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The map label for this gene is crt [H]

Identifier: 86749236

GI number: 86749236

Start: 2406794

End: 2407639

Strand: Reverse

Name: crt [H]

Synonym: RPB_2115

Alternate gene names: 86749236

Gene position: 2407639-2406794 (Counterclockwise)

Preceding gene: 86749245

Following gene: 86749234

Centisome position: 45.16

GC content: 69.03

Gene sequence:

>846_bases
ATGCGGATGATCAACTCCCATTGCGGCGTGGCCGCCGACGATCGCGGCGTCGTCCGGCTGACGATCTGCGACGCCGGGCC
GCTCAACATCCTGAATTCGCAGGTGATCGACGCGGTGCGCCAGGGTGTCGCGCAACTCGCAGCCGATGCGTCGAACCGCG
TGCTGATCCTCGCCGGCGAAAGCGGCCGCAGCATGATCGGCGGCGCCGACATCAAGGAAATGGCGACGCTGGATCAGGCC
TCCGCCGAGCGTTTCATCACCGGGCTCGCCGATCTGTGCGAAACGATACGCACCGTGCCGTATCCGGTGATCGCGCGAAT
CCCGGGCTGGTGCCTCGGCGGCGGGCTGGAAGTCGCCGCCGCCTGCGACTTCCGCGTCGCCACCGCGGACGCGAAATTCG
CCATGCCGGAGGTGCGGGTCGGGATTCCCTCGGTGATCCACGCCGCGCTGCTGCCGCGGCTGATCGGCTGGAGCCGCACC
CGCTGGCTGCTGATGACCGGCGACACGATCGACGCGCCGACCGCGCTGGGCTGGGGCCTGATCGACAAGATCGCGCCGCC
GGACGCGCTCGACGACGCCGTCGAGAGCCTGGTCGCCTCGCTGCTCGCCGGCGCGCCGCAGGCGCTTCGGGCGCAGAAGG
CGCTGCTGACCGCGTGGCACGATATGCCACTGCGCGAGTCGGTCGAACTCTCGGTCAAGGTGTTCGGGGAATCCTACCTC
ACCGGCGAACCGCAGAGGCTGATGGGCGAATTCCTCAACCGGAAGCGGCGAGGCGGCGACGGCGGATCTTCAGCCGCTCG
GTCTACGTCAGCCACCGCGCCCGATGAAGCGCAACAGTTGACGTAG

Upstream 100 bases:

>100_bases
ACGCCACCGCCGAAACCGCCGACCGGGCGGCTGCGCTTGACAAACAGCCGGCTTCGCCGGGACATGCGCCTCGGGGAAAC
GTGAGAAGAGCCAAAAAGCC

Downstream 100 bases:

>100_bases
GCGATCAGAACCGGATTCCTGCGCCTCGCATCGCACGCGTCGCGGATGATCGCAGCACATGAAACGTCATCGGTTCAGAA
CCTCAATCGGCCTGTCGGAT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRMINSHCGVAADDRGVVRLTICDAGPLNILNSQVIDAVRQGVAQLAADASNRVLILAGESGRSMIGGADIKEMATLDQA
SAERFITGLADLCETIRTVPYPVIARIPGWCLGGGLEVAAACDFRVATADAKFAMPEVRVGIPSVIHAALLPRLIGWSRT
RWLLMTGDTIDAPTALGWGLIDKIAPPDALDDAVESLVASLLAGAPQALRAQKALLTAWHDMPLRESVELSVKVFGESYL
TGEPQRLMGEFLNRKRRGGDGGSSAARSTSATAPDEAQQLT

Sequences:

>Translated_281_residues
MRMINSHCGVAADDRGVVRLTICDAGPLNILNSQVIDAVRQGVAQLAADASNRVLILAGESGRSMIGGADIKEMATLDQA
SAERFITGLADLCETIRTVPYPVIARIPGWCLGGGLEVAAACDFRVATADAKFAMPEVRVGIPSVIHAALLPRLIGWSRT
RWLLMTGDTIDAPTALGWGLIDKIAPPDALDDAVESLVASLLAGAPQALRAQKALLTAWHDMPLRESVELSVKVFGESYL
TGEPQRLMGEFLNRKRRGGDGGSSAARSTSATAPDEAQQLT
>Mature_281_residues
MRMINSHCGVAADDRGVVRLTICDAGPLNILNSQVIDAVRQGVAQLAADASNRVLILAGESGRSMIGGADIKEMATLDQA
SAERFITGLADLCETIRTVPYPVIARIPGWCLGGGLEVAAACDFRVATADAKFAMPEVRVGIPSVIHAALLPRLIGWSRT
RWLLMTGDTIDAPTALGWGLIDKIAPPDALDDAVESLVASLLAGAPQALRAQKALLTAWHDMPLRESVELSVKVFGESYL
TGEPQRLMGEFLNRKRRGGDGGSSAARSTSATAPDEAQQLT

Specific function: Unknown

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=232, Percent_Identity=29.3103448275862, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI68989263, Length=170, Percent_Identity=31.7647058823529, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4502327, Length=250, Percent_Identity=29.2, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI70995211, Length=234, Percent_Identity=27.3504273504274, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI20127408, Length=185, Percent_Identity=30.2702702702703, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI31542718, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788682, Length=174, Percent_Identity=35.632183908046, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI221142681, Length=180, Percent_Identity=32.7777777777778, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788597, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790281, Length=193, Percent_Identity=25.9067357512953, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082183, Length=193, Percent_Identity=26.4248704663212, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17540714, Length=183, Percent_Identity=32.2404371584699, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25145438, Length=242, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17560910, Length=252, Percent_Identity=29.3650793650794, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=245, Percent_Identity=25.7142857142857, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=169, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=233, Percent_Identity=26.6094420600858, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=228, Percent_Identity=25.8771929824561, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=183, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=28.5140562248996, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=28.5140562248996, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24653139, Length=190, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922422, Length=246, Percent_Identity=20.7317073170732, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357171, Length=198, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920382, Length=207, Percent_Identity=28.0193236714976, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921000, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583077, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583079, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 29695; Mature: 29695

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMINSHCGVAADDRGVVRLTICDAGPLNILNSQVIDAVRQGVAQLAADASNRVLILAGE
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
SGRSMIGGADIKEMATLDQASAERFITGLADLCETIRTVPYPVIARIPGWCLGGGLEVAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCEEEE
ACDFRVATADAKFAMPEVRVGIPSVIHAALLPRLIGWSRTRWLLMTGDTIDAPTALGWGL
ECCEEEEECCCHHCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
IDKIAPPDALDDAVESLVASLLAGAPQALRAQKALLTAWHDMPLRESVELSVKVFGESYL
HHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHC
TGEPQRLMGEFLNRKRRGGDGGSSAARSTSATAPDEAQQLT
CCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure
MRMINSHCGVAADDRGVVRLTICDAGPLNILNSQVIDAVRQGVAQLAADASNRVLILAGE
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
SGRSMIGGADIKEMATLDQASAERFITGLADLCETIRTVPYPVIARIPGWCLGGGLEVAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCEEEE
ACDFRVATADAKFAMPEVRVGIPSVIHAALLPRLIGWSRTRWLLMTGDTIDAPTALGWGL
ECCEEEEECCCHHCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
IDKIAPPDALDDAVESLVASLLAGAPQALRAQKALLTAWHDMPLRESVELSVKVFGESYL
HHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHC
TGEPQRLMGEFLNRKRRGGDGGSSAARSTSATAPDEAQQLT
CCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]