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The map label for this gene is melC2 [H]

Identifier: 86749288

GI number: 86749288

Start: 2458560

End: 2459810

Strand: Reverse

Name: melC2 [H]

Synonym: RPB_2167

Alternate gene names: 86749288

Gene position: 2459810-2458560 (Counterclockwise)

Preceding gene: 86749289

Following gene: 86749287

Centisome position: 46.14

GC content: 67.39

Gene sequence:

>1251_bases
ATGCAGGTCCAAATCGATATTCCCGGTGAAGATGCCCAAGGTCGCGTGTTTCTCGGCTGGACGCCCGTTCAGGCCAGCGC
CCGGTTGTTGCAGGGTCCAGGTGCCGGCTCCGTCGACGTCGAGATCAGCAGCGCCGGCGCGGTCGGCGGGCTGGTGTTCG
ATACGGCGCGAACGCACAACGGCGGCTCGCGCCTGACGCTCGGCCTGCCGGGTGACGGCCGGCCGGTGACGTTCTTCGTC
GCGGGCGAATTCCTCAAGCCGAGTTCGCGTTACGGCGACGCCGCCATCGCCGTGAAGGACAAGGCCAGCGGCGCCCCGCT
CGCCAGCAAGCCGGTGATGGTGCGCATCCGCAAAAATGCGGTCACGTTGAGCCAGGAGGAGCGCGACGACTTCCTCGCCG
CGCTCGGCACCCTGAATGCGCGCGGCCAGGGTCCCTATCGTATCGTTCGCGATATGCACGACGCCGATTCGGATCTCGAA
ATCCATCGCAACGAAGGCTTCCTGCCGTGGCACCGCGCCTACGTGCTCGGGCTCGAGCGCGCGCTCCAGGCGATCAACCC
GGTGGTGACGCTGCCCTATTGGCAGTTCGACGCGCCCGCGCCTGTGCTCTTCACCATCGACTACATGGGACGATCCGACG
AATCCGGCCACGTCGTTTTCCGGCCCGGGCACTCGCTCGAGCACTGGGTGGCGAAGGATACGCCCGGGATCGTCCGCGTG
CCGCGATTTGCGTCCGACGCTCCGGCGCTGGTCATCAGCGAAGACGATACGATCAGGCTCGGCGGGGCGACAGCCGATTT
CGCCCTGTTTCGGCAAATGGAGGGCGGGCCGCACGGTCAGGCGCACAACAGCTTTGCCGCCCCCAGCCCGCTCAGGTACC
CCGCCCTCGCCGTCTATGATCCTTTGTTCTTCCTGCTCCACTGCAATGTCGACCGGCTGTGGACGAAATGGCAGTGGATC
AAGCACCGCACGGACAGCTCCGACCGGCTCGCCTACAGCGACGGCACGCGCGCCGGCACCAAGCGCGGCGACACGATGTG
GCCGTGGAATGGCATCCACGGCAATCCGCGGCCGCCGACTGCACCGGGCGGACCGTTTCCTCCGACCAGTACCACGCCGG
CGCCGGGCCGCACGCCAAGGGTCAGCGACATGCTCGATGCGATGGCGCTCAAGGCGCCCGATCCGCTCGGCTTCGCCTAC
GACGACGTGCCGTTCCAGCTGCCGCCGACCGTGGTTGCAGGTCATGCCTAG

Upstream 100 bases:

>100_bases
TTGCTGCGCTTATGTGTGCGTCGCGGAAAATCCGCGACCTGTTACCTTGTTCGATTGCCTCGCGATTATTTTCAGCCGCT
TGCGCGTGGAGAACCGCGAC

Downstream 100 bases:

>100_bases
CCTGACTACGTGAACCGAAGACGGCCGAGCCGAAGCGCCTCGAACGCGGAGCCATTGCGATGGACGTCGAACAATATCGA
AGGGACTACGAAGCCCGATT

Product: tyrosinase

Products: NA

Alternate protein names: Monophenol monooxygenase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MQVQIDIPGEDAQGRVFLGWTPVQASARLLQGPGAGSVDVEISSAGAVGGLVFDTARTHNGGSRLTLGLPGDGRPVTFFV
AGEFLKPSSRYGDAAIAVKDKASGAPLASKPVMVRIRKNAVTLSQEERDDFLAALGTLNARGQGPYRIVRDMHDADSDLE
IHRNEGFLPWHRAYVLGLERALQAINPVVTLPYWQFDAPAPVLFTIDYMGRSDESGHVVFRPGHSLEHWVAKDTPGIVRV
PRFASDAPALVISEDDTIRLGGATADFALFRQMEGGPHGQAHNSFAAPSPLRYPALAVYDPLFFLLHCNVDRLWTKWQWI
KHRTDSSDRLAYSDGTRAGTKRGDTMWPWNGIHGNPRPPTAPGGPFPPTSTTPAPGRTPRVSDMLDAMALKAPDPLGFAY
DDVPFQLPPTVVAGHA

Sequences:

>Translated_416_residues
MQVQIDIPGEDAQGRVFLGWTPVQASARLLQGPGAGSVDVEISSAGAVGGLVFDTARTHNGGSRLTLGLPGDGRPVTFFV
AGEFLKPSSRYGDAAIAVKDKASGAPLASKPVMVRIRKNAVTLSQEERDDFLAALGTLNARGQGPYRIVRDMHDADSDLE
IHRNEGFLPWHRAYVLGLERALQAINPVVTLPYWQFDAPAPVLFTIDYMGRSDESGHVVFRPGHSLEHWVAKDTPGIVRV
PRFASDAPALVISEDDTIRLGGATADFALFRQMEGGPHGQAHNSFAAPSPLRYPALAVYDPLFFLLHCNVDRLWTKWQWI
KHRTDSSDRLAYSDGTRAGTKRGDTMWPWNGIHGNPRPPTAPGGPFPPTSTTPAPGRTPRVSDMLDAMALKAPDPLGFAY
DDVPFQLPPTVVAGHA
>Mature_416_residues
MQVQIDIPGEDAQGRVFLGWTPVQASARLLQGPGAGSVDVEISSAGAVGGLVFDTARTHNGGSRLTLGLPGDGRPVTFFV
AGEFLKPSSRYGDAAIAVKDKASGAPLASKPVMVRIRKNAVTLSQEERDDFLAALGTLNARGQGPYRIVRDMHDADSDLE
IHRNEGFLPWHRAYVLGLERALQAINPVVTLPYWQFDAPAPVLFTIDYMGRSDESGHVVFRPGHSLEHWVAKDTPGIVRV
PRFASDAPALVISEDDTIRLGGATADFALFRQMEGGPHGQAHNSFAAPSPLRYPALAVYDPLFFLLHCNVDRLWTKWQWI
KHRTDSSDRLAYSDGTRAGTKRGDTMWPWNGIHGNPRPPTAPGGPFPPTSTTPAPGRTPRVSDMLDAMALKAPDPLGFAY
DDVPFQLPPTVVAGHA

Specific function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tyrosinase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17551924, Length=249, Percent_Identity=26.1044176706827, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193202602, Length=250, Percent_Identity=26.8, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008922
- InterPro:   IPR002227 [H]

Pfam domain/function: PF00264 Tyrosinase [H]

EC number: =1.14.18.1 [H]

Molecular weight: Translated: 45030; Mature: 45030

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00497 TYROSINASE_1 ; PS00498 TYROSINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVQIDIPGEDAQGRVFLGWTPVQASARLLQGPGAGSVDVEISSAGAVGGLVFDTARTHN
CEEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCC
GGSRLTLGLPGDGRPVTFFVAGEFLKPSSRYGDAAIAVKDKASGAPLASKPVMVRIRKNA
CCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCE
VTLSQEERDDFLAALGTLNARGQGPYRIVRDMHDADSDLEIHRNEGFLPWHRAYVLGLER
EEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHH
ALQAINPVVTLPYWQFDAPAPVLFTIDYMGRSDESGHVVFRPGHSLEHWVAKDTPGIVRV
HHHHCCCEEECCEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHCCCCCEEEC
PRFASDAPALVISEDDTIRLGGATADFALFRQMEGGPHGQAHNSFAAPSPLRYPALAVYD
CCCCCCCCEEEEECCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
PLFFLLHCNVDRLWTKWQWIKHRTDSSDRLAYSDGTRAGTKRGDTMWPWNGIHGNPRPPT
HEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
APGGPFPPTSTTPAPGRTPRVSDMLDAMALKAPDPLGFAYDDVPFQLPPTVVAGHA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MQVQIDIPGEDAQGRVFLGWTPVQASARLLQGPGAGSVDVEISSAGAVGGLVFDTARTHN
CEEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCC
GGSRLTLGLPGDGRPVTFFVAGEFLKPSSRYGDAAIAVKDKASGAPLASKPVMVRIRKNA
CCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCE
VTLSQEERDDFLAALGTLNARGQGPYRIVRDMHDADSDLEIHRNEGFLPWHRAYVLGLER
EEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHH
ALQAINPVVTLPYWQFDAPAPVLFTIDYMGRSDESGHVVFRPGHSLEHWVAKDTPGIVRV
HHHHCCCEEECCEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHCCCCCEEEC
PRFASDAPALVISEDDTIRLGGATADFALFRQMEGGPHGQAHNSFAAPSPLRYPALAVYD
CCCCCCCCEEEEECCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
PLFFLLHCNVDRLWTKWQWIKHRTDSSDRLAYSDGTRAGTKRGDTMWPWNGIHGNPRPPT
HEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
APGGPFPPTSTTPAPGRTPRVSDMLDAMALKAPDPLGFAYDDVPFQLPPTVVAGHA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3932128 [H]