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The map label for this gene is groEL [H]

Identifier: 86748959

GI number: 86748959

Start: 2102255

End: 2103907

Strand: Reverse

Name: groEL [H]

Synonym: RPB_1836

Alternate gene names: 86748959

Gene position: 2103907-2102255 (Counterclockwise)

Preceding gene: 86748960

Following gene: 86748958

Centisome position: 39.46

GC content: 66.24

Gene sequence:

>1653_bases
ATGTCAGCCAAGGACGTCAAATTCGGTGGAGACGCGCGCGATCGGATGCTGCGCGGCGTCGACATCCTCGCCAATGCGGT
CAAGGTCACGCTCGGCCCGAAGGGCCGGAACGTGCTGATCGAGAAGAGCTTCGGCGCTCCCCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAGATCGAGCTCGACGACAAGTTCGAGAACATGGGCGCGCAGATGCTGCGCGAAGTCGCCTCCAAG
ACCAACGACCTCGCCGGTGACGGCACCACCACAGCGACCGTGCTGGCCCAGGCGATCGTCCGCGAAGGCGCCAAGTCGGT
GGCCGCCGGCATGAACCCGATGGATCTGCGCCGCGGCATCGAGATCGCGGTCCAGGCCGTGGTCAAGGACATCCAGAAGC
GCGCCCGTCCGGTCGCCTCCTCGGCCGAGATCGCCCAGGTCGGTACCATCTCGGCCAATGGCGACGCGCCGATCGGCAAG
ATGATCGCCCAGGCGATGCAGAAGGTCGGCAACGAGGGCGTCATCACCGTCGAAGAGAACAAGTCGCTCGAGACCGAAGT
CGACATCGTCGAGGGCATGAAGTTCGATCGCGGCTACCTGTCGCCCTATTTCGTCACCAACGCCGAGAAGATGACCGTCG
AGCTCGACGACGTCTACATCCTGCTGCACGAGAAGAAGGTGTCGGGCCTGCAGTCGATGCTGCCGGTGCTCGAAGCCGTG
GTGCAGTCTGGCAAGCCGCTGCTGATCATCGCCGAGGATGTCGAAGGCGAAGCGCTGGCGACGCTGGTGGTCAACCGGCT
GCGCGGCGGCCTCAAGGTCTCGGCCGTCAAGGCGCCGGGCTTCGGCGATCGCCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACCGGCGGTCAGCTGATCTCGGAAGAAATCGGCATCAAGCTCGAGAGCGTCACGCTGAAGATGCTCGGCCGCGCC
AAGAAGGTGGTGATCGACAAGGAGAACACCACCATCGTCGGCGGCGCCGGCAAGAAGCCGGACATCGAGGCCCGCGTCCA
GCAGATCAAGGCGCAGATCGAGGAGACCTCCTCGGACTACGACCGTGAGAAGCTGCAGGAGCGTCTGGCCAAGCTCGCCG
GCGGCGTCGCGGTGATCCGCGTCGGCGGCGCCACCGAGGTCGAGGTCAAGGAGAAGAAGGACCGTGTCGAGGACGCGCTG
AACGCGACCCGCGCCGCGGTGCAGGAAGGCATCGTCCCGGGCGGCGGCGTCGCGCTGCTGCGCGCCAAGAAGGCGGTCGG
CCGCATCCACAACGACAATGCCGACGTCCAGGCCGGCATCAACATCGTGCTGAAGGCGCTGGAAGCTCCGATCCGCCAGA
TCGCCGAGAACGCCGGCGTCGAAGGCTCGATCGTGGTCGGCAAGATCCTCGAGAACAAGTCGGAGACGTTCGGCTTCGAC
GCCCAGACCGAGGACTATGTCGACATGCTCGCCAAGGGCATCGTCGATCCGGCCAAGGTGGTCCGCACCGCGCTGCAGGA
CGCCTCGTCGGTCGCGGCGCTGCTGGTGACCACCGAAGCCATGGTCGCCGAACTGCCGAAGGAAGCCGCGCCGGCGATGC
CGGGTGGCGGCGGCATGGGCGGAATGGGGGGCATGGGCGGCATGGGCTTCTGA

Upstream 100 bases:

>100_bases
AGATCAAGCTCGACGGCCAGGAGCTCCTGATCATGAAGGAGTCGGACATCATGGGCGTGGTCGGCTGATCACCTCGCAAC
AGACATCAGGAGCAAATTGA

Downstream 100 bases:

>100_bases
GCCCTCGCGCCTCGCCTCTCCCACCGATATCGATCACGCAAGGCCGCCTCCGGGCGGCCTTGTTTTTTGGCGCCCGCCCG
GCGGATTTGCTAGTCAGGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MSAKDVKFGGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEIELDDKFENMGAQMLREVASK
TNDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGIEIAVQAVVKDIQKRARPVASSAEIAQVGTISANGDAPIGK
MIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAV
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEEIGIKLESVTLKMLGRA
KKVVIDKENTTIVGGAGKKPDIEARVQQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDAL
NATRAAVQEGIVPGGGVALLRAKKAVGRIHNDNADVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKSETFGFD
AQTEDYVDMLAKGIVDPAKVVRTALQDASSVAALLVTTEAMVAELPKEAAPAMPGGGGMGGMGGMGGMGF

Sequences:

>Translated_550_residues
MSAKDVKFGGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEIELDDKFENMGAQMLREVASK
TNDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGIEIAVQAVVKDIQKRARPVASSAEIAQVGTISANGDAPIGK
MIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAV
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEEIGIKLESVTLKMLGRA
KKVVIDKENTTIVGGAGKKPDIEARVQQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDAL
NATRAAVQEGIVPGGGVALLRAKKAVGRIHNDNADVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKSETFGFD
AQTEDYVDMLAKGIVDPAKVVRTALQDASSVAALLVTTEAMVAELPKEAAPAMPGGGGMGGMGGMGGMGF
>Mature_549_residues
SAKDVKFGGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEIELDDKFENMGAQMLREVASKT
NDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGIEIAVQAVVKDIQKRARPVASSAEIAQVGTISANGDAPIGKM
IAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAVV
QSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEEIGIKLESVTLKMLGRAK
KVVIDKENTTIVGGAGKKPDIEARVQQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALN
ATRAAVQEGIVPGGGVALLRAKKAVGRIHNDNADVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKSETFGFDA
QTEDYVDMLAKGIVDPAKVVRTALQDASSVAALLVTTEAMVAELPKEAAPAMPGGGGMGGMGGMGGMGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=56.1669829222011, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=56.1669829222011, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI5453607, Length=534, Percent_Identity=22.8464419475655, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=65.4716981132075, Blast_Score=683, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.820415879017, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=55.9241706161137, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17564182, Length=545, Percent_Identity=22.5688073394495, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.8441064638783, Blast_Score=602, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=56.9259962049336, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=56.9259962049336, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=52.9411764705882, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=52.9411764705882, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=52.9411764705882, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI17864606, Length=555, Percent_Identity=46.1261261261261, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=38.1308411214953, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=38.1308411214953, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24645179, Length=501, Percent_Identity=22.7544910179641, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57979; Mature: 57848

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDVKFGGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEC
ELDDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EIAVQAVVKDIQKRARPVASSAEIAQVGTISANGDAPIGKMIAQAMQKVGNEGVITVEEN
HHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECC
KSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAV
CCCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCEEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEEIGIKLESVTLKMLGRAKKVVIDKENTTIVGGAGKKPDIEARVQQIKAQIEETSSDY
HHHHHCCEEHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVGRIHNDNADVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKSETFGFD
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCC
AQTEDYVDMLAKGIVDPAKVVRTALQDASSVAALLVTTEAMVAELPKEAAPAMPGGGGMG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
GMGGMGGMGF
CCCCCCCCCC
>Mature Secondary Structure 
SAKDVKFGGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEC
ELDDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EIAVQAVVKDIQKRARPVASSAEIAQVGTISANGDAPIGKMIAQAMQKVGNEGVITVEEN
HHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECC
KSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAV
CCCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCEEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEEIGIKLESVTLKMLGRAKKVVIDKENTTIVGGAGKKPDIEARVQQIKAQIEETSSDY
HHHHHCCEEHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVGRIHNDNADVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKSETFGFD
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCC
AQTEDYVDMLAKGIVDPAKVVRTALQDASSVAALLVTTEAMVAELPKEAAPAMPGGGGMG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
GMGGMGGMGF
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA