCGGCGATTT
CGTGCTGCCGTTCTTCAAGGTGATCGAGGAGAGCGGAAGCCTGCCTTATTTCACGCTGAGCCACGAGCCGGCGGTCGGCT
TCGCGGCGGATGCGGCGTCGCGCTACCGCGGCGGTATCGGCGTCGCAGTGGTGACCTACGGCGCCGGCGCGTTCAATCTG
GTCAATTCGATCGCTGGCGCTTACGCGGAGCGCTCGCCGGTGGTGGTGATCGCCGGCGCGCCCGGCGCGCGCGAACGCAC
CAGTGGCTATCTGCTGCACCATCAGGTCCGCACCGTCGACACGCAACTCGCGGTGTTCAAGGAAGTCACCTGCGCGCAGG
CGGTGCTGAACGATCCCGCCACCGCGCCGGCCGAGATCGCCCGCGTGCTGCGCAGCTCGCTGGAACTGTCGCTGCCGGTC
TACATCGAATTCCCCCGCGACATGGTCGACGCCAAGGTCGAGCCGGTCGAGAAGCTGCCGCAGCGGGCGGCCGACCCCGG
CGCGTGCGCCGAATGTTCCGAGGAAATTCTTGACCGGATCGCCAAGGCCAAGTCGCCGGTGGTCGTGGTCGACGTCGAAA
TCCGCCGCTACGGCGTCGAGAAGCAGGTCGCCGCACTGGCGCGCAAGCTCGGCCTGCCGGTGGTGACGACGTTCATGGGC
CGCGGGCTGCTCGAAGGCGACGACGACGTCGTTGCCGGCACCTATATGGGCGCCGCCGGCGATCCCGGCCTGTCGGCGCT
GGTAGAAGAGTCCGACCTGGTGCTGATGTTCGGGGTGATCCTGTCCGACACCAATTTCGCGCTGTCGACCAACATGACCG
ATCCGCGCCGCACCGTGCTCGCCACCGGGCGCGAGGTGCAGATCGGCCATCACGTCTATCGTGACCTGCCGCTGGCGGAT
CTGATCGCCGGGCTCGACGCTCACGCCACGGCGCATCCGCCGCGACCGCGCAATGCTGGGCAGGGCATGGTCTATCCGCG
CAAGCTGGTCGCCGATTCCGGCGCGATCGCACCGTCCGATATCGCCACCGCGATCAACGACCTGTTCGACAAGCACGGCA
AGATGCCGATGACCGCCGACATCGGCGACTGCCTGTTCACCGCGATGGAGATCGACAACACCGCGCTGGCGGCGCCGGGC
TACTACGCCGGCATGGGCTTCGGCGTGCCGGCGGGCGTCGGCGTCGCCGCCACCGGGTTGCGGCCGCTGATCCTGGTCGG
CGACGGCGCGTTCCAGATGACCGGCTGGGAGCTCGGCAATTGTAAGCGCTACGGCCTCGATCCGATCGTGGTGCTGTTCA
ACAATTGCAGCTGGGAGATGCTGCGGGTGTTCCAGCCGGAGTCGAAGTTCAACGATCTCGACGACTGGCACTTCGCCGAC
ATCGCGCCGTCGATCGGCGGCCACGGCGTGCGCGTCACCACCCGCGCCGAACTCGCCGCGGCGCTCGATGCCGCCGTCGC
GCGGCGCGGGCAGTTCTCGCTGATCGAAGTGATGCTGCCGCGTGGCGCCACCTCGCATACGCTGGCGCGGTTCGTCAAAG
GCTTCAAGGCCGCGCGCGAGCGGATGAAGTGA

Upstream 100 bases:

>100_bases
AACAGAGGCCCGGTGTATCGCGACCGCTCGCGATGTTGGTCGAAGGTCGCGGCTCTGGTAAAGCGGTGCGGTCTATCCCG
CGCGACGCTCAGGAGCCGCC

Downstream 100 bases:

>100_bases
GCGCCTGAGCATGATGCGCCGCCTCGCGCTTGCGTGCTTCGGCATGGTGCTGGCGACGGCGGCGCGCGCGCAGCCGCTGC
CCGACGATTTCGTCTATCTG

Product: indole-3-pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MPTLATALLDALKDHGAKEIFGIPGDFVLPFFKVIEESGSLPYFTLSHEPAVGFAADAASRYRGGIGVAVVTYGAGAFNL
VNSIAGAYAERSPVVVIAGAPGARERTSGYLLHHQVRTVDTQLAVFKEVTCAQAVLNDPATAPAEIARVLRSSLELSLPV
YIEFPRDMVDAKVEPVEKLPQRAADPGACAECSEEILDRIAKAKSPVVVVDVEIRRYGVEKQVAALARKLGLPVVTTFMG
RGLLEGDDDVVAGTYMGAAGDPGLSALVEESDLVLMFGVILSDTNFALSTNMTDPRRTVLATGREVQIGHHVYRDLPLAD
LIAGLDAHATAHPPRPRNAGQGMVYPRKLVADSGAIAPSDIATAINDLFDKHGKMPMTADIGDCLFTAMEIDNTALAAPG
YYAGMGFGVPAGVGVAATGLRPLILVGDGAFQMTGWELGNCKRYGLDPIVVLFNNCSWEMLRVFQPESKFNDLDDWHFAD
IAPSIGGHGVRVTTRAELAAALDAAVARRGQFSLIEVMLPRGATSHTLARFVKGFKAARERMK

Sequences:

>Translated_543_residues
MPTLATALLDALKDHGAKEIFGIPGDFVLPFFKVIEESGSLPYFTLSHEPAVGFAADAASRYRGGIGVAVVTYGAGAFNL
VNSIAGAYAERSPVVVIAGAPGARERTSGYLLHHQVRTVDTQLAVFKEVTCAQAVLNDPATAPAEIARVLRSSLELSLPV
YIEFPRDMVDAKVEPVEKLPQRAADPGACAECSEEILDRIAKAKSPVVVVDVEIRRYGVEKQVAALARKLGLPVVTTFMG
RGLLEGDDDVVAGTYMGAAGDPGLSALVEESDLVLMFGVILSDTNFALSTNMTDPRRTVLATGREVQIGHHVYRDLPLAD
LIAGLDAHATAHPPRPRNAGQGMVYPRKLVADSGAIAPSDIATAINDLFDKHGKMPMTADIGDCLFTAMEIDNTALAAPG
YYAGMGFGVPAGVGVAATGLRPLILVGDGAFQMTGWELGNCKRYGLDPIVVLFNNCSWEMLRVFQPESKFNDLDDWHFAD
IAPSIGGHGVRVTTRAELAAALDAAVARRGQFSLIEVMLPRGATSHTLARFVKGFKAARERMK
>Mature_542_residues
PTLATALLDALKDHGAKEIFGIPGDFVLPFFKVIEESGSLPYFTLSHEPAVGFAADAASRYRGGIGVAVVTYGAGAFNLV
NSIAGAYAERSPVVVIAGAPGARERTSGYLLHHQVRTVDTQLAVFKEVTCAQAVLNDPATAPAEIARVLRSSLELSLPVY
IEFPRDMVDAKVEPVEKLPQRAADPGACAECSEEILDRIAKAKSPVVVVDVEIRRYGVEKQVAALARKLGLPVVTTFMGR
GLLEGDDDVVAGTYMGAAGDPGLSALVEESDLVLMFGVILSDTNFALSTNMTDPRRTVLATGREVQIGHHVYRDLPLADL
IAGLDAHATAHPPRPRNAGQGMVYPRKLVADSGAIAPSDIATAINDLFDKHGKMPMTADIGDCLFTAMEIDNTALAAPGY
YAGMGFGVPAGVGVAATGLRPLILVGDGAFQMTGWELGNCKRYGLDPIVVLFNNCSWEMLRVFQPESKFNDLDDWHFADI
APSIGGHGVRVTTRAELAAALDAAVARRGQFSLIEVMLPRGATSHTLARFVKGFKAARERMK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=583, Percent_Identity=25.2144082332762, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=24.2201834862385, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786717, Length=566, Percent_Identity=23.6749116607774, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321524, Length=547, Percent_Identity=26.1425959780622, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323163, Length=547, Percent_Identity=26.3254113345521, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6323073, Length=552, Percent_Identity=26.268115942029, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320123, Length=564, Percent_Identity=24.468085106383, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6320588, Length=589, Percent_Identity=24.9575551782683, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 57796; Mature: 57665

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLATALLDALKDHGAKEIFGIPGDFVLPFFKVIEESGSLPYFTLSHEPAVGFAADAAS
CCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
RYRGGIGVAVVTYGAGAFNLVNSIAGAYAERSPVVVIAGAPGARERTSGYLLHHQVRTVD
HHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHH
TQLAVFKEVTCAQAVLNDPATAPAEIARVLRSSLELSLPVYIEFPRDMVDAKVEPVEKLP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCHHHHHH
QRAADPGACAECSEEILDRIAKAKSPVVVVDVEIRRYGVEKQVAALARKLGLPVVTTFMG
HHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCHHHHHHHHHHHHCCHHHHHHHC
RGLLEGDDDVVAGTYMGAAGDPGLSALVEESDLVLMFGVILSDTNFALSTNMTDPRRTVL
CCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEEEEHHHCCCCEEEECCCCCCCHHHH
ATGREVQIGHHVYRDLPLADLIAGLDAHATAHPPRPRNAGQGMVYPRKLVADSGAIAPSD
CCCCEEEECHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHH
IATAINDLFDKHGKMPMTADIGDCLFTAMEIDNTALAAPGYYAGMGFGVPAGVGVAATGL
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEECCCCHHCCCCCCCCCCCCHHCCC
RPLILVGDGAFQMTGWELGNCKRYGLDPIVVLFNNCSWEMLRVFQPESKFNDLDDWHFAD
CEEEEEECCCEEECCCCCCCCEECCCCEEEEEECCCCHHHHHEECCCHHCCCCCCCCHHH
IAPSIGGHGVRVTTRAELAAALDAAVARRGQFSLIEVMLPRGATSHTLARFVKGFKAARE
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
RMK
HCC
>Mature Secondary Structure 
PTLATALLDALKDHGAKEIFGIPGDFVLPFFKVIEESGSLPYFTLSHEPAVGFAADAAS
CHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
RYRGGIGVAVVTYGAGAFNLVNSIAGAYAERSPVVVIAGAPGARERTSGYLLHHQVRTVD
HHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHH
TQLAVFKEVTCAQAVLNDPATAPAEIARVLRSSLELSLPVYIEFPRDMVDAKVEPVEKLP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCHHHHHH
QRAADPGACAECSEEILDRIAKAKSPVVVVDVEIRRYGVEKQVAALARKLGLPVVTTFMG
HHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCHHHHHHHHHHHHCCHHHHHHHC
RGLLEGDDDVVAGTYMGAAGDPGLSALVEESDLVLMFGVILSDTNFALSTNMTDPRRTVL
CCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEEEEHHHCCCCEEEECCCCCCCHHHH
ATGREVQIGHHVYRDLPLADLIAGLDAHATAHPPRPRNAGQGMVYPRKLVADSGAIAPSD
CCCCEEEECHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHH
IATAINDLFDKHGKMPMTADIGDCLFTAMEIDNTALAAPGYYAGMGFGVPAGVGVAATGL
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEECCCCHHCCCCCCCCCCCCHHCCC
RPLILVGDGAFQMTGWELGNCKRYGLDPIVVLFNNCSWEMLRVFQPESKFNDLDDWHFAD
CEEEEEECCCEEECCCCCCCCEECCCCEEEEEECCCCHHHHHEECCCHHCCCCCCCCHHH
IAPSIGGHGVRVTTRAELAAALDAAVARRGQFSLIEVMLPRGATSHTLARFVKGFKAARE
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
RMK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]